AF-2285

Faculty of Pharmacy Technology

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B.Pharm. (Semester–VI) (New) Examination

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MEDICINAL CHEMISTRY–III

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BP601T

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Time : Three Hours] [Maximum Marks : 75

AR INSTRUCTIONS TO CANDIDATES

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(i) Answer all questions.

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(ii) Illustrate your answer wherever necessary with the help of neat sketches.

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(iii) Use pen of Blue/Black ink/refill only for writing the answer book.
1. (1) Oxytetracycine is obtained from : 20
(a) Streptomyces rimosus (b) Streptomyces aureofaciens
(c) Streptomyces kanamyeliticus (d) Streptomyces rimosus
(2) The following drug is radical curative in vivax malaria.
(a) Quinine (b) Primaquine

(3)
(c) Mefluquine
Penicilin G is example of ______. a il
(d) Chloroquine

(a) Aminopenicillins E m
(b) Penicillinase resistant
(c) Carboxy penicillins
E G (d) Natural penicillins
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What is target for clavulanic acid ?
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(c) Lactamase
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(a) The transpeptidase enzyme (b) Penicillin acylase
(d) L-alaracemase
(5) Which is naturally occuring antimalaria drug ?
(a) Artemisinin (b) Mefloquine
(c) Quinacrine (d) Mepacrine
(6) Choose the azole antifungal drug which is used only topically :
(a) Ketoconazole (b) Fluconazole
(c) Ifraconazole (d) Econozole
(7) Remdesivir have structural similarity with :
(a) Adenosine monophosphate
(b) Adenosine diphosphate
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(c) Adenosine triphosphate
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(8) E G
(d) Guanine monophosphate
The following anthelmentics are found to be safe in pregnancy : E G
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(a) Thiabendazole (b) Piperozine
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(c) Albendazole (d) A
Pyrantel pamolate

LV–23622 1 (Contd.)
 (9) The quinolones class of UTI was evolved by ______ of nalidixic acid.
(a) Chlorination (b) Methylation
(c) Fluorination (d) Acetylation

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(10) Drug of choice for malaria in pregnancy is ______.
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(a) Quinine (b) Chloroquine

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(c) Pyrimethamine (d) Primaquine

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(11) Identify the metabolite of prontosil responsible for its antibacterial activiy :
(a) Sulphacetamide (b) Probenec

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(c) PABA (d) Sulphanilamide

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(12) In QSAR, study of medicinal chemistry Q stands for

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(a) Qualitative (b) Quantitaive
(c) Both (d) Quantum
(13) Which of the following is non competitive inhibitor of the enzyme reverse transcriptase in
HIV ?
(a) Lamivudine (b) Nevirapine
(c) Ritonavir (d) Tenofovir

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(14) Benzyl pencillinn is chemical name for which of following penicillin ?
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(a) Penicillin-F (b) Penicillin-G

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(c) Penicillin-V (d) Phenethean

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(15) Chloroquine can be synthesized by reaction of 4- diethylamino-1-methylbuty lamine with ?
(a)  -naphthol (b) 4, 7-dichloroquinoline
(c)  -naphthol (d) None of the above
(16) Aminoglycosides works by irreversible binding to the ______
(a) 30 S (b) 50 S
(c) Both (d) None of above
(17) Sulphonamides do not have adverse drug interaction with :
(a) Oral coagulants (b) Sulphon ylureas
(c) Hydantoin anticoagulants (d) Dihydrofolate reductase inhibitors

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(18) A combination of medications which are applied to treat tuberculosis is :
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(a)
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1-thia-4-azabicyclo [3,2.1] heptane
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(b)
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4-thia-1-azabicyclo [3.2] heptane
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(c)
R R 4-thia-1-azabicyclo [3.2.0] heptane
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(d) 1-thia-4-azabicyclo [1,2.3] heptane
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LV–23622 2 (Contd.)
 (19) Basic Nucleus of cephalosporins and penicillins is ______
(a) Lactone (b)  -lactam ring
(c) Thiazole

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(d) Lactum ring
(20) Chloramphenecol has two asymmetric centers. What is the configuration and optical activity of

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the active form of the antibiotics ?
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(a) D-threo (–) (b) L-threo, (+)

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(c) D-erythro, (–) (d) L-erythro, (+)
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Solve any two : 20

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(1) Classify  -Lactam antibiotics, explain SAR of penicillin in detail with application.

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(2) Classify antitubercular drugs in detail; explain SAR of any one class and synthesis of Isoniazide.

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(3) What are quinolones ? Classify them with their SAR and synthesis of nitrofurantoin in detail.
3. Solve any seven : 35
(1) Classify antifungal agents in detail.
(2) Classify anti-protozoal agents and synthesis of metronidazole.
(3) Classify antimalarials with SAR of any two drugs.
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What is QSAR ? Write details about parameters used in QSAR study.
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(5) m
What is combinatorial chemistry ? Give its applications.
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(6)
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Write about folate reductase inhibitors in detail.
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(7)
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What is prodrug ? Give its applications in detail.
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(8)
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Write synthesis of para amino salicylic acid.
(9) Write SAR and synthesis of acyclovir.

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E G E G
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