HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells (Q33990552)

30 July 2017

title

HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells (English)

1 reference

30 July 2017

Jessamina E Harrison

3

0 references

Craig B Wilen

object named as

Craig B Wilen

2

0 references

Benhur Lee

object named as

Benhur Lee

5

0 references

Robert W. Doms

6

object named as

Robert W Doms

1 reference

30 July 2017

Jennifer M Pfaff

1

1 reference

30 July 2017

James F Demarest

4

1 reference

30 July 2017

John C Tilton

7

1 reference

30 July 2017

language of work or name

English

0 references

publication date

21 April 2010

1 reference

30 July 2017

number of pages

10

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inferred from page(s)

published in

Journal of Virology

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30 July 2017

volume

84

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30 July 2017

issue

13

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30 July 2017

page(s)

6505-6514

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HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry

30 July 2017

cites work

1 reference

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Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc

5 July 2018

1 reference

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A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus strains

5 July 2018

1 reference

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Entry inhibitors in the treatment of HIV-1 infection

5 July 2018

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Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry

5 July 2018

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5 July 2018

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Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities

5 July 2018

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Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.

5 July 2018

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Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope

5 July 2018

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5 July 2018

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5 July 2018

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Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120.

5 July 2018

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Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

5 July 2018

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Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection

5 July 2018

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V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies

5 July 2018

1 reference

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Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

5 July 2018

1 reference

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HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry

5 July 2018

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5 July 2018

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5 July 2018

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Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir

5 July 2018

1 reference

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Interaction of small molecule inhibitors of HIV-1 entry with CCR5.

5 July 2018

1 reference

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Structural and molecular interactions of CCR5 inhibitors with CCR5.

5 July 2018

1 reference

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Antiviral activity and safety of 873140, a novel CCR5 antagonist, during short-term monotherapy in HIV-infected adults

5 July 2018

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Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D).

5 July 2018

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Structure of an unliganded simian immunodeficiency virus gp120 core

5 July 2018

1 reference

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The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

5 July 2018

1 reference

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Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor

5 July 2018

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5 July 2018

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The HIV Env-mediated fusion reaction

5 July 2018

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Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

5 July 2018

1 reference

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Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 binding

5 July 2018

1 reference

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The crown and stem of the V3 loop play distinct roles in human immunodeficiency virus type 1 envelope glycoprotein interactions with the CCR5 coreceptor

5 July 2018

1 reference

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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

5 July 2018

1 reference

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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

5 July 2018

1 reference

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HIV fusion and its inhibition

5 July 2018

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Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes

5 July 2018

1 reference

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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

5 July 2018

1 reference

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The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis

5 July 2018

1 reference

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

5 July 2018

1 reference

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Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

5 July 2018

1 reference

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Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

5 July 2018

1 reference

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

5 July 2018

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A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

5 July 2018

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HIV entry and its inhibition

5 July 2018

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Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1.

5 July 2018

1 reference

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A Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5

5 July 2018

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Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1

5 July 2018

1 reference

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The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

5 July 2018

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CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

5 July 2018

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Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity

5 July 2018

1 reference

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Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652.

5 July 2018

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Long-term persistence of HIV-1 vaccine-induced CD4+CD45RA-CD62L-CCR7- memory T-helper cells

29 October 2018

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Entry of R5X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4.

29 October 2018

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Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120

29 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20410277

12 December 2020

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Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20410277

12 December 2020

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Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20410277

12 December 2020

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Identifiers

DOI

10.1128/JVI.00374-10

1 reference

30 July 2017

1 reference

30 July 2017

1 reference