FILARIASIS

FILARIASIS
◦Filaria worms is a class of vertebrate
animal member
◦Filaria worms can live for 4-6 years in the
lymph
◦The phylum of filaria worms is
nemathelmintes
Causes of Filariasis

Causes by: filaria Filarial worms enter

worm the human body
Filariasis or (Wuchereria through mosquito
elephantiasis bancrofti, Brugia bites ( Anopheles,
malayi, Brugia Culex, Mansonia
timori) dan Aedes

The main vector of

filariasis are
anopheles farauti
and anopheles
punctulutas
Structure of Wuchereria bancrofti

• The adult worms is long, cylindrical,

slender, and smooth with rounded
ends. It is white in colour and almost
transparent
• It has a short cephalic or head
region connected to the main body
by a short neck, which appears as a
constriction
• The body is quite delicate, making
removing it from tissues difficult
Brugia malayi
◦ The tail is shaped like a ribbon
and is rather round
◦ the anterior end extends to the
rounded head.
◦ The size is longer than B. timori.
◦ The colour is yellow
Different structure of filaria worms
Wuchereria bancrofti Brugia malayi

female long 6-10 cm 80-100 mm

vulva is near the level of their is near the level of the
esophagus middle of their
esophagus

male long 40 mm 13.5 – 20.5 mm

tail curved Curved ventrally

Female Somatic nuclei Equal sized, visualized Unequal sized, tightly

and male individually packed

Terminal nuclei No Two

do not have nuclei in end of tail Have nuclei in end of
tail
The different of filaria worms
Wuchereria bancrofti
Wuchereria Brugia malayi Brugia timori
bancrofti
Nucleus or smooth and Rough and Has 2
body core regular not additional
Brugia timori overlapping cores at the
tail end
Comparison 1:1 2:1 3:1
of the width
and length of
headroom
vector Culex Mansonia mansonia
mosquitoes and
anopheles
Brugia malayi
distribution worldwide asian Island of timor
Found in Urban areas In swamp In rice fields
with high forest along
Different structure of filaria worms
Wuchereria Brugia Brugia timori
bancrofti malayi
The colour No colour pink No colour
of the
holster
Picture of Like a ribbon The tip is a The tip is a
the tail end toward the bit blunt bit blunt
end
Length 240-300 175-230 265-325
(μm)
The life cycle of filaria worms

The first stage, the

development of
Filaria worms in
mosquito bodies as
a vector with a
growth period of
approximately 2
weeks.
The second stage,
the development
of Filaria worms in
the human body
(host) is
approximately 7
months.
 Filarial Worm Life Cycle
• When sucking blood, infected
mosquitoes transmit larvae (third
stage) to the skin of the human
host through a "bite" wound.
• Larvae develop into adult filarial
worms in lymph nodes.
• Adult worms produce
microfilariae that have a
protective layer and move
actively in the bloodstream.
Filarial Worm Life Cycle
◦ Microfilariae in the blood are
also ingested by mosquitoes
that "bite" infected humans.
• Microfilariae release the
protective layer and live on
the mosquito's stomach.
• Microfilariae then develop
into the first stage larvae.
Filarial Worm Life Cycle
• Developing again into third
stage larvae.
• The third stage larvae move to
the head and "proboscis"
mosquitoes to be ready to
infect humans when
mosquitoes "bite" humans.
References
◦ http://www.depkes.go.id/resources/download/info-
terkini/PMK%20No.%2094%20ttg%20Penanggulangan%20Filariasis.pdf
◦ https://www.sciencedirect.com/science/article/pii/S0022283610012799
◦ https://en.wikipedia.org/wiki/Brugia_malayi
◦ https://www.academia.edu/10200153/BRUGIA_MALAYI
◦ http://mhswkeslingternate20.blogspot.com/2014/04/tugas-post-uts-wuchereria-
bancrofti.html
◦ https://medlab.id/brugia-malayi/
◦ https://www.topsimages.com/images/filarial-worm-life-cycle-c1.html
◦ https://www.scribd.com/doc/242980735/Brugia-Malayi-Dan-Timori
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