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Gold Collection: Anti-Neoplastic

This document summarizes several chemotherapy drugs, their mechanisms of action, and common uses. It describes how cyclosporine protects against organ transplant rejection without bone marrow suppression. It also discusses how cyclophosphamide is an alkylating agent used to treat chronic lymphocytic leukemia, and how cisplatin causes nephrotoxicity and ototoxicity. Methotrexate is described as an antifolate that can be rescued by leucovorin to reduce its toxicity. Bleomycin can cause pneumonitis and pulmonary fibrosis.

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61 views41 pages

Gold Collection: Anti-Neoplastic

This document summarizes several chemotherapy drugs, their mechanisms of action, and common uses. It describes how cyclosporine protects against organ transplant rejection without bone marrow suppression. It also discusses how cyclophosphamide is an alkylating agent used to treat chronic lymphocytic leukemia, and how cisplatin causes nephrotoxicity and ototoxicity. Methotrexate is described as an antifolate that can be rescued by leucovorin to reduce its toxicity. Bleomycin can cause pneumonitis and pulmonary fibrosis.

Uploaded by

SSGFL1
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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Gold Collection Anti-neoplastic

Cyclosporine

Protects against rejections from organ transplants Does not induce bone marrow depression

Cyclophosphamide

Alkylating agent of both purine & pyrimidine bases of DNA Txt CLL

Cisplatins toxicities

Nephro- & Ototoxicity

Methotrexate

Antimetabolite of folic acid: ()dihydrofolate reductase

Leucovorin Rescue

Can block/reduce Methotrexate = increase folic acid via a reduced folate

Bleomycin toxicities

Pneumonitis & pulmonary fibrosis

Azathiorine

Used in organ transplantation = kidney allografts Allopurinol can increase its activity by (-) its biotransformation to xanthine oxidase

Chemotherapy used in the txt of Hodgkins disease

MOPP M = Mechlorethamine - nitrogen mustard O = Oncovin (Vincristine) prevents microtubule assembly P = Procarbazine P = Prednisone - glucocorticoid, inducing apoptosis

Tamoxifen

(-) estrogen receptor Txt of breast tumors, can see associated endometrial CA

Flutamide

Antiandrogenic Used w/ Leuprolide (LH-RH analog) Txt prostatic CA

Megestrol

(-) progesterone receptor Txt endometrial CA

Fluoxymesterone

Androgenic steroid Txt mammary CA in postmenopausal women

Methotrexate

Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase Txt of ALL Txt of Psoriasis

Brain tumor Txt

Lomustine Carmustine - Causes pulmonary fibrosis

Streptozocin

Attaches to cells Txt of pancreatic insulinomas

Cytarabine (AraC)

Pyrimidine analog DOC for AML

Dactinomycin

Used for Wilms tumor & rhabdomyosarcoma

Etoposide

Used for oat cell CA

Paclitaxel

Used for ovarian CA

Amifostine

Can decrease nephrotoxicity due to chronic use of Cisplatin

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