Oxidative Stress in Lung Diseases Volume 1
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Editors
Sajal Chakraborti Tapati Chakraborti
Department of Biochemistry and Biophysics Department of Biochemistry and Biophysics
University of Kalyani University of Kalyani
Kalyani, West Bengal, India Kalyani, West Bengal, India
Salil Kumar Das Dhrubajyoti Chattopadhyay
Department of Biochemistry Amity University
and Cancer Biology Kolkata, West Bengal, India
Meharry Medical College
Nashville, TN, USA
ISBN 978-981-13-8412-7 ISBN 978-981-13-8413-4 (eBook)
https://doi.org/10.1007/978-981-13-8413-4
© Springer Nature Singapore Pte Ltd. 2019
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Singapore
This book is dedicated to Prof. Padmanabhan
Balaram, who was born on 19 February,
1949. Professor Padmanabhan Balaram is
an outstanding Indian biochemist, an
exceptional academic administrator, and a
former director of the Indian Institute of
Science (IISc), Bangalore, India.
vi
He is currently the distinguished professor of
Molecular Biophysics at the IISc, Bangalore,
India. His main research interests are in
bioorganic chemistry and molecular
biophysics. He is the author of over 580
research papers with more than 16, 800
citations.
Prof. Balaram received his bachelor’s degree
in Chemistry from Fergusson College,
Savitribai Phule Pune University, M.Sc. from
the Indian Institute of Technology-Kanpur
(1969), and PhD in Chemistry with Prof.
Aksel A. Bothner-By from Carnegie Mellon
University, Pittsburgh, USA (1972). During
his PhD, he studied the use of negative
nuclear Overhauser effect signals as probes
of macromolecular conformations. He did
his postdoctoral research at Harvard
University with Nobel laureate Prof. Robert
Burns Woodward. As a postdoc with Prof.
Woodword, he worked on the synthesis of the
antibiotic erythromycin.
Prof. Balaram is a fellow of the Indian
Academy of Sciences, the Indian National
Science Academy, and the Third World
Academy of Sciences, Trieste, Italy. He has
received many awards/honors in recognition
of his work, of which mention must be made
of the Shanti Swarup Bhatnagar Prize of the
CSIR (1986), Alumni Award for Excellence
in Research of the IISc (1991), G.D. Birla
Award for Scientific Research (1994),
Distinguished Alumnus Award of the IIT
Kanpur (2000), and Padma Shri by the
Government of India (2002). He also
received the third highest Indian civilian
honor of Padma Bhushan (2014). He has
vii
served on many committees like CSIR, DST,
DBT, DAE, DRDO, ICMR, and UGC of the
Government of India and is currently a
member of the Science Advisory Committee
to the Union Cabinet and Scientific Advisory
Council to the Prime Minister, among others.
He has been the editor of Current Science
since 1995. He is currently serving in the
editorial board of the following journals:
ChemBioChem, Biopolymers, and Protein
Engineering, Design and Selection.
Prof. Balaram undoubtedly is a legendary
figure in Indian Science. He has excellent
ability to inspire and motivate young
researchers. We feel honored to dedicate this
book to him and wish him good health and
success in his long fruitful activities.
Preface
“The aim of science is not to open
the door to infinite wisdom,
but to set a limit to infinite error.”
Bertolt Brecht: Life of Galileo
The number of diseases in which detrimental oxidative stress has been proposed to
play a causative or exacerbating role has grown steadily over the past two decades.
Among them, the most prevalent one is the oxidant-mediated lung diseases.
As the lungs lie in the interface between environment and oxidative processes of
tissues, it must possess several mechanisms to prevent excessive degree of stress.
Enzymatic and nonenzymatic antioxidant systems can quench a wide range of ROS.
Diseases like asthma, chronic obstructive pulmonary disease (COPD), and acute
respiratory distress syndrome (ARDS) occur from a number of sources, including
greater exposure to environmental prooxidants, airway infiltration of inflammatory
cells, metabolic dysregulation, and reduced levels of antioxidants.
The oxidant burden in the lung is enhanced in smokers by the release of ROS
from macrophages and neutrophils. Oxidants present in cigarette smoke can stimu-
late alveolar macrophages to produce ROS and to release a host of mediators, some
of which attract neutrophils and other inflammatory cells in the lungs, thereby gen-
erating ROS via NADPH oxidase system. A marked increase in the numbers of
neutrophils and macrophages was observed in the lungs of cigarette smokers com-
pared with those of the non-smokers. Moreover, the lungs of smokers with airway
obstruction have more neutrophils than smokers without airway obstruction.
Circulating neutrophils from cigarette smokers and patients with exacerbations of
COPD release more O2−. Cigarette smoke is associated with a marked increase in
the production of myeloperoxidase (MPO) in neutrophils, which can be correlated
with the degree of pulmonary dysfunction.
This book contains 23 state-of-the-art chapters contributed by established inves-
tigators working on the different oxidative stress-induced aspects of lung diseases.
Each chapter of the book summarizes information from basic research that hints to
possible pharmacological intervention. We hope that this book will be useful for the
postgraduate students and biomedical researchers to better understand the
ix
x Preface
mechanisms associated with oxidant-induced lung diseases and to identify targets
for drug development for different types of lung diseases.
Our sincere gratitude goes to all contributors for their considerable energy, time,
and effort to accomplish a complete chapter with no quid pro quo benefit. We are
thankful to Dr. Madhurima Kahali and Raagai Priya Chandrasekaran (Springer
Nature) for their cooperation and support during the preparation of this book.
Kalyani, West Bengal, India Sajal Chakraborti
Contents
Part I General Implications of Oxidative Stress on Lungs
1 Nutrition in Inflammatory Lung Diseases�������������������������������������������� 3
Daisy Karina Aguilar-López, Carlos Olvera-Sandoval,
Diego Estrada-Luna, Jeannett Alejandra Izquierdo-Vega,
Ashutosh Sharma, and Gabriel Betanzos-Cabrera
2 Oxidative Stress and Smoke-Related Lung Diseases:
A Tentative Approach Through the Blood, Lungs, and Gut���������������� 27
Francesco Marotta, Jaganath Arunachalam, Antara Banerjee,
Roberto Catanzaro, Sudhir Adalti, Aparimita Das,
Alexander Kolyada, and Surajit Pathak
3 Oxidative Stress in Neonatal Lung Diseases������������������������������������������ 51
Ru-Jeng Teng
4 DNA Repair Protein OGG1 in Pulmonary Infection
and Other Inflammatory Lung Diseases������������������������������������������������ 85
Ping Lin, Qinqin Pu, Shugang Qin, Jacob Schettler,
Mariah Thoemke, Guoping Li, Jianxin Jiang, and Min Wu
5 The Dual Role of Oxidative Stress in Lung Cancer������������������������������ 99
Asmaa M. Ahmed
6 Cigarette Smoke-Induced Oxidative Stress in Type I
and Type II Lung Epithelial Cells���������������������������������������������������������� 115
Subodh Kumar, Phulen Sarma, Bikash Medhi,
and Krishan L. Khanduja
7 Infectious Lung Diseases and Endogenous Oxidative Stress �������������� 125
Kasturi Sarkar and Parames C. Sil
8 Role of MMPs and Oxidants in Lung Diseases ������������������������������������ 149
Nilanjana Deb, Sudipta Mallick, Ashish Jaiswal, Anirban Manna,
Ulaganathan Mabalirajan, and Snehasikta Swarnakar
xi
xii Contents
9 Role of Chemical Exposure in Oxidant-Mediated
Lung Diseases ������������������������������������������������������������������������������������������ 171
Satabdi Banerjee, Suman K. Nandy, and Sajal Chakraborti
Part II Inflammatory Lung Diseases
10 Oxidative Stress and Immune Regulation During
Chronic Respiratory Diseases ���������������������������������������������������������������� 187
Soumya Chatterjee, Kaustav Chakraborty, Shauryabrota Dalui,
and Arindam Bhattacharyya
11 Immunological Basis of Oxidative Stress-Induced
Lung Inflammation in Asthma and COPD�������������������������������������������� 195
Gurupreet Singh Sethi, Vivek Dharwal, and Amarjit Singh Naura
12 Contribution of Aldose Reductase-Mediated Oxidative
Stress Signaling in Inflammatory Lung Diseases���������������������������������� 225
Himangshu Sonowal, Ashish Saxena, and Kota V. Ramana
13 Oxidative Stress and Pulmonary Carcinogenesis Through
Mechanisms of Reactive Oxygen Species. How Respirable
Particulate Matter, Fibrous Dusts, and Ozone Cause
Pulmonary Inflammation and Initiate Lung Carcinogenesis�������������� 247
Athanasios Valavanidis
Part III Other Lung Diseases
14 The Redoxomics of Bronchopulmonary Dysplasia������������������������������ 269
William L. Stone, Des Bharti, Darshan S. Shah,
and Shawn Hollinger
15 Oxidative Stress in Environmental Lung Diseases�������������������������������� 293
Hsiao-Chi Chuang
16 Bronchopulmonary Dysplasia and Oxidative
Stress in the Newborn������������������������������������������������������������������������������ 309
Serafina Perrone, Elisa Laschi, Elisabetta Grande,
and Giuseppe Buonocore
17 Pulmonary Oxidative Stress and Antioxidant Defence
System in the Lung Ageing and Fibrotic and Diabetic Lungs ������������ 325
Fusun Oztay, Ozgecan Kayalar, and Merve Yildirim
18 Mitochondrial Alterations and Oxidative Stress
in Cystic Fibrosis�������������������������������������������������������������������������������������� 355
Ángel Gabriel Valdivieso
Contents xiii
Part IV Degenerative Lung Diseases
19 Oxidative Stress in Chronic Obstructive Pulmonary Disease�������������� 375
Mariana A. Antunes, Fernanda F. Cruz, and Patricia R. M. Rocco
20 Oxidative Stress-Induced Autophagy Impairment
and Pathogenesis of Chronic Obstructive Lung Diseases�������������������� 389
Manish Bodas and Neeraj Vij
Part V Preventionand Therapeutics
21 Therapeutic Targeting of Oxidative Stress and Inflammation
in Asthma and COPD and Pharmacological
Interventions with Phytochemicals�������������������������������������������������������� 429
Nasiruddin Nalban, Sateesh Alavala, Rajendra Sangaraju,
Salma Mukhtar Mir, and Ramakrishna Sistla
22 Diallyl Trisulfide Prospectively Retrieves Arsenic Induced
Lung Oxidative Stress, Inflammation Through
the Activation of Nrf2/HO-1 Signaling�������������������������������������������������� 451
S. Miltonprabu, N. C. Sumedha, S. Thangapandiyan,
and K. Shagirtha
23 Molecular Therapeutic Targets in Tobacco-Induced
Lung Pathology���������������������������������������������������������������������������������������� 477
Pramod K. Avti and Krishan L. Khanduja
Editors and Contributors
About the Editors
Sajal Chakraborti is a Professor of Biochemistry at the University of Kalyani,
West Bengal, India. His research covers the role of proteases, oxidant, and Ca2+
signaling in the pathogenesis of a variety of diseases. Prof. Chakraborti obtained his
Ph.D. from Calcutta University and D.Sc. from Kalyani University. He did
postdoctoral research at Johns Hopkins University, University of Utah, and
New York Medical College. He received DBT-Senior Overseas Research Award for
his research at the University of Florida, Gainesville. He has been engaged in
teaching and research in biochemistry for the past 40 years. He has published over
120 original papers, 22 book chapters, and 15 review articles and also edited
12 books published by Springer.
Tapati Chakraborti is currently a Professor of Biochemistry in the Department of
Biochemistry and Biophysics, University of Kalyani, West Bengal India. She
obtained her Ph.D. from CSIR-Indian Institute of Chemical Biology, Kolkata
(1993). She did her postdoctoral research at the University of Florida, Gainesville,
Florida, USA. Her postdoctoral research mainly focused on beta-adrenergic recep-
tor regulation in heart diseases. She is currently doing research on oxidant and cal-
cium signaling-mediated pathogenesis of lung diseases and also parasitic diseases
especially leishmaniasis. She published over 90 original research papers in different
internationally reputed journals and 20 book chapters in different books published
by Springer and Academic Press. She also edited 4 books.
Salil Kumar Das is a Professor of Biochemistry and Cancer Biology at the
Meharry Medical College, University of Tennesse, Nashville, TN, USA. He
obtained his Sc.D. from Massachusetts Institute of Technology and D.Sc. from
Calcutta University. He published over 150 original research papers in different
international journals of repute. He also contributed 12 book chapters in different
books of different international publishing companies.
xv
xvi Editors and Contributors
Dhrubajyoti Chattopadhyay is at present the Vice Chancellor of Amity
University, Kolkata. He obtained his Ph.D. from Bose Institute, Kolkata, India. He
did his postdoctoral research at the Department of Cell Biology, Roche Institute of
Molecular Biology, Nutley, New Jersey, USA (1985–1987); and also in the
Department of Molecular Biology, The Cleveland Clinic Foundation, Cleveland,
Ohio, USA. He has published over 100 original research papers and also several
chapters in different books published by internationally reputed publishers.
Contributors
Sudhir Adalti Department of CVTS, U N Mehta institute of cardiology and
research centre, Ahmedabad, Gujarat, India
Daisy Karina Aguilar-López UNEME EC Tula, Secretaría de Salud de Hidalgo,
Tula, Hidalgo, México
Asmaa M. Ahmed Pathology Department, Faculty of Medicine, Assiut University,
Assiut, Egypt
Sateesh Alavala Department of Applied Biology, CSIR-Indian Institute of
Chemical Technology (IICT), Hyderabad, India
Mariana A. Antunes Laboratory of Pulmonary Investigation, Carlos Chagas Filho
Institute of Biophysics, Federal University of Rio de Janeiro, Centro de Ciências da
Saúde, Rio de Janeiro, RJ, Brazil
Jaganath Arunachalam Faculty of Allied Health Sciences, Chettinad Hospital &
Research Institute (CHRI), Chettinad Academy of Research and Education (CARE),
Kelambakkam, Chennai, India
Pramod K. Avti Department of Biophysics, Postgraduate Institute of Medical
Education and Research, Chandigarh, India
Antara Banerjee Faculty of Allied Health Sciences, Chettinad Hospital &
Research Institute (CHRI), Chettinad Academy of Research and Education (CARE),
Kelambakkam, Chennai, India
Satabdi Banerjee Department of Environmental Management, William Carey
University, Shillong, Meghalaya, India
Gabriel Betanzos-Cabrera Tecnologico de Monterrey, School of Engineering
and Sciences Campus Queretaro, Queretaro, Mexico
Des Bharti Department of Pediatrics, East Tennessee State University, Johnson
City, TN, USA
Arindam Bhattacharyya Immunology Laboratory, Department of Zoology,
University of Calcutta, Kolkata, West Bengal, India
Editors and Contributors xvii
Manish Bodas The Johns Hopkins University SOM University, Baltimore, MD,
USA
Giuseppe Buonocore Department of Molecular and Developmental Medicine,
University of Siena, Siena, Italy
Roberto Catanzaro Department of Clinical & Experimental Medicine,
Gastroenterology Section, University of Catania, Catania, Italy
Sajal Chakraborti Department of Biochemistry & Biophysics, University of
Kalyani, Kalyani, West Bengal, India
Kaustav Chakraborty Immunology Laboratory, Department of Zoology,
University of Calcutta, Kolkata, West Bengal, India
Soumya Chatterjee Immunology Laboratory, Department of Zoology, University
of Calcutta, Kolkata, West Bengal, India
Hsiao-Chi Chuang School of Respiratory Therapy, College of Medicine, Taipei
Medical University, Taipei, Taiwan
Fernanda F. Cruz Laboratory of Pulmonary Investigation, Carlos Chagas Filho
Institute of Biophysics, Federal University of Rio de Janeiro, Centro de Ciências da
Saúde, Rio de Janeiro, RJ, Brazil
Shauryabrota Dalui Immunology Laboratory, Department of Zoology, University
of Calcutta, Kolkata, West Bengal, India
Aparimita Das Faculty of Medicine, Chettinad Hospital & Research Institute
(CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil
Nadu, India
Nilanjana Deb Cancer Biology and Inflammatory Disorder Division, CSIR-Indian
Institute of Chemical Biology, Kolkata, West Bengal, India
Vivek Dharwal Department of Biochemistry, Panjab University, Chandigarh,
India
Diego Estrada-Luna Instituto Nacional de Cardiología “Ignacio Chávez”, Ciudad
de México, México
Elisabetta Grande Department of Molecular and Developmental Medicine,
University of Siena, Siena, Italy
Shawn Hollinger Department of Pediatrics, East Tennessee State University,
Johnson City, TN, USA
Jeannett Alejandra Izquierdo-Vega Área Académica de Medicina, Instituto de
Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca,
Hidalgo, México
Ashish Jaiswal Cell Biology and Physiology Division, CSIR-Indian Institute of
Chemical Biology, Kolkata, West Bengal, India
xviii Editors and Contributors
Jianxin Jiang State Key Laboratory of Trauma, Burns and Combined Injury,
Institute of Surgery Research, Daping Hospital, Army Medical University,
Chongqing, People’s Republic of China
Ozgecan Kayalar Faculty of Science, Biology Department, Molecular Biology
Section, Istanbul University, Istanbul, Turkey
Krishan L. Khanduja Department of Biophysics, Postgraduate Institute of
Medical Education and Research, Chandigarh, India
Alexander Kolyada National Academy of Medical Sciences of Ukraine,
Chebotareva Institute of Gerontology, Kiev, Ukraine
Subodh Kumar Experimental Pharmacology Laboratory (EPL), Pharmacology,
PGIMER, Chandigarh, India
Elisa Laschi Department of Molecular and Developmental Medicine, University
of Siena, Siena, Italy
Guoping Li Pulmonary and Allergy Institute, Affiliated Hospital, Southwestern
Medical University, Luzhou, China
Ping Lin Department of Biomedical Sciences, School of Medicine and Health
Sciences, University of North Dakota, Grand Forks, ND, USA
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery
Research, Daping Hospital, Army Medical University, Chongqing, People’s
Republic of China
Ulaganathan Mabalirajan Cell Biology and Physiology Division, CSIR-Indian
Institute of Chemical Biology, Kolkata, West Bengal, India
Sudipta Mallick Cancer Biology and Inflammatory Disorder Division, CSIR-
Indian Institute of Chemical Biology, Kolkata, West Bengal, India
Anirban Manna Cancer Biology and Inflammatory Disorder Division, CSIR-
Indian Institute of Chemical Biology, Kolkata, West Bengal, India
Francesco Marotta ReGenera R&D International for Aging Intervention, Milan,
Italy
VCC Preventive Medical Promotion Foundation, Beijing, China
Bikash Medhi Experimental Pharmacology Laboratory (EPL), Pharmacology,
PGIMER, Chandigarh, India
S. Miltonprabu Department of Zoology, University of Madras, Chennai, Tamil
Nadu, India
Salma Mukhtar Mir Department of Applied Biology, CSIR-Indian Institute of
Chemical Technology (IICT), Hyderabad, India
Nasiruddin Nalban Department of Applied Biology, CSIR-Indian Institute of
Chemical Technology (IICT), Hyderabad, India
