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Simona Vlad Nicolae Marius Roman (Eds.)
•

International Conference on
Advancements of Medicine and Health Care
through Technology; 12th – 15th October 2016
Cluj-Napoca, Romania
MEDITECH 2016

123
Editors
Simona Vlad Nicolae Marius Roman
Faculty of Electrical Engineering Faculty of Electrical Engineering
Technical University of Cluj-Napoca Technical University of Cluj-Napoca
Cluj-Napoca Cluj-Napoca
Romania Romania

ISSN 1680-0737 ISSN 1433-9277 (electronic)

IFMBE Proceedings
ISBN 978-3-319-52874-8 ISBN 978-3-319-52875-5 (eBook)
DOI 10.1007/978-3-319-52875-5

Library of Congress Control Number: 2017930147

© Springer International Publishing AG 2017

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 Foreword

The 5th Conference on Advancements of Medicine and Health Care through Technology - MediTech2016 took place in Cluj-
Napoca in October 12–15, 2016. The Conference aimed to provide opportunities for Romanian and foreign professionals
involved in basic research, R&D, industry and medical applications to exchange their know-how and build up collaboration in
one of the most important fields of science and technology - medical engineering.
MediTech is intended to be an international forum for researchers and practitioners interested in the advance in, and
applications of biomedical engineering to exchange the latest research results and ideas in areas like hardware and software
technologies, medical devices, biosignal and image processing, biomaterials, biomechanics, telemedicine, etc. The importance
of this kind of scientific events was proven by the interest of the prestigious researchers from Romania and abroad who decided
to take part in the 5th edition of MediTech. Moreover, we were honored to receive the visit of Prof. Kang-Ping Lin, Secretary
General of IFMBE.
All papers submitted for presentation went through a review process and were evaluated by two reviewers. The papers
chosen to be presented at the conference were accompanied by manuscripts to be published in these Proceedings.
We would like to kindly thank the members of the Scientific and Organizing Committees for their hard work and dedication
and we hope that they will continue supporting MediTech.

MediTech2016 Conference Chair

Professor Nicolae Marius Roman
 Organization

Organizer

Romanian National Society for Medical Engineering and Biological Technology

Endorsed by

International Federation for Medical and Biological Engineering

Partners

Technical University of Cluj-Napoca, Romania

“Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania
Medical University of Vienna, Austria
The University of Sheffield, United Kingdom
“Dr. Constantin Papilian” Military Emergency Hospital, Cluj-Napoca, Romania

Conference Chair
Nicolae Marius Technical University of Cluj-Napoca, Romania
Roman

Honorary Chair
Radu Vasile Ciupa Technical University of Cluj-Napoca, Romania

Scientific Advisory Committee

Laura Bacali (RO) Laura Grindei (RO)

Doina Baltaru (RO) Flavius Gruian (SE)
Maria Beudean (RO) Sorin Hintea (RO)
Corina Botoca (RO) Rodica Holonec (RO)
Remus Brad (RO) Rod Hose (UK)
Simion Bran (RO) Adrian Iancu (RO)
Macarie Breazu (RO) Beriliu Ilie (RO)
Lelia Ciontea (RO) Ioan Jivet (RO)
Radu Ciorap (RO) Mircea Leabu (RO)
Radu V. Ciupa (RO) Patricia Lawford (UK)
Hariton Costin (RO) Angela Lungu (RO)
Cecilia Cristea (RO) Eugen Lupu (RO)
Vanessa Diaz-Zuccarini (UK) Dan Mandru (RO)
Gabriele Dubini (IT) Avram Manea (RO)
Anca Galaction (RO) Alma Maniu (RO)
Stefan Gergely (RO) Raul Malutan (RO)
Zoltan German-Sallo (RO) Winfried Mayr (A)
VIII Organization

Amalia Mesaros (RO) Traian Petrisor (RO)

Dan D. Micu (RO) Petre G. Pop (RO)
Ioan Mihu (RO) Dan V. Rafiroiu (RO)
Dan Milici (RO) Corneliu Rusu (RO)
Petru Mircea (RO) Dan I. Stoia (RO)
Alexandru Morega (RO) Mihai Tarata (RO)
Mihaela Morega (RO) Vasile Topa (RO)
Marius Muji (RO) Mircea Vaida (RO)
Calin Munteanu (RO) Doru Ursutiu (RO)
Mihai S. Munteanu (RO) Liliana Verestiuc (RO)
Andrew Narracott (UK) Radu C. Vlad (RO)
Anca I. Nicu (RO) Simona Vlad (RO)
Maria Olt (RO) Daniel Volovici (RO)
Sever Pasca (RO) Dan Zaharia (RO)
Alessandro Pepino (IT)

Local Organizing Committee

Alexandru Avram Radu A. Munteanu

Radu V. Ciupa Anca I. Nicu
Rodica Holonec Maria Olt
Beriliu Ilie Dan V. Rafiroiu
Angela Lungu Nicolae Marius Roman
Calin Munteanu Debora E. Tomsa
Mihai S. Munteanu Simona Vlad

Invited Speakers

Kang-Ping Lin, IFMBE Secretary-General, Chung-Yuan Christian University, Taiwan

Heart, Heart Rate, & Heart Rate Variability with RSA Application

Helmut Hutten, Institute of Medical Engineering, Graz University of Technology, Austria

Innovations – From Good Ideas to Successful Products on the Market
Alessandro Pepino, University of Naples “Federico II”, Italy
The Discrete Event Simulation for Studying of Organizational Models in Health Care
Winfried Mayr, Medical University of Vienna, Austria
Interfacing neurons and muscles

Rod Hose - University of Sheffield, United Kingdom

ANSYS Healthcare Solutions
Lucio Tommaso De Paolis, University of Salento, Italy
Virtual Reality and Augmented Visualization in Medicine and Surgery
Mircea Gelu Buta, “Babeş-Bolyai” University of Cluj-Napoca, Romania
The Report between the Technics and Medical Clinic

Doru Ursuţiu, “Transilvania” University of Braşov, Romania

Online Technologies and Virtual Instrumentation in Sensing - Monitoring – Medicine. “Cloud Instrumentation and IoT
Organization IX

Mircea Leabu, University of Medicine and Pharmacy “Carol Davila” and “Victor Babeş” National Institute of Pathology,
Bucharest, Romania
Half a Century for Jumping to Live Cell Studies at Nanolevel Resolution

Mihai Tărâţă, University of Medicine and Pharmacy of Craiova, Romania

Advantages of Frequency Domain Processing, in Monitoring the Neuro-muscular Fatigue
Radu George Ciorap, University of Medicine and Pharmacy “Grigore T. Popa”, Iaşi, Romania
Medical Device Testing – a Key Issue for Patient Safety
Doina Baltaru, “Dr. Constantin Papilian” Emergency Military Hospital of Cluj-Napoca, Romania
Aspects of Medical Technology in Military Medical System

Sponsors

Laitek Medical Software

Comelf SA, Avena Medica SRL, Tehno Industrial SA, Cefmur SA, Temco SRL, Constelatia Construct SRL
 Contents

Clinical engineering assessment

Ultrasonographic Correlations and Challenges in Liver Hemangiomas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3

I. Grigorescu, Z. Sparchez, R. Badea, M. Dragoteanu, C.D. Piglesan, and D.L. Dumitrascu

Impact of Spectralis Optical Coherence Tomography in the Clinical Practice . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

S.D. Nicoară

Laparoscopic Repair of Morgagni Hernia – Transfascial Suturing with Extracorporeal Knotting . . . . . . . . . . . . . . . 13

F. Graur, E. Moiș, N. Al-Momani, and N. Al-Hajjar

Ambulatory Heart Rate Variability Correlates with High-Sensitivity C - Reactive Protein in Type 2 Diabetes
and Control Subjects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
D.M. Ciobanu, A.E. Crăciun, I.A. Vereşiu, C. Bala, and G. Roman

Heart Rate Dynamics Study on the Impact of “Mirror Therapy” in Patients with Stroke. . . . . . . . . . . . . . . . . . . . . 21
D. Andriţoi, C. Corciovă, C. Luca, D. Matei, and R. Ciorap

Assessment of Nerve Fibers Dysfunction Through Current Perception Threshold Measurement in Diabetic
Peripheral Neuropathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
G.V. Inceu, G. Roman, and I.A. Veresiu

Implantable Ports in Oncology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31

B. Micu, C. Micu, T-R. Pop, and N. Constantea

Robotic Splenectomy using the DaVinci Platform . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35

B. Micu, C. Micu, T-R. Pop, and N. Constantea

Classical Chemometrics Methods Applied for Clinical Data Analysis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39

R. Bleiziffer, M. Culea, C. Sarbu, P. Podea, S. Suvar, A. Iordache, and C. Mesaros

What do job adverts tell Higher Education about the ‘shape’ of Biomedical Engineering Graduates? . . . . . . . . . . . . 43
A.E. Ward, B. Baruah, A. Gbadebo, and N.J. Jackson

Ozone and Intense Electric Fields Applyance in Treating of External Wounds Become Overinfected . . . . . . . . . . . . 49
R.E. Suarasan, I. Suarasan, S.R. Budu, M.I. Suarasan, A. Maniu, and R. Morar

Comparative Analysis of Cardiovascular Risk Profile, Cardiac and Cervical Arterial Ultrasound in Patients
with Chronic Coronary and Peripheral Arterial Ischemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
M.A. Stoia, A.D. Farcaș, F.P. Anton, A.I. Roman, and L.A. Vida-Simiti

Cardiovascular Risk Profile, Cardiac and Cervical Artery Ultrasound in Patients with Peripheral Artery Disease . . . . 59
A.D. Farcaș, M.A. Stoia, F.A. Anton, A.I. Roman, and L.A. Vida-Simiti

Medical devices, measurements and instrumentation

A Single-character Refreshable Braille Display with FPGA Control. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63

M.C. Ignat, P. Faragó, S. Hintea, M.N. Roman, and S. Vlad
XII Contents

Assessing Microcirculation for Predictive Purposes with the Aim of Reducing the Amputation Rate in the Case
of Patients with Critical Lower Limb Ischemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
O. Andercou, B. Stancu, A. Mironiuc, and H. Silaghi

An EIT Belt Reference Design with Active Electrodes and Digital Output . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
I. Jivet

Age Simulation Suits for Training, Research and Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77

H.L. Groza, S. B. Sebesi, and D.S. Mandru

Low Cost Command and Control System for Automated Infusion Devices. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
B. Tebrean, S. Crisan, C. Muresan, and T.E. Crisan

Monitoring System for the Emotional States . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85

M. Cenușă, M. Poienar, L.D. Milici, and S.D. Pața

Low Cost Prototype for Viewing a Map of Vascularization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89

D. Iudean, R. Munteanu jr., E.M. Bindea, D.F. Muresanu, and O. Selejan

Modular Multi-channel Real-time Bio-signal Acquisition System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95

C. Kast, M. Krenn, W. Aramphianlert, C. Hofer, O.C. Aszmann, and W. Mayr

An ECG Front-End Device based on ADS1298 Converter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99

C.M. Fort, A.M. Ciupe, and S. Vlad

New Approach for the Electrochemical Detection of Dopamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103

M. Tertiș, A. Florea, A. Adumitrachioaie, D. Bogdan, C. Cristea, and R. Săndulescu

Aptamer-based Electrochemical Sensor for the Detection of Ampicillin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107

B. Feier, I. Băjan, C. Cristea, and R. Săndulescu

Determination of the Electrical Parameters of Some ECG Electrodes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111

A.R. Iusan, N.M. Bîrlea, M. Paunescu, and A.M. Ciupe

How to Describe the Skin’s Electrical Nonlinear Response. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115

N.M. Bîrlea, S.I. Bîrlea, and E. Culea

Case Study of Static and Dynamic Postural Balance of an Overweight Pregnant Woman . . . . . . . . . . . . . . . . . . . . 119
D. Cotoros, A. Stanciu, and I. Serban

Multipoint Wireless Network for Complex Patient Monitoring based on Embedded Processors . . . . . . . . . . . . . . . . 123
T. Sumalan, E. Lupu, R. Arsinte, and E. Onaca

Automated Titration of Oxygen Fraction in Inspiratory Mixture in Mechanical Ventilation of Life-size Mannequin . . . 127
M. Rožánek, P. Kudrna, and V. Králová

A Study of the Effects of Geometry on the Efficiency of Single Slot Microwave Ablation Antennas
Used in Hepatic Tumor Hyperthermia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
V. Neagu

The Influence of an Orifice Plates as a Flow Sensors on the Removal of Carbon Dioxide in High Frequency
Oscillatory and Jet Ventilation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
P. Kudrna and M. Rožánek

Evaluation of the Electric and Magnetic Field near High Voltage Power Lines . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Ș.F. Braicu, L. Czumbil, D. Șteț, and D.D. Micu
Contents XIII

Analysis of Pulse Wave During Magneto-Therapy Session . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147

C. Luca, D. Andriţoi, C. Corciovă, and R. Ciorap

Three Element Windkessel Model to Non-Invasively Assess PAH Patients: One Year Follow-up . . . . . . . . . . . . . . 151
A. Lungu, D.R. Hose, D.G. Kiely, D. Capener, J.M. Wild, and A.J. Swift

Thermal Rehabilitation Influence upon the Comfort in Hospitals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155

A. Abrudan, T. Rus, and R. Mare

Modelling the Passive Behavior of the Nervous Cell. Influence of Electric Parameters Variation . . . . . . . . . . . . . . . 159
M. Crețu, L. Darabant, and A. Răcășan

Simulation of Teeth Movement in the Case of Orthodontic Treatment Procedures . . . . . . . . . . . . . . . . . . . . . . . . . 165

T. Coloşi, V. Mureşan, O. Nemeş, M. Olt, and N.M. Roman

Biomedical signal and image processing

Non-linear Analysis of Heart Rate Variability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173

Z. German-Sallo

Dependency of Tidal Volume on Mean Airway Pressure in High-Frequency Oscillatory Ventilation . . . . . . . . . . . . 177
J. Matejka and M. Rozanek

Towards a Trial-Based,Time-Scale Dynamic Detection of M1 and M2 Components from the EMG Stretch
Reflex Response . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181
M. Tarata, M. S. Serbanescu, D. Georgescu, D.O. Alexandru, and W. Wolf

Discriminate Animal Sounds Using TESPAR Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185

G.P. Pop

Robust Analysis of Non-Stationary Cortical Responses: Tracing Variable Frequency Gamma Oscillations
and Separating Multiple Component Input Modulations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189
A. Dăbâcan and R.C. Mureşan

Comparison of Classifiers for Brain Tumor Segmentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195

L. Lefkovits, Sz. Lefkovits, M.F. Vaida, S. Emerich, and R. Măluțan

Abnormalities Identification in Mammograms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201

L.D. Chiorean, M.F. Vaida, and C. Striletchi

Telemedicine and health care information systems

Interconnecting Heterogeneous Non-smart Medical Devices using a Wireless Sensor Networks (WSN)
Infrastructure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207
B. Iancu, R. Kovacs, V. Dadarlat, and A. Peculea

Algorithm with Heuristics for Kidney Allocation in Transplant Information System. . . . . . . . . . . . . . . . . . . . . . . . 213
S. Luscalov, L. Loga, D. Luscalov, A. Lăcătuș, G. Dragomir, and L. Dican

Exploring Hierarchical Medical Data stored as Multi-trees in a Relational Database. . . . . . . . . . . . . . . . . . . . . . . . 219

P. Olah, I. Movileanu, N. Suciu, M. Muji, M. Marusteri, D. Simionescu, and C. Avram

Development of a Complex Acquisition and Storage System of Medical Data Used in a Clinical Environment . . . . . 223
R. Pop Kun, M. Munteanu, D. Rafiroiu, D. Pop Kun, and R. Moga
XIV Contents

Elderly Fall Risk Prediction System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 228

O. Stan, L. Miclea, and A. Sarb

Particle Swarm Optimization Based Method for Personalized Menu Recommendations . . . . . . . . . . . . . . . . . . . . . 232
V. Chifu, R. Bonta, E. St. Chifu, I. Salomie, and D. Moldovan

Diet Generator for Elders using Cat Swarm Optimization and Wolf Search . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238
D. Moldovan, P. Stefan, C. Vuscan, V.R. Chifu, I. Anghel, T. Cioara, and I. Salomie

Telemonitoring Systems and Technologies for Independent Life of Elderly . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 244

S.B. Sebesi, H.L. Groza, and D. Mândru

Automatic Learning of Medical Text Annotation Rules – a Case Study on Endoscopies . . . . . . . . . . . . . . . . . . . . 248
R.R. Slavescu, M.N. Oltean, A.P. Torok, and K.C. Slavescu

Use of Machine Learning for Improvement of Similarity Searches of Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . 252

B. Petrovan, B. Orza, and A. Vlaicu

Biomechanics, Robotics and Rehabilitation

Motor Imagery Brain-Computer Interface for the Control of a Shoulder-Elbow Rehabilitation Equipment. . . . . . . . . 259
A. Ianoși-Andreeva-Dimitrova, D.S. Mândru, M.O. Tătar, and S. Noveanu

Performance and Efficiency Feedback in Rehabilitation Program with Kinematic Analysis System – a Case Study
in Rehabilitation after Lumbar Discectomy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263
S.A. Moldoveanu, D. Şardaru, L. Pendefunda, and C. Luca

Assistive Technology Product Innovation Through Undergraduate Projects. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 267

A. Ward, I. Grout, L. Grindei, and D. Mândru

Health technology assessment

Baby Wearing Buying Decision-making - A Focus Group Exploratory Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277

A. Constantinescu-Dobra and M.A. Coțiu

A Critical Analysis of Self-assessment Tools for Improving Workers’ Health and Work Performance . . . . . . . . . . . 283
S.C. Anca

Promoting a Dental Practice on Facebook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287

A.I. Iancu and S.D. Cîrstea

Generation Z and Online Dentistry. An Exploratory Survey on the Romanian Market . . . . . . . . . . . . . . . . . . . . . . 291
A. Constantinescu-Dobra and V. Maier

Patient Satisfaction with Diabetes Care in Romania – An Importance-performance Analysis . . . . . . . . . . . . . . . . . . 297

M.A. Coțiu and A. Sabou

Analysis of Factors that Influence OTC Purchasing Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303

S.D. Cîrstea, C. Moldovan-Teselios, and A.I. Iancu

Wireless Systems with Reduced PAPR Using K-means Modified PTS Implemented for Epilepsy Classification
from EEG Signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309
Sunil Kumar Prabhakar and Harikumar Rajaguru
Contents XV

Efficient Wireless System for Telemedicine Application with Reduced PAPR Using QMF Based PTS Technique
for Epilepsy Classification from EEG Signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313
Sunil Kumar Prabhakar and Harikumar Rajaguru

The Impact of Dizziness in Life’s Quality of Elderly Patients with Vestibular Disorders and Their Caregivers . . . . . 317
A. Maniu, G.S. Chiș, O.E. Harabagiu, R. Holonec, and A.I. Roman

Prioritization of Medical Devices for Maintenance Decisions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323

C. Corciovă, D. Andriţoi, C. Luca, and R. Ciorap

Development of Wireless Biomedical Data Transmission and Real Time Monitoring System . . . . . . . . . . . . . . . . . 327
C.M. Fort, S. Gergely, and A.O. Berar

Miscellaneous topics

Preparation, Characterization and Preliminary Evaluation of Magnetic Nanoparticles based on Biotinylated

N-palmitoyl Chitosan. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 333
V. Balan, M. Butnaru, and L. Verestiuc

Cellular Nanostructures and Their Investigation. History and Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337

C.M. Niculițe, A.O. Urs, E. Fertig, C. Florescu, M. Gherghiceanu, and M. Leabu

Chemical Stability of Vitamin B5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341

D. Cașcaval, M. Poștaru, L. Kloetzer, A.C. Blaga, and A.I. Galaction

Study upon the Mechanical Properties of Most Used Dental Restoration Materials . . . . . . . . . . . . . . . . . . . . . . . . 345
D. Cotoros, A. Stanciu, and M.M. Scutariu

Principles to Build a Stochastic Model for a Minimal Biological Cell with Built-in Feedback
Reaction Capabilities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351
D. Stoicovici, A. Cotetiu, M. Banica, M. Ungureanu, and I. Craciun

Microarray Gene Expression Analysis Using R . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 358

I. Petre and C. Buiu

Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363

Keyword Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365

 Part I
Clinical Engineering Assessment
 Ultrasonographic Correlations and Challenges in Liver Hemangiomas

I. Grigorescu1, Z. Sparchez2, R. Badea2, M. Dragoteanu2, C.D.Piglesan2 and D.L. Dumitrascu1

1
2nd Medical Department, „I.Hatieganu” University of Medicine and Pharmacology Cluj-Napoca, Romania
2
„Octavian Fodor” Regional Institute for Gastroenterology and Hepatology Cluj-Napoca, Romania

Abstract/"QDLGEVKXGU0"Itc{/uecng"wnvtcuqpqitcrj{"*WU+" such cases, complementary explorations like: liver scintigra-

tgrtgugpvu"vjg"hktuv"ogvjqf"qh"fgvgevkpi"hqecn"nkxgt"ngukqpu0"Vjg" phy, angioscintigraphy, contrast-enhanced CT and MR, or
ckou"qh"qwt"uvwf{"ygtg"vq"guvcdnkuj"kp"nkxgt"jgocpikqocu"rquuk/ even invasive methods (puncture-biopsy, diagnostic laparos-
dng" eqttgncvkqpu" dgvyggp" vwoqtcn" cpf" nkxgt" gejqigpkekv{=" vw/ copy) with histological examination, are mandatory. Alt-
oqtcn"uk|g"cpf"rtgugpeg"qh"ejtqpke"nkxgt"fkugcugu"*ENF+="rtgu/
hough the typical aspect of hemangioma at US is of nodular
gpeg" qh" rgtkvwoqtcn" tko/" vwoqtcn" cpf" nkxgt" gejqigpkekv{."
vwoqtcn" uk|g" cpf" rtgugpeg" qh" ENF0" OCVGTKCN" CPF" hyperechoic, well defined mass, without peritumoral rim,
OGVJQFU0"Vjg"uvwf{"kpxqnxgf"574"nkxgt"ocuugu"kp"492"rcvkgpvu" without Doppler signal [1], there exist also atypical forms:
ykvj" vjg" rtguworvkxg" fkcipquku" qh" dgpkip" nkxgt" vwoqt" ocuugu." heterogeneous and/or hypoechogenicity hemangiomas, or
guvcdnkujgf" d{" codwncvqt{" WU." jqurkvcnk|gf" cv" vjg" Gogtigpe{" with hyperechoic rim [3].
Jqurkvcn" $Rtqh0" Ft0" Qevcxkcp" Hqfqt$" cpf" 4pf" Ogfkecn" Enkpke" The aims of our study were to establish in liver hemangi-
Enwl/Pcrqec"dgvyggp"4228/42370"Vjg"hkpcn"fkcipquku"ycu"guvcd/ omas possible correlations between tumoral and liver echo-
nkujgf"dcugf"qp"vjg"tguwnvu"qh"kpxguvkicvkqpu"uwej"cu"WU"*itc{/ genicity; tumoral size and presence of chronic liver diseases
uecng"cpf"eqnqt"Fqrrngt+."URGEV."nkxgt"cpikquekpvkitcrj{."EV." (CLD); presence of peritumoral rim- tumoral and liver echo-
OTK."ncrctqueqr{."jkuvqnqi{."eqttqdqtcvgf"ykvj"enkpkecn"cpf"dk/
genicity, tumoral size and presence of CLD. "
qnqikecn"gzcokpcvkqpu0"TGUWNVU0"Vjg"v{rkecn"kocig"qh"ygnn/fg/
hkpgf" *;60:3'" qh" ecugu+." j{rgtgejqke" ocuu" *:306:'" qh" ecugu+."
ykvjqwv"Fqrrngt"ukipcn"*76029'"qh"ecugu+."ycu"fgvgevgf"kp"oquv"
jgocpikqocu0"Rtgugpeg"qh"uvgcvquku1pqpcneqjqnke"uvgcvqjgrcvkvku"
*PCUJ+"kp"8;"kocigu"htqo"qwt"uvwf{"tgxgcngf"vjg"hqnnqykpi"rcv/ II. MATERIAL AND METHODS
vgtpu" qh" jgocpikqocu<" j{rq/" *3818;" ecugu+." kuqgejqke" *418;"
ecugu+" cpf" jgvgtqigpgqwu" *7318;" ecugu+0" Hkujgt" )u" gzcev" vguv" The study involved in the experiment group 270 patients
ujqyu"vjcv"vjgtg"gzkuvu"oqfgtcvg"cuuqekcvkqp"dgvyggp"j{rgtgej/ (156 women, 114 men), aged 25-81 years, with the presump-
qke"tko"cpf"j{rqgejqke"jgocpikqocu="vjgtg"ygtg"pq"qvjgt"uvc/
vkuvkecnn{" ukipkhkecpv" cuuqekcvkqpu" hqwpf" dgvyggp<" vwoqt/nkxgt"
tive diagnosis of benign liver tumor masses, established by
gejqigpkekv{."j{rqgejqke"tko"cpf"vwoqt"uk|g/nkxgt"gejqigpkekv{0" ambulatory US, hospitalized at the Emergency Hospital
EQPENWUKQP0"Encuuke"WU"etkvgtkc"qh"jgocpikqoc"ycu"hqwpf" "Prof. Dr. Octavian Fodor" and 2nd Medical Clinic Cluj-Na-
kp":30:7'0"J{rq/"cpf"kuqgejqke"jgocpikqocu"oqfgtcvgn{"eqt/ poca between 2006-2015. There were found 352 liver masses
tgncvg"ykvj"vjg"rtgugpeg"qh"c"j{rgtgejqke"tko0"Pq"uvcvkuvkecn"eqt/ in these 270 patients, 30 of them having concomitant other
tgncvkqp"ycu"hqwpf"dgvyggp"vjg"wpfgtn{kpi"ENF"cpf"vjg"jgocp/ tumor tumors, and 52 being with multiple hemangiomas (he-
ikqoc)u"gejqigpkekv{."pqt"ykvj"vjg"rtgugpeg"qh"cp{"vwoqtcn"tko0" mangiomatosis).
The control group consisted of 60 patients (38 women, 22
Keywords- jgocpikqoc."wnvtcuqwpf."gejqigpkekv{ " men), aged 36-82 years with malignant hepatic tumors. Their
diagnosis at admittance consisted of hepatocellular carci-
noma (HCC) (12), metastasis (7), cholangiocarcinoma (3),
I. INTRODUCTION hemangioma (2), hamartoma (1), tumor of unknown etiology
(28) and the rest in other extra-hepatic pathologies.
Gray-scale ultrasonography (US) is the first way of Investigation of patients in this retrospective study was
detecting focal liver lesions, but with lower specificity in performed using ultrasonographs Logiq 7 (GE, USA),
establishing their etiology. Typical hemangiomas at US are Si2000 Sonoline with transducers having 3,5MHz (for pre-
hyperechoic, well defined masses, without peritumoral rim, operative diagnosis) and 7,5MHz frequency (for intraopera-
without Doppler signal [1], but there exist also atypical forms tive diagnosis), tomographic scintillation SPECT Orbiter
(especially if the tumor is grafted on chronic liver disease- Siemens camera, computed tomography (CT) and magnetic
CLD): heterogeneous and/or hypoechogenicity hemangio- resonance imaging (MRI), along with clinical and biological
mas, or with hyperechoic rim. Preoperative US, although examination.
sometimes their etiology is difficult to establish as gray-scale All patients (both the experiment and the control group)
US has low specificity in characterizing liver tumors [2]; in underwent abdominal US examination in gray scale and color

© Springer International Publishing AG 2017 3

S. Vlad and N.M. Roman (eds.), International Conference on Advancements of Medicine and Health Care through Technology;
12th - 15th October 2016, Cluj-Napoca, Romania,
IFMBE Proceedings 59,
DOI: 10.1007/978-3-319-52875-5_1