CMB REVIEWER 10.
G proteins bound to GDP are said to
be
SIGNALS TRANSDUCTION - Are off
11.What is the most important function
1. Which of the following is true for of G proteins?
messengers and receptors involved in - Formation of second messengers
signal transduction? 12.If G alpha subunit is bound to GTP
- Receptors are located on receiving and not separate from G beta gamma
cells subunits, the G protein is considered
2. Which of the following is true for to be:
autocrine signals? - Inactive
- Act on the same cell that produce 13.Which of the following enzymes
the signal form cAMP from ATP?
3. What is the type of bonds that exist - Adenylyl cyclase
between ligands and their receptors? 14.Which of the following degrades
- Noncovalent cAMP?
4. Receptors with a low Kd are said to - Phosphodiesterase
be 15.PIP2 is generated when this enzyme
- Most of the are occupied is activated
5. Cells show which of the following if - Phospholipase C
receptors are occupied for prolonged 16.Which of the following contains the
periods? receptor for diacylglycerol?
- Tolerance - None of the choices
6. Which of the following is the most 17.The ligand PDGF is responsible for
common methods of cellular fibroblasts forming new connective
desensitization? tissue. What is the matching receptor
- Phosphorylation for the ligand?
7. When a ligand binds to a receptor, - Receptor tyrosine kinase
which of the following events take/s 18.Which of the following describes
place? constitutive mutations?
- Causes receptors to cluster - Receptors are not ligand
8. Which of the following receptors dependent
does morphine bind to? 19.Which of the following is true of
- Opioid beta-adrenergic receptors?
9. How are g protein receptors - Regulates flow to heart, lungs, and
regulated? skeletal muscles
- arrestin binds phosphorylated 20.Which of the following is incorrect
adrenergic receptors and inhibits of Akt in insulin signaling?
them
- Moves GLUT 4 to the nuclear - Lung cancer rates fall for smokers
membrane, allowing glucose who have quit smoking
uptake 11.Which of the following is incorrect
about carcinogens?
- None of the choices are correct
12.In mutated p53, what base changes
CANCER CELL are seen?
- CC TO TT
1. Which of the following is 13.Which of the following is a
responsible for cancer development? mechanism of oncogenesis?
- Both - The agents cause tissue destruction
2. Which of the following cancer came and inflammation
from epithelial cells such as 14.Normal cellular genes that contribute
coverings of the body surface? to the regulation of cell growth and
- Carcinomas survival.
3. Which of the following cancers came - Proto-oncogene
from tissue such as fat and bones? 15.What is the simplest mechanism for
- Sarcinomas converting a proto-oncogene into an
4. Cancer refers to any of the following oncogene?
EXCEPT - Point mutation
- Benign neoplasms 16.What gene is stimulates cell
5. Which of the following is incorrect? proliferation in Burkitt lymphoma?
- Cancer can be removed surgically - MYC
6. What happens when cancers release 17.Which oncogene is seen in Breast
angiogenesis activators? cancers?
- Activators bind receptors on - CYCD1
surface of endothelial linings 18.Which of the following is not a
7. What is the first mechanism for caretaker gene?
cancer cells to leave their original - PTen
location? 19.DNA methylation in what sites can
- Loss of cell adhesion silence the adjacent genes?
8. Which of the following is defective - CG
in cancer cells which promote 20.Which of the following is incorrect
invasion? for benign cancers?
- E-cadherin - High mitotic index
9. Restoring which of the following
inhibits invasiveness of cells?
- E-cadherin
10.Which of the following relationships
is true?
