Aldol Condensation
Aldol Condensation
CONDENSATION
PRESENTED BY: SAMIKSHA NANAWARE
INTRODUCTION
• Aldol condensation is a
fundamental organic
reaction that forms a
carbon-carbon bond.
It's used in many
industrial and academic
applications, including
the synthesis of natural
products.
INTRODUCTION TO ALDOL CONDENSATION
• Alpha-Hydrogen
The reaction involves the enolate of one
carbonyl compound, created by the removal of an
alpha-hydrogen, acting as a nucleophile.
• Carbonyl Compound
The nucleophilic enolate attacks the carbonyl
group of the second carbonyl compound. This
leads to the formation of a beta-hydroxy carbonyl
compound called an aldol.
MECHANISM OF ALDOL CONDENSATION
(base is used)
• The reactivity of
aldehydes and ketones
in aldol condensation is
influenced by factors
like steric hindrance and
the electron-
withdrawing effect of
substituents.
ALDEHYDE KETONE
Aldol condensation is very versatile and valuable yhing for organic synthesis
Advantages Limitations
• Forms a carbon-carbon • Can produce mixtures
bond. It's very useful in of products. It can be
making cyclic difficult to control
compounds and natural stereochemistry. It
products. It is a widely requires a specific set of
applicable reaction. conditions.
SYNTHETIC APPLICATIONS
Aldol condensation is a
powerful tool for organic
synthesis, allowing for
the formation of new
carbon-carbon bonds.
The reaction can be
tailored for specific
needs by varying the
reactants, conditions,
and reaction type.