Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)

Bull, C. J. et al. (2024) Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes. EBioMedicine, 100, 104977. (doi: 10.1016/j.ebiom.2024.104977) (PMID:38290287) (PMCID:PMC10844806)

Neuhaus, M. et al. (2023) EHD2 regulates plasma membrane integrity and downstream insulin receptor signaling events. Molecular Biology of the Cell, 34(12), ar124. (doi: 10.1091/mbc.e23-03-0078) (PMID:37703099) (PMCID:PMC10846623)

Holman, N. , Barron, E., Young, B., Gregg, E. W., Khunti, K., Valabhji, J. and Sattar, N. (2023) Comparative incidence of diabetes following hospital admission for COVID-19 and pneumonia: a cohort study. Diabetes Care, 46(5), pp. 938-943. (doi: 10.2337/dc22-0670) (PMID:36657086)

Koester, A. M. et al. (2022) EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes. Bioscience Reports, 42(7), BSR20221181. (doi: 10.1042/BSR20221181) (PMID:35735144) (PMCID:PMC9272592)

Lean, M. , McCombie, L. and Xin, Y. (2022) Forget polypharmacy for type 2 diabetes! Weight management is a better investment. Nephrology Dialysis Transplantation, 37(5), pp. 844-846. (doi: 10.1093/ndt/gfaa250) (PMID:33263751)

Rehackova, L., Taylor, R., Lean, M. , Barnes, A., McCombie, L., Thom, G. , Brosnahan, N. , Leslie, W. S. and Sniehotta, F. F. (2022) Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals. Diabetic Medicine, 39(3), e14752. (doi: 10.1111/dme.14752) (PMID:34837259)

Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)

Jesuthasan, A., Zhyzhneuskaya, S., Peters, C., Barnes, A. C., Hollingsworth, K. G., Sattar, N. , Lean, M. E.J. , Taylor, R. and Al-Mrabeh, A. H. (2022) Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss. Diabetologia, 65(1), pp. 226-233. (doi: 10.1007/s00125-021-05583-4) (PMID:34657182) (PMCID:PMC8660759)

Black, H. L. et al. (2022) Knockout of Syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion. Journal of Cell Science, 135(1), jcs258375. (doi: 10.1242/jcs.258375) (PMID:34859814) (PMCID:PMC8767277)

Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)

Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)

Brosnahan, N. , Leslie, W., McCombie, L., Barnes, A., Thom, G. , McConnachie, A. , Messow, C. M. , Sattar, N. , Taylor, R. and Lean, M. E.J. (2021) Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). Journal of Human Nutrition and Dietetics, 34(3), pp. 472-479. (doi: 10.1111/jhn.12839) (PMID:33406285)

Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)

Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, K., Salt, I. P. and Göransson, O. (2021) A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner. Biochemical Journal, 478(3), pp. 633-646. (doi: 10.1042/BCJ20200659) (PMID:33493298)

Alghamdi, F., Alshuweishi, Y. and Salt, I. P. (2020) Regulation of nutrient uptake by AMP-activated protein kinase. Cellular Signalling, 76, 109807. (doi: 10.1016/j.cellsig.2020.109807) (PMID:33038517)

Al-Mrabeh, A., Hollingsworth, K. G., Shaw, J. A.M., McConnachie, A. , Sattar, N. , Lean, M. E.J. and Taylor, R. (2020) 2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 8(12), pp. 939-948. (doi: 10.1016/S2213-8587(20)30303-X) (PMID:33031736)

Xin, Y. , Davies, A., Briggs, A. , McCombie, L., Messow, C. M. , Grieve, E. , Leslie, W. S., Taylor, R. and Lean, M. E.J. (2020) Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/Counterweight-Plus weight management programme. Diabetologia, 63, pp. 2112-2122. (doi: 10.1007/s00125-020-05224-2) (PMID:32776237) (PMCID:PMC7476973)

Zhyzhneuskaya, S. V., Al-Mrabeh, A., Peters, C., Barnes, A., Aribisala, B., Hollingsworth, K. G., McConnachie, A. , Sattar, N. , Lean, M. E.J. and Taylor, R. (2020) Time course of normalization of functional β-cell capacity in the Diabetes Remission Clinical Trial after weight loss in type 2 diabetes. Diabetes Care, 43(4), pp. 813-820. (doi: 10.2337/dc19-0371) (PMID:32060017)

Morris, S. et al. (2020) Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes. PeerJ, 8, e8751. (doi: 10.7717/peerj.8751) (PMID:32185116) (PMCID:PMC7060922)

Al-Mrabeh, A. et al. (2020) Hepatic lipoprotein export and remission of human type 2 diabetes after weight loss. Cell Metabolism, 31(2), 233-249.e4. (doi: 10.1016/j.cmet.2019.11.018) (PMID:31866441)

Gould, G. , Bowman, P. and Smith, G. (2019) Cardiac SNARE expression in health and disease. Frontiers in Endocrinology, 10, 881. (doi: 10.3389/fendo.2019.00881) (PMID:31920989) (PMCID:PMC6930865)

Xin, Y. , Davies, A., McCombie, L., Briggs, A. , Messow, C.-M. , Grieve, E. , Leslie, W.S., Taylor, R. and Lean, M.E.J. (2019) Type 2 diabetes remission: economic evaluation of the DiRECT/Counterweight‐Plus weight management programme within a primary care randomized controlled trial. Diabetic Medicine, 36(8), pp. 1003-1012. (doi: 10.1111/dme.13981) (PMID:31026353)

Bowman, P. R.T., Smith, G. L. and Gould, G. W. (2019) GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE, 14(7), e0217885. (doi: 10.1371/journal.pone.0217885) (PMID:31920989) (PMCID:PMC6930865)

Katwan, O. J., Alghamdi, F., Almabrouk, T. A. , Mancini, S. J., Kennedy, S. , Oakhill, J. S., Scott, J. W. and Salt, I. P. (2019) AMP-activated protein kinase complexes containing the β2 regulatory subunit are upregulated during and contribute to adipogenesis. Biochemical Journal, 476(12), pp. 1725-1740. (doi: 10.1042/BCJ20180714) (PMID:31189568) (PMCID:PMC6595317)

Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)

Xin, Y. , Davies, A., McCombie, L., Briggs, A. , Messow, C.-M. , Grieve, E. , Leslie, W. S., Taylor, R. and Lean, M. E.J. (2019) Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes. Lancet Diabetes and Endocrinology, 7(3), pp. 169-172. (doi: 10.1016/S2213-8587(18)30346-2) (PMID:30581081)

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S. and Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)

Taylor, R., Al-Mrabeh, A., Zhyzhneuskaya, S., Peters, C., Barnes, A. C., Aribisala, B. S., Hollingsworth, K. G., Mathers, J., Sattar, N. and Lean, M. E.J. (2018) Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery. Cell Metabolism, 28, pp. 1-10. (doi: 10.1016/j.cmet.2018.07.003) (PMID:30078554)

Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)

Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)

Gao, X., Salomon, C. and Freeman, D. J. (2017) Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? Frontiers in Endocrinology, 8, 202. (doi: 10.3389/fendo.2017.00202)