Compare the Top Application Control Software for Mac as of October 2026

What is Application Control Software for Mac?

Application control software, sometimes referred to as application whitelisting software, provides organizations with the ability to monitor and manage applications installed on computers. It allows for the automated enforcement of regulatory compliance policies, including restricting user access to specific applications or functions. Application control software can also be used for enforcing cross-platform usage rights and tracking application resource utilization. Compare and read user reviews of the best Application Control software for Mac currently available using the table below. This list is updated regularly.

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    Airlock Digital

    Airlock Digital

    Airlock Digital

    Airlock Digital is an application control solution that enforces a Deny by Default security posture. It enables organizations to define trusted applications, scripts, libraries, and processes at a granular level using file hash, path, publisher, or parent process. Only those explicitly defined as trusted are allowed to execute. The platform supports Windows, macOS, and Linux systems, including legacy operating systems and operational technology (OT) environments. Airlock Digital includes allowlisting and blocklisting capabilities, integrated file reputation checks via VirusTotal, and detailed logging for audit and compliance. Exception management is supported through features such as rule-based overrides and time-bound One-Time Passwords (OTPs). Centralized policy management allows consistent enforcement across large and distributed environments. The platform is available as an on-premises deployment, in the cloud, or as a managed hosted service.
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  • 2
    Securden Endpoint Privilege Manager
    Securden EPM helps enforce granular application control on endpoints through allowlisting and blocklisting. Grant temporary access to specific applications through request-release workflows. Track application usage with pinpoint accuracy using the Securden Audit Engine. Restrict users from downloading and installing malicious applications through robust privilege management.
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  • 3
    ManageEngine Endpoint Central
    ManageEngine Endpoint Central enforces comprehensive application control across every managed endpoint ensuring only trusted, approved applications can execute while blocking unauthorized, untrusted, and potentially harmful software before it runs. A default-deny approach with intelligent allowlisting prevents malicious applications, unauthorized tools, and unapproved software from executing across the endpoint fleet significantly reducing the risk of ransomware, malware, and insider threats. Administrators can create and manage allowlists and blocklists centrally, with granular policy controls targeting specific device groups, user roles, and organizational units. Application discovery provides complete visibility into all software running across the network before enforcement, ensuring legitimate business applications are accounted for and policies are built on real usage data rather than assumptions that could block productivity or leave gaps in security coverage.
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    Starting Price: $1.09/endpoint/month
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  • 4
    ThreatLocker

    ThreatLocker

    ThreatLocker

    ThreatLocker is a Zero Trust Platform that prevents cyber threats by blocking unknown applications, enforcing least privilege, and controlling what can run across your environment. Using Allowlisting, Ringfencing, Network Control, and more, ThreatLocker stops ransomware, zero-day attacks, and unauthorized activity before execution, rather than relying on detection after the fact. Built for modern IT and cybersecurity teams, the platform delivers centralized visibility and policy management across endpoints, users, and applications. ThreatLocker reduces attack surface, limits lateral movement, and supports compliance with detailed audit logs. With fast deployment, a large built-in application library, and streamlined approvals, organizations can strengthen security while minimizing operational overhead and maintaining business continuity.
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    Securden Unified PAM
    Securden Unified PAM is a privileged access security solution that lets you discover, centrally store, organize, share, manage, and keep track of all privileged identities, passwords, keys, documents, and other identities. It helps you establish a centralized password management system, automate management with approval workflows, control ‘who’ can access ‘what’, monitor, and record all access to critical IT assets, and enforce password security best practices. The major modules of Securden Unified PAM are password management, privileged account management, secure remote access, application control, endpoint privilege management, privileged session management, and SSH key management. The platform supports compliance with NIS2, DORA, NIST, PCI-DSS, HIPAA, and ISO-IEC 27001. Installation typically takes only a few minutes, and a complete production-ready PAM can be achieved in less than a month with Securden Unified PAM.
    Starting Price: Per User Pricing
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    Heimdal Endpoint Detection and Response (EDR)
    Heimdal® Endpoint Detection and Response is our proprietary multi-solution service providing unique prevention, threat-hunting, and remediation capabilities. It combines some of the most advanced threat-hunting technologies: - Next-Gen Antivirus - Privileged Access Management - Application Control - Ransomware Encryption Protection - Patch & Asset Management - Email Security - Remote Desktop - Threat Prevention ( DNS based ) - Threat Hunting & Action Center With 9 modules working together seamlessly under one convenient roof, all within one agent and one platform, Heimdal Endpoint Detection and Response grants you access to all the essential cybersecurity layers your business needs to protect itself against both known and unknown online and insider threats. Our state-of-the-art product empowers you to quickly and effortlessly respond to sophisticated malware with stunning accuracy, protecting your digital assets and your reputation in the process as well.
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    Starting Price: $0/month
  • 7
    PC Matic

    PC Matic

    PC Matic

    PC Matic Pro's application whitelisting is a critical preventative layer of cyber-protection that resides on top of other endpoint security solutions. zero trust whitelisting solutions prevent hacking and cyber-attacks. Block all malware, ransomware, and malicious scripts from executing. Protect your business data, users, and network with our whitelist cybersecurity solution. PC Matic Pro represents a long overdue shift in the cybersecurity industry to absolute prevention. Today's threats to critical infrastructure, industry, and all levels of government demand nothing less. PC Matic Pro provides a patented default-deny security layer at the device that blocks all unknown executions without introducing headaches for IT. Unlike traditional security solutions, customer infections aren’t required to strengthen the whitelist architecture. Local overrides can be added after prevention with a focus on accuracy and without concern for responding to an already active infection.
    Starting Price: $50 per year
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