A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates (Q60650856)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30158150%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

title

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates (English)

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20 April 2020

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primates

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1

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20 April 2020

Norikazu Kiguchi

2

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20 April 2020

Pankaj Daga

4

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20 April 2020

Paul W Czoty

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20 April 2020

Nurulain T Zaveri

9

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20 April 2020

Mei-Chuan Ko

10

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20 April 2020

author name string

Dennis Yasuda

3

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20 April 2020

Willma E Polgar

5

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20 April 2020

James J Lu

6

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20 April 2020

Shiroh Kishioka

8

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20 April 2020

language of work or name

English

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publication date

1 August 2018

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Science Translational Medicine

20 April 2020

published in

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20 April 2020

volume

10

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20 April 2020

issue

456

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

20 April 2020

page(s)

eaar3483

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cites work

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https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Opioid physical dependence development: effects of single versus repeated morphine pretreatments and of subjects' opioid exposure history

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Orphanin FQ/nociceptin blocks acquisition of morphine place preference

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

A labor-supply analysis of cocaine self-administration under progressive-ratio schedules: antecedents, methodologies, and perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Principles of drug abuse liability assessment in laboratory animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

The role of central mu opioid receptors in opioid-induced itch in primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

75 years of opioid research: the exciting but vain quest for the Holy Grail

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Effects of butorphanol on morphine-induced itch and analgesia in primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Activities of mixed NOP and mu-opioid receptor ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Comparison of the antinociceptive and antirewarding profiles of novel bifunctional nociceptin receptor/mu-opioid receptor ligands: implications for therapeutic applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

The Nociceptin/Orphanin FQ Receptor (NOP) as a Target for Drug Abuse Medications

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mous

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

A comprehensive review of opioid-induced hyperalgesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Homology modeling and molecular dynamics simulations of the active state of the nociceptin receptor reveal new insights into agonist binding and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Species differences and molecular determinant of TRPA1 cold sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

The global epidemiology and burden of opioid dependence: results from the global burden of disease 2010 study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Why primate models matter

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Structure-based virtual screening of the nociceptin receptor: hybrid docking and shape-based approaches for improved hit identification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Trends in opioid analgesic abuse and mortality in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Prescription Opioid Misuse, Abuse, and Treatment in the United States: An Update

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Differential Opioid Tolerance and Opioid-induced Hyperalgesia: A Clinical Reality

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Relationship between Nonmedical Prescription-Opioid Use and Heroin Use

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Central N/OFQ-NOP Receptor System in Pain Modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Cebranopadol: novel dual opioid/NOP receptor agonist analgesic

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Targeting multiple opioid receptors - improved analgesics with reduced side effects?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Utility of Nonhuman Primates in Substance Use Disorders Research

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

The Role of Science in Addressing the Opioid Crisis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30158150

12 December 2020

10.1126/SCITRANSLMED.AAR3483

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30158150%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

1 reference

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20 April 2020

PubMed publication ID

30158150

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