Geoffrey LAM MBBS FRANZCO discusses the possibility of a "bionic eye" to help restore sight to the blind. Current retinal prosthesis devices, like the Argus II, have up to 60 electrodes that allow some patients to detect motion and objects. Researchers are working to develop higher resolution implants with over 1,000 electrodes that could enable recognizing faces and reading large print. While challenges remain, bionic eyes may one day restore meaningful vision to many blind individuals.
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Geoffrey LAM MBBS FRANZCO discusses the possibility of a "bionic eye" to help restore sight to the blind. Current retinal prosthesis devices, like the Argus II, have up to 60 electrodes that allow some patients to detect motion and objects. Researchers are working to develop higher resolution implants with over 1,000 electrodes that could enable recognizing faces and reading large print. While challenges remain, bionic eyes may one day restore meaningful vision to many blind individuals.
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Giving sight to the Blind
The Bionic Eye
Fact or Myth?
Geoffrey LAM MBBS FRANZCO
In other words Can we design an eye implant that can make a blind person see again? What is a Bionic Eye? An electronic device which gives eye sight to the blind, by converting the visual scene, like a camera, into some form of electric signals, which will then stimulate the visual system to give vision. Geoffrey LAM MBBS FRANZCO Clinical Associate Professor School of Ophthalmology and Visual Science University of Western Australia
Giving sight to the blind
40 million blind people in the world Approximately half a million in Vietnam Giving sight to the blind Giving sight to the blind Can we make the blind see? J esus touched their (blind) eyes. Immediately they regained their sight Matt 20:34 EYE TRANSPLANT? Is it possible? If you cannot connect up the optic nerve fibres correctly one by one, then you cannot put the image back together in the correct order! THE NON-BIONIC EYE A non-electronic device to help to see better Implantable Miniature Telescope (IMT) Enlarges images 2.2 or 3 times
Why is it called Bionic Eye? How the idea came about Foersters experiment 1929, discovered that stimulating the occipital pole with electricity, a blind person can see a phosphene (a bright spark of light) Foersters experiment (1929) By giving appropriate radio signals, the patient experience sensations of light ('phosphenes').
Retinal stimulation Graham Tassicker (1956) inserted a light sensitive photocell (like a solar battery) behind the retina in a blind patient and elicited phosphene Where do we stimulate the visual system to get vision? The retina The optic nerve, optic tract The visual cortex Bionic Eye An electronic implant in the eye Aim for bionic eyes Able to see at least to count fingers And eventually later, maybe ability to recognize the letters of the alphabet Able to walk around obstacles Current trial patients Age related macular degeneration Previously seeing patients, now blind with loss of retinal photo-receptors, but intact neuro-retina
Retinitis pigmentosa Current BIONIC EYES (retinal prosthesis or artificial retina) Retina implants - 4 components 1. Camera - capture image 2. Computer chip to change image to electrical signal 3. Retinal implant - stimulate the retinal cells 4. Intact optic nerve to send signals to visual cortex in brain Where to put the retinal implant 2 locations 1. Retina surface (epi- retina) 2. Inside retina (sub- retinal) Retinal surface implants =Epi-Retinal implants Argus I (2002) Doheny Institute 16 electrodes 250x500 micrometers
Argus I 16 ELECTRODES Argus II 60 electrodes Improve motion detection Some improvement in mobility Recognise common household objects Subretinal prostheses Between bipolar cell layer and RPE Epiretinal vs subretinal implants Epiretinal-retinal surface Surgically easier large vitreous space to house and as heat sink Upgrade easily
Disadvantage Stimulate ganglion cells, so no processing by eye
Epiretinal vs subretinal implants Subretinal Some processing by bipolar and amacrine cells Can shape the retinal response
Disadvantage Tight space Heat issue More difficult to implant Self powered retinal implant Self-power lasts forever Low efficiency, low output voltage Needs multiple diodes to elicit visible phosphene Reduced sharpness Investigating group bankrupted The Australian Story
Australian Federation Government awarded a total of A$50m for bionic eye projects
Device 1: Wide View Device 98 electrodes implanted in the suprachoroidal space Aim: to provide patients the ability to move around large objects Device 2: High-acuity device over one thousand electrodes Aim: to recognise faces and read large print first tests with patients in 2014 Image Resolution BUT
Each stimulus is only perceived as a white light No colour No grey scale High acuity devices (>1000 electrodes) Other areas of stimulation Non- retinal implants Optic nerve/tract stimulation
Optic nerve/tract stimulation
Cortical stimulator Difficulties Intra-cranial surgery Power supply of the electronics Do not understand how the stimulator and neurons communicate at this stage Do not know what to do to get images other than spark of light at the moment
Etc.,etc.,etc.,.. Children? Deprived By depriving kittens from using one eye, they showed that these kittens did not develop areas in the primary visual cortex serving vision for the deprived eye.
In summary We are still years away from a truly functional bionic eye, however, one day, we shall give sight to the blind. The eye is the lamp of the body. If your eyes are good, your whole body will be full of light.
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