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Organic Bioelectronics: Safa Riyaz

The document is a student paper on organic bioelectronics that provides an introduction to the field. It discusses how organic bioelectronics bridges electronics and medicine by using organic electronic materials that can interface with biological systems. A key organic material used is PEDOT, which when doped forms a better interface with tissue than inorganic materials. Applications discussed include using organic bioelectronics for neural interfaces, medical implants, and developing artificial sensory organs.

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64 views21 pages

Organic Bioelectronics: Safa Riyaz

The document is a student paper on organic bioelectronics that provides an introduction to the field. It discusses how organic bioelectronics bridges electronics and medicine by using organic electronic materials that can interface with biological systems. A key organic material used is PEDOT, which when doped forms a better interface with tissue than inorganic materials. Applications discussed include using organic bioelectronics for neural interfaces, medical implants, and developing artificial sensory organs.

Uploaded by

s.r.
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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ORGANIC

BIOELECTRONICS
for a better tomorrow

SAFA RIYAZ
Course No. EL-380
Class Sr. No. 39

Department of Electronics Engineering


Aligarh Muslim University, Aligarh
2017-18
OUTLINES:
 INTRODUCTION
 BRIDGE BETWEEN ELECTRONICS AND MEDICINE
 BIOELECTRONICS
 ORGANIC BIOELECTRONICS
 INTERFACING BETWEEN ORGANIC ELECTRONIC
MATERIALS AND BIOLOGY
 ORGANIC BIOELECTRONIC MATERIALS
 BIOELECTRONICS IN A HISTORICAL PERSPECTIVE
 STATE OF THE ART ORGANIC BIOELECTRONIC
MATERIAL
 APPLICATIONS OF ORGANIC BIOELECTRONICS
 REFERENCES

2
A Brief Introduction

 The field of biology and medicine have been


heavily aided by electronic devices
 Common Examples include:
 X-Ray
 Electrocardiograph
 MRI
 Pacemaker, etc.

Multidisciplinary nature of organic bioelectronics


Source:Luís Joaquim Alcácer, Scientific Area Coordinator
- Instituto de Telecomunicações, lisboa
www.lx.it.pt/~alcacer/TM_Group/Bioelectronics.pdf 3
What exactly is Bioelectronics?

 Coined in 1991, at the first CEC workshop,


Brussels
 Def: “Use of biological materials and biological
architectures for information processing systems
and new devices.”
 Focus: Measurement of electrical signals
induced by the body - Basis of the
Electrocardiogram
 Today, bioelectronics incorporates a range of
topics at the interface of biology and electronics.
4
Branches Of Bioelectronics

http://www.fz-juelich.de/ics/ics-8/EN/Research/_node.html 5
Bioelectronics In A Historical
Perspective
 Luigi Galvani (1780s) ; Applied static electricity
provided from an inorganic metal scalpel to the nerve
of detached frogs’ legs - made it move.
 From devices like pacemaker to wearables ,
bioelectronics is used everywhere
 Earlier, metal used for implant, as electrodes for
recording and stimulation.
Later: Flexible Inorganic CMOS circuits. [1]
“International Workshop of Recent Advances in Organic Bioelectronics”,
www.polyu.edu.hk/ap/obe_workshop/obe.ap.polyu.edu.hk/index.html [1] 6
Applications Of Bioelectronics
•Early Detection: Heart Disease, Cancer, Stroke
•Disease Treatment: Respiratory, Diabetes, Kidney, etc.
DRIVERS
•Artificial Sensory Organs: Eyes, Nose, etc.

•Bioinstrumentation
MEASUREMENTS •Enzyme-based, tissue-based, immuno-sensors, DNA
biosensors.

•BioDSP
DEVICES •Nano- Delivery devices

•Wireless Networks
•3-D Integration
TECHNOLOGIES
•Two way Interfaces with bio-tissues
7
Organic Bioelectronics

 Application of organic electronic materials to


the field of bioelectronics
 Organic materials (i.e. containing carbon) -
promising interface with biological systems.
 Electrical signals generated by carbon-
based electrically active materials are translated
into bio-signals and vice versa.[2]

https://en.wikipedia.org/wiki/Bioelectronics [2] 8
Organic Bioelectronics and Biology

◎ 2015
Roisin Owens , George Malliaras, “Organic Electronics at the Interface with Biology”, MRS bulletin, vol. 35,
9
State Of The Art Organic
Bioelectronic Material

 State of the art Material - conducting polymer


coatings.
 Advantages:
 Lowering of the electrical impedance,
 more efficient recording and stimulation
 Improved implant lifetime, and the ability to
deliver drugs
 Better Interfacing; Reduces inflammation [3]

Daniel T. Simon, Erik O. Gabrielsson, Klas Tybrandt and Magnus Berggren ,“Organic Bioelectronics: Bridging the Signaling
Gap between Biology & Technology”, Chem. Reviews, 116(21), 13009–13041,2016 [3] 10
Contd.
 Polymer: poly(3,4-ethylenedioxythiophene)
 PEDOT – Relatively high conductivity and stability.
 Typically doped with either TOS or PSS.
 PEDOT: PSS – Available
as a solution.
Easy photolithography.
 PEDOT: TOS – Not solution;
Processable.
Easier to manipulate.
PEDOT
https://en.wikipedia.org/wiki/Poly(3,4ethylendioxythiophene) 11
PEDOT With Dopants
“

Renee Kroon, Desalegn Alemu Mengistie, David Kiefer, Jonna Hynynen, Jason D. Ryan, Liyang, Christian Muler,
“Thermoelectric plastics: from design to synthesis, processing and structure–property relationships”
Chemical Society Reviews, vol 45, 2017 12
Applications Of Organic
Bioelectronics
(Contemporary Areas)

 Regulation of the physiology and processes of cells,


tissues, and organs in a chemically specific manner.
 Selectively sense, record, and monitor different signals
and physiological states in living organisms.[4]
 Electrodes and OECTs for Neural Interfaces
 Artificial sensory organs.

Róisín Owens, Peter Kjall, Agneta Richter, Fabio Cicoira, “Organic bioelectronics — Novel applications in biomedicine”,
Biochimica et Biophysica Acta (BBA)-General Subjects, 1830(9), 4283-4285, 2013 [4] 13
Organic Bioelectronics In The
Brain
 Development of neural prostheses capable of
recording and stimulating neuronal tissue
 Combats the inflammation caused by
implantation of silicon probes
 Conducting polymers were being used for
neural prosthetic applications(1980s). Later
researches proved doped PEDOT to have better
performance .
14
Contd.

 Prof. George Malliaras (2017) devised an organic


electronic ion micro pump to enable the use of
drugs to get past the blood barrier and be delivered
directly into the brain thereby providing localized
chemotherapy.
 Applications lie in epileptic patients where surgery is
the only option. [6]

Roisin Owens , George Malliaras, “Organic Electronics at the Interface with Biology”, MRS bulletin, 35, 2015 [6] 15
Implantable Organic
Bioelectronics for Pain Treatment
 Current drugs do not fully relieve pain due to
inefficient drug targeting.
 Experimental implant delivers GABA to spinal chord;
Relieves pain in rats
 Implant is an organic electronic ion pump to conduct
electricity
 The conducting polymers in the device allow
electronic pulses to be transduced into biological
signals.[7]
Amanda Jonsson, Zhiyang Song, David Nilsson, Björn A. Meyerson, “Therapy using implanted organic bioelectronics”,
Science Advances,1( 4), 2015 [7] 16
Implants using OEIP and The
Geometry Of Implantable Device

◎ Amanda Jonsson, Zhiyang Song, David Nilsson, Björn A. Meyerson,


“Therapy using implanted organic bioelectronics”, Science Advances, Vol 1, 4, 2015

17
Key Points So Far

 Organic bioelectronics - Field concerned with


the application of biological materials and
processes in electronics, and the use of
electronic devices in living systems.
 The need of “organic” bioelectronics arose due
to the inflammation caused by inorganic or
metallic bioelectronic materials while
performing implants.

18
Contd

 These are devices made of conducting polymers


that form an interface with the biological
substances.
 The most common polymer used is PEDOT and
when doped with pss/tos, provides much better
efficiency.
 Potential Areas: Implants, E-tongue, E-nose,
Interfacing with the brain, etc.

19
REFERENCES
“International Workshop of Recent Advances in Organic Bioelectronics”,
www.polyu.edu.hk/ap/obe_workshop/obe.ap.polyu.edu.hk/index.html [1]
https://en.wikipedia.org/wiki/Bioelectronics [2]
Daniel T. Simon, Erik O. Gabrielsson, Klas Tybrandt and Magnus Berggren
,“Organic Bioelectronics: Bridging the Signaling Gap between Biology &
Technology”, Chem. Reviews, 116(21), 13009–13041,2016 [3]
Róisín Owens, Peter Kjall, Agneta Richter, Fabio Cicoira, “Organic
bioelectronics — Novel applications in biomedicine”, Biochimica et
Biophysica Acta (BBA)-General Subjects, 1830(9), 4283-4285, 2013 [4]
Alphus D. Wilson, Manuela Baietto, “Applications and Advances in
Electronic-Nose Technologies”, SENSORS, 9,5099-5148, 2009 [5]
Roisin Owens , George Malliaras, “Organic Electronics at the Interface with
Biology”, MRS bulletin, 35, 2015 [6]
Amanda Jonsson, Zhiyang Song, David Nilsson, Björn A. Meyerson,
“Therapy using implanted organic bioelectronics”, Science Advances,1( 4),
2015 [7] 20
21

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