Inhibitor monoaminske oksidaze

Inhibitori monoaminske oksidaze (MAOI) su molekuli koji inhibiraju dejstvo enzimske familije monoaminskih oksidaza. Oni imaju dugu istoriju upotrebe kao lekovi za tretman depresije. Oni se takođe koriste u tretmanu Parkinsonove bolesti i nekoliko drugih oboljenja.

Zbog mogućih letalnih dijetarnih i farmakoloških interakcija, inhibitori monoaminske oksidaze su istorijski bili rezervisani kao zadnja linija tretmana, i korišćeni su samo kad druge klase antidepresanata (na primer selektivni inhibitori preuzimanja serotonina i triciklični antidepresivi) nisu uspešne.^[1] Nedavna istraživanja ove klase lekova sugerišu da najveći deo problema usled njihovih opasnih interakcija sa hranom potiče od miskoncepcija i neobaveštenosti, te da je ova klasa lekova nedovoljno korišćena uprkos njene efektivnosti.^[2]^[3]

Reference

↑ Mayo Clinic Staff, "Depression (major depression): Treatment and drugs"
↑ Grady, Meghan M.; Meghan M. Grady and Stephen M. Stah (2012). „Practical guide for prescribing MAOIs: debunking myths and removing barriers”. CNS Spectrums 17: 17, pp 2–10. DOI:10.1017/S109285291200003X.
↑ Beverly J. McCabe-Sellers, Cathleen G. Staggs, Margaret L. Bogle. „Tyramine in foods and monoamine oxidase inhibitor drugs: A crossroad where medicine, nutrition, pharmacy, and food industry converge”. Journal of Food Composition and Analysis 19 (2006) S58–S65. Arhivirano iz originala na datum 2013-04-08. Pristupljeno 2014-01-25.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Povezano

Reverzibilni inhibitor monoaminske oksidaze A (RIMA)
Hidrazin (antidepresiv)
MAO, MAO-A, MAO-B

[1] Mayo Clinic Staff, "Depression (major depression): Treatment and drugs"

[2] Grady, Meghan M.; Meghan M. Grady and Stephen M. Stah (2012). „Practical guide for prescribing MAOIs: debunking myths and removing barriers”. CNS Spectrums 17: 17, pp 2–10. DOI:10.1017/S109285291200003X.

[3] Beverly J. McCabe-Sellers, Cathleen G. Staggs, Margaret L. Bogle. „Tyramine in foods and monoamine oxidase inhibitor drugs: A crossroad where medicine, nutrition, pharmacy, and food industry converge”. Journal of Food Composition and Analysis 19 (2006) S58–S65. Arhivirano iz originala na datum 2013-04-08. Pristupljeno 2014-01-25.

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