Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent (Q24656023)

9

0 references

Dirk Jochmans

Dirk Jochmans

3

0 references

Urs Ruegg

Urs T Ruegg

5

0 references

Andrew P Halestrap

Andrew P Halestrap

4

0 references

Philippe A Gallay

2

Philippe A Gallay

0 references

Michael D Bobardt

7

Michael D Bobardt

0 references

Jean-Maurice Dumont

11

Jean-Maurice Dumont

0 references

Pietro Scalfaro

12

Pietro Scalfaro

0 references

Brigitte Rosenwirth

15

Brigitte Rosenwirth

0 references

Roger G Ptak

1

Roger G Ptak

0 references

author name string

Luke A Pallansch

6

0 references

Marie-Pierre de Béthune

8

0 references

Kamel Besseghir

13

0 references

Roland M Wenger

Antimicrobial Agents and Chemotherapy

14

0 references

language of work or name

English

0 references

publication date

April 2008

0 references

published in

0 references

volume

52

0 references

issue

4

0 references

page(s)

1302-17

0 references

cites work

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

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Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells

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The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

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Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid

7 April 2017

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Cyclophilin, TRIM5, and innate immunity to HIV-1

7 April 2017

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Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A

7 April 2017

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Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions

7 April 2017

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Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication

7 April 2017

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Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A

7 April 2017

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Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog

7 April 2017

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Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides

7 April 2017

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7 April 2017

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(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication

7 April 2017

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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

7 April 2017

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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

7 April 2017

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Intrinsic dynamics of an enzyme underlies catalysis

7 April 2017

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Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

7 April 2017

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Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

7 April 2017

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Cyclophilin: a specific cytosolic binding protein for cyclosporin A

7 April 2017

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Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein

7 April 2017

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A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA.

28 September 2017

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Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection

28 September 2017

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Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures

28 September 2017

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Novel activities of cyclophilin A and cyclosporin A during HIV-1 infection of primary lymphocytes and macrophages

28 September 2017

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Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics

28 September 2017

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Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1.

28 September 2017

1 reference

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Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir

28 September 2017

1 reference

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The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

28 September 2017

1 reference

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Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells

28 September 2017

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Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop

28 September 2017

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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

28 September 2017

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Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells

28 September 2017

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28 September 2017

Emerging anti-HIV drugs

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Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities

28 September 2017

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Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides

28 September 2017

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Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells

28 September 2017

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Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity

28 September 2017

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Selection for loss of Ref1 activity in human cells releases human immunodeficiency virus type 1 from cyclophilin A dependence during infection

28 September 2017

1 reference

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Influence of gag on human immunodeficiency virus type 1 species-specific tropism

28 September 2017

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2004: which HIV-1 drug resistance mutations are common in clinical practice?

28 September 2017

1 reference

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Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid

28 September 2017

1 reference

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Capsid is a dominant determinant of retrovirus infectivity in nondividing cells

28 September 2017

1 reference

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Binding and susceptibility to postentry restriction factors in monkey cells are specified by distinct regions of the human immunodeficiency virus type 1 capsid

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Specific inhibition of hepatitis C virus replication by cyclosporin A.

28 September 2017

1 reference

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Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes

28 September 2017

1 reference

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Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells

28 September 2017

1 reference

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Human and simian immunodeficiency virus capsid proteins are major viral determinants of early, postentry replication blocks in simian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Restriction of lentivirus in monkeys

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Differential dependence of the infectivity of HIV-1 group O isolates on the cellular protein cyclophilin A.

28 September 2017

1 reference

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A quantitative assay for HIV DNA integration in vivo

28 September 2017

1 reference

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Antiretroviral therapy: state of the HAART.

28 September 2017

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Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines.

28 September 2017

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Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels

28 September 2017

1 reference

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Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins.

28 September 2017

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Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence

28 September 2017

1 reference

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The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.

28 September 2017

1 reference

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Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins

28 September 2017

1 reference

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The effect of cyclosporine on the progression of human immunodeficiency virus type 1 infection transmitted by transplantation--data on four cases and review of the literature.

28 September 2017

1 reference

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Functional association of cyclophilin A with HIV-1 virions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Specific incorporation of cyclophilin A into HIV-1 virions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Molecular Mechanisms of Immunosuppression by Cyclosporins

28 September 2017

1 reference

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Immunophilins and nervous system

28 September 2017

1 reference

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Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription

28 September 2017

1 reference

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Cyclosporine and analogues--isolation and synthesis--mechanism of action and structural requirements for pharmacological activity

28 September 2017

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Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody

28 September 2017

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Cyclosporine-induced deterioration in patients with AIDS.

28 September 2017

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Pharmacology of cyclosporine (sandimmune). I. Introduction

28 September 2017

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A three-dimensional model to analyze drug-drug interactions

28 September 2017

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The NMR structure of cyclosporin A bound to cyclophilin in aqueous solution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Molecular mechanisms of immunosuppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

An epimer of 5'-noraristeromycin and its antiviral properties.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Differential antiviral activity of derivatized dextrans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

A continuous spectrophotometric direct assay for peptidyl prolyl cis-trans isomerases.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

The effect of cyclosporine A on infection of susceptible cells by human immunodeficiency virus type 1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Characterization of an HIV-1 Isolate Displaying an Apparent Absence of Virion-Associated Reverse Transcriptase Activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Adequate immunotoxicity testing in drug development

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Are the 2-isomers of the drug rimantadine active anti-influenza A agents?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Transformation of normal human cord lymphocytes by co-cultivation with a lethally irradiated human T-cell line carrying type C virus particles

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292519

Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18212100

12 December 2020

inferred from PubMed ID database lookup

DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18212100

12 December 2020

inferred from PubMed ID database lookup

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18212100

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://api.crossref.org/works/10.1128%2FAAC.01324-07

7 January 2021

inferred from DOI database lookup

Synthetic routes to NEtXaa4-cyclosporin A derivatives as potential anti-HIV I drugs

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FAAC.01324-07

7 January 2021

inferred from DOI database lookup

[Melle4]Cyclosporin, a Novel Natural Cyclosporin with anti-HIV Activity: Structural Elucidation, Biosynthesis and Biological Properties

1 reference

Crossref