GLASS method for estimating attributable mortality of antimicrobial resistant bloodstream infections

Overview

This is a GLASS master template protocol to be used for the generation of reliable estimates of in-hospital mortality attributable to AMR Blood Stream Infections (BSIs), at a minimum including ESBL E. coli and MRSA BSIs, both for community and hospital-origin infections, in the patient population that seeks care in a healthcare facility.

The defined methodology is for a prospective cohort study. For each target species of infection (e.g. MRSA), up to three cohorts of patients will be followed-up until hospital discharge, including patients with AMR BSIs of each target species, drug-susceptible BSIs of each target species and patients without BSI of the target species (at enrolment). The protocol describes both sample size calculation. Sample size calculation, variables to be collected, questionnaire and informed consensus templates are included.