SAFETY DATA SHEET

Creation Date 28-Apr-2009 Revision Date 24-Dec-2021 Revision Number 8

1. Identification
Product Name Acetone

Cat No. : A9-4; A9-20; A9-200; A11-1; A11-4; A11-20; A11-200; A11S-4; A13-20;
A13-200; A16F-1GAL; A16P-1GAL; A16P-4; A16S-4; A16S-20; A18-1;
A18-4; A18-20; A18-20LC; A18-200; A18-200LC; A18-500; A18CU1300;
A18FB-19; A18FB-50; A18FB-115; A18FB-200; A18P-4; A18POP-19;
A18POPB-50; A18RB-19; A18RB-50; A18RB-115; A18RB-200;
A18RS-28; A18RS-50; A18RS-115; A18RS-200; A18S-4; A18SK-4;
A18SS-19; A18SS-28; A18SS-50; A18SS-115; A18SS-200; A19-1;
A19-4; A19RS-115; A19RS-200; A40-4; A928-4; A929-1; A929-4;
A929-4LC; A929RS-19; A929RS-50; A929RS-200; A929SK-4;
A929SS-28; A929SS-50; A929SS-115; A929SS-200; A946-4; A946-4LC;
A946FB-200; A946RB-19; A946RB-50; A946RB-115; A946RB-200;
A949-1; A949-4; A949-4LC; A949CU-50; A949N-119; A949N-219;
A949POP-19; A949RS-28; A949RS-50; A949RS-115; A949SK-1;
A949SK-4; A949SS-19; A949SS-28; A949SS-50; A949SS-115;
A949SS-200; BP2403-1; BP2403-4; BP2403-20; BP2403-RS200;
BP2404-1; BP2404-4; BP2404-SK1; BP2404-SK4; HC300-1GAL;
S70091; 22050131; 22050295
CAS No 67-64-1
Synonyms 2-Propanone; Dimethyl ketone; (Certified ACS, HPLC, OPTIMA, Histological,
Spectranalyzed, NF/FCC/EP, Pesticide, Electronic, GC Resolv, SAFE-COTE)

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Company
Fisher Scientific Company
One Reagent Lane
Fair Lawn, NJ 07410
Tel: (201) 796-7100

Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300

CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identification
Classification

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This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable liquids Category 2

Serious Eye Damage/Eye Irritation Category 2
Specific target organ toxicity (single exposure) Category 3
Target Organs - Central nervous system (CNS).
Specific target organ toxicity - (repeated exposure) Category 2
Target Organs - Kidney, Liver, spleen, Blood.

Label Elements

Signal Word
Danger

Hazard Statements
Highly flammable liquid and vapor
Causes serious eye irritation
May cause drowsiness or dizziness
May cause damage to organs through prolonged or repeated exposure

Precautionary Statements
Prevention
Wash face, hands and any exposed skin thoroughly after handling
Do not breathe dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Wear protective gloves/protective clothing/eye protection/face protection
Keep cool
Response
Get medical attention/advice if you feel unwell
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Call a POISON CENTER or doctor/physician if you feel unwell
Skin
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store in a well-ventilated place. Keep container tightly closed
Store locked up

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Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
Repeated exposure may cause skin dryness or cracking

3. Composition/Information on Ingredients
Component CAS No Weight %
Acetone 67-64-1 >95

4. First-aid measures
General Advice If symptoms persist, call a physician.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,
call a physician.

Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if
symptoms occur.

Ingestion Clean mouth with water and drink afterwards plenty of water.

Most important symptoms and . Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:
effects May cause pulmonary edema
Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may
be used to cool closed containers.

Unsuitable Extinguishing Media Water may be ineffective

Flash Point -20 °C / -4 °F

Method - CC (closed cup)

Autoignition Temperature 465 °C / 869 °F

Explosion Limits
Upper 12.8 vol %
Lower 2.5 vol %
Oxidizing Properties Not oxidising

Sensitivity to Mechanical Impact No information available

Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Flammable. Risk of ignition. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may
travel to source of ignition and flash back.

Hazardous Combustion Products

Carbon monoxide (CO). Carbon dioxide (CO2). Formaldehyde. Methanol.

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Protective Equipment and Precautions for Firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.

NFPA
Health Flammability Instability Physical hazards
2 3 0 N/A

6. Accidental release measures

Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Remove all
sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions Should not be released into the environment.

Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.

7. Handling and storage

Handling Do not get in eyes, on skin, or on clothing. Wear personal protective equipment/face
protection. Ensure adequate ventilation. Avoid ingestion and inhalation. Keep away from
open flames, hot surfaces and sources of ignition. Use only non-sparking tools. To avoid
ignition of vapors by static electricity discharge, all metal parts of the equipment must be
grounded. Take precautionary measures against static discharges.

Storage. Flammables area. Keep containers tightly closed in a dry, cool and well-ventilated place.
Keep away from heat, sparks and flame. Incompatible Materials. Strong oxidizing agents.
Strong reducing agents. Strong bases. Peroxides. Halogenated compounds. Alkali metals.
Amines.

8. Exposure controls / personal protection

Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Acetone TWA: 250 ppm (Vacated) TWA: 750 ppm IDLH: 2500 ppm TWA: 500 ppm
STEL: 500 ppm (Vacated) TWA: 1800 mg/m3 TWA: 250 ppm STEL: 750 ppm
(Vacated) STEL: 2400 TWA: 590 mg/m3
mg/m3
(Vacated) STEL: 1000 ppm
TWA: 1000 ppm
TWA: 2400 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration
NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations
and safety showers are close to the workstation location. Use explosion-proof
electrical/ventilating/lighting equipment.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

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Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties

Physical State Liquid
Appearance Colorless
Odor sweet
Odor Threshold 19.8 ppm
pH 7
Melting Point/Range -95 °C / -139 °F
Boiling Point/Range 56 °C / 132.8 °F
Flash Point -20 °C / -4 °F
Method - CC (closed cup)
Evaporation Rate 5.6 (Butyl Acetate = 1.0)
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 12.8 vol %
Lower 2.5 vol %
Vapor Pressure 247 mbar @ 20 °C
Vapor Density 2.0
Specific Gravity 0.790
Solubility Soluble in water
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 465 °C / 869 °F
Decomposition Temperature > 4°C
Viscosity 0.32 mPa.s @ 20 °C
Molecular Formula C3 H6 O
Molecular Weight 58.08
Refractive index 1.358 - 1.359

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Heat, flames and sparks. Incompatible products. Keep away from open flames, hot
surfaces and sources of ignition.

Incompatible Materials Strong oxidizing agents, Strong reducing agents, Strong bases, Peroxides, Halogenated
compounds, Alkali metals, Amines

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Formaldehyde, Methanol

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Acetone 5800 mg/kg ( Rat ) > 15800 mg/kg (rabbit) 76 mg/l, 4 h, (rat)
> 7400 mg/kg (rat)

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Toxicologically Synergistic Carbon tetrachloride; Chloroform; Trichloroethylene; Bromodichloromethane;

Products Dibromochloromethane; N-nitrosodimethylamine; 1,1,2-Trichloroethane; Styrene;
Acetonitrile, 2,5-Hexanedione; Ethanol; 1,2-Dichlorobenzene
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Acetone 67-64-1 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Central nervous system (CNS)

STOT - repeated exposure Kidney Liver spleen Blood

Aspiration hazard No information available

Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:
delayed May cause pulmonary edema

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information

Ecotoxicity
.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Acetone NOEC = 430 mg/l (algae; 96 Oncorhynchus mykiss: LC50 EC50 = 14500 mg/L/15 min EC50 = 8800 mg/L/48h
h) = 5540 mg/l 96h EC50 = 12700 mg/L/48h
Alburnus alburnus: LC50 = EC50 = 12600 mg/L/48h
11000 mg/l 96h
Leuciscus idus: LC50 =
11300 mg/L/48h
Salmo gairdneri: LC50 =
6100 mg/L/24h
Persistence and Degradability Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

Component log Pow

Acetone -0.24

13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

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Component RCRA - U Series Wastes RCRA - P Series Wastes

Acetone - 67-64-1 U002 -

14. Transport information

DOT
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
TDG
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
IATA
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1090
Proper Shipping Name ACETONE
Hazard Class 3
Packing Group II
15. Regulatory information
United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory

Active-Inactive Flags
Acetone 67-64-1 X ACTIVE -

Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Acetone 67-64-1 X - 200-662-2 X X X X X KE-29367

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313 Not applicable

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act Not applicable

OSHA - Occupational Safety and Not applicable

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Health Administration

CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
substance under the Comprehensive Environmental Response Compensation and Liability
Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs

Acetone 5000 lb -

California Proposition 65 This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know

Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Acetone X X X - X

U.S. Department of Transportation

Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland This product does not contain any DHS chemicals.
Security

Other International Regulations

Mexico - Grade Serious risk, Grade 3

Authorisation/Restrictions according to EU REACH

Component REACH (1907/2006) - Annex XIV - REACH (1907/2006) - Annex XVII - REACH Regulation (EC
Substances Subject to Restrictions on Certain Dangerous 1907/2006) article 59 - Candidate
Authorization Substances List of Substances of Very High
Concern (SVHC)
Acetone - Use restricted. See item 75. -
(see link for restriction details)

https://echa.europa.eu/substances-restricted-under-reach

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of

Pollutant Potential Hazardous
Substances (RoHS)
Acetone 67-64-1 Listed Not applicable Not applicable Not applicable

Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Acetone 67-64-1 Not applicable Not applicable Not applicable Annex I - Y42

16. Other information

Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: [email protected]

Creation Date 28-Apr-2009

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Revision Date 24-Dec-2021

Print Date 24-Dec-2021
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of SDS

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