DEDEPARTMENT OF BIOCHEMISTRY, SVNGMC YAVATNMAL
PRELIMINARY EXAMINATION OF FIRST MBBS 2024 BATCH
BIOCHEMISTRY THEORY PAPERI
Date - 07 /07 / 2025 Time - 3 HourS Marks - (100)
SECTION-A-MCQ
INSTRUCTIONS:- 1) All MCQs are compulsory. [20 Marks]
2) Each MCQcarries 1 mark
3) No negative marking. No overwriting or double answer allowed
1) Allthe following are enzymes of gluconeogenesis EXCEPT
a) Pyruvate kinase b) PEP-CK c) Pyruvate carboxylase d) Glucose-6-Phosphatse
2) Example of Lyase is d) Aldolase
a) Catalase b) Trypsin c) Arginase
3) The following enzyme level increases in acute pancreatitis
a) Lipase b) Amylase c) Acid phosphatase d) Alkaline phosphatase
4) Enzyme used for therapeutic purpose is
A) Enolase b) Urease c) Streptokinase d) Fumarase
5)Substrate level phosphorylation In TCA Cycleb)occurs at step catalysed by
Succinate Dehydrogenase,
a) Malate Dehydrogenase,
c) Succinate Thiokinase d) a-Ketoglutarate Dehydrgenase
6) Basal metabolic rate is increased by all of the following, EXCEPT
a) Fever b) Starvation c) Cold limate d) Hypethyroidism
7) Cholesterol serves as a precursor for the synthesis of all of the following EXCEPT
a) Lecithin b) Cholecalciferol c) Bile acids d) Steroid hormones
8) Refsum's disease is due to accumulation of following fatty acid
a) Cervonic acid b) Lignoceric acid c) Chaulmoogric acid d) Phytanic acid
9) Allthe following classes of lipids are components of biologicalmembraned)EXCEPT
Phospholipids
a) Triacylglycerol b) Cholesterol c) Glycolipids
10) Retinoblastoma (RB) gene is a
a) Proto-oncogene b) Oncogene c) Carcinogene d) Antioncogene
11) Which ofthe following has highest Calorific value
a) Proteins b) Carbohydrates c) Fats d)Alcohol
12) In hydroxylation of proline and lysine in collagen, which of the following is required
a) Vitamin A b) Vitamin C c) Vitamin D d) Vitamin E
13) Which of thefollowing is Essential Fatty acid
a) Oleic acid b) Arachidonic acid c) Cervonic acid d) Elaidicacid
14) Decrease level of which of the following leads to myocardial infarction
a) LDL b) VLDL c) HDL d) Chylomicron
15) The limiting amino acid in pulses is
a) Methioine b) Lysine c) Isoleucine d) Leucine
16) The heteropolysaccharide which does NOT contain uronic acid is
a) Hyaluronic acid b) Heparin c) Heparan sulphate d) Keratan sulphate
17) In erythrocytes, the end product of glycolysis is:
a) Pyruvate b) Acetyl-CoA c) Lactate d) 2,3 Bisphosphoglycerate
18) Example of phase two detoxification reaction is
a) Sulphation b) Acetylation c) Methylation d) All of the above
19) HMP shunt produces
a) ATP b) NADPH c) NADH d) FADH2
20) Which of following component of ETC possesses isoprenoid units
a) Coenzyme Q b) Cytochrome b c) Cytochrome c d) Cytochrome oxidase
DEPARTMENT OF BIOCHEMISTRY, SVNGMC YAVATMAL
PRELIMINARY EXAMINATION OF FIRST MBBS 2024 BATCH
BIOCHEMISTRY THEORY -PAPER I
SECTIONB
Note : Write answers in Sequence. Draw diagrams or Flowchart wherever necessary
Que 2. Long Answer Questions ) (1 LAQ12 marks) [12 Marks]
a) Add
Describe the reactions of glycogenolysis. (6 marks). Discuss its regulation (4 marks).
a note on Von Gierks disease .(2 marks)
Que 3 Reasoning questions [5 questions 4 marks each] [20 Marks]
a) Disadvantages of Saturated Fats in diet &Advantages of Unsaturated fats in diet
b) Physicalcharacteristic and chemical composition of CSF
c) Describe inherited disorders of Fructose metabolism
d) Athree year old boy from poor illiterate family reported with bilateral pitting oedema,
discolouration of hair, anemia and diarrhoea. His serum albumin was 2.1 gm%
i. What is probable diagnosis
ii. What is biochemical basis of oedema
i. How can this condition be treated
iv. What are functions of Albumin
e) A patient came to the emergency depatment with symptoms of chest pain and profuse
sweating. ECG was done which showed variation and ST segment elevation
i)Which different cardiac biomarkers must be estimated in this patient and what is their
significarnce .(2 marks)
)Explain the importance of enzymes and isoenzymes in diagnosis of disease. (2 marks)
Que 4 Short Notes (any 4 out of 5) [5 marks each] [20 Marks]
a) Enumerate Free radicals and their harmful effects. Add a note on Non-enzymatic
antioxidants and how they act in body
b) Classify Tumour markers. Explain their uses
c) Classification of Biomedical waste with suitable examples
d) Classify the enzymes involved in Biological Oxidation (2 marks). Add a note on inhibitors &
uncouplers of ETC. (3 marks)
e) Transport across CellMembrane
Que 5 Short Answer Ques tions (any 4 out of 5) [7 marks each] (28 Marks]
a) Role of Physician as a lifelong learner
b) Enumerate proteins in Extracellular matrix.. Describe their functions
c) Discuss the phase 1 reactions of detoxification with examples
d) Discuss competitive and non competitive inhibition of Enzymes with suitable
examples.and drugs
e) Name the Ketone bodies. Describe the synthesis and utilisation of ketone bodies.
(1+3+3 marks)
