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Immunologically Sensitive Field Effect Transistor (IMFET)

The document discusses the immunologically sensitive field effect transistor (IMFET), which is similar to an ISFET but uses a polarized membrane interface rather than an unpolarized one. The IMFET operates based on antigen-antibody reactions, with antibodies immobilized on the membrane attached to the field effect transistor insulator, allowing it to be used as an antigen sensor. By immobilizing an antigen instead, it could also function as an antibody sensor by measuring the electric charge of absorbing species on the membrane.

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Prasidha Prabhu
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3K views4 pages

Immunologically Sensitive Field Effect Transistor (IMFET)

The document discusses the immunologically sensitive field effect transistor (IMFET), which is similar to an ISFET but uses a polarized membrane interface rather than an unpolarized one. The IMFET operates based on antigen-antibody reactions, with antibodies immobilized on the membrane attached to the field effect transistor insulator, allowing it to be used as an antigen sensor. By immobilizing an antigen instead, it could also function as an antibody sensor by measuring the electric charge of absorbing species on the membrane.

Uploaded by

Prasidha Prabhu
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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Biomedical Instrumentation

Ms. Divya B AP/BME


Immunologically sensitive field effect
transistor (IMFET)
• IMFET is similar in structure to the ISFET except that the
solution membrane intertface is polarized rather than
unpolarized that is charged species cannot pass through
the membrane.
• ISFET interacts through an ion exchange mechanism
with the chemical analyte that is being measured where
as IMFET operation is based on antigen – antibody
reaction.
• An antibody is immobilized on the membrane that is
attached to the insulator of a FET.
• In this way the device is used as an antigen sensor

3 v 1.2
• An antibody could be detected in a similar way by
immobilizing an antigen on the membrane.
• IMFET measures charge, so in order to be sensed, the
absorbing species on the membrane must possess a net
electric charge.

4 v 1.2

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