In The News

Thrasyvoulos Karydis Thrasyvoulos Karydis

Deepcure’s DC-9476 ameliorates rheumatoid arthritis scores

The bromodomain and extra terminal domain (BET) family of proteins, including BRD4, regulates the transcription of multiple proinflammatory and immunoregulatory genes. BRD4 is involved in immune-related disorders such as rheumatoid arthritis (RA).

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Thrasyvoulos Karydis Thrasyvoulos Karydis

AI in Drug Design: From Hype to Real-World Results

So, is AI washing adversely impacting the field of drug design? Less than one might suppose, suggests Kfir Schreiber, co-founder and CEO of DeepCure. He points out that emerging technologies in drug discovery often follow a familiar pattern: they start with great excitement, face a period of skepticism, and eventually gain renewed interest as they begin to deliver real results.

So, is AI washing adversely impacting the field of drug design? Less than one might suppose, suggests Kfir Schreiber, co-founder and CEO of DeepCure. He points out that emerging technologies in drug discovery often follow a familiar pattern: they start with great excitement, face a period of skepticism, and eventually gain renewed interest as they begin to deliver real results.

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Thrasyvoulos Karydis Thrasyvoulos Karydis

DeepCure to Present In Vivo Data Showing Its Selective BRD4 (BD2) Inhibitor DC-9476 is Superior to Etanercept in Rheumatoid Arthritis

DeepCure, a therapeutics company using AI to discover novel drugs for inflammation and immune diseases, today announced it will present data showing its selective BRD4 (BD2) inhibitor DC-9476 is superior to anti-TNF-α treatment in the collagen antibody-induced arthritis (CAIA) rheumatoid arthritis (RA) mouse model at the 11th International Conference on Autoimmunity: Mechanisms and Novel Treatments in Crete, Greece.

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Thrasyvoulos Karydis Thrasyvoulos Karydis

DeepCure to Present In Vivo Efficacy and Safety Data of BRD4 (BD2) Inhibitor DC-9476 for Macrophage Activation Syndrome at EMBO Conference

DeepCure, a therapeutics company using AI to discover novel drugs for inflammation and immune diseases, today announced it will present early safety and efficacy data for their BRD4 (BD2) Inhibitor DC-9476 for macrophage activation syndrome (MAS) at the European Molecular Biology Organization (EMBO) 2024 Conference, held September 24–27 in Germany.

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Thrasyvoulos Karydis Thrasyvoulos Karydis

How DeepCure taps reinforcement learning for first-in-class therapies

Boston-based DeepCure may be an AI-focused biotech, but it sets itself apart by focusing its AI-powered platform on historically challenging drug targets that have eluded traditional approaches. “While AI in drug discovery is often viewed as a means to accelerate and reduce costs, our focus at DeepCure is on achieving true novelty in drug development to address targets that have eluded researchers for decades,” said CEO Kfir Schreiber.

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Thrasyvoulos Karydis Thrasyvoulos Karydis

DeepCure Announces Collaboration with Leeds Institute to Evaluate DC-9476 in Rheumatoid Arthritis

DeepCure, a therapeutics company using AI to discover novel drugs for inflammation and immune diseases, today announced a collaboration with one of the world’s premier research centers for rheumatoid arthritis (RA), the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM). The collaboration will investigate DC-9476, a third-generation selective BRD4 (BD2) inhibitor, as a potential treatment for over a million patients worldwide with RA who do not respond well to current standard of care.

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