Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms (Q36993953)

17 August 2017

Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms (English)

1 reference

17 August 2017

2

Roger G Ptak

1 reference

17 August 2017

Philippe A Gallay

1

1 reference

17 August 2017

Michael D Bobardt

3

1 reference

17 August 2017

Jean-Maurice Dumont

4

1 reference

17 August 2017

Grégoire Vuagniaux

5

1 reference

17 August 2017

Brigitte Rosenwirth

6

1 reference

17 August 2017

language of work or name

1 reference

22 March 2013

1 reference

17 August 2017

1 reference

17 August 2017

5

1 reference

17 August 2017

3

1 reference

17 August 2017

981-997

1 reference

Creative Commons Attribution 4.0 International

17 August 2017

start time

22 March 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

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Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

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29 September 2017

Cyclophilin inhibitors

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Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

29 September 2017

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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

29 September 2017

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Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type

29 September 2017

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Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors

29 September 2017

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Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

29 September 2017

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Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent

29 September 2017

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Cyclophilin inhibitors in hepatitis C viral infection

29 September 2017

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A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA.

29 September 2017

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Trim5alpha accelerates degradation of cytosolic capsid associated with productive HIV-1 entry

29 September 2017

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Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection

29 September 2017

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NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

29 September 2017

1 reference

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Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1.

29 September 2017

1 reference

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Diverse Effects of Cyclosporine on Hepatitis C Virus Strain Replication

29 September 2017

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The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

29 September 2017

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Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells

29 September 2017

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Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop

29 September 2017

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Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells

29 September 2017

1 reference

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Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells

29 September 2017

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Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins

29 September 2017

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Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells

29 September 2017

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Selection for loss of Ref1 activity in human cells releases human immunodeficiency virus type 1 from cyclophilin A dependence during infection

29 September 2017

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Influence of gag on human immunodeficiency virus type 1 species-specific tropism

29 September 2017

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Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

29 September 2017

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Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid

29 September 2017

1 reference

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Binding and susceptibility to postentry restriction factors in monkey cells are specified by distinct regions of the human immunodeficiency virus type 1 capsid

29 September 2017

1 reference

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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

29 September 2017

1 reference

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Specific inhibition of hepatitis C virus replication by cyclosporin A.

29 September 2017

1 reference

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Restriction of multiple divergent retroviruses by Lv1 and Ref1

29 September 2017

1 reference

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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

29 September 2017

1 reference

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

29 September 2017

1 reference

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Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein

29 September 2017

1 reference

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Differential dependence of the infectivity of HIV-1 group O isolates on the cellular protein cyclophilin A.

29 September 2017

1 reference

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Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1.

29 September 2017

1 reference

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Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels

29 September 2017

1 reference

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Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence

29 September 2017

1 reference

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The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells

29 September 2017

1 reference

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Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid

29 September 2017

1 reference

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Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A

29 September 2017

1 reference

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Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses

29 September 2017

1 reference

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Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription

29 September 2017

1 reference

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Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins

29 September 2017

1 reference

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Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

29 September 2017

1 reference

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Functional association of cyclophilin A with HIV-1 virions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Specific incorporation of cyclophilin A into HIV-1 virions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A

29 September 2017

1 reference

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Immunophilins and nervous system

29 September 2017

1 reference

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Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog

29 September 2017

1 reference

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Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Cyclosporine and analogues--isolation and synthesis--mechanism of action and structural requirements for pharmacological activity

29 September 2017

1 reference

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Pharmacology of cyclosporine (sandimmune). I. Introduction

29 September 2017

1 reference

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The NMR structure of cyclosporin A bound to cyclophilin in aqueous solution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Molecular mechanisms of immunosuppression

29 September 2017

1 reference

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Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity

29 September 2017

1 reference

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Cyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

27 June 2018

1 reference

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Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705307

Structure of the amino-terminal core domain of the HIV-1 capsid protein

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23524389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23524389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23524389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Melle4]Cyclosporin, a Novel Natural Cyclosporin with anti-HIV Activity: Structural Elucidation, Biosynthesis and Biological Properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1177/095632029400500507

Identifiers

DOI

10.3390/V5030981

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

23524389

1 reference