BIOMATERIALS FOR

ADDITIVE MANUFACTURING
 STEPS IN
ADDITIVE
ADDITIVE
MANUFACTURIN BIOMATERIALS
MANUFACTURIN
G
G

INDEX PROPERTIES OF APPLICATION OF WHY 3D-

BIOMATERIALS BIOMATERIALS PRINTING?

HOW TO 3D
LITERATURE
BIOPRINTING PRINT A HUMAN
REVIEW
TISSUE
LITERATURE SURVEY
SR.         TITLE​               AUTHOR         OVERVIEW 
• THE MAJOR MATERIALS AND TECHNOLOGY ADVANCES IS THREE
DIMENSIONAL PRINTING, SELECTIVE LASER SINTERING AND 3D
PLOTTING.

• SOLID FREE FORM FABRICATION (SFF) HAS ALLOWED FOR THE

Recent advances in 3d printing   Helena n chia and benjamin m wu DESIGN AND FABRICATION OF COMPLEX 3D STRUCTURES.
1.​
of biomaterials 
• TISSUE ENGINEERS HAVE USED 3DP TO FABRICATE POROUS
CERAMIC SCAFFOLDS. A HIGHLY POROUS SCAFFOLD WAS
CREATED USING THIS 3DP TECHNOLOGY.

• REVIEW HERE THE MOST IMPORTANT AREAS OF BIOMEDICAL

RESEARCH AND CLINICAL PRACTICE THAT HAVE BENEFITED
FROM RECENT DEVELOPMENTS IN ADDITIVE MANUFACTURING 
​ dditive manufacturing of
A
biomaterials, tissues, and organs  AMIR A. ZADPOOR AND JOS • TECHNIQUE LIKE  IMPLANTS,MEDICAL
2.​ MALDA INSTRUMENTS,PROSTHETICS, ORTHOTICS,ADDITIVELY
MANUFACTURED OBJECTS USED FOR MEDICAL VISUALIZATION
AND COMMUNICATION

• Biomaterials are natural or synthetic materials that are useful

towards the repair of damaged body parts

• Advanced manufacturing techniques are constantl

Susmita bose, dongxu ke,
to process biomaterials to reduce cost, minimize inventory and
Additive manufacturing of himanshu sahasrabudhe, and
3.​ biomaterials amit bandyopadhyay
maximize performance

• Two major sets of applications for  biomaterials: orthopedic and

dental implants. Tissue engineering 
SR.         TITLE​               AUTHOR         OVERVIEW 

• 3D PRINTING IS USED TO MAKE NFCM'S 

• 3D PRINTING TECHNIQUES USED :FDM ( FUSED DEPOSITION     

3D PRINTING OF NATURAL FIBER   XIAOYU BI , RUNZHOU HUANG  MODELLING),SLA ( STEREOLITHOGRAPHY    APPARATUS),DIW ( DIRECT
4.​ AND COMPOSITES INK             WRITING),DLP ( DIGITAL LIGHT        PROCESSING)
• .

• TO MAKING 3D PRINTING SUSTAINABLE, SCHOLARS ARE WORKING ON

THE USE OF DIVERSE BIO-DERIVED MATERIALS FOR 3D PRINTING
​APPLICATION OF POLYMER AND
BIOMATERIALS FOR 3D PRINTING
5.​ TECHNOLOGY
DHRUVIN PATEL • DEVELOPMENTS FOR BIOMATERIAL AND POLYMER PRINTING USING
FUSED DEPOSITION MODELING (FDM) FOR THE MEDICAL SECTOR.
ADDITIVE
MANUFACTURING

Additive Manufacturing is the industrial

production name for 3D-printing.

It is a computer controlled process that creates

three dimensional objects.

It creates prototypes layer by layer from a

computer aided design (CAD).
ADDITIVE MANUFACTURING
 Additive Manufacturing is the industrial
production name for 3D-printing.
 It is a computer controlled process that
creates three dimensional objects.
 It creates prototypes layer by layer from a
computer aided design (CAD).
 3D CAD Model

STL file conversion

File transfer to machine

STEPS IN
Machine Setup
ADDITIVE
MANUFACTURING Fabrication

Object Removal

Post Processing
 BIOMATERIALS

BIOMATERIALS ARE MATERIALS THEY ARE EITHER USED FOR BIOMATERIALS ARE NON-VIABLE
THAT HAVE BEEN DESIGNED TO THERAPEUTIC (TREAT, AUGMENT, MATERIALS USED IN MEDICAL
INTERFACE WITH BIOLOGICAL REPAIR, OR REPLACE A TISSUE DEVICES, AND ARE INTENDED TO
SYSTEMS, FOR THE TREATMENT, FUNCTION OF THE BODY) OR INTERACT WITH BIOLOGICAL
AUGMENTATION, OR DIAGNOSTIC PURPOSE. ECOSYSTEM.
REPLACEMENT OF BIOLOGICAL
FUNCTIONS.
 PROPERTIES OF BIOMATERIALS

Mechanical Optical Surface

Properties Properties Properties

Thermal Electric
Properties Properties
Mechanical Properties

o Includes characteristics of material that describe behaviour under action

of force.

o Can be determined by conducting experimental test on the material

specimen.

o Various mechanical properties are:

i) Elasticity ii) Plasticity iii) Ductility iv) Malleability v) Hardness
Thermal Properties

o It means the response of a material to the application of heat.

o Thermal properties of a material are essential in order to evaluate the

thermal behaviour of the solid i.e. their response to thermal changes.

o Various thermal properties are:

i) Heat Capacity ii) Thermal Expansion iii) Thermal Conductivity
iv) Melting Point
Electrical Properties
o It is the ability of a material to permit or resist the flow of electricity.

o Various electrical properties are:

i) Resistivity ii) Conductivity iii) Di-electric Strength
iv) Thermoelectricity

Optical Properties
o Various optical properties are:
i) Absorptivity ii) Photosensitivity iii) Refractive Index
iv) Scattering v) Electromagnetic Radiations
APPLICATION OF BIOMATERIALS
 Medical Implants – heart valves, stents, artificial joints, ligaments, hearing loss
implants, dental implants.
 Regenerate human tissues
 Promotes healing of damaged tissues
 Helps in the drug delivery system

Dental Implant
WHY 3D-PRINTING?
 3D – Printing is flexible with design.
 Rapid Process. Faster as compared to traditional method.
 Additive Manufacturing is print on demand.
 3D–Printing is fast to design and easy for production.
 It has minimum wastage.
 It is environment friendly and is cost effective.
BIOPRINTING
 Bioprinting is an additive manufacturing process
similar to 3D printing.
 It uses a digital file as a blueprint to print an object
layer by layer.
 It is a form of additive manufacturing that uses cells
and biomaterials instead of traditional metals and
plastics to create 3D constructs.

Bio-Inks : (printable materials that contain biocells)

• Bio-ink is the material used to produce engineered (artificial)
live tissue using 3D printing technology.​
• They mimic the composition of tissue that is to be bioprinted.
Bio-mask
Bio-Inks (printable material
that contains biocells)​

Bio-ink is the material used to produce

engineered (artificial) live tissue using 3D
printing technology.​
They mimic the composition of tissue that is
to be bioprinted.
HOW TO 3D PRINT A HUMAN TISSUE
BIOMATERIALS FOR BIOPRINTING
 Pluronic 127 :

• It is a synthetic copolymer that is used mostly as a support biomaterial.

• Pluronic 127 is used for bioinks to keep a 3D shape together after deposition.
• It is used as a training material. It is cheap and easy to use as is optimal to practice
bioprinting and test diff. shapes.

 GelMA :
• Gelatin-Methacryloyl (GelMA) is a naturally derived bioink and contains cell-binding motifs, making it
compatible with a variety of cell types.
• This material uses techniques such as coaxial bioprinting to create sophisticated 3D shapes.
• GelMA has applications not only in tssue engineering but also in cell signaling research, bio sensing and gene
delivery.
 Sodium alginate :
 This polysaccharide is used in laboratories arounf the world for cell encapsulation and
biopriniting.
 It can create a great and soft 3D environment for embedding cells. It can form hydrogel
when exposed to divalent cations like Ca2+ and Br2+
 It is a low cost and low toxicity biomaterial.

 Lifeink 200 :
 It is one of the most abundant extracellular matrix protein in native tissue.
 Combined with the FRESJ bioprinting method Lifeink 200 can be printed into
sophisticated 3D shapes, creating robust constructs that support cell survival and growth.
 Its neutral pH and physiological salt concentration make Lifeink 200 cell-friendly and
convenient to use. 

 PhotoHA :
 Hyaluronic acid (HA) not only provides cell attachment but also regulates processes such as
migration, differentiation, and proliferation.
 Another advantage of PhotoHA is that it is translucent, so if you plan on checking your
bioprinted constructs under a microscope – PhotoHA will minimize problems with light
penetration.
REFERENCES :
 https://www.allevi3d.com/top-5-biomaterials-for-bioprinting/
 https://www.allevi3d.com/what-is-3d-bioprinting/
 https://www.twi-global.com/technical-knowledge/faqs/what-is-3d-printing/pros-a
nd-cons