Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Ruyue Tian¹, Guiping Zhao¹, Anni Zhou², Huihui Li¹, Bangwei Cao¹, Shuilong Guo^2,*

Show Less

Affiliation

¹ Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

² Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, 100050, China

Send correspondence to: Shuilong Guo, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, 100050, P. R. China., Tel:86-010-63138067, E-mail: [email protected]

Front. Biosci. (Landmark Ed) 2021, 26(4), 692–705; https://doi.org/10.2741/4913

Published: 1 October 2020

(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)

Abstract

Ovarian serous adenocarcinoma is one of the most common and fatal malignancies among women worldwide. The tumor microenvironment plays a critical role in tumor initiation, proliferation, and metastasis. Immune scores and stromal scores of the tumor microenvironment were determined using the ESTIMATE. Immune cell infiltration was assessed using TIMER and differentially expressed genes (DEGs) were determined using the R/Bioconductor package of edgeR. Survival analysis was carried out using a univariate Cox model and Kaplan-Meier survival, and gene functional information was obtained through Gene Ontology and KEGG pathway analysis. Survival analysis revealed 39 DEGs that significantly influenced the prognosis of ovarian serous adenocarcinoma patients and were correlated with immune cell abundance. Functional enrichment and protein-protein interaction network analyses further indicated that these genes are primarily involved in immune-related responses. Finally, we verified the prognostic value of these genes via GEO. The present results reveal the genes associated with the tumor microenvironment of ovarian adenocarcinoma, potentially providing prognostic information.

Keywords

Gene expression omnibus

The cancer genome atlas

tumor microenvironment

prognosis

ovarian serous adenocarcinoma

Figures

Figure 1

Previous article in this issue

Next article in this issue

Front. Biosci. (Landmark Ed) Print ISSN 2768-6701 Electronic ISSN 2768-6698