Industrial Training at

VASU Healthcare Pvt. Ltd., Vadodara

By
Ms. Suthar Dhvani Naimeshbhai
(Enrollment Number: 192200290061)

Guided By
Dr. Kinjal Shah
(Head of Department)

A REPORT SUBMITTED TO
GUJARAT TECHNOLOGICAL UNIVERSITY
In partial fulfilment of the requirement of the degree of
“BACHELOR OF PHARMACY”

Winter 2022

B. PHARMACY COLLEGE, RAMPURA

KAKANPUR-388 713
November 2022

i
 CERTIFICATE

This is to certify that Ms. Suthar Dhvani Naimeshbhai student of 7th semester Bachelor of Pharmacy (B.
Pharmacy college Rampura Kakanpur) has successfully completed her 150 hours of Industrial training report
on “VASU Healthcare Pvt. Ltd., Vadodara” in the partial fulfilment of requirement for the award of degree
of Bachelor of Pharmacy of Gujarat Technological University in session Winter 2022

Date:
Place:

Signature and Name of Supervisor Signature and Name of Principal

Seal of Institute

ii
 REPORT APPROVAL

This is to certify that content embodies in this report entitled “Industrial Training at VASU Healthcare Pvt.
Ltd., Vadodara” carried out by Ms. Suthar Dhvani Naimeshbhai (Enrollment No.:192200290061) is
approved for the Bachelor of Pharmacy by B. Pharmacy college, Rampura, Kakanpur 220)

Date:

Place:

Examiners sign and Name

………………………………… ………………………………..

………………………………… ………………………………..

(Supervisor) (Examiner)

iii
 SELF DECLARATION

We the student of B. Pharmacy collage, Rampura undersigned solemnly declare that the training report is
based on own work carried out during the course of our study under the supervision of Dr. Kinjal Shah (Head
of department of B. Pharmacy college, Rampura).

I assert the statement made and conclusion drawn are an outcome of my research work.

I further certify that

1. The report is original and has been done by me under the general supervision of my supervisor.

2. This has not been submitted to any other institution for any other degree/diploma/certificate in this
university of India or abroad.

3. Whenever I have used material (data, therapeutical analysis and text) from other source, I have given
due to credit to them in the text of report and giving their detail in the reference.

Name Enrollment No. Signature

iv
TRAINING CERTIFICATE

v
 ACKNOWLEDGMENT

The work that I have presented today to you stands as a testimony to the sincere efforts put in by me
and to the guidance and help given to me by so many people directly or indirectly, for whom I would
like to thank from the abyss of my heart.

The joy of completion is never complete till the fruits are shared with the once who helped me to
achieved my aim to some extent.

I would like to express my sincere gratitude to my project guide Dr. Kinjal Shah and Principal Sir Mr.
Suresh Jain for giving guidance and taking active interest throughout my project work.

………………………….

Name

vi
 TABLE OF CONTENTS

Title Page i

Certificate Page ii

Approval Page iii

Acknowledgement vi

Table of Contents vii

Abstract viii

Chapter 1: Introduction 1

1.1: About the Company 1

1.2: Vision and Mission of Company 2

Chapter 2: Layout & Department 3

Chapter 3: Production Section 5

3.1: Introduction of Ointment 5

3.2: Flow Chart 6

3.3: Available Equipment 7

3.4: Different Products 9

Chapter 4: Packaging & Labeling 12

Chapter 5: QA and QC 15

5.1: Available Equipment 15

5.2: QC Tests 16

Chapter 6: Conclusion 18

Reference 19

Appendices 20

vii
 ABSTRACT

Pharmacy is a profession which is concerned with the art and science of preparing suitable and
convenient material for distribution and use in the treatment and prevention of disease, so it is a fully
technical profession where practical knowledge. According to curriculum of a four year integrated
degree course of BACHLOR OF PHARMACY each student has to undergo practical training for a
periods of 150 hours in various pharmaceutical industries. As it is to be done during 7 th July to 15th
August 2022. I was directed to undergo the 4th year training at “VASU Healthcare Pvt. Ltd.” And this
report contains a brief description of the above pharmaceutical industry which was observed during
the training program.

viii
 CHAPTER 1: INTRODUCTION TO INDUSTRY

The Pharmaceutical industry discovers, develops, produces and markets drugs or pharmaceutical drugs for use
as medication to be administered to patients, with the aim to cure them, vaccinated them or alleviate the
symptoms.

About the Company

It was established on 3rd March 1980. Director of VASU Healthcare Pvt. Ltd. Is Hardik Ukani.

VASU HEALTHCARE PVT. LTD. (An ISO 9001, GMP & HACCP Certified Company) is a leading
company in India engaged in manufacture & marketing of Phyto-Pharmaceutical Therapeutical, OTC,
Personal care and Herbal Supplements, since 1980.

VASU has pan India market presence plus footprint in 50+ countries worldwide.

Motto of VASU is “Health To You Naturally!!”

VASU offers a full range of products in niche segments like Skincare, Haircare, Gynecology, Urology etc. in
Oral & Topical form (Tablet, Capsule, Cream, Granules, Syrup, Ointment, Shampoos, Oils etc.) State of the
Art Manufacturing units at Vadodara are armed with manufacturing lines, IPQC.

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Vision & Mission

Vision:

To Become Global Leader In The Field Of Healthcare.

Mission:

We Commit Ourselves To Mankind’s Pursuit For Longer, Healthier & Happier Lives By Providing Remedies
From Nature.

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 CHAPTER 2: LAYOUT & DEPARTMENTS

Once you have decided on where to locate your pharmaceutical company, the next important thing you need
to do is do plan a suitable layout for your pharmaceutical plant. While designing a pharmaceutical plant, you
need to understand and follow the basic regulatory requirements for the construction of a pharmaceutical plant.

According to National Agency for Food and Drug Administration (NAFDAC), your proposed layout and
design should aim at minimizing the risk of errors and permit effective cleaning and maintenance in other to
avoid cross-contamination, build-up of dust or dirt and in general, any adverse effect on the products.
The best way to achieve this goal is to design the layout in such a way that it follows a logical order
corresponding to the steps of the operation.

Feature of a good pharmaceutical plant layout

A good pharmaceutical plant layout should process the following characteristics

• There should be adequate floor space for machines installation and utilization

• The machine should be properly arranged to facilitate minimum material handling is necessary for low
cost processing

• The layout should facilitate smooth and continuous flow of production process from one point to
another without any form of delay

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 • It must incorporate adequate health, safety and security features such as first aid box, fire extinguisher,
emergency exit and access point

• A good layout should allow effective supervision, coordination and control of the production processes

• These should be room for adjustment and modification whenever the need arises.

❖ Departments

1.Quality Control (QC):

Quality control is concerned with sampling, specifications and testing as well as the organisation,
documentation and release of the product procedures.

2.Quality Assurance (QA):

Quality assurance is a wide ranging concept which covers all matters individually or collectively that influence
the quality of a product. It is the sum or total of the organized arrangements made with the object of ensuring
the medicinal products are of the quality required for their intended use.

3.Raw Material:

Raw materials are materials or substances used in the primary production or manufacturing of goods. Raw
materials are the input goods or inventory that a company needs to manufacture its products.

4.Production Department:

A production department is a group of functions within a business that is responsible for the manufacture of
goods. The production department can be the largest organization with in a business. It may employee
mechanics, machine setup specialists, maintenance personnel and machine operators.

5.Packaging & Storage:

The packaging department is the area that prepares picked material for shipment by performing the
consolidation, packing, marking and documentation tasks required. The packing department may also be
responsible for locating and picking materials for outgoing shipments.

Store keeping is the task of maintaining safe custody of all items of supplies, raw materials, finished parts,
purchased parts, and other items

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 CHAPTER 3: PRODUCTION SECTION

❖ Introduction to Ointment

Definition:

A smooth substance that you put on store skin or on an injury to help it get better. Pain relieving,
itching, wound infection, skin infection ointments were made by this industry frequently.

Raw Materials Required

• Products can be either a water in oil or oil in water emulsion, consisting of waxes, emollients and
lubricants dispersed in an oil phase, and a water phase containing emulsifying, stabilizing and
thickening agents, preservatives and in some cases, colorant. Active ingredients are dispersed in either
phase or added when the emulsion has been formed and allowed to cool.

• Common ingredients found in ointments include mineral oil and petroleum jelly.

• Mineral oil and petroleum jelly used to treat or prevent dry, rough, scaly, itchy skin and minor skin
irritations.

• Petroleum jelly is stored at 25 F to 75 F. (-3 to 23˚C)

• Mineral oil is stored at room temperature.

Manufacturing Process:

• The vessels are jacketed, insulated cladded and with suitable agitator assembly in each vessel.

• Wax was melted in wax melting vessel.

• Water was heated in water heating vessel.

• Both wax and water are transferred into the manufacturing vessel automatically through vaccum.

• In manufacturing vessel both wax and water are homogenized to make a uniform emulsion and cooled
by passing chilled water into the jacket manufacturing vessel.

• After the emulsion if formed active ingredients/ colors are added and are thoroughly mixed.

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 • The same is transferred by bump pump into the storage vessel.

• From the storage vessel it is automatically transferred into filling machine by means of metering
pump.

• Flow rate of metering pump can be set as per the tube filling machines speed and capacity.

❖ Flow Chart:

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 ❖ Available Equipment

• Planetary machine
(Akshar engineering works)

Model: BJY-BM40N

Planetary mixer is used to give a homogenous mixture of water and wax (mineral oil and petroleum jelly).
And for ointment high speed emulsifier is provided for homogenous mixture and to make product lustrous.

Planetary mixer is multipurpose equipment where the attachment move in planetary fashion. It can be used for
multiple application like whipping, mixing and other preparations. 5 liters and 7 liters dough maker can also
be used for nitrogen ice cream mixing.

Planetary mixer are available between 5 liters to 30 liters capacity.

• Manufacturing Vessel

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Ointment manufacturing plants are ideal tools for the pharmaceutical & cosmetic industries for the production
of ointment, cream, lotion, tooth paste & other emulsion & homogenization.

Manufacturing vessel is a jacketed cylindrical vessel with a conical bottom and anchor type agitator. It is used
to mix the viscous product from the water and wax phase vessels. Heating by steam or hot water circulation.

• Wax phase vessel

(Akshar engineering works)

The wax phase vessel is a jacketed cylindrical tank with torrispherical dish ends. A propeller type stirrer is
provided for agitating the wax or oil. A conical filter filters out impurities before the wax is transferred to the
manufacturing vessel.

• Vaccum pump
(Bhagwati Pharma)

Model: E25700

Vaccum pumps are mechanical devices that enable the removal of air and gas molecules from a sealed area to
create an area devoid of air or gas. Generally, their purpose is to clean and seal. Vaccum pumps come in wet
or dry variants depending on the media being pumped through them.

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 • Storage tanks
(Bhagwati Pharma)

Model: RPV-75

Storage tanks are used for holding and storing liquids, semi solid, solid and keeping your product or suspension
homogeneously mixed in a mixing system.

Since end products are in contact with the walls of the storage tank, it is imperative that the fabrication of this
vessel complies with standard CGMP’s and are sanitary for use.

❖ Different Products

Some common Ointments made by VASU:

1.DAZZLE Ointment:

Ingredients; Pippermint Oil

Devdaru Oil
Gandhpuro Oil
Narayan Oil

Strength: 30 g

Uses: VASU DAZZLE Ointment contains a blend of several ayurvedic herbs to treat arthritis pain. This pain
relief gel is indicated in pain associated with osteoarthritis, backache and muscle stiffness.

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2.KULON Ointment:

Ingredients; Nirgundi Oil

Jatyadi Oil
Neem Oil
Karanj Oil

Strength: 30 g

Uses: KULON Ointment provides relief from the painful condition that affect anal region.

3.UVA Cream:

Ingredients; Kumkumadi Oil

Yashtimadhu
Aloe Vera
Haridra
Strength: 50 g

4.ACNOVIN Cream:

Ingredients; Manjishta
Lemon
Neem
Strength: 15 g

Uses: ACNOVIN Cream has antiseptic, skin vitalizing properties and is suitable for all types of skin, especially
in cases of acne, pimples, blackhead, chapped skin.

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5.DAZZLE PAIN REALIVING Ointment:

Ingredients; Gaultheria fragrantissima

Cedrus deodara
Menthol
Cinnamomum camphora
Eucalyptus Oil

Strength: 50 g

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 CHAPTER 4: PACKAGING & LABELING

What is Packaging ??

Packaging is the science, art and technology of enclosing or protecting products for distribution, storage, sale
and use.

Packaging also refers to the process of designing, evaluating and producing packages. Packaging can be
described as a coordinated systems of preparing goods for transport, warehousing, logistics sale and end use.

Packaging contains protects, preserves, transports, informs and sells.

Types

• Primary packaging is the material that first envelops the product and holds it. The usually is the smallest
unit of distribution or use and is the package which is in direct contact with the contents.

• Secondary packaging is outside the primary packaging, and may be used to prevent pilferage or to
group primary packages together.

• Tertiary or transit packaging is used for bulk handling, warehouse storage and transport shipping. The
most common form is palletized unit load that packs tightly into containers.

What is labelling ??

The labels are an aid to move the production order to the warehouse, and contain information such as the
production order, the kind of item in the production order, the warehouse to which the items must be
transferred, and so on.

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 ❖ Instrument

1) Tube Filling Machine:

Tube Fillers Sealer machine fill products in cylindrical metal/ laminate/ plastic tubes and close tubes. Tube
filler machine capacities ranging from 35 to 150 tubes/ minute.

Tube filler machine can Filling viscous and semi-viscous products are handled, like Gel, shampoo, ointment,
cosmetics, toothpaste, cream/gel, adhesive, sealant, chocolate, mayonnaise and many more.

The tube filling machine shall be designed to allow manual loading of tubes ergonomically into the magazine
with automatic tube feeding into the dosing station.

2) Cap Sealing Machine:

Cap Sealing machine is multi purpose cap sealing machine in which you can adjustable sealing height
according to your tube. Greater performance with best quality cap sealing machine.

Manual tube sealing machine is basically the best of its class with sealing quality as good as fully automatic
tube sealing machine.

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3) Tube Labeling Machine:

Tube Labeling Machine: This tube labelling machine or the automatic tube labeler machine is simple to
operate and easy to maintain. It is highly appropriate for tubes with diameters varying from 19 mm up to 60
mm. this tube labelling equipment has the capacity to operate at a labelling speed of up to 60 tubes in a
single minute. Moreover, an automatic feeding and air ejection system is also included for loading and
unloading the tubes.

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 Chapter 5: QA and QC Departments

What is Quality Assurance Department ?

In the pharmaceutical industry, Quality Assurance is essential for ensuring that pharmaceutical products are
manufactured to a safe and consistent standard. QA is a very broad field that refers to any aspect that may
affect a drug’s quality during its research, development, manufacturing and sales phases.

What is Quality Control Department ?

Quality Control Department functions for assuring the quality of all the batches manufactured, at every stage
of manufacturing drug products…Sampling, inspection & testing as per specifications of in-process product
for release or rejection for further processing & its documentation.

❖ Available Equipment in Quality Control

1.pH Meter:
(Sharma Scientific Instruments)

Model: LT501

Working: The pH meter works by measuring the potential difference of test solution and calculate the pH

Use: It used to measured acidity and alkalinity of solution.

2. Viscometer:
(Sharma Scientific Instruments)

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Model: S-9251
Working: It is a instrument that is used to measure the viscosity of a fluid.
Use: Measurement of viscosity at different flow conditions.

❖ Quality Control Tests:

1. Impurities:

The impurities arising from degradation od drug substance and during the manufacturing process of drug
product should be assessed and controlled.

2. Physical Appearance:

The main characteristics need to be checked are:

• Cracking
• Development of granular
• Marked change in viscosity
• Crystal growth
• Microbial contamination

3. Weight variation:

• Select 10 filled containers, clean, remove the label and weight individually
• Remove the contents and wash the containers
• Dry the containers and again weigh the empty container together with its corresponding, take
difference as weight of contents
• The average net weight of contents of 10 containers should not be less than the lebelled amount
• The net weight of contents of any single container should not be less than 90% of the labelled amount

4. Solubility test:

• The preparation should be soluble in 9 parts of water and 1.7 parts of hot water.
• The preparation should be miscible with alcohol, ether, chloroform.

5. Active Ingredients:

• Assay of active ingredients should be performed according to monograph.

• % contents should be within the official limit

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Result Table

Parameter Result
1.Appearance Semi Solid
2.Colour White
3.Odour No Characteristic odour
4.Smoothness Smooth in texture
5.pH 9.0
6.Sensitivity test No irritation effect is found

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 Chapter 6: Conclusion

During the semester training period, a lot of experience, knowledge and exposure that I have handy. All
disclosures were awaken myself in a boost of self confidence to face life more challenging now. Practical is a
complement to the science or theory learned. This is clearly the concept of science and charity, where they
have learned without practice will be lost and will not give anything- what effect. So if we do without the
knowledge of course there will be problems in terms of grip and stance ever- changing.

During my industrial training, there are many changes from the point of learning environments and discussion
among colleagues. It can directly increase the dedication and rational attitude toward
Myself.

However; there are still some weaknesses that can be improved in the future. Therefor I conclude that the
industrial training program has provided many benefits to students even if there are minor flaws that are
somewhat disfiguring condition; so that this weakness can be rectified in the future.

I can conclude that this industry is through training I received a lot of exposure in the computing world. I
would like to thank the team members for sharing their own experience with having industrial training like
this.

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 References

• Kibbe, A. H., ed. Handbook of Pharmaceutical Excipients. 3 rd edition ed. 2000, American
pharmaceutical association & pharmaceutical press Washington, DC & London UK.

• Jones. D. (2008) Fasttrack Pharmaceuticals – Dosage form and Design. London Pharmaceutical press.

• Leon Lachman, Herbant A Lieberman, “ The theory and practice of Industrial Pharmacy” special
Indian edition-2009 CBS publisher & Distributors Pvt. Ltd.

• http;//www.heliosppharma.com/

• http;//www.pharmatutor.org/articles/the-pharmaceutical-packaging-article

• Mehta R. M “Pharmaceutics – 1” 4th edition Vallabh Prakashan, (Page No: 269-274)

• Aulton M. E “ Pharmaceutics” Churchill livingstone publication 2nd edition.

• P. D. Sethi, Quantitative Analysis of Drugs and Pharmaceuticals.

• Lachman, L., Lieberman, H. A, and Kanig, J. L., (1986), the theory and practice of Industrial Pharmacy
, 3rd edition, Philadelphia : Lea and Febiger Page No 1-74

• Martindale, The complete Drug Reference (multi volume) LSM/ REF/ RS 141.3.M4

• WHO Expert Committee on specifications for Pharmaceutical Preparations. 34th report, Geneva, World
Health Organisation, 1996.

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 Appendices

List of abbreviation

S. No. Abbreviation Full form

1 LSM Laboratory Safety Manual
2 WHO World Health Organization
National Agency for Food and Drug Administration &
3 NAFDAC
Control
4 IPQC In Process Quality Control
5 OTC Over The Counter
6 HACCP Hazard Analysis Critical Control Point
7 GMP Good Manufacturing Practice
8 ISO International Organization for Standardization

List of Tables

Table No. Caption Page No.

1 Result Table 17

List of Figures

Figure No. Caption Page No.

1 Planetary Machine 7
2 Manufacturing Vessel 7
3 Wax Phase Vessel 8
4 Vaccum Pump 8
5 Storage Tank 9
6 Tube Filling Machine 13
7 Cap Sealing Machine 13
8 Tube Labeling Machine 14
9 pH Meter 15
10 Viscometer 15

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