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Oxford Textbook of Neuro-Oncology 1st Edition Tracy Batchelor PDF Download

The Oxford Textbook of Neuro-Oncology, edited by Tracy T. Batchelor and others, provides a comprehensive overview of the management and treatment of central nervous system tumors, integrating molecular and genetic insights into clinical practice. It is structured according to the World Health Organization classification and features contributions from leading experts in the field. This textbook aims to educate clinicians on the evolving landscape of neuro-oncology and enhance patient care through updated knowledge and treatment strategies.

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32 views59 pages

Oxford Textbook of Neuro-Oncology 1st Edition Tracy Batchelor PDF Download

The Oxford Textbook of Neuro-Oncology, edited by Tracy T. Batchelor and others, provides a comprehensive overview of the management and treatment of central nervous system tumors, integrating molecular and genetic insights into clinical practice. It is structured according to the World Health Organization classification and features contributions from leading experts in the field. This textbook aims to educate clinicians on the evolving landscape of neuro-oncology and enhance patient care through updated knowledge and treatment strategies.

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Oxford Textbook of

Neuro-Oncology

2
Oxford Textbooks in Clinical Neurology

PUBLISHED
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Oxford Textbook of Clinical Neurophysiology
Edited by Kerry R. Mills
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Edited by Sudhansu Chokroverty and Luigi Ferini-Strambi

FORTHCOMING
Oxford Textbook of Neuro-Oncology
Edited by Tracy T. Batchelor, Ryo Nishikawa, Nancy J. Tarbell,
and Michael Weller
Oxford Textbook of Headache Syndromes

3
Edited by Michel Ferrari, Joost Haan, Andrew Charles, David
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Oxford Textbook of Neuro-ophthalmology
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Edited by Sebastian Brandner and Tamas Revesz

4
Oxford Textbook of
Neuro-Oncology

Edited by
Tracy T. Batchelor
Count Giovanni Auletta Armenise-Harvard Professor of
Neurology, Harvard Medical School, Executive Director,
Stephen E. and Catherine Pappas Center for Neuro-
Oncology, Massachusetts General Hospital; Associate
Clinical Director, Massachusetts General Hospital
Cancer Center; Co-Leader, Neuro-Oncology Program,
Dana-Farber/Harvard Cancer Center, Boston, MA, USA
Ryo Nishikawa
Professor and Chair, Department of Neurosurgery, Head,
Department of Neuro-Oncology, Comprehensive Cancer
Center, International Medical Center, Saitama Medical
University, Saitama, Japan
Nancy J. Tarbell
CC Wang Professor of Radiation Oncology, Dean for
Academic and Clinical Affairs, Harvard Medical School,
Boston, MA, USA
Michael Weller
Professor and Chairman, Department of Neurology,
University Hospital and University of Zurich, Zurich,
Switzerland

Series Editor
Christopher Kennard

5
6
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work.

7
Foreword

During my 50 years of laboratory research and caring for patients with


central nervous system (CNS) tumours, I have witnessed and participated
in many developments that at first seemed promising, but dead-ended in
disappointing blind alleys; fortunately, others resulted in greater
knowledge and clarity about CNS diseases as well as improved outcomes.
Over the years, books published on CNS cancer and its treatment were
met with mixed reviews by small audiences, but, nonetheless, helped
educate multiple generations of physicians and scientists. When I began
my career, I was one of very few in the world willing to focus on CNS
cancer research and treatment. Learning from books and experts in other
fields helped in that process. Book chapters, being less constrained than
articles, can provide more contextual information for the reader than a
single article can provide. In my view, a book is frequently the best vehicle
for educating others. After moving to Houston, Texas, United States, to
become Chair of the Department of Neuro-Oncology at The University of
Texas MD Anderson Cancer Center, I wanted to write a textbook, which
became Cancer in the Nervous System (1996, 2002, Oxford University
Press), to educate a new generation of neuro-oncologists and address
problems in treatment as well as concerns about symptom management for
tumour- and treatment-related effects.
We are now at another crossroads in information because of the
explosion of molecular and genetic studies that affect the way we classify
tumours and, in turn, how we treat the considerable number of rare benign
and malignant tumours of the CNS. I believe this novel paradigm was why
so many senior international authors from the multiple specialties essential
to our field took the time to create this well-structured and highly
informative book. This book brings together the changing neuropathology
landscape, important molecular–genetic drivers of these tumours, and
provides thoughtful discussions by experts on how best to treat and
manage patients afflicted with these rare tumours. Each generation must
strive to educate the next generation of clinicians and scientists if we are to
make progress in the care of our patients. This requires a book, such as the
Oxford Textbook of Neuro-Oncology, to bring together the relevance of

8
pathology, molecular–genetic associations, prospective clinical trials, and
the experiential insights gained by experts who have treated the very rare
tumours absent from formal clinical trials. This panoply of knowledge is
well conveyed in this textbook. Taken together, it informs and affects how
these tumours are understood today and how best to approach their diverse
treatments.
This 21-chapter book, modeled after the World Health Organization
classification of central nervous system tumors, takes a ‘meet the
professor’ approach. It provides a framework to assist the reader prepare to
understand how we treat and inform patients with respect to treatment
options and prognosis when new molecular–genetic knowledge is
revealed. Is this textbook the last word? Certainly not, but it is the current
word and, as such, deserves a special place in the library of those who care
for individuals with CNS tumours and those who research possibilities for
improving their survival.

Victor A. Levin, M.D.


Emeritus Professor, Department of Neuro-Oncology,
The University of Texas,
MD Anderson Cancer Center, Houston, TX, USA
Clinical Professor, Department of Neurosurgery, University of
California San Francisco, San Francisco, CA, USA

9
Preface

The practice of neuro-oncology entails the management of many different


types of tumours of the nervous system by a multidisciplinary team of
healthcare providers. These tumours represent a diverse spectrum of
underlying molecular biological subtypes, prognostic categories, age
distributions, and treatment recommendations. The World Health
Organization (WHO) classification of central nervous system tumours is
the foundation for the categorization and, by extension, clinical
management and treatment of patients with all types of nervous system
tumours. The WHO classification has traditionally been based on light
microscopic description of the cellular elements of tumours in the brain,
spinal cord, nerves, and meninges. The 2016 WHO classification of central
nervous system tumours for the first time incorporates molecular markers
into the categorization of some types of nervous system tumours,
particularly gliomas. This revised classification will serve as the basis for
future clinical trials and, ultimately, management recommendations for
these newly recognized pathological-molecular subsets of central nervous
system tumours. Current management guidelines are derived, however,
from clinical trials and studies utilizing earlier versions of the WHO
classification system. This book is intended for clinicians as a complement
to the WHO classification system with a focus on clinical management of
nervous system tumours in adults and children. Each chapter is co-
authored by a multidisciplinary, international group of leading authorities
in adult and paediatric neuro-oncology. The book is organized according
to the 2007 WHO classification of central nervous system tumours and
each chapter follows a similar framework. The introductory chapter
reviews the 2016 revision of the WHO classification of central nervous
system tumours and how these changes may influence future clinical trials,
clinical practice, and subsequent editions of this book.
Tracy T. Batchelor
Ryo Nishikawa
Nancy J. Tarbell
Michael Weller

10
Contents

Abbreviations
Contributors

1 The 2016 revision of the WHO classification of tumours of the


central nervous system
Paul Kleihues, Elisabeth Rushing, and Hiroko Ohgaki
2 Astrocytic tumours: pilocytic astrocytoma, pleomorphic
xanthoastrocytoma, and subependymal giant cell astrocytoma
Brian P. O’Neill, Jeffrey Allen, Mitchell S. Berger, and Rolf–Dieter
Kortmann
3 Astrocytic tumours: diffuse astrocytoma, anaplastic astrocytoma,
glioblastoma, and gliomatosis cerebri
Michael Weller, Michael Brada, Tai–Tong Wong, and Michael A.
Vogelbaum
4 Oligodendroglial tumours
Wolfgang Wick, Colin Watts, and Minesh P. Mehta
5 Ependymal tumours
Mark R. Gilbert and Roberta Rudà
6 Choroid plexus tumours
Maria Santos, Eric Bouffet, Carolyn Freeman, and Mark M.
Souweidane
7 Other neuroepithelial tumours: astroblastoma, angiocentric
glioma, and chordoid glioma
Martin J. van den Bent, Frederic Dhermain, and Walter Stummer
8 Neuronal and mixed neuronal–glial tumours
Riccardo Soffietti, Hugues Duffau, Glenn Bauman, and David Walker
9 Embryonal and pineal tumours
Roger E. Taylor, Barry L. Pizer, Nancy J. Tarbell, Alba A. Brandes,
and Stephen Lowis

11
10 Tumours of the cranial nerves
Joerg–Christian Tonn and Douglas Kondziolka
11 Meningiomas
Rakesh Jalali, Patrick Y. Wen, and Takamitsu Fujimaki
12 Other tumours of the meninges
M. Yashar S. Kalani, Sith Sathornsumetee, and Charles Teo
13 Tumours of the haematopoietic system
Tracy T. Batchelor, Oussama Abla, Zhong–ping Chen, Dennis C.
Shrieve, and Samar Issa
14 Germ cell tumours
Claire Alapetite, Takaaki Yanagisawa, and Ryo Nishikawa
15 Familial tumour syndromes: neurofibromatosis, schwannomatosis,
rhabdoid tumour predisposition, Li–Fraumeni syndrome, Turcot
syndrome, Gorlin syndrome, and Cowden syndrome
Scott R. Plotkin, Jaclyn A. Biegel, David Malkin, Robert L. Martuza,
and D. Gareth Evans
16 Familial tumour syndromes: von Hippel–Lindau disease
Hiroshi Kanno and Joachim P. Steinbach
17 Familial tumour syndromes: tuberous sclerosis complex
Howard Weiner and Peter B. Crino
18 Pituitary tumours
Edward R. Laws, Jr, Whitney W. Woodmansee, and Jay S. Loeffler
19 Metastatic brain tumours
Matthias Preusser, Gabriele Schackert, and Brigitta G. Baumert
20 Metastatic tumours: spinal cord, plexus, and peripheral nerve
David Schiff, Jonathan Sherman, and Paul D. Brown
21 Neoplastic meningitis: metastases to the leptomeninges and
cerebrospinal fluid
Marc C. Chamberlain, Stephanie E. Combs, and Soichiro Shibui

Index

12
Abbreviations

5-ALA 5-aminolevulinic acid


AED antiepileptic drug
ASCT autologous stem cell transplantation
CBTRUS Central Brain Tumor Registry of the United States
CBV cerebral blood volume
CCG Children’s Cancer Group
CHOP cyclophosphamide, doxorubicin, vincristine, and prednisone
CI confidence interval
CNS central nervous system
COG Children’s Oncology Group
CPC choroid plexus carcinoma
CPP choroid plexus papilloma
CPT choroid plexus tumour
CR complete response
CSF cerebrospinal fluid
CSI craniospinal irradiation
CSRT craniospinal radiotherapy
CT computed tomography
DI diabetes insipidus
DIA desmoplastic infantile astrocytoma
DIG desmoplastic infantile ganglioglioma
DIPG diffuse intrinsic pontine glioma
DLBCL diffuse large B-cell lymphoma
DNET dysembryoplastic neuroepithelial tumour
EANO European Association for Neuro-Oncology
EBRT external beam radiotherapy
ED Erdheim–Chester disease
EFS event-free survival
EGFR epidermal growth factor receptor
EMA epithelial membrane antigen

13
EOR extent of resection
EORTC European Organization for Research and Treatment of Cancer
ESCC epidural spinal cord compression
ETMR embryonal tumour with multilayer rosettes
FAP familial adenomatous polyposis
FLAIR fluid-attenuated inversion recovery
GC gangliocytoma
GFAP glial fibrillary acidic protein
GG ganglioglioma
GH growth hormone
GTR gross total resection
HAART highly active antiretroviral therapy
HAR hyperfractionated accelerated radiotherapy
HDT high-dose therapy
HFRT hyperfractionated radiotherapy
HIV human immunodeficiency virus
HL Hodgkin’s lymphoma
HNPCC hereditary nonpolyposis colorectal cancer
IARC International Agency for Research on Cancer
IDH isocitrate dehydrogenase
IELSG International Extranodal Lymphoma Study Group
iGCT intracranial germ cell tumour
IPCG International PCNSL Collaborative Group
ISCM intramedullary spinal cord metastasis
JXG juvenile xanthogranuloma
KPS Karnofsky performance score
LDD Lhermitte–Duclos disease
LEAT long-term epilepsy-associated tumour
MB medulloblastoma
MGMT O6-methylguanine-DNA methyltransferase
MPNST malignant peripheral nerve sheath tumour
MRI magnetic resonance imaging
MRS magnetic resonance spectroscopy
mTOR mammalian target of rapamycin
NCCN National Comprehensive Cancer Network
NF neurofibromatosis
NGGCT non-germinomatous germ cell tumour

14
NHL non-Hodgkin’s lymphoma
NIH National Institutes of Health
NK natural killer
NM neoplastic meningitis
NOA Neuro-Onkologische Arbeitsgemeinschaft/German Neuro-
Oncology Group
NSCLC non-small cell lung cancer
NSE neuron-specific enolase
ONG optic nerve glioma
ONSM optic nerve sheath meningioma
OS overall survival
PA pilocytic astrocytoma
PCNSL primary central nervous system lymphoma
PCV procarbazine, CCNU (lomustine), and vincristine
PET positron emission tomography
PFS progression-free survival
PNET primitive neuroectodermal tumour
PPT primary parenchymal tumour
PTEN phosphatase and tensin homologue
PXA pleomorphic xanthoastrocytoma
RDD Rosai–Dorfman disease
RGNT rosette-forming glioneuronal tumour
RTOG Radiation Therapy Oncology Group
SBRT stereotactic body radiotherapy
SEER Surveillance, Epidemiology and End Results
SEGA subependymal giant cell astrocytoma
SFOP Société Française d’Oncologie Pédiatrique/French Pediatric
Oncology Society
SFT solitary fibrous tumour
SIOP International Society of Paediatric Oncology
SRS stereotactic radiosurgery
SRT stereotactic radiotherapy
TSC tuberous sclerosis complex
UKCCSG United Kingdom Children’s Cancer Study Group
VAD ventricular access device
VPS ventriculoperitoneal shunt
WBRT whole-brain radiotherapy

15
WHO World Health Organization

16
Contributors

Oussama Abla, Staff Oncologist, Division of Haematology/Oncology,


Department of Paediatrics, The Hospital for Sick Children, Toronto, ON,
Canada; Associate Professor of Paediatrics, University of Toronto, ON,
Canada
Claire Alapetite, Institut Curie, Radiation Oncology Department, Paris &
Proton Therapy Center, Orsay, France
Jeffrey Allen, Otto and Marguerite Manley and Making Headway
Foundation Professor of Pediatric Neuro-Oncology, Department of
Pediatrics; Professor, Department of Neurology, NYU Langone Medical
Center, New York, USA
Tracy T. Batchelor, Count Giovanni Auletta Armenise-Harvard Professor
of Neurology, Harvard Medical School, Executive Director, Stephen E.
and Catherine Pappas Center for Neuro-Oncology, Massachusetts General
Hospital, Associate Clinical Director (Academic Affairs), Massachusetts
General Hospital Cancer Center, Co-Leader, Neuro-Oncology Program,
Dana-Farber/Harvard Cancer Center, Boston, MA, USA
Glenn Bauman, Department of Oncology, Western University and
London Regional Cancer Program, London, ON, Canada
Brigitta G. Baumert, Department of Radiation Oncology and Clinical
Cooperation Unit Neurooncology, MediClin Robert Janker Clinic &
University of Bonn Medical Center, Bonn, Germany
Martin J. van den Bent, Neuro-oncology Unit, The Brain Tumor Center
at Erasmus MC Cancer Institute, Rotterdam, The Netherlands
Mitchell S. Berger, Professor and Chairman, Department of Neurological
Surgery, Bethold and Belle N. Guggenheim Endowed Chair, Director,
Brain Tumor Research Center, University of California, San Francisco,
CA, USA
Jaclyn A. Biegel, Chief, Division of Genomic Medicine, Director, Center
for Personalized Medicine, Department of Pathology and Laboratory

17
Medicine, Children’s Hospital Los Angeles, Professor of Clinical
Pathology (Clinical Scholar), USC Keck School of Medicine, Los
Angeles, CA, USA
Eric Bouffet, Professor of Paediatrics, Director, Brain Tumour Program,
The Hospital for Sick Children, Toronto, ON, Canada
Michael Brada, University of Liverpool, Department of Molecular &
Clinical Cancer Medicine and Department of Radiation Oncology,
Clatterbridge Cancer Centre, Wirral, UK
Alba A. Brandes, Chair, Medical Oncology Department, AUSL-IRCCS
Institute of Neurological Sciences, Bologna, Italy
Paul D. Brown, Department of Radiation Oncology, Mayo Clinic,
Rochester, MN, USA
Marc C. Chamberlain, University of Washington, Department of
Neurology and Neurological Surgery, Division of Neuro-Oncology, Fred
Hutchinson Research Cancer Center, Seattle Cancer Care Alliance, Seattle,
WA, USA
Zhong–ping Chen, Professor and Chairman, Department of Neurosurgery
and Neuro-oncology, Sun Yat-Sen University Cancer Center, Guangzhou,
China
Stephanie E. Combs, Institute of Innovative Radiotherapy (IRT),
Department of Radiation Sciences (GAS), Helmholtz Zentrum München,
Oberschleißheim, Germany
Peter B. Crino, Professor and Chairman, Department of Neurology,
University of Maryland School of Medicine, Baltimore, MD, USA
Frederic Dhermain, Department of Radiation Oncology, Gustave Roussy
University Hospital, Cancer Campus Grand Paris, France
Hugues Duffau, Department of Neurosurgery, Gui de Chauliac Hospital,
Montpellier, Montpellier, France
D. Gareth Evans, Department of Genomic Medicine, MAHSC,
University of Manchester, Division of Evolution and Genomic Medicine,
St Mary’s Hospital, Manchester, UK
Carolyn Freeman, Professor of Oncology and Pediatrics and Mike
Rosenbloom Chair of Radiation Oncology, Department of Radiation
Oncology, McGill University Health Centre, Montreal, QC, Canada

18
Takamitsu Fujimaki, Professor, Department of Neurosurgery Saitama
Medical University, Japan
Mark R. Gilbert, Director, Neuro-Oncology Branch, National Cancer
Institute and National Institute of Neurologic Disorders and Stroke,
National Institutes of Health, Bethesda, MD, USA
Samar Issa, Consultant Haematologist, Clinical Head, Lymphoma
Services, Founding Chair, Lymphoma Network of New Zealand, Member,
Scientific Advisory Committee, Auckland Regional Tissue Bank,
Honorary Academic, Department of Molecular Medicine & Pathology,
University of Auckland School of Medicine, Middlemore Hospital,
Auckland, New Zealand
Rakesh Jalali, Professor of Radiation Oncology, Tata Memorial Hospital,
Mumbai, India
M. Yashar S. Kalani, Department of Neurosurgery, University of Utah
School of Medicine, Salt Lake City, UT, USA
Hiroshi Kanno, Department of Neurosurgery, International University of
Health and Welfare Atami Hospital, Atami, Japan
Paul Kleihues, Medical Faculty, University of Zurich, Zurich, Switzerland
Douglas Kondziolka, NYU Langone Medical Center, NYU Neurosurgery
Associates, New York, USA
Rolf–Dieter Kortmann, Department of Radiation Oncology, Leipzig,
Germany
Edward R. Laws, Jr, Department of Neurosurgery, Brigham and
Women’s Hospital and Harvard Medical School, Boston, MA, USA
Jay S. Loeffler, Joan and Herman Suit Professor of Radiation Oncology,
Departments of Neurosurgery and Radiation Oncology, Chair, Department
of Radiation Oncology, Massachusetts General Hospital and Harvard
Medical School, Boston, MA, USA
Stephen Lowis, MacMillan Consultant in Paediatric and Adolescent
Oncology, Department of Paediatric Haematology, Oncology and BMT,
Bristol Royal Hospital for Children, Bristol, UK
David Malkin, Professor, Department of Paediatrics, University of
Toronto, Senior Oncologist, Division of Haematology/Oncology, Senior
Scientist, Genetics and Genome Biology Program, The Hospital for Sick
Children, Toronto, ON, Canada

19
Robert L. Martuza, William and Elizabeth Sweet Professor in
Neuroscience, Harvard Medical School, Department of Neurosurgery,
Massachusetts General Hospital, Boston, MA, USA
Minesh P. Mehta, Deputy Director and Chief of Radiation Oncology,
Miami Cancer Institute, Miami, FL, USA
Ryo Nishikawa, Professor and Chair, Department of Neurosurgery; Head,
Department of Neuro-Oncology, Comprehensive Cancer Center,
International Medical Center, Saitama Medical University, Saitama, Japan
Brian P. O’Neill, Professor of Neurology, Department of Neurology,
Mayo Clinic, Rochester, MN, USA
Hiroko Ohgaki, Molecular Pathology Section, International Agency for
Research on Cancer (IARC), Lyon, France
Barry L. Pizer, Consultant Paediatric Oncologist, Alder Hey Children’s
Hospital; Honorary Professor, Institute of Translational Medicine,
University of Liverpool, UK
Scott R. Plotkin, Professor of Neurology, Associate Director, Stephen E.
and Catherine Pappas Center for Neuro-Oncology, Massachusetts General
Hospital and Harvard Medical School, Boston, MA, USA
Matthias Preusser, Department of Medicine I and Comprehensive Cancer
Center, Medical University of Vienna, Vienna, Austria
Roberta Rudà, Division of Neuro-Oncology, Departments of
Neuroscience and Oncology, University and San Giovanni Battista
Hospital, Turin, Italy
Elisabeth Rushing, Institute of Neuropathology, University Hospital
Zurich, Zurich, Switzerland
Maria Santos, Neurosurgery Department, University Hospital of Santa
Maria, Lisbon, Portugal
Sith Sathornsumetee, Associate Professor and Director of Neuro-
Oncology Program, Department of Medicine (Neurology), Faculty of
Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Gabriele Schackert, Department of Neurosurgery, University of Dresden,
Germany
David Schiff, Departments of Neurology, Neurological Surgery, and
Medicine (Hematology-Oncology), University of Virginia, Charlottesville,

20
VA, USA
Jonathan Sherman, Department of Neurological Surgery, George
Washington University, Washington, DC, USA
Soichiro Shibui, Department of Neurosurgery, Teikyo University
Hospital, Tokyo, Japan
Dennis C. Shrieve, Huntsman Cancer Institute Chair in Cancer Research,
Professor and Chair, Department of Radiation Oncology, University of
Utah School of Medicine, The Huntsman Cancer Hospital, Salt Lake City,
UT, USA
Riccardo Soffietti, Department of Neuro-Oncology, University and City
of Health and Science Hospital, Turin, Italy
Mark M. Souweidane, Professor of Neurological Surgery, Weill Cornell
Medical College, New York, NY, USA
Joachim P. Steinbach, Dr. Senckenberg Institute of Neuro-Oncology,
Department of Neurology, Frankfurt University Hospital, Frankfurt,
Germany
Walter Stummer, Department of Neurosurgery, University of Münster,
Albert-Schweitzer Campus, Münster, Germany
Nancy J. Tarbell, CC Wang Professor of Radiation Oncology, Dean for
Academic and Clinical Affairs, Harvard Medical School, Boston, MA,
USA
Roger E. Taylor, Professor of Clinical Oncology, College of Medicine,
Swansea University, Swansea, UK; Honorary Consultant Clinical
Oncologist, South West Wales Cancer Centre, Singleton Hospital,
Swansea, UK
Charles Teo, Centre for Minimally Invasive Neurosurgery, Sydney, NSW,
Australia
Joerg–Christian Tonn, Department of Neurosurgery, Ludwig Maximilian
University Muenchen, Munich, Germany
Michael A. Vogelbaum, Professor of Surgery (Neurosurgery), The Robert
W. and Kathryn B. Lamborn Chair for Neuro-Oncology, Cleveland Clinic
Lerner College of Medicine of Case Western Reserve University,
Associate Director, Rose Ella Burkhardt Brain Tumor and Neuro-
Oncology Center, Cleveland Clinic, Cleveland, OH, USA

21
David Walker, Department of Paediatric Oncology, Nottingham, UK
Colin Watts, Reader in Neurosurgical Oncology, University of
Cambridge, Department of Clinical Neurosciences, Division of
Neurosurgery, Addenbrooke’s Hospital, Cambridge, UK
Howard Weiner, Chief of Neurosurgery, Texas Children’s Hospital,
Houston, TX, USA
Michael Weller, Professor and Chair, Department of Neurology,
University Hospital and University of Zurich, Zurich, Switzerland
Patrick Y. Wen, Professor of Neurology, Harvard Medical School,
Director, Center For Neuro-Oncology, Dana-Farber Cancer Institute,
Boston, MA, USA
Wolfgang Wick, Chairman and Professor, Neurology Clinic, Heidelberg
University Medical Center, Clinical Cooperation Unit Neurooncology,
German Cancer Research Center, Heidelberg, Germany
Tai–Tong Wong, Division of Pediatric Neurosurgery, Taipei Veterans
General Hospital, National Yang Ming University School of Medicine,
Taipei, Taiwan, China
Whitney W. Woodmansee, Division of Endocrinology and Metabolism,
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA,
USA
Takaaki Yanagisawa, Professor, Division of Paediatric Neuro-oncology,
Department of Neurosurgery, Jikei University School of Medicine, Tokyo,
Japan

22
CHAPTER 1

The 2016 revision of the WHO


classification of tumours of the
central nervous system
Paul Kleihues, Elisabeth Rushing, and Hiroko
Ohgaki

Introduction
Uniform classification and nomenclature of human cancers are a
prerequisite for epidemiological studies of cancer causation, comparison of
clinical trials, and the validation of novel cancer therapies. In 1957, the
World Health Organization (WHO) established a worldwide network of
collaborating centres to establish uniform histological criteria for the
diagnosis of human neoplasms. The first edition of the Histological Typing
of Tumours of the Central Nervous System was edited by K.J. Zülch and
published in 1979 (1). Considering the highly divergent views held in the
Americas, Asia, and Europe, this classification and grading scheme was a
remarkable achievement, although some misclassifications were soon
recognized. These were eliminated in the second edition published in
1993, mainly due to the introduction of more sophisticated diagnostic
methods, in particular immunohistochemistry (2, 3). A further refinement
in the typing of brain cancers was achieved with the addition of genetic
profiling, reflected in the title of the third edition: Pathology and Genetics
of Tumours of the Nervous System (4, 5). A revision of the 2007 fourth
edition (6, 7) has been published in 2016 and comprises several newly
recognized tumour entities (8). Some of these are histologically
recognized, but an ever increasing fraction of CNS neoplasms are now
defined by their genetic profile (Table 1.1).
The WHO Classification of Tumours of the Central Nervous System has
become the internationally accepted nomenclature for brain neoplasms.
Cancer registries worldwide now routinely assign the morphology code of

23
the International Classification of Diseases for Oncology (ICD-O) to each
tumour entity (9), which facilitates the generation of population-based,
epidemiological data on brain tumour incidence and mortality. The WHO
grading system assigns a malignancy grade to each neoplasm that is
widely used in clinical practice, particularly for gliomas.

Table 1.1 2016 WHO classification of tumours of the central nervous


system

Diffuse astrocytic and oligodendroglial tumours


Diffuse astrocytoma, IDH-mutant 9400/3
Gemistocytic astrocytoma, IDH-mutant 9411/3
Diffuse astrocytoma, IDH-wildtype 9400/3
Diffuse astrocytoma, NOS 9400/3
Anaplastic astrocytoma, IDH-mutant 9401/3
Anaplastic astrocytoma, IDH-wildtype 9401/3
Anaplastic astrocytoma, NOS 9401/3
Glioblastoma, IDH-wildtype 9440/3
Giant cell glioblastoma 9441/3
Gliosarcoma 9442/3
Epithelioid glioblastoma 9440/3
Glioblastoma, IDH-mutant 9445/3*
Glioblastoma, NOS 9440/3
Diffuse midline glioma, H3 K27M–mutant 9385/3*
Oligodendroglioma, IDH-mutant and 1p / 19q-codeleted 9450/3
Oligodendroglioma, NOS 9450/3
Anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted 9451/3
Anaplastic oligodendroglioma, NOS 9451/3
Oligoastrocytoma, NOS 9382/3
Anaplastic oligoastrocytoma, NOS 9382/3
Other astrocytic tumours
Pilocytic astrocytoma 9421/1
Pilomyxoid astrocytoma 9425/3
Subependymal giant cell astrocytoma 9384/1
Pleomorphic xanthoastrocytoma 9424/3

24
Anaplastic pleomorphic xanthoastrocytoma 9424/3
Ependymal tumours
Subependymoma 9383/1
Myxopapillary ependymoma 9394/1
Ependymoma 9391/3
Papillary ependymoma 9393/3
Clear cell ependymoma 9391/3
Tanycytic ependymoma 9391/3
Ependymoma, RELA fusion–positive 9396/3*
Anaplastic ependymoma 9392/3
Other gliomas
Chordoid glioma of the third ventricle 9444/1
Angiocentric glioma 9431/1
Astroblastoma 9430/3
Choroid plexus tumours
Choroid plexus papilloma 9390/0
Atypical choroid plexus papilloma 9390/1
Choroid plexus carcinoma 9390/3
Melanotic schwannoma 9560/1
Neurofibroma 9540/0
Atypical neurofibroma 9540/0
Plexiform neurofibroma 9550/0
Neuronal and mixed neuronal-glial tumours
Dysembryoplastic neuroepithelial tumour 9413/0
Gangliocytoma 9492/0
Ganglioglioma 9505/1
Anaplastic ganglioglioma 9505/3
Dysplastic cerebellar gangliocytoma (Lhermitte–Duclos disease) 9493/0
Desmoplastic infantile astrocytoma and ganglioglioma 9412/1
Papillary glioneuronal tumour 9509/1
Rosette-forming glioneuronal tumour 9509/1
Diffuse leptomeningeal glioneuronal tumour
Central neurocytoma 9506/1

25
Extraventricular neurocytoma 9506/1
Cerebellar liponeurocytoma 9506/1
Paraganglioma 8693/1
Tumours of the pineal region
Pineocytoma 9361/1
Pineal parenchymal tumour of intermediate differentiation 9362/3
Pineoblastoma 9362/3
Papillary tumour of the pineal region 9395/3
Embryonal tumours
Medulloblastomas, genetically defined
Medulloblastoma, WNT-activated 9475/3*
Medulloblastoma, SHH-activated and TP53-mutant 9476/3*
Medulloblastoma, SHH-activated and TP53-wildtype 9471/3
Medulloblastoma, non-WNT/non-SHH 9477/3*
Medulloblastoma, group 3
Medulloblastoma, group 4
Medulloblastomas, histologically defined 9470/3
Medulloblastoma, classic 9471/3
Medulloblastoma, desmoplastic/nodular 9471/3
Medulloblastoma with extensive nodularity 9474/3
Medulloblastoma, large cell/anaplastic 9470/3
Medulloblastoma, NOS 9470/3
Embryonal tumour with multilayered rosettes, C19MC-altered 9478/3*
Embryonal tumour with multilayered rosettes, NOS 9478/3
Medulloepithelioma 9501/3
CNS neuroblastoma 9500/3
CNS ganglioneuroblastoma 9490/3
CNS embryonal tumour, NOS 9473/3
Atypical teratoid/rhabdoid tumour 9508/3
CNS embryonal tumour with rhabdoid features 9508/3
Tumours of the cranial and paraspinal nerves 9560/0
Schwannoma
Cellular schwannoma 9560/0

26
Plexiform schwannoma 9560/0
Perineurioma 9571/0
Hybrid nerve sheath tumours
Malignant peripheral nerve sheath tumour 9540/3
Epithelioid MPNST 9540/3
MPNST with perineurial differentiation 9540/3
Medulloblastoma with extensive nodularity 9474/3
Meningiomas
Meningioma 9530/0
Meningothelial meningioma 9531/0
Fibrous meningioma 9532/0
Transitional meningioma 9537/0
Psammomatous meningioma 9533/0
Angiomatous meningioma 9534/0
Microcystic meningioma 9530/0
Secretory meningioma 9530/0
Lymphoplasmacyte-rich meningioma 9530/0
Metaplastic meningioma 9530/0
Chordoid meningioma 9538/1
Clear cell meningioma 9538/1
Atypical meningioma 9539/1
Papillary meningioma 9538/3
Rhabdoid meningioma 9538/3
Anaplastic (malignant) meningioma 9530/3
Mesenchymal, non-meningothelial tumours
Solitary fibrous tumour/haemangiopericytoma
Grade 1 8815/0
Grade 2 8815/1
Grade 3 8815/3
Haemangioblastoma 9161/1
Haemangioma 9120/0
Epithelioid haemangioendothelioma 9133/3
Angiosarcoma 9120/3

27
Kaposi sarcoma 9140/3
Ewing sarcoma/PNET 9364/3
Lipoma 8850/0
Angiolipoma 8861/0
Hibernoma 8880/0
Liposarcoma 8850/3
Desmoid-type fibromatosis 8821/1
Myofibroblastoma 8825/0
Inflammatory myofibroblastic tumour 8825/1
Benign fibrous histiocytoma 8830/0
Fibrosarcoma 8810/3
Undifferentiated pleomorphic sarcoma/ malignant fibrous histiocytoma 8802/3
Leiomyoma 8890/0
Leiomyosarcoma 8890/3
Rhabdomyoma 8900/0
Rhabdomyosarcoma 8900/3
Chondroma 9220/0
Chondrosarcoma 9220/3
Osteoma 9180/0
Osteochondroma 9210/0
Osteosarcoma 9180/3
Melanocytic tumours
Meningeal melanocytosis 8728/0
Meningeal melanocytoma 8728/1
Meningeal melanoma 8720/3
Meningeal melanomatosis 8728/3
Lymphomas
Diffuse large B-cell lymphoma of the CNS 9680/3
Immunodeficiency-associated CNS lymphomas
AIDS-related diffuse large B-cell lymphoma
EBV-positive diffuse large B-cell lymphoma, NOS
Lymphomatoid granulomatosis 9766/1
Intravascular large B-cell lymphoma 9712/3

28
Low-grade B-cell lymphomas of the CNS
T-cell and NK/T-cell lymphomas of the CNS
Anaplastic large cell lymphoma, ALK-positive 9714/3
Anaplastic large cell lymphoma, ALK-negative 9702/3
MALT lymphoma of the dura 9699/3
Histiocytic tumours
Langerhans cell histiocytosis 9751/3
Erdheim–Chester disease 9750/1
Rosai–Dorfman disease
Juvenile xanthogranuloma
Histiocytic sarcoma 9755/3
Germ cell tumours
Germinoma 9064/3
Embryonal carcinoma 9070/3
Yolk sac tumour 9071/3
Choriocarcinoma 9100/3
Teratoma 9080/1
Mature teratoma 9080/0
Immature teratoma 9080/3
Teratoma with malignant transformation 9084/3
Mixed germ cell tumour 9085/3
Tumours of the sellar region
Craniopharyngioma 9350/1
Adamantinomatous craniopharyngioma 9351/1
Papillary craniopharyngioma 9352/1
Granular cell tumour of the sellar region 9582/0
Pituicytoma 9432/1
Spindle cell oncocytoma 8290/0
Metastatic tumours
The morphology codes are from the International Classification of Diseases for
Oncology (ICD-O) (9). Behaviour is coded /0 for benign tumours; /1 for unspecified,
borderline, or uncertain behaviour; /2 for carcinoma in situ and grade III intraepithelial
neoplasia; and /3 for malignant tumours.
*These new codes were approved by the IARC/WHO Committee for ICD-O.

29
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Evelyn r 11 Hilltop av ((Fst H) HY 7847 — Ford r 103 Avenue rd KI
5290 — Jas E (Daws Bakery) h 36 Bellefair av GR 9762 — John L
gdnr h 148 Cedric av (Frbk) — Peter elk Shaw & Begg r 40 College
— Wm H h 4 Bowman — Wm H mech Dunlop Tire h 7 Aldwych av (E
Y) GL 6131 Daw's Bakery (Jas E Daw) 2032 Queen e HO 2729
Dawber Dorothy emp Eatons r 984 Ossinigton av LO 6049 — Geo
cabt mkr Genl Steel Wares h 42 Howie av GL 1241 — Geo A r 42
Howie av GL 1241 (act ser) Dawbon Chas drftsmn CGE h 289 Balliol
HU 8186 — Marjorie E stenog Chas Warnock & Co r 289 Balliol HU
8186 Dawe A Z carp h 129 Westmoreland av — Alexander prntr
Eatons h 284 Beech av GR 0113 — Alexander S teller Royal Bank
(454 Yonge) r 184 Beech av — Alfred parcel wrapper Eatons r 29
Oak Park av — ALLan A r 1, 937 Avenue rd n HY 7128 (active
service) — Alonzo ctr Gutta Percha h 130 West Lodge av LO 3095 —
Annie (wid Wm E) h 1798 Dufferin KE 3816 - — Audrey sis elk
Eatons r 284 Beech av — Audrey E nurse r 29 Oak Pk av GR 5557 —
Audrey E typist B A Oil r 133 Strathallan blvd HU 1425 — Azariah lab
Imp Oil h 30 Blandford (Frbk) LO 0036 — Beatrice L priv sec Empire-
Hanna Coal r 101 Walmsley blvd — Bryan J r 1777 Danforth av HO
0047 (act ser) — Carrie elk Eatons res Willowdale — Catherine M elk
W E Booth Co r 391 Manning av KI 1081 — Chas T blrmkr Lloyd &
Westwood h 3 Rockvale av (Frbk) LO 9932 - — Chas T staty tob &
conf 1777 Danforth av h same HO 0047 — Clarence elk Graham Nail
h 393 Oakwood av (Frbk) — Dinah (wid Nicholas) h 30Vz Blandford
(Frbk) — Doris J opr United Ch Pub House r 3 Rockvale av (Frbk) LO
9932 — Earle S vice-pres E W Woods & Co h 113 Strathallan blvd HU
1425 — Edwd lab De Havilland Aircraft h 477 Westminster av (Frbk)
— Eli B carman CNR h 128 Alcorn av RA 1778 — Fredk F stl wkr
Dorn Bridge h 983 Shaw — Geo H pntr & dec 36 Lawrence av w h
same HU 0344 Dawe Geo K leather wkr A R Clarke h 172 Virginia av
(E Y) - — Gordon L r 29 Oak Park av GR 5557 (act ser) — Harold
hlpr Globe & Mail h 37 Hastings av HA 9152 — Henry lab Massey-
Harris h 44 Main s (Wstn) ph 1012 — Henry W stek kpr A L Gillies Co
h 136 Spears (Mt D) JU 7072 — Hubert A slsmn Tuckett Ltd h 234
Heath e MO 9685 — Jas Rev clergyman Br Israel Federation h 29
Oak Park av GR 5557 — Jas H asst mgr Eatons h 167 Atlas av
(Wych) LA 8371 — John opr McQuay-Norris r 136 Spears (Mt D) JU
7072 — John B opr TTC h 112 Fermanagh av — John M supt Federal
Bldg h 391 Manning av KI 1081 — Kathleen C stenog Dawe's
Monthly Accounting Service Bureau r 1, 937 Avenue rd n HY 7123 —
Lester W opr TTC h 1066A St Clair av w LA 3214 — Lewis E br mgr C
Beck Co r 111 Linnsmore cres (E Y) HA 7449 - — Margt I elk Link-
Belt r 37 Hastings av HA 9152 — -Marion elk Langleys r 32 St Joseph
— Marjorie sis elk Loblaws r 29 Oak Park av — Marjorie elk
Manufacturers Life r 113 Strathallan blvd HU 1425 — -Marlow T r
101 Walmsley blvd HY 9675 (act ser) — Mary M (wid Wm) h 20, 5
Donlands av HA 1736 — Mildred (wid Chas) slsldy Peggy Anderson r
35 Eastwood rd - — Mona typist Simpsons r 136 Spears (Mt D) JU
7072 — Neil R bench hand Wright Industries r 539 Dovercourt rd -
— Norman C slsmn Standard Store Equipment h 4 Ashland av —
Orlando mech McGregor's Service Stn h 110 Curzon HA 7622 —
Pearl stenog Candn Fairbanks Morse r 391 Manning av KI 1081 —
Randolph A h 57 Alameda av (Frbk) LA 9413 — Regd emp Gutta
Percha r 130 West Lodge av LO 3095 — Roy extractor Langleys r
477 Westmount av — Ruby stenog Eatons r 663 Dufferin ME 7435 —
Ruby B stenog Dept of Wks r 663 Dufferin - — Russel slsmn 7-Up h
42 McKenzie cres - — Sarah r 213 Lauder av (Oak) KE 1696 — Sarah
(wid Nicholas) r 30 Blandford (Frbk) LO 0036 — Sidney R mech
Wheel & Rim h 16 Rosemount av LL 5034 - — Theo S druggist
Franklin P Oliver h 34 Langford av HA 1296 — Thos G dec Geo H
Dawe h 150 Livingstone av (Frbk) KE 9591 — Victor h 1, 3033A
Dundas w JU 8848 (act ser) — Violet stenog r 391 Manning av KI
1081 — Wm r 663 Dufferin ME 7435 — Wm r 1 Dunbar rd RA 5896
— Wm elk Graham Nail r 393 Oakwood av (Frbk) — Wm lab r 477
Westmount av (Frbk) — Wm lab CGE h 14 Hatherby rd (Frbk) - —
Wm mach Tor Shipbldg h 68 Teignmouth av (Earlscourt) — Wm A
(Dorn Income Tax Service Bureau) (Dawe's Monthly Accounting
Service Bureau) h 1, 937 Avenue rd n HY 7128 — Wm G blrmkr
Lloyd & Westwood h 218 Cedric av (Frbk) ME 3715 Dawe's Monthly
Accounting Service Bureau (Wm A Dawe) 137 Jarvis EL 7465-6
Dawes Aldyne slsldy Eatons r 79 Beachview cres — Alfred box mkr h
117 Woodycrest av (E Y) — Allen (Crown Fish Store) h 349Vz
Broadview av HA 0904 — Annie (wid Percy) h 173 Coxwell av —
Arthur h 57 Marjory av HA 9591 (act ser) — Audrey model Photo
Engravers r 70 Hiawatha rd GE 4718 — Austin foreman Gault
Elevator Co r 41 Oakcrest avenue — Catherine hsekpr 843 St Clair av
w LL 8145 — Chas B tchr Western Tech-Comml Schl h 8 Laws JU
7389 — Chas mach Chas P Wayman Co h 73 Sparkhall av GL 2957
— Daisy h 35 Vernon JU 0737 — Edwd C emp Eatons r 73 Sparkhall
av GL 2957 — Eleanor prsr Snow White Hand Laundry r 70 Hiawatha
rd — Evelyn M stenog Dorn Bridge r 79 Beachview cres — Evelyn
stenog Home Ins r 312 Indian rd LA 3251 — Frank C asst suprvsr
Eatons h 2174 Gerrard e GR 4579 — Fredk J elk CP Exp h 738 Huron
MI 4049 — Grace Mrs chief elk Hunt's r 88 Carlton — Gordon H asst
mgr Household Finance Corp h 24 Yonge blvd HY 8171 — Henry J r
70 Hiawatha rd GE 4718 (act ser) — J Stewart cash Lake Simcoe Ice
h 73 Laird dr s (Leas) HU 7914 — Jas A asst treas Marelco Ltd h 22
Springbank blvd (Bch C) HO 0549 — Jas T lab Associated Bottlers h
15 Thompson — John purch agt Cober Elev h 24 Yonge blvd HY
8171 — Jos H elk Military Hdqrts h 43 Spruce Hill rd - — Jos L
display man Millinery Supplies h 70 Hiawatha rd GE 4718 —
Lawrence D elk CGE h 80 Dentonia Park av (E Y) — Mae (wid Elgin)
(St Clair Fish & Chips) h 655A St Clair av w LA 3749 — Margt stenog
Philco Corp h 206 Fairview av LY 1614 — Marion J bkpr Chocolate
Products r 173 Coxwell avenue — P Arthur plshr Super Health
Aluminum Products h 389 Jones av — Philip T drftsmn Frankel Bros
h 402, 18 Tichester rd (Wych) ME 7924 — Road Gospel Mission 65
Dawes rd Dawes Rosalyn tchr Scarboro Collegiate r r Gerrard e GR
4579 — S Jas engnr CPR h 206 Fairview av LY '• — Thos C reprmn
TTC res Etobicoke — W Austin h 79 Beachview cres HO 8081 — W P
emp Massey-Harris r 61 St Clair * MI 6453 — Wilfred r 73 Sparkhall
av GL 2957 Dawgela Paul gdnr Bishop Strachan Sch! • Adelaide w EL
2660 Dawich Mary (wid John) r 207 John EL i;\ — Maurice r 207
John EL 2016 (act ser) — Philip emp Canada Strip Mill h 207 EL 2016
Dawkes C Geo real est and ins 1696 Queen ■ 3500 h 1 Orchard Park
blvd GR is;; Dawkins Alice (wid J L) h 57 Roselann a 4226 —
Charlotet (wid John) h 12 Madison av KI j — Cliff serv stn attdt Wm
G Webster r 143 i ; vale av WA 9627 - — Ethel Mrs hrdrssr r 210,
1233 Yonge K] — Freda h 206, 14 Chatsworth dr HU 9354 ' 1 — Geo
A dry gds and confy 857 BroaCi u * same GE 3145 — Harry stekpr
Neilsons h 486 Concord j ! 5517 — Isabel stenog John Northway r
148 Go> : av WA 9627 — Jack B r 269 Forest Hill rd (Fst H) Vi ‘ (act
ser) — John R mng dir Yardley & Co (Can) Ltd • " Forest Hill rd (Fst
H) MA 1804 — Lyall slsmn Candn Johns-Manville h 23 * dr MA 3703
— Murray slsmn Skinners Sport Shop r 4S6 cord av LL 5517 — Percy
pres Tod & Dawkins Co Ltd k , Kingston rd — Victor H repairmn Imp
Optical h 148 Ere av WA 9627 — Wm W asst Geo L Monte & Son r
53 ^ beck HA 0195 Dawks M emp John Inglis h 300 St Geo- . 7040
♦Dawley, see also Dolley — John cond CNR h 54A Galley av LA 45 —
Lail K pilot Dominion Skyways (Trailing-' h 10, 628 Shaw - — Roy A
routemn Ont News r 54A Galtej 4597 — Wm doormn Imp Theatre h
10 Sactaille . Dawn Annie Mrs h 564 Manning av ME 2! — Dorothy
sis elk John Northway r 223 Vr. ta LL 4970 — Evelyn book bndr r 564
Manning av ME 2 — John mech r 564 Manning av ME 23*3 j —
Jonathan L elect Wilson Motor Bodes Manning av ME 2849 —
Products Div Lou H Wainica mng ci,: equipment 413, 137 Wellington
* Ei ’ ' — W Gordon adjuster Wawanesa Mutual is L Hanna rd (Leas)
HY 5001 Dawney Oliver F chefs hlpr Simpsons r 12- , berland KI
4336 Daws Arthur J ctr Princeton Suspender i wear h 261 Willard av
— Geo A with Bell Tel r 131 Strathmore I - . 3518 — Helen color
artist Mayfair Studios r ; dale av GE 3695 — Horace A messr Dom
Bank (King and . v 131 Strathmore blvd GE 3518 — Philip h 30
Cumberland KI 2482 (ad si. — Wm P h 3 Russell KI 4963 Dawson A
E & Co (A E Dawson) briers 3 j. Bay AD 6091 - — A Ernst (A E
Dawson & Co) h 74 . road MI 9906 — Adrian elk Mnfrs Life r 79
Huntley — Agnes C elk Bank of Can (Tor Age--.' . — Agnes R stenog
Masco Co r 79 U*' . HY 9830 — Alan K fin reporter Star h 191 Co
road (Scar) HO 6017 — Albert E h 17 Dearbourne av GE 3k T- —
Alexander h 174 Willow av — Alex vice-pres & mgr Tor Iron Vie L
Teddington Pk av HU 6249 —Alexander R C ftr TTC r 105 Ferrier z. ,
— Alice M swtchbd opr Arnoldi, Pa rr; : : bell r 169 Gilbert av —
Allan h 756 Dufferin — Allan h 239 Russell Hill rd MI 8469 i — Amy
(wid Jas) h 92 Apple Grove ai < j — Andrew F plmbr Bennett &
Wrig* , Concord av LL 8528 — Anna M acct Ont Lndry Co Ltd h
Wellesley • — Anne bkpr Baker Platinum h 308, 26 av KI 9267 —
Annie r 23 Hiltz av HA 1669 _ , j. — Annie (wid Geo) cigars & tob
235 • av h same GL Q232 — Annie E (Wid Jas) emp Textile » , ,
Somerset av LO 8211 —Ariel E (wid Wm A) h 29 Bloom;: , 8459 —
Arthur h 1117 Queen e (act ser) i, — Arthur elk Eatons r 54
Sutherland - , —Arthur emp CPR h 101 Bernice cres . LY 8505 —
Arthur gdnr City Parks Dept h * , blvd HY 3543 —Arthur mus h 477
Northdiffe b« ‘ , — Arthur E ctr Louis Berger Ltd “ rose av HU 3841
— Arthur J (Hillcrest Taxi) h 1®0 “ (Frbk) KE 3233 . ■[ — Arthur 0
vice-pres L C Smith & writers of Can Ltd h 1, 1003 * HU 3632 —
Barbara radio coll r 74 Crescent —Barbara teller Royal Bank of Can
D* , r 110 Wanless av — Beauty Parlor (Myrtle Dawson) Birchcliff av
((Bch C) HO 6419 _ —334^ 
TTC h 65 Grandvi lie av (Mt D) 121 Langford av HA 4050 nr
h 2 Delane rd (E Y) GR 0294 id opr Huron & Erie Mort Corp r irne
Frank Dawson mgr 2 Woodfield Sandwich Bar) h 1413 Danforth y
Continuous Forms r 123 Clinton 407 Sackville MI 4928 B A Motors h
60 Glen Manor dr 02 Tyndall av LA 6320 mn MacFeeters Creamery h
4 (Rnny) Bathurst (act service) iyal York Hotel r 176 Oakcrest av 96
Arlington av (Wych) LL 4022 Inglis h 395 Mortimer av (E Y) .96
Manning av ME 3644 Wonder Bakeries r 41 Wellesley ires Gibson
Cleaners Ltd h 14 A 4461 Swan Service h 160 Hendon av l andn
Steam Boiler Equipment Co rater av (E Y) GR 5535 F A) r 100 thirty-
ninth (Long B) CNR h 332 Montrose av Candn Nat Institute Blind r n
ME 7822 lgr Simpsons h 305, 204 Kingmach TTC h 105 Ferrier av GL
iv sec Simpsons r 17 Dearbourne r kpr Bank of Toronto (2440 212,
2001 Bloor w LY 7913 Carlton agon Leather Gds r 123 Clinton it Idgr
kpr Dorn Bank (Queen & Ferrier av Ismn Dorn Linseed Co h 330
(Frbk) escent rd MI 9906 (act ser) hog Silverware Products r 14 mp
REL h 136 Eglinton av e |V Robinson & Son r 110 Wanless I > Id
CCM r 3 First av (Wstn) i 201, 2 Clarendon av It Crescent rd MI 9906
(act ser) I Sandwich Bar) r 35 Pearson av I. Victoria blvd (Mt D) I
Bell Tell r 246 Kingswood rd I ons r 4 Laurier av RA 1769 I Bank of
Com (Tor Br) r 541 «lvd GR 2243 1 elk Star r 46 Playter cres GE
inisholm av (E Y) (act ser) J: Bowser Co r 80 Wellesley ilas Co h 219
Ashdale av GL res Willowdale #:sch Dept TTC r 35 Pearson av findn
Liquid Air h 20 Bicknell I 9148 I hur S Leitch Co r 32 Maher av «>hn
H) h 45 Alhambra av LL 5 lutual MI 5147 il Corley & Keen r 105
Ferrier av siog Public Trustee of Ont r 46 H. 6497 item av Eatons r
320 Ontario Dominion Bldg h 248 Withrow ltyne av (Scar) GR 7030
ton Gear & Mach r 85 Van 6 4' ;l en kd yr Glenlake av LL 0719 91
Neville Pk blvd GR 9700 ollywood cres GR 5063 Munro ■ Bank of
Com (156 Pearl) h av HU 2371 256 Blantyre av (Scar) GR ar h 544
Balliol HY 6516 Hygienic Hairdressing Salon r t dr GR 0167 n 1 i
Bridge h 252 Roehampton av irect-Winters h 46 Dearbourne r 83
Woodington av /lacdonald Mfg h 1006 DoverEmergency Training h 6
2932 Yonge MA 3255 s Maurice Glancey r a Curzo.i gton av LO 7023
her & Down r 430 Church Cluny dr RA 6816 Oil h 337 Sutherland
Drive 1 T oho R £ >tn for Ol llis h 818 Gerrard e GL 4883 lglis h 62
Kenilworth av GR 'awson h 51 Rawlinson av MO h 19 Glenmount Pk
rd n Smith Mfg h 73 Birchcliffe 6419 Dawson Geo A baggage master
CNR Frt h 245 Hillsdale av e HY 6798 — Geo A mach Bennet & Elliott
r 114 Cluny dr RA 6816 — Geo A mech RCAF h 1 Northview av
(Scar) HO 7501 — Geo E h 8 Greendale cres (Mt D) (act ser) — Geo
H r 24 Somerset av LO 8211 (act ser) — Geo H mgr Moyer School
Supplies h 33W, 10 Tichester rd (Wych) KE 4826 —Geo T h 237
Royce av LL 8143 — Geo T opr Tor Feather & Down r 430 Church —
Geo W opr CIL r 164 Dinnick cres MO 6725 — Geo W mach Massey-
Harris h 125 Brownville av (Mt D) LY 4864 — Geraldine emp Kirk Dial
Co r 497 Jones av GL 0312 — Glenholme r 252 Roehampton av MO
2605 (act service — Gordon r 8 Wellesley av RA 7830 (act ser) —
Gordon mach John Inglis h 48 Victoria blvd (Mount Dennis) —
Gordon prsmn Beare's Ltd h 13 Coady av GL 1586 - — Gordon mech
Anderson McLaughlin-Buick Pontiac h 391 Davisville av HY 9107 —
Gwendolyn r 81 Day av KE 6613 (act ser) — Harold glass wks
Central Ornamental Glass Co h 83 McCaul AD 0617 - — Harold trav
Hewitson Shoes h 62 Airdrie rd (Leas) MA 4645 — Harold L bkpr Star
r 169 Gilbert av KE 1836 — Harold S h 100, 51 Grosvenor (act ser)
— Harry A slsmn Warwick Bros & Rutter h 280 Inglewood dr HY
3804 — Harry C drftsmn Railway & Power h 637 Greenwood av —
Helen priv sec Wright & McMillan r 46 Playter cres GE 6381 —Helen
A stenog Baker & Linton r 2453 Dundas west — Helen M typist
Simpsons r 25 Surrey pi — Henry S engnr REL h 7 Coldstream av MA
5835 — Herbert emp Massey-Harris r 28 Camden — Herbert lab h
169 Coleman av — Herbert F form mkr Clatworthy & Son r 14 St
Paul — -Horace E h 632 Bloor w — Howard W groc mgr Dorn Stores
Ltd (607 Mount Pleasant rd) h 52A Duggan av MO 6242 — Howard
W trainmn TTC r 16 Iona av HO 3434 — Hugh J r A Sultan KI 7277 ■
— Ida opr New Method r 120 Hollywood cres GR 5063 —Irene
stenog Wholesale Radio r 60 St George — Irvig R slsmn Irwin
Specialty h 302, 404 Spadina rd (Fst H) MO 7111 — Isaac chart acct
Imp Oil h 1, 873 Avenue rd n HY 7071 — Jack h 4 Curzon — Jack r
251 Sherbourne KI 9350 — -Jas emp Simpsons h 68 Orchard View
blvd — Jas bench wrkr John Inglis h 1308 Lansdowne av LL 9915 —
Jas E elk TTC h 207 Pacific av JU 2254 — Jas G r 207 Pacific av JU
2254 (act ser) — Jas T mach John Inglis r 2 Westport av JU 6095 —
Jas T Rev pastor British Methodist Episcopal Church h 219 Augusta
av EL 6584 — Jas W slsmn J F Hartz Co h 410 Glenlake av JU 7065
— Jemima (wid Peter) h 1077 Dufferin ME 7822 — John elect h 85
Van Horne LO 5716 — John slsmn Marvelo Mfg r 256 Blantyre av
(Scar) GR 7030 - — -John tanner Wickett & Craig h 63 Coady av —
John A emp Eatons h 18 Osborne av GR 8849 — John A geologist
Macassa Mines Ltd r 36 Prince Arthur av — John C metal spinner
Genl Steel Wares h 136 Curzon HA 8315 — John H pipe fitter h 1431
Kingston rd (Bch C) HO 9401 — John H announcer CFRB h 366
Soudan av HU 0557 — John J elk Sun Ins h 329 Huron KI 1508 —
John J slsmn Candn Westinghouse h A7, 1477A King w LA 6815 —
John McK h 22 Hartford av (act ser) — John R asst genl sis mgr
British American Oil Co Ltd h 5 Donegall dr (Leas) HY 8633 — John
R prntr MacLean Pub h 333 Castlef ield av HU 3016 — John W emp
Acme Carbon & Ribbon r 86 Beaconsfield av LL 4401 — John W
sheet mtl wkr Anaconda Amer Brass h 37 Third (New T) — John W
refrigeration mech Bordon Co r 1431 Kingston rd (Bch C) HO 9401 —
Joseph Mrs h 9 Sussex av RA 4616 — -Julia nurse h 218 Pacific av JU
2225 — Kenneth A artist 63 Gerrard w r same WA 1219 — Kenneth
C r 110 Wanless av MO 9762 — Kenneth T Genl Engnrg r 66
Woodycrest av GL 4385 — Laurence C tchr Parkdale Coll Inst r 3,
444 Walmer rd (Wych) RA 3396 — Leo B assmblr L C Smith h 133
Rosemount av LL 5694 - — Leo 8 elk Bank of Com (Tor Br) h 146
Algoma (Mimico) — Leonard G elk Great-West Life Assce r 6 Mallon
av — Lillian B emp Neilsons r 237 Royce av LL 8143 — Lillian G
stenog Dept of Wks r 22 Hartford av —Lillie M (wid Geo) h 46 Kent
rd HA 6497 — Lily (wid Frank) h 20 Eaton av — Lois (wid Alfred) h
81 Day av KE 6613 — Loraine elk Langleys r 252 Roehampton av MO
2605 — Louis C emp Salada Tea h 25 Mayfield av (Swan) LY 4129 —
Louise Mrs parceller Eatons r 3, 29 Enderby rd GR 5264 Dawson
Louise (wid Geo) caretkr Eatons h 6 Mallon — Louise E stenog Bank
of Toronto (313-315 Eglinton av w) r 24 Falcon HY 6308 — M Frank
mgr Dawson Boathouse h 246 Kingswood rd GR 1331 — Madeline
compt opr CGE r 1, 1416 Dundas w LO 8346 — Madeline stenog r 8
Wellesley av RA 7830 — Margt elk Dorn of Can Genl Ins res
Willowdale — Margt (wid Alex) r 667 Ossington av LL 3411 — Margt
(wid John) r 880 Dundas e GL 3667 — Margt E office sec Student
Christian Movement of Can h 6, 25 Mossom rd (Swan) LY 3562 —
Maria r 141 Macoherson av RA 4508 — Marshall elk Candn Genl Ins r
133 Rosemount av LL 5694 — Martha (wid Jas) r 17 West Lynn av
GR 9597 — Mary Mrs r 497 Jones av GL 0312 — Mary Mrs r 317
Rose Park dr HU 5235 — Mary (wid Alex) r 43 Bloomfield av HA
0459 - — Mary (wid Alex) h 30 Soudan av MO 3890 — Mary (wid
Chas) h 46 Playter cres GE 6381 — Mary (wid John) r 7 Cunningham
av - — Mary A wrapper Barrymore Cloth r 1416 Dundas w LO 8346
— -Mary E (wid Robt) r 32, 2 Glen Elm av HY 0659 — -Mary E (wid
Wm) h 62 Barton av — Mary I acct W L McKinnon & Co r 47 Marion
KE 3879 — Mary K Idgrkpr Dom Bank (Spadina av and Adelaide) r 3,
444 Walmer rd (Wych) RA 3396 — Maud (wid Chas) h 110 Wanless
av MO 9762 — May h 23 Rathnelly av MI 3357 ■ — May emp
Sangamo Electric r 174 Willow av — Mina R Mrs h 35 Pearson av LL
8929 — Muriel E nurse r 110 Wanless av MO 9762 —Murray K r 5,
312 Lonsdale rd (Fst H) HU 2153 (act ser) — Murray R elk CNR Off
Vice-Pres & Genl Mgr r 432 Christie LA 8672 — Norma parceller
Eatons r 818 Gerrard e GL 4883 — Norma H stenog McAinsh & Co r
1308 Lansdowne av LL 9115 — Norman r 391 Davisville av HY 9107
— -Norman emp John Inglis h 24 Erskine av MO 1736 — Norman F
slsmn Shell Oil r 8 Wellesley av RA 7850 — Orvalle emp Way Sagless
Spring Co h 3, 153 Augusta av - — Pat Miss h 6, 85 Bloor e —
Patricia Mrs r 127 Walker av MI 7922 — Paul C asst genl mgr Dom
Oxygen h 24 Weybourne cres MA 5803 — Paul R dept foremn Shell
Oil h 1 Curzon HA 3272 — Pearl H r 100 Dynevor rd (Frbk) KE 3233
—Percy dsgnr Society Sports Wear h 91 Neville Park blvd GR 9700 —
Percy iron wrkr r 16 Iona av HO 3434 — Percy L iron wrkr h 16 Iona
av HO 3434 — Peter r 209 George WA 4254 ■ — Peter N mgr E J
Fetherstonhaugh & Son r 64 Binscarth rd KI 1558 — Phyllis B nurse
VON h 32, 6 St Thomas KI 1835 - — R MacGregor professor U of T h
20 Oriole gdns HU 8657 — Ralph belt man Can Packers h 24
Florence cres (La M) JU 9276 — Ralph C h 82V2 Cambridge av —
Richard h 5, 312 Lonsdale rd (Fst H) HU 2153 — Richard app
Howards Garage r 22 Hartford av — Richard caretaker Eatons r 320
Ontario RA 4912 ■ — Richard pipe organ bldr and tuner h 194
Springdale blvd (E Y) HO 9455 — Richard L mgr Eatons h 39 Watson
av (H Crest) LY 0063 ' — Richard V h 322, 398 Avenue rd RA 1054
(act service) — Robt acct Liquor Control Board r 593 Brock av LL
6573 — Robt emp De Havilland Aircraft h 223 Bowood av MO 1901
— Robt mech De Havilland Aircraft h 94 Balmoral av KI 9030 — Robt
pressmn Eatons h 432 Christie LA 8672 — Robt with Tor Hydro h
1252 Gerrard e HA 6893 — Robt E plmbr and heating contr 24
Falcon h same HY 6308 — Robt E trk drvr Conger Coal h 8 Myrtle av
— Ronald r 66 Woodycrest av GL 4385 (act ser) —Rose (wid Alex) h
8 Wellesley av RA 7830 — Ross A r 29 Bloomfield av HA 8459 (act
ser) — Roy J stkpr Globe Envelopes r 100 Bleecker MI 6208 — Ruth
B elk Candn Kodak r 225 Grenadier rd LO 9644 — Ruth M bookfolder
United Ch Pub House r 66 Woodycrest av GL 4385 —Sami leather
wkr h 123 Clinton — Sarah (wid Thos) h 530 Crawford — Sarah J
Mrs emp St Michaels Hosp h 2 Northview av (Scar) — Sebastian
officer Dept of N & N H (Veterans Welfare Div) h 8 Scarborough
Beach blvd HO 8229 — Sidney r 81 Day av KE 6613 (act ser) —
Stephen B mfrs agt h 3, 315 Lonsdale rd (Fst H) HU 4028 — Stewart
A emp B A Oil h 43 Bloomfield av HA 0459 — Stuart h 47 Victoria
Park av (Scar) HO 2847 — T M Rev curate St Matthews (Ang)
Church — Theresa M opr Geo Hees & Co r 62 Barton av — Thos
radiator man Levy Auto Parts r 136 Curzon HA 8315 —Thos H
drftsmn r 541 Strathmore blvd GR 2243 — Thos J r 530 Crawford —
Thos J lab Gooderham & Worts h 66 Woodycrest av GL 4385 DAY
DAY Dawson Thos S aircraftman Malton Airport h 29 Hazelwood av
— Thos W h 541 Strathmore blvd GR 2243 — Thos W dentist 33, 12
Bloor e KI 8802 h 9 Lauder av LL 6950 — Velma W stenog Cnt Hydro
r 95 Lyndhurst av MI 2693 — Verna opr Monarch Marking System r
133 Rosemount av LL 5694 — Violet R stenog CNR Right of Way
Dept r 63 Coady av HA 4883 — W Clark mgr Real Estate Tor Genl
Trusts h 83 Binscarth rd RA 2620 — W V Ltd A W McNaughton Tor
mgr paper envelopes grnd fir, 100 Adelaide w EL 2939 — Walter
decorator Eatons h 14 Denarda (Mt D) JU 4639 — Walter emp
Sangamo Electric r 174 Willow av — Walter fitter Delamere &
Williams h 293 Harvie av (Erls) ME 1751 — Walter I c PO h 359
Howland av — Walter plmbr h 131 Laird dr HY 7679 — -Walter B r
231 Lansdowne av LL 6644 — Walter B jr h 231 Lansdowne av LL
6644 — Walter W carp Dufferin Constn h ((rear) 315 College —
Wesley E A r 54 Balliol HY 6516 (act ser) — Whitmore h 369
Dovercourt rd LO 2534 —Wilfred emp Sterling Tower Bldng r 245
Gilmour av JU 6065 — Wm (Central Ornamental Glass Co) h 369
Willard av LY 6867 — Wm adviser CPR h 88 Manor rd e MO 8505 —
Wm chef h 157 Delaware av — Wm crane opr Dom Bridge h 108
Kennedy av (Swan) JU 4374 — Wm cutter Candn Natl Inst for the
Blind r 291>/z George RA 4874 — Wm engnr Massey-Harris r
Gladstone Hotel ME 6731 - — Wm filing Ont Hydro r 157 Bowie av
KE 7307 — Wm foremn Rowntree Co h 186 Pacific av JU 8191 —
Wm mgr Simpsons ml order, h 54 Sutherland dr (Leas) HU 5954 — -
Wm mng editor Candn Home Journal h 24 Victor av (Mim) — Wm
paint foremn A Muirhead Co h 532 Crawford LO 3051 — Wm A h 49
Dupont RA 6595 (act ser) — Wm D I c PO h 176 Oakcrest av — Wm
E elk PO h 144 Woodycrest av (E Y) GE 1259 — Wm H carp
McBrides Garage h 2453 Dundas w — Wm H with Bank of Mont h
212, 2001 Bloor w LY 7913 — Wm M purch mgr United Cigar Stores
h 40, 15 Sherwood av MO 2883 — Wm Subscription Service Ltd
Albert E Moss mgr magazines 70 King e EL 4138 — Willis E h 100
Bleecker MI 6208 — Wilmer J foremn Canada Dairies h 1252Vz Bloor
w KE 1092 Dawson's Pleating Co (J Dawson Large) pleating, covered
buttons and buckles 7 McCaul AD 8900 — Sandwich Bar (E R and C
E Dawson) rest 1413 Danforth av Dawz Veitch (Mrs Dawz D Sims)
interior dsgnr 12 Ellis av MI 2193 Dawzy Agnes h 31 Gloucester KI
4290 — Mary r 31 Gloucester KI 4290 Dax Rudolph maintenance
man Coulter Mfg h 296 Scarborough rd Daxon Harry welder Ideal
Welding h 26 Snider av (Frbk) LO 5556 — Henry mach h 124
Kirknewton rd (Frbk) — Jas jr emp Massey-Harris r 594 Lauder av
(Frbk) KE 7067 — Jas insp CGE Royce Av Wks h 594 Lauder av
(Frbk) KE 7067 — John fitters hlpr CGE Royce Av Wks r 594 Lauder
av (Frbk) — Walter r 124 Kirknewton rd (Frbk) ♦Day, see also Dey —
A E h 1320A Queen w LA 9409 (act ser) — A Jas h 74 Vernon — Albt
E h 151 Marlborough av MI 5342 — Albt E (Days Cartage) h 528
Whitmore av (Frbk) LO 8220 — Albt E pekr Scales & Roberts h 1
Raglan av LO 2752 — Albt E porter Imp Life h 197 Westmoreland av
KE 4070 — Albt E with Bell Tel h 505 Donlands av (E Y) —Albt T h
91 Gledhill av (E Y) HO 0739 — Alberta E r 27 Emerson av LO 5862
— Alexander h 86 Bartlett av LA 0165 - — Alfred emp Bd of Educ r
407 Clinton ME 7815 — Alfred T supt Aluminium Goods Ltd h 105
Clendenan av JU 4485 — Alice Mrs emp Simpsons h 245 Rusholme
rd LO 8004 —Alice (wid M A) h B2, 98 Leuty av GR 3715 — Alice E r
23 Goldwin av (Mt D) JU 2852 (act service) — Allan h 50 De Were
Gardens (Nth Y) — Allan G pattern mkr John Inglis h 294 Cedarvale
av (E Y) HO 0544 — Allan V h 374 Beresford av LY 3781 — Alvin drill
hand CCM r 15 Norval JU 9567 — Anna h 22, 6 St Clair av w —
Annie (wid Jacob) h 425 Manning av MI 3831 — Annie B Mrs h 135
Marion KE 9007 — Arthur h 2 Macklem av ME 4394 (act ser) —
Arthur foremn CCM h 15 Norval (Rnny) JU 9567 Alphabetical, White
Page 335
DAY DAY Day Arthur J stkpr Northern Inst of Technology h
1, 26 Howland av ME 1837 — Arthur T laboratory asst Connaught
Laboratories h 12 Gloucester — Aubrey elk Eatons r 26 McRoberts av
KE 4368 — Bernard h 247 Pacific av LY 2222 - — Bernard legal elk
Briggs, Frost & Birks r 305 George RA 5362 — Bernice elk United Ch
Pub House r 16 Rainsford rd - — Bert T r 74 Priscilla av (Rnny) JU
6264 (act service) • — Bessie V opr Bell Tel r 140 William (Wstn ph
968) - — Betty bkpr Watsons Food Products r 27 Carlton — Betty F
assorter Crown Cork & Seal Co r 28 Lamb av • — Building 124-128
Richmond w — C Raymond staty engnr Candn Kodak h 40 Emmett
av (Mt D) — Carlet A treas Candn Press h 35 Crang av (Oak) ME
7546 — Catherine (wid Edwd) h 30 Mackay av ■ — Cecil J h 68
Fulton av GL 4846 (act ser) — Chas ctr Eatons h 1225 College —
Chas lab h 174 Curzon — Chas S emp Factor's Custom Built Furn h
233 Jarvis EL 7992 - — Clarence H genl mgr C Smythe Ltd res
Islington - — Danl T mach Burke Elect & X-Ray h 228 Albany av KE
0447 — David M tchr h 349 Markham RA 2318 — Dennis punch
press opr CCM h 74 Coulter av (Weston) — Donald r 145 Silverthorn
av JU 2441 (act ser) — Donald emp John Inglis r 118 Nairn av KE
6866 — Donald G storekpr Rennies Seed Co h 51 Langley av GL
2686 — Dorinda stenog Genl Accdt Assce r 145 Silverthorn av JU
2441 — Doris E hlpr Automatic Paper Box r 194 Coxwell avenue —
Doris I r 97 Northcate av — Dorothy salad mkr Eatons r 248 Eglinton
av e HU 3905 - — Dorothy wtrs Alps Rest r 8 Sarnia av — Dorothy A
r 79 Bartlett av LO 2270 — Dorothy L elk Langleys r 228 Atlas av
(Oak) LA 7177 — Douglas P mach John Inglis h 597 Gladstone av LO
7571 — Edith (wid Walter) h 27 Emerson av LO 5862 — Edith K insp
Schraeder's Valve r 27 Emerson av LO 5862 — Edith M opr Candn
Kodak r 23 Goldwin av (Mt Dennis) —Edith M opr Jones Neckwear r
91 Gledhill av (E Y) HO 0739 — Edwd cement fnshr r 77 Gledhill av
(E Y) GR 0895 — Edwd glazier Superior Sash h 5 Mackay av LL 9881
- — Edwd mach opr Candn Acme Screw & Gear h 45 Indian rd KE
2072 — Edwd with RCMP r 45 Indian rd KE 2072 —Edwd A h 77
Gledhill av (E Y) GR 0895 — Edwd C emp Dept Customs & Excise h
79 Bartlett av LO 2270 - — Edwd E emp John Inglis h 5 Rockcliffe
blvd (Mt D) JU 7367 - — Edwd G r 23 Goldwin av (Mt D) JU 2852 —
Edwd J acctg dept Harrisons & Crosfield r 2, 47 Grosvenor RA 8513
— Edwd W h 442 Logan av GE 5063 (act ser) — Edwin L r 96
Woodington av (act ser) - — Edwin S h 96 Woodington av — Elman
H assembly De Havilland Aircraft r 51 Salem av KE 3846 — Emma L
hsekpr r 187A Emerson av LO 0145 — Ernest plastering contr 164
Hope h same — Ernest H shpr Dorn Glass Co h 62 Givens LL 3627 -
— Ernest J emp Amalgamated Electric r 96 Woodington av — Ethel
attdt Candn Natl Inst for the Blind h 20, 595 Sherbourne - — Ethel
mlnr h 7, 2453 Yonge - — Eva M asst to acet The Synod r 93
Highcroft rd GR 8851 - — Evelyn Mrs r 3 Langley av GL 0734 —
Evelyn M stenog Empire Sales r 502 Hillsdale av e HY 8619 - —
Fannie B (wid Geo) h 24A Roehampton av MO 2916 DAY,
FERGUSON, WILSON & KELLY (James E Day KC, Thomas J Day,
Roland F Wilson LL.B. and Arthur Kelly), Barristers, Solicitors, Room
1116, 85 Richmond West, Phones ADelaide 23452346-2347 - —
Francis J engnr Massey-Harris h 94 The Kingsway (Kngswy Pk) MU
1969 —Frank J Rev h 19 Edgar av MI 8907 — Frank L aud H T
Jamieson & Co h 86 Queensbury av (Bch C) HO 9421 — Frank W
slsmn Paper Sales h 23 Standish av KI 9666 — Fred decorator h 519
Huron KI 8188 — Fredk J wrehsemn Northern Elect h 20 McGill TR
0882 — Geo r 248 Eglinton av e HU 3905 (act ser) - — Oeo h 115
Pickering (act ser) — Geo asst mgr Kresges (179 Roncesvalles av) h
82 Hogarth av HA 1337 ■ — Geo service man Ingram & Bell h 300
Arlington av (Wych) LA 8803 Day Geo E lab Dept St Clng h 459
Rhodes av — Geo E pattern mkr Moffats Ltd h 26 McRoberts av KE
4368 — Geo J elk CNR Acctg Dept h 547 Delaware av — Geo L fire
chief Simpsons h 145 Silverthorn av JU 2441 — Geo S tchr Malvern
Coll Inst h 115 Springmount av LL 9665 — Geo T r 97 Northcote av
— Geo W N r 135 Marion KE 9007 — Geraldine M Mrs off mgrs
Borden Co r 120 Delaware av LO 7379 — Gladys E r 43 Lillian MO
1941 — Gladys M elk Income Tax r 245 Poplar Plains rd MI 6411 —
Gordon A maintenance man Wright Industries h 1333 Queen e —
Gordon H mus h 408 Fairlawn av (Nth Y) HU 0751 — Grace Mrs
parcel ler Eatons r 27 Emerson av — H E r 350, 121 Carlton — H G
emp John Inglis h 199 Fulton av GL 5391 — Harold r 75 Prince
Arthur av RA 7523 - — Harold trainmn CPR h 13 Norval (Rnny) LY
4950 - — Harold V beveller Advance Glass h 74 Priscilla av (Rnny) JU
6264 — Harold W insp of weighing CPR Transp Dept h 279 St
Clements av MO 8385 — Harry C r 30 Mackay av (act ser) — Harry L
slsmn Alliance Dairy h 70 Howland av KE 0503 — Harry N hrdrsr J
Nelson Day r 240 Glen Elm av HY 3585 - — Harry R insp of revenue
Unemployment Ins Commn h 34 Inglewood dr MO 7236 — Harvey J
emp Goodyear Tire r 117 Eighth (New T ph 1714J) — Hazel A r 4,
425A Church — Hedley A r 228 Atlas av (Oak) LA 7177 (act service)
— Helen (wid Frederick) h 2, 47 Grosvenor RA 8513 — Helen G sec-
treas Women's Miss Soc United Ch h A8, 245 Howland av KI 8793 —
Henry carp h 248 Eglinton av e HU 3905 — Henry janitor Manning
Pool h 301V2 Rhodes av — Henry W h 23 Goldwin av (Mt D) JU
2852 —Henry W elect h 228 Atlas av (Oak) LA 7177 — Horace G h
306, 2707 Yonge HU 6430 (act service) - — Hugh stand opr Candn
Natl Inst for the Blind h 475 Millwood rd MO 9387 — Ida Mrs clnr
Barber Ellis h 30, 195 Wellesley KI 0092 — Irving S h 4, 425A
Church — Isabelle M r 126 Broadway av MO 2710 — J Gordon elk
Shell Oil r 47 Grosvenor — J Nelson Ltd, Mrs Walleress Day pres, J
Sidney Day vice-pres and mng dir, hrdrsrs 132 Yonge AD 9011-2-3
and Royal York Hotel EL 3842 — J Sidney vice-pres and mng dir J
Nelson Day Ltd h 52 Braemar av MO 7023 — Jack r 25 Main s (Wstn
ph 1065M) (act ser) — Jas candy mkr Pattersons h 19 Roblock av ■
— -Jas E KC (Day, Ferguson, Wilson & Kelly) h 62 Elm av MI 7463 —
Jas G slsmn Supertest Petroleum h 49 Maxwell av MO 9185 — Jas J
emp McCall Corp h 428 Gainsborough rd — -Jas S r 1035 Woodbine
av (E Y) GR 4994 (act ser) - — Jas W emp John Inglis h 77 East
Lynn av GR 2389 — Jane McK stenog Chas A Smith Ltd r 95 Dunn av
LA 5571 — Jesse with Tor Hydro h 99 Millicent ME 4098 • — Jesse S
inform elk Parlt Bldgs h 1035 Woodbine av (E Y) GR 4994 — Jessie
M drsmkr r 97 Northcote av — Joan M elk Workmen's Compensation
Bd r 28 Lamb av GE 1463 , — Johanna Mrs r 162 Wolfrey av GE
4302 — John lab Lever Bros r 760 Gerrard e — John pntr r 120
Shuter — John C lab Robt Page h 228 Albany av KE 0447 — John C
pntr and dec 186 Hamilton h same GE 3216 — John F pres Day Sign
Co Ltd h 47 Astley av MI 6254 - — John F radio technician Seeley
Systems h 176 Dowling av LA 4531 — John G slsmn Westons
Biscuits r 49 Maxwell av MO 9185 — John N r 1226 King w LA 1069
— John W h 95 Dunn av LA 5571 — Johnson h 305, 540 Russell Hill
rd (Fst H) HY 2512 (act ser) — Jos C toolmkr John Inglis h 1, 590
Bayview av MO 4258 — Jos H h 407 Spadina av MI 9678 - —
Kathleen E elk City Treas r 27 Emerson av — Kathleen M bkpr Cook
Clothing r 147 Franklin avenue — L Spencer mgr Toronto Gold Leaf
Co r 2, 10 Boulton dr MI 4739 — Laurene opr Macdonald Mfg r 294
Cedarvale av (E Y) — Lawrence Mrs h 2, 10 Boulton dr MI 4739 ■ —
Leonard G lab John Inglis r 128 Dovercourt rd LA 8443 — Lewis emp
Coleman Lamp r 105 Uxbridge av LY 9264 — Lillian M r 126
Beaconsfield av — Lloyd drvr Scotts Cartage r 2231 Gerrard e - —
Lloyd W serviceman Hoover Co h 147 Dewhurst blvd (E Y) HA 2362
— Loretta typist Richards Glass r 220 Rosemount avenue — Lome R
elk Candn Bitumuls Co r 475 Millwood rd MO 9387 - — Lorraine emp
Rogers- Majestic r 42 Shirley ME 4146 — Louis tnsmth 813
Broadview av h same GE 5152 — Louis W emp Hobbs Glass r 27
Emerson av LO 5862 — Louise h 38, 8 Mallory gdns Day M E Miss h
4, 1924 Yonge RA 1249 — Margt elev opr Royal York Hotel r 147
Franklin avenue — Margt J Mrs h 220 Rosemount av — Marguerite A
stenog Plan for Hosp Care r 475 Millwood rd ■ — Marjorie R emp
Gutta Percha h A5, 569 Broadview av GL 4067 - — Mark stenci I ler
John Inglis h 90 Olive av LA 2329 — Martha Mrs r 158 Spadina rd RA
7122 — Mary (wid John) r 611A Mt Pleasant rd HY 8183 — Mary
(wid Wm) r 115 Springmount av LL 9665 - — Mary J stenog
Compensation Bd r 409 St Clarens av ME 0757 —Melrose A h 325,
219 College MI 4205 — Mildred J elk Dun & Bradstreet r 228 Albany
avenue — Milton C r 26 McRoberts av KE 4368 (act service) —
Minnie L Mrs prsr CNR S & D Car Dept h 272 Montrose av ME 8529
— Muriel stenog Canadian Pad & Paper r 45 Indian rd — Neil G const
Stn 1 h 192 Withrow av GE 1737 ■ — Nellie h 4, 40 Hazelton av RA
7237 — Nina Mrs r 105 Uxbridge av LY 9264 — Noel R asst cash
Metropolitan Transp Ltd r 60 Humewood dr (Wych) LA 2445 —
Norman yd mn CPR h 2, 209 Mavety JU 3824 — Norman H lab
Candn Hanson & Van Winkle h 332 Margueretta LO 0230 — Norman
J with Tor Hydro h 42 Shirley ME 4146 — Oscar P trav Harry Horne h
29 Austin terr LA 5670 — Otto J mng dir St Regis Hotel h 392
Sherbourne RA 4135 — Percival emp Massey-Harris r 43 Lillian MO
1941 - — Percy E shpr R B Hayhoe & Co r 442 Quebec av JU 6990 ■
— Percy P coll Glass Bros r 100 Greenwood av HA 2570 — Phyllis
Mrs bkpr Kilmer, van Nostrand & Co r 987 Avenue rd n — R Don serv
slsmn Packard-Ont Motor h 231 Glengrove av w HY 2351 — R Harry
pntr Cloke Constn h 111 Gillard av GE 6796 — Ralph h 107 Hatherley
rd (Frbk) (act ser) — Ralph A r 105 Clendenan av JU 4485 (act ser)
— Ralph C (The Ralph Day Co) h 4 Castle Frank dr RA 7011 — Ralph
Co The (Ralph C Day) funeral directors 172-182 Danforth av GE
3870 • — Ralph W r 99 Cumberland — Raymond V h 166 Symington
av LL 3951 — Richd trk drvr h 25 New — Richd A barber 1256
Dundas w h 43 Armadale av (Swan) JU 9718 —Robt h 255
Blythwood rd — Robt h 151 Westmount av (Oak) KE 2522 — Robt
emp Parks Dept h 502 Hillsdale av e HY 8619 — Robt slsmn Eatons
h 60 Humewood dr (Wych) LA 2445 — Robt E pres Bulova Watch h
88 Castlewood rd MO 2430 — Robt W engnr Campbell Milling Co h
97 Northcote av — Rosa (wid Chas W) h 140 William (Wstn ph 968)
— Rosene emp Parker Pen r 42 Shirley ME 4146 — Roy locksmith
Aikenheads h 30 Norway av HO 6460 — Sami R messr Bank of Tor
(Hd Off) res Lansing • — Sarah Mrs r 8 Sarnia av LL 5689 — Sarah L
r 51 Salem av KE 3846 — Selma (wid Lawrence) r 2, 10 Boulton dr
MI 4739 — Sidney H with Tor Hydro h 28 Lamb av GE 1463 — Sign
Co Ltd John F Day pres, Frank W Day vice-pres, Mollie S Ingrouville
sec-treas (rear) 112 Adelaide w AD 2343 — Silas carp Cloke Constn
h 34 Sanderstead av (Frbk) — Stanley F r 140 William (Wstn ph 968)
(act service) — Steve emp Casino Rest r 60 St Patrick - — Sydney B
sec-treas Century Motor Sales Ltd h 24 Roehampton av — Sydney I
sprayer De Havilland Aircraft h 16 Elmwood av ME 3010 — Sydney
W slsmn John S Brown & Sons h 30 Brookdale av HU 8633 — T Geo
test lab asst Bakelite Corp h 234 Floyd av (E Y) — The Mrs D
Dworkin agt publications 525 Dundas w EL 9337 - — Thelma elk
Eatons r 233 Jarvis EL 7992 — Thelma emp Richards Glass r 220
Rosemount av — Theodore hlpr James A Johnstone r 14 Blong av —
Thos A r 45 Indian rd KE 2072 (act ser) — Thos J (Day, Ferguson,
Wilson & Kelly) h 177 Teddington Pk av HY 7023 — Thos S dental
lab 1, 1034Vi Bloor w LO 7629 h 692 Hillsdale av e MO 7826 — Val P
stewardess Trans Can Air Lines h 43, 6 St Thomas RA 7816 — Vera
Mrs sec Christian Science Committee on Publications for Ont r 306,
2707 Yonge — Vernon E pntr CPR h 147 Franklin av — Victor C
foremn Drug Trading h 769 Sammon av (E Y) — Victor L elk Eatons
h 38 Dilworth cres (E Y) HA 1228 — Violet R opr Bell Tel r 27
Emerson av LO 5862 — W Carl drvr Tor Fuels h 14 Blong av —
Walleress Mrs pres J Nelson Day Ltd h 20 Glen Elm av HY 3585 —
Walter A dept mgr Brown Bros — Walter J 'slsmn Stand Brands r 79
Bartlett av LO 2270 —Walter J slsmn Watson's Food Products h 27
Carlton EL 2678 , 151 Westmount av (gg Day Walter R r 43 Lillian
MO 1941 — Wm h 2 Aberdeen av MI 9669 — Wm h 1134 Queen w
(act ser) - — Wm artist r 24 Fernwood Pk av GR jn — Wm carp h
277 Eglinton av e HY Sin - — Wm emp Anaconda Amer Brass r lr
(New T ph 1714J) — Wm fir plshr h 2522 — Wm foremn Eatons h 43
Lillian HO Hr — Wm C sis elk Wrought Iron Range r zV; cord av LL
5517 — Wm D pres Metropolitan Transport m i • Chaplin cres MO
1402 — Wm G emp Serv Stn Equip r SI L* \ (Scar) — Wm H crater
Moffats Ltd h 1216 Jan* i,L JU 1452 — Wm H emp Natl Cash
Register r 35 fn . (Oak) ME 7546 — Wm J const Stn 3 h 234 Boon av
— Wm J mach Acme Machine Wks h 2511 , av JU 4623 - — Wm N
mach United Steel h 19, igui w LA 8272 — Wm P dir Tor Feather &
Down h 53 ( av JU 4548 — Wm W foremn L C Smith h 79 East hi GR
7263 — Winnifred nurse Sick Childrens H& i< Breadalbane MI 5776
— & Martin Canada Ltd O'Cedar of Can .! 1 365 Sorauren av ME
5723 Day's Cartage (Albt E Day) 166 Sybil* r LL 3951 Dayce Edwd
wdwkr Aristocrat Mfg h 5ij Gr JU 2033 Dayday Mitchell r 113V2
Lansdowne av t! J • Daye Edith M deaconess St Peters Argi::- , r
402, 1-5 Homewood av Ml 5372 — Naomi hsekpr S A Grace Hosp r 2
j 3504 Oayes Agnes (wid John) r 141 McRoberts ; 2629 — Jas W
safety insp Industrial Accident tion Assns h 141 McRoberts av KE tit
Dayholos Max carp r 15 Stanley av ( Daykin Elvin sis elk Eatons r 27
Otter 5445 — Esca B h 12 St Leonards cres MO 3271" — Hume A
mgr Bank of Tor (3174 Y«j'? Hillholme rd MO 6037 — John M reprmn
TTC r 332 Albany av *’ - — Stephen h 27 Otter av WA 5445 (act,.
Daylight Studio (Philip Demitroff) Ita ’ Queen e EL 7593 Dayman Albt
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