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Roller Compaction Granulation Technology

This document summarizes roller compaction as a dry granulation technique for forming granules. It discusses the introduction, principle, theory, equipment, process variables, merits and demerits, and applications of roller compaction. The key aspects covered include how roller compaction works by applying pressure between two counter-rotating rolls to form ribbons or flakes from powder, which are then milled and screened to form granules. Process variables that affect granule properties like roll pressure, roller gap, and roll speed are also outlined. The document concludes by listing some applications of roller compaction in pharmaceutical formulations.

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Chairman Pharmaceutical Sciences
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313 views

Roller Compaction Granulation Technology

This document summarizes roller compaction as a dry granulation technique for forming granules. It discusses the introduction, principle, theory, equipment, process variables, merits and demerits, and applications of roller compaction. The key aspects covered include how roller compaction works by applying pressure between two counter-rotating rolls to form ribbons or flakes from powder, which are then milled and screened to form granules. Process variables that affect granule properties like roll pressure, roller gap, and roll speed are also outlined. The document concludes by listing some applications of roller compaction in pharmaceutical formulations.

Uploaded by

Chairman Pharmaceutical Sciences
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 14

﷽

GRANULATION BY ROLLER
COMPACTION
GROUP MEMBERS:
GULNAZ BADAR
NAYAB LIAQAT
ANEES ANJUM
YUSRA JAVID
Contents

 Introduction
 Formulation design
 Equipment design
 Roller compaction theory
 Design of roller compaction
 Process variables
 conclusions
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

Roller compaction is the single


operation process of the dry
granulation

Oldest technique of granules formation


is slugging
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

A technique which induced


pressure in the agglomeration
method from which
granules are formed with
good flow ability and
compaction characteristics.
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

Loose powder

The principle of compaction is based on 1


Nip
the space is generally divided in three entry
angle angle
2
regions:
 Slip-region (feeding zone)  3

 Nip-region (compaction zone)


 Extrusion-region (release zone)
Ribbon
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

Feeder Design
Roll Surface
Gravity Feeder
Smooth
Forced Feeder Crumpled
Fluted
Crusher

Regions
Orientation Screening
Slip
Horizontal Nip
Vertical Extrusion
In-cline
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

Feed
01
02 Compression

Flake Crushing
03
04 Screening
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

Roll pressure Feed


screw
speed
Roller gap
ROLL PRESSURE
Roll speed
Screen size
Horizontal / vertical feed screw speed Roll speed

Roller gap
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

Merits Demerits
Major advantage of dry granulation over wet granulation A major disadvantage of roller compaction is the
is the absence of water or any other organic solvents. production of non-compacted powders.

Suitable for those drugs which are moisture or heat Because no liquid binder is used
sensitive.

Suitable for the compounds which have a low melting Less product yields obtained as compared to the wet
point or degrade rapidly on heating. granulation process.

Low operational cost.

Roller compaction results in capsules that forms porous


table.

Dust problems are minimized or avoided and filling


during tableting is improved.
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits

 Preparation of directly compressible excipients.


 Compaction of drugs and drug formulations.
 Granulation of herbal dry extracts.
 Immediate release formulation and enhanced dissolution.
 Controlled release formulations.
QUIZ
1. Angle between the axis of roll and heap of the powder called….
(i) Nip region
(ii) Extra angle

(iii) Nip angle


2. The drugs which have low or absent compressibility are …… to
granulate.
(i) Easily
(ii) Difficult
(iii) Not effected
REFRENCE:

INTERNATIONAL JOURNAL OF PHARMATECH RESEARCH


“ROLLER COMPACTION DESIGN AND CRITICAL PARAMETERS IN
DRUG FORMULATION AND DEVELOPMENT”.

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