Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics (Q34310045)

25274545

1 August 2017

title

Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics (English)

1 reference

1 August 2017

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25274545%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Christopher J De Feo

1

1 reference

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4 June 2020

Wei Wang

2

1 reference

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4 June 2020

Meng-Lun Hsieh

3

1 reference

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4 June 2020

Min Zhuang

4

1 reference

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4 June 2020

Russell Vassell

5

1 reference

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4 June 2020

publication date

2 October 2014

1 reference

1 August 2017

1 reference

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4 June 2020

volume

11

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4 June 2020

page(s)

86

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Creative Commons Attribution 4.0 International

4 June 2020

copyright license

start time

2 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

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Resistance of Human Immunodeficiency Virus Type 1 to a Third-Generation Fusion Inhibitor Requires Multiple Mutations in gp41 and Is Accompanied by a Dramatic Loss of gp41 Function

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In vitro selection and characterization of HIV-1 variants with increased resistance to sifuvirtide, a novel HIV-1 fusion inhibitor

6 July 2018

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Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors

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Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation

6 July 2018

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6 July 2018

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6 July 2018

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HR-2 mutations in human immunodeficiency virus type 1 gp41 restore fusion kinetics delayed by HR-1 mutations that cause clinical resistance to enfuvirtide

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41.

6 July 2018

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6 July 2018

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The cytoplasmic tail slows the folding of human immunodeficiency virus type 1 Env from a late prebundle configuration into the six-helix bundle

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites

6 July 2018

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6 July 2018

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HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process

6 July 2018

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Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region

6 July 2018

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Design and properties of N(CCG)-gp41, a chimeric gp41 molecule with nanomolar HIV fusion inhibitory activity

6 July 2018

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6 July 2018

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Protein design of an HIV-1 entry inhibitor

6 July 2018

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Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Atomic structure of a thermostable subdomain of HIV-1 gp41

6 July 2018

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6 July 2018

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6 July 2018

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Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection

6 July 2018

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A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion

6 July 2018

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6 July 2018

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Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates

28 October 2018

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A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes

28 October 2018

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28 October 2018

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The inhibitory activity of an HIV type 1 peptide correlates with its ability to interact with a leucine zipper structure

28 October 2018

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Rapid emergence of enfuvirtide resistance in HIV-1-infected patients: results of a clonal analysis

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25274545

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Full fusion competence rescue of the enfuvirtide resistant HIV-1 gp41 genotype (43D) by a prevalent polymorphism (137K)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25274545

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

Dimensions Publication ID

1 reference

https://scigraph.springernature.com/pub.10.1186/s12977-014-0086-8

release_3wvxqkqlonarxb7jskfulrhsvi

9 September 2019

Fatcat ID

1 reference

Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25274545%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

25274545

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25274545%20AND%20SRC:MED&resulttype=core&format=json