Understanding
Seborrheic Dermatitis
M by Dr. Mahmud Hassan
general physician
Mechanism of Action
Increased Sebum
1 Inflammatory Response 2 3 Role of Immune System
Production
The immune system
Seborrheic Dermatitis Excessive sebum plays a key role in the
involves an inflammatory production triggers the pathogenesis of
response to Malassezia condition, causing the Seborrheic Dermatitis,
yeast on the skin, leading characteristic greasy contributing to the
to flaking and redness. scales and itchiness. chronic nature of the
condition.
Topical Treatments
Corticosteroids Antifungal Agents Calcineurin Inhibitors
Tacrolimus and
Antifungal creams or
Topical corticosteroids are pimecrolimus are used to
shampoos containing
commonly used to reduce modulate the immune
ketoconazole or ciclopirox
inflammation and itching in response and reduce
are effective in targeting
Seborrheic Dermatitis. symptoms of Seborrheic
Malassezia yeast.
Dermatitis.
Systemic Treatments
Oral Antifungals Immunomodulators
In severe cases, oral antifungal medications Systemic immunomodulators such as
like fluconazole or itraconazole may be methotrexate or cyclosporine are reserved
prescribed to address systemic yeast for refractory cases of Seborrheic
overgrowth. Dermatitis.
Biologics
Biologic agents like ustekinumab have
shown promise in targeting specific immune
pathways involved in the pathogenesis of
Seborrheic Dermatitis.
Toxicities of Drugs
Topical Drug Toxicities Systemic Drug Toxicities Biologic Drug Toxicities
Topical corticosteroids can Oral antifungals may cause Biologic agents carry risks of
lead to skin thinning, liver toxicity, gastrointestinal immunosuppression,
telangiectasia, and steroid- disturbances, and drug infusion reactions, and
induced dermatitis with interactions, necessitating increased susceptibility to
prolonged use. monitoring. infections.
Clinical Considerations
Adverse Effects
1 Monitoring Parameters 2 3 Patient Education
Management
Regular monitoring of Prompt recognition and Educating patients on the
liver function, renal management of adverse importance of
function, and blood effects like drug-induced adherence, potential side
counts is essential during hepatitis or effects, and long-term
systemic drug therapy for hypersensitivity reactions management is vital for
Seborrheic Dermatitis. are crucial in treatment. successful outcomes.
Research and Development
Personalized Medicine
Novel Therapeutic Targets Drug Delivery Innovations
Approaches
Ongoing research focuses on Advancements in genomics
Innovations in drug delivery
identifying novel therapeutic and personalized medicine
systems aim to enhance the
targets to address the may lead to tailored
efficacy and safety of topical
underlying mechanisms of treatment strategies based
and systemic treatments for
Seborrheic Dermatitis more on individual genetic
Seborrheic Dermatitis.
effectively. predispositions.
Future Perspectives
Precision Medicine Biological Therapies
The future of Seborrheic Dermatitis Advancements in biologic therapies hold
treatment may involve precision medicine promise for more targeted and effective
approaches that target specific molecular management of Seborrheic Dermatitis with
pathways for personalized care. fewer side effects.
Integrated Care Models
Integrated care models that combine
dermatology, immunology, and genetics
may offer comprehensive solutions for
complex cases of Seborrheic Dermatitis.
References
Journal of Dermatological American Academy of National Eczema
Science Dermatology Association
https://
https://www.aad.org/
https://doi.org/10.1016/ nationaleczema.org/
public/diseases/a-z/
j.jdermsci.2021.08.001 eczema/types-of-eczema/
seborrheic-dermatitis
seborrheic-dermatitis/
Thank You
