Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers (Q46808283)

25 December 2017

http://europepmc.org/abstract/MED/18195053

title

Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers (English)

1 reference

25 December 2017

http://europepmc.org/abstract/MED/18195053

1 reference

1 reference

Monika Schöller-Gyüre

1

1 reference

25 December 2017

http://europepmc.org/abstract/MED/18195053

Wim van den Brink

2

1 reference

25 December 2017

http://europepmc.org/abstract/MED/18195053

Thomas N Kakuda

3

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25 December 2017

http://europepmc.org/abstract/MED/18195053

Brian Woodfall

4

1 reference

25 December 2017

http://europepmc.org/abstract/MED/18195053

Goedele De Smedt

5

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25 December 2017

http://europepmc.org/abstract/MED/18195053

Hilde Vanaken

6

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25 December 2017

http://europepmc.org/abstract/MED/18195053

Tanja Stevens

7

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25 December 2017

http://europepmc.org/abstract/MED/18195053

Monika Peeters

8

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25 December 2017

http://europepmc.org/abstract/MED/18195053

Kati Vandermeulen

9

1 reference

25 December 2017

http://europepmc.org/abstract/MED/18195053

Richard M W Hoetelmans

10

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25 December 2017

http://europepmc.org/abstract/MED/18195053

publication date

14 January 2008

1 reference

25 December 2017

http://europepmc.org/abstract/MED/18195053

published in

The Journal of Clinical Pharmacology

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25 December 2017

http://europepmc.org/abstract/MED/18195053

volume

48

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25 December 2017

http://europepmc.org/abstract/MED/18195053

issue

3

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25 December 2017

http://europepmc.org/abstract/MED/18195053

page(s)

322-329

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25 December 2017

http://europepmc.org/abstract/MED/18195053

cites work

TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

An open-label assessment of TMC 125--a new, next-generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

A randomized, double-blind, placebo-controlled trial of TMC125 as 7-day monotherapy in antiretroviral naive, HIV-1 infected subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Enantiomeric metabolic interactions and stereoselective human methadone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Initial validation of two opiate craving questionnaires the obsessive compulsive drug use scale and the desires for drug questionnaire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Method development and validation for quantitative determination of methadone enantiomers in human plasma by liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

QTc interval prolongation in patients on long-term methadone maintenance therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Impact of methadone treatment on cardiac repolarization and conduction in opioid users

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

Efficacy and safety of etravirine (TMC125) in patients with highly resistant HIV-1: primary 24-week analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270007310387

21 January 2018

Identifiers

DOI

10.1177/0091270007310387

1 reference

25 December 2017

http://europepmc.org/abstract/MED/18195053

1 reference

25 December 2017