HIV-1 clinical isolates resistant to CCR5 antagonists exhibit delayed entry kinetics that are corrected in the presence of drug (Q35665842)

9 August 2017

title

HIV-1 clinical isolates resistant to CCR5 antagonists exhibit delayed entry kinetics that are corrected in the presence of drug (English)

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9 August 2017

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ChEBI release 2020-05-28

3

Timothy J Henrich

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9 August 2017

9

Daniel R Kuritzkes

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9 August 2017

10

Athe M N Tsibris

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9 August 2017

8

Roy M Gulick

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9 August 2017

Opass Putcharoen

1

1 reference

9 August 2017

Sun Hee Lee

2

1 reference

9 August 2017

Zixin Hu

4

1 reference

9 August 2017

Jakapat Vanichanan

5

1 reference

9 August 2017

Eoin Coakley

6

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9 August 2017

Wayne Greaves

7

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9 August 2017

language of work or name

English

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publication date

16 November 2011

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9 August 2017

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9 August 2017

volume

86

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9 August 2017

issue

2

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9 August 2017

page(s)

1119-1128

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New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection

9 August 2017

cites work

1 reference

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27 July 2018

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27 July 2018

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Characterization of emergent HIV resistance in treatment-naive subjects enrolled in a vicriviroc phase 2 trial

27 July 2018

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Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5.

27 July 2018

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HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry

27 July 2018

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Rapid dissociation of HIV-1 from cultured cells severely limits infectivity assays, causes the inactivation ascribed to entry inhibitors, and masks the inherently high level of infectivity of virions

27 July 2018

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Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation

27 July 2018

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27 July 2018

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HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes

27 July 2018

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Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics

27 July 2018

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Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response

27 July 2018

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Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities

27 July 2018

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Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.

27 July 2018

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HR-2 mutations in human immunodeficiency virus type 1 gp41 restore fusion kinetics delayed by HR-1 mutations that cause clinical resistance to enfuvirtide

27 July 2018

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Maraviroc for previously treated patients with R5 HIV-1 infection

27 July 2018

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Molecular architecture of native HIV-1 gp120 trimers

27 July 2018

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In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject

27 July 2018

1 reference

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Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120.

27 July 2018

1 reference

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High throughput functional analysis of HIV-1 env genes without cloning

27 July 2018

1 reference

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Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

27 July 2018

1 reference

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HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry

27 July 2018

1 reference

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Chemokine antagonists as therapeutics: focus on HIV-1.

27 July 2018

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Distribution and three-dimensional structure of AIDS virus envelope spikes

27 July 2018

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Structural and molecular interactions of CCR5 inhibitors with CCR5.

27 July 2018

1 reference

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Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1

27 July 2018

1 reference

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Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion

27 July 2018

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Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D).

27 July 2018

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Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry

27 July 2018

1 reference

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Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization

27 July 2018

1 reference

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Kinetic factors control efficiencies of cell entry, efficacies of entry inhibitors, and mechanisms of adaptation of human immunodeficiency virus

27 July 2018

1 reference

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The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

27 July 2018

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HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion

27 July 2018

1 reference

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Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity

27 July 2018

1 reference

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Relative replicative fitness of human immunodeficiency virus type 1 mutants resistant to enfuvirtide (T-20).

27 July 2018

1 reference

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The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection

27 July 2018

1 reference

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Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor

27 July 2018

1 reference

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Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C.

27 July 2018

1 reference

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Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

27 July 2018

1 reference

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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

27 July 2018

1 reference

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The possible involvement of CXCR4 in the inhibition of HIV-1 infection mediated by DP178/gp41.

27 July 2018

1 reference

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Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

27 July 2018

1 reference

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Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1

27 July 2018

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Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus

27 July 2018

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Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

27 July 2018

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Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

27 July 2018

1 reference

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CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

27 July 2018

1 reference

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Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1.

27 July 2018

1 reference

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Dissociation of gp120 from HIV-1 virions induced by soluble CD4.

27 July 2018

1 reference

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Oligomeric organization of gp120 on infectious human immunodeficiency virus type 1 particles

27 July 2018

1 reference

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Mapping and Characterization of Vicriviroc Resistance Mutations From HIV-1 Isolated from Treatment-Experienced Subjects Enrolled in a Phase II Study (VICTOR-E1)

27 July 2018

1 reference

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Shift in phenotypic susceptibility suggests a competition mechanism in a case of acquired resistance to maraviroc

25 September 2018

1 reference

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Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo

25 September 2018

1 reference

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Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing.

25 September 2018

1 reference

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Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1.

25 September 2018

1 reference

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Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir

25 September 2018

1 reference

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Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

25 September 2018

1 reference

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Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

25 September 2018

1 reference

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A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes

25 September 2018

1 reference

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Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22090117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.06421-11

1 reference

9 August 2017

1 reference

9 August 2017

1 reference