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Seminar: Course Instructor-Prof Dr. S. Dhara

This seminar discusses strategies for nerve tissue regeneration, including approaches based on nerve conduits, acellular grafts, and mimicking nerve structure. Specifically, the seminar covers how 3D printing can be used to create nerve guidance conduits tailored for individual patients, how scaffolds provide structural support and can deliver stem cells to damaged brain tissue, and how scaffolds allow cell infiltration and promote local regeneration while serving as a delivery method for transplanted cells.

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81 views14 pages

Seminar: Course Instructor-Prof Dr. S. Dhara

This seminar discusses strategies for nerve tissue regeneration, including approaches based on nerve conduits, acellular grafts, and mimicking nerve structure. Specifically, the seminar covers how 3D printing can be used to create nerve guidance conduits tailored for individual patients, how scaffolds provide structural support and can deliver stem cells to damaged brain tissue, and how scaffolds allow cell infiltration and promote local regeneration while serving as a delivery method for transplanted cells.

Uploaded by

skycall28
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Seminar

Course
Instructor-
Prof Dr. S.
Dhara
Presented by
Atul Kumar Ojha
Nerve tissue regeneration strategy

1. Based on nerve conduits

2. Based on acellular grafts

3. Mimicking nerve structure

4. Scaffolds generation strategy


Srikanth, M. & Kessler, J. A. Nature. Rev. Neurol. 2012
The hope is that the conduits could be used to replace current methods of
repairing peripheral nerve damage, which involve surgery to graft together
the nerve endings. Not only does this often yield imperfect results that do
not return sensation to damaged area, but it can also require two surgery
sites.[1]
This laser technique, on the other hand, is so precise that it allows the NGCs
to be adapted for any nerve damage or for a specific patient. In the
researchers' tests on mice, they were able to demonstrate successful
regrowth over a 21-day period to a 3mm nerve gap. "The advantage of 3D
printing is that NGCs can be made to the precise shapes required by
clinicians," says John Haycock, professor of Bioengineering at Sheffield.
"We've shown that this works in animal models, so the next step is to take
this technique towards the clinic.
Scaffold based neural regeneration

a | Placing scaffolds into


a region of damaged
brain tissue can provide
structural support to the
surrounding tissue to
minimize secondary
cellular degeneration
. b | Scaffolds are also
being increasingly used
for controlled and
programmable delivery
of neural stem cells.

Dwaine F. Emerich et al, nature reviews september 2009 |


VoluME 10
Scaffold based approach

When implanted into the brain these material characteristics may prove
important for the recapitulation of specific aspects of the normal and
regenerating brain microenvironment, and this allows improved cell graft
integration and function.[2]
It allow cells from the adjacent parenchyma to infiltrate the scaffold
potentially promoting local tissue regeneration. In addition, these scaffolds
can serve as delivery vehicles for transplanted cells, facilitating neuronal
outgrowth and connectivity between grafted and host cells[2]
Refrences

[1]Srikanth, M. & Kessler, J. A. Nature. Rev. Neurol. 2012

[2]Dwaine F. Emerich et al, nature reviews september 2009 | VoluME 10

[3] Clara Ballerini et al, Nano Lett. 2013, 13, 60986105

[4]Yun Chen et al, ACS Omega 2017, 2, 74717481

[5]Christine E. Schmidt et al ACS Biomater. Sci. Eng. 2017, 3, 14511459


Thank you

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