MINISTRY OF HEALTH, COMMUNITY DEVELOPMENT, GENDER
ELDERLY AND CHILDREN
CITY COLLEGE OF HEALTH AND ALLIED SCIENCES
Phone: 0714242413 / 0712227773 / 0717957316, email: [email protected], P.O.BOX 90372 DAR ES SALAAM
DEPARTMENT OF PHARMACEUTICAL SCIENCES
(NTA LEVEL 4)
END OF SEMISTA ONE EXAMINATION
MODULE CODE: PST04105
MODULE NAME: PHARMACEUTICAL CALCULATION
DATE.................................
TIME: 2HRS
Instructions:
(a) This examination consist of five sections (5) A,B,C,D and E
(b) Section A comprises ten (10) multiple choice questions, Section B comprises four (8) multiple True and False
questions , Section C comprises ten (10) matching questions, Section D comprises five (5) short answers and
section E comprises of two (2) Essay questions, Candidates are required to answer ALL questions.
(c) Cellular phones are NOT allowed in the examination room.
(d) Write your examination number on every page of your answer sheet you use
SECTION TYPE OF QUESTIONS MARKS SCORED MARKERS VERIFIERS
SIGNATURE SIGNATURE
ALLOCATION MARKS
A MULTIPLE CHOICE 10
B MULTIPLE TRUE AND 20
FALSE
C MATCHING 10
D SHORT ANSWER 40
E GUIDED ESSAY 20
Total 100
SECTION A: MULTIPLE CHOICE QUESTIONS (10MARKS)
INSTRUCTIONS
This section consists of (10) questions
Encircle the letter of the most correct answer
One(1) mark will be awarded for each correct answer
1. How much Lidocaine is required to prepare 1: 1000, 30ml solution of Lidocaine?
A. 10 mg
B. 0.03 mg
C. 30 mg
D. 300 mg
E.0.003mg
2. If 60 gm of 1% hydrocortisone is mixed with 80 gm of 2.5% of hydrocortisone, what
is the % of hydrocortisone in final mixture?
A. 2.2 % w/w
B. 1.85 % w/w
C. 0.25 % w/w
D. 1.75 % w/w
E.0.8%
3. If the dose of the drug is 200mg,how many doses are contained in 10g
A. 100doses
B. 20doses
C. 50doses
D. 200doses
E. 5doses
4. How many tea spoonful will be prescribed in each dose of an elixir if 180ml contained
18doses?
A. 1teaspoonful
B. 5teaspoonful
C. 18teaspoonful
D. 3teaspoonful
E. 2teaspoonful
5. How many millilitre of a liquid medicine would provide a patient with 2 tablespoonful
dose to be taken three times a day for 16 days?
A. 240ml
B. 480ml
C. 1440ml
D. 500ml
E. 380ml
6. Given a 20%w/v solution of chlorhexidine gluconate, what volume is required to make
400ml of a 2%w/v solution
A. 40ml
B. 20ml
C. 80ml
D. 2ml
E. 4ml
7. Which of the following shows the correct amounts of sodium chloride and anhydrous
glucose present in 500ml of intravenous infusion containing sodium chloride 0.18%w/v and
anhydrous glucose 4%w/v
A. Sodium chloride 0.18g and anhydrous glucose 20.0g
B. Sodium chloride 0.90g and anhydrous glucose 20.0g
C. Sodium chloride 0.90g and anhydrous glucose 40.0g
D. Sodium chloride 1.80g and anhydrous glucose 20.0g
E. Sodium chloride 1.80g and anhydrous glucose 40.0g
8. If 5g of boric acid is added to 100ml .What is the percentage strength (w/w) of the
solution
A. 3.6%
B. 4.76%
C. 2.3%
D. 5%
E. 4.65
9. How many grams of phenol should be used to prepare 240g 0f a 5 %( w/w) solution in
water
A. 6g
B. 14g
C. 24g
D. 12g
E. 36g
10. What is the % of acetic acid in 1:20?
A. 2%
B. 0.5%
C. 1%
D. 5%
E. 1.5%
SECTION B: MULTIPLE TRUE AND FALSE QUESTIONS 20MARKS
This section consist of 8 questions with five options each .Write the word
“TRUE” and not letter “T” for a correct statement and the word “FALSE”
not letter “F” for the incorrect statement. Each correct response carries
equal marks of 0.5mark
1. Percentage weight-in-volume indicates;
A. ................ The number of parts by weight (gm) of active ingredient contained in
the total volume of the solution or mixture considered as 100 parts by volume
B. ................The number of parts by weight (kgm) of active ingredient contained in
the total volume of the solution or mixture considered as 100 parts by volume
C. .............The number of parts by weight (gm) of active ingredient contained in the
total volume of the solution or mixture considered as 1000 parts by volume
D. ................The number of parts by weight (mg) of active ingredient contained in
the total volume of the solution or mixture considered as 100 parts by volume
E. ...............The number of parts by weight (gm) of active ingredient present in the
total volume of the solution or mixture considered as 10 parts by volume
2. When a ratio strength for example 1:1000, is used to designate a concentration, it is
to be interpreted as follows:
A. ..................For solids in liquids = 1 gm of solute or constituents in 1000 mL of
solution or liquid preparation
B. ................For liquids in liquids = 1 mL of constituents in 1000 mL of solution or
liquid preparation
C. ..................For liquids in liquids = 1mL of constituents in 1000L of solution or
liquid preparation
D. ................For liquids in liquids = 1 gm of constituents in 1000g of solution or
liquid preparation
E. .................For liquids in liquids = 1 mL of constituents in 100mL of solution or
liquid preparation
3. Regarding common strength of pharmaceutical preparations
A. ............. In case of solid ingredients in liquid vehicle ,the ratio is w/v
B. ............ In case of a liquid ingredient in a solid vehicle ,the ratio is w/w
C. ............ In case of both ingredients are liquid, the ratio is v/v
D. ............ In case of both ingredients are solids ,the ratio is w/v
E. ........... Can be expressed in ratio strength
4. Dilution of a substance
A. ..............Addition of a concentration of a substance
B. ...............Addition of the vehicle to lower strength of solution
C. ..................Addition of the vehicle will increase the concentration of the drug
D. ...............Decreasing the number of particles in a substance will lower the concentration
E. .................Diluent includes phenol, water and DW5%
5. Pharmaceutical drugs in children may differ from adults for several reasons such as
A. ....................Age,body compostion,sex
B. ..................Sex,gender,function of the liver and kidney
C. ..................Age, maturation of enzymatic throughout the life span from neonates to adult
D. .................Gender, age
E. ..............Functional of the liver and kidney
6. Concerning heparin
A. ..............A drug that has coagulant effect
B. ..............Increasing clotting time and used as anticoagulant
C. ..............Include high molecular weight heparin
D. ...............Heparin salts are administered as salts by intravenous infusion
E. ............Fractioned heparin is the most used
7. Parts per million (ppm)
A. .............The strength of very dilute solution is commonly expressed in terms of parts per
million
B. ................The number of parts of the agent per one million parts of the whole
C. .................Examples are fluorinated drinking water
D. ..................Ppm concentration may be expressed in quantitatively equivalent values of the
percentage strength or ratio strength
E. ................Used in calculating the ratio strength of a substance in the whole product
8. Following are the different measures of weight
A. ……………………1 kilogram (kg)=1000000 milligram
B. …………………...1 hectogram (hg)=100 gram
C. …………………...1 dekagram (dag)=10 gram
D. ……………………1 gram (g)=1gram
E. ………………….1 decigram (dg) =0.1 gram
SECTION C: MATCHING ITEMS QUESTIONS 10MARKS
In each question, match the items from the column B with those of column A by
writing the correct CAPITAL LETTER on the response column, each response
carry 1mark, one option in column B should be used only.
PART A: About the households units, match options in column A with the
corresponding options in column B
SNO GROUP A ANSWER GROUP BS
. S
1 1gallon A:454liters
2 1pint B:454mls
3 1pound C:568mls
4 1grain D:0.454kg
5 1/2Table spoonful E:0.545kg
F:0.454mgs
G:65mg
H:7.5mls
PARTB: Concerning the metric units of length, match options in column A with
the corresponding options in column B
SNO GROUPA ANSWERS A:
.
1 1dm B:0.01km
2 1dam C:100dm
3 1mm D:1000mm
4 1Km E:0.000001M
5 1Micro meter F:100mm
G:0.001m
SECTION D: SHORT ANSWER QUESTIONS 40MARKS
There are eight (8) questions in this section, write your answer in space provided
wherever provided under the question. Each question carries 05marks only.
1 a. Calculate the dose of a child weighs 17.5kg when the adult dose is 0.5kg
(2.5marks)
b.If the adult dose of a drug is 75mg, what will be the dose for a child weighing 40
lb? (2.5marks)
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2: i) what is the density of a solution weigh 250g and 248mL? (2.5marks)
ii) What is the specific gravity of 365mL of glycerol weigh 460g? (2.5marks)
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3. What is the percentage strength (v/v) of alcohol in a mixture of 3000 mL of 40% (v/v)
alcohol, 1000 mL of 60% (v/v) alcohol, and 1000 mL of 70% (v/v) alcohol? Assume no
contraction of alcohol after mixing (05marks)
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4a) Calculate the volume of alcohol 90% v/v needed to prepare 400 mL of alcohol 70%
v/v (2.5marks)
b) How many mL of formalin 2% v/v will be prepared from 350 mL of formalin
36% v/v (2.5marks)?
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5: If 50 glycerine suppositories are made from the following formula, how many millilitres
of glycerine having a specific gravity of 1.25, would be used in the preparation of 96
suppositories (05Marks)
Glycerine ...........................91g
Sodium stearate...................9g
Purified water.....................5g
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6: How many millilitres of liquefied phenol should be used in compounding the
following prescription? (05MARKS)
Rx Liquefied phenol……………………2.5%
Calamine lotion………….…ad 240.0 mL
Sig. For external use
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7: In preparing 250ml of a certain solution a pharmacist used 4ml of a liquefied
phenol. What was the percentage v/v of a liquefied phenol in the lotion? (05marks)
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8. The concentration of the drug additive in an animal feed is 12.5 ppm. How many mgs
of drugs should be used in preparing 5.2 kg of feed? (05marks)
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SECTION E: LONG ANSWER QUESTIONS
20MARKS
This section carries two questions, each question carries 10marks, start a new page
for a new question
1. An intravenous infusion contained 20,000 units of heparin sodium in 1000 mL of D5W.
The rate of infusion was set at 1600 units per hour for a 160-lb. patient (10marks)
Calculate:
(a) The concentration of heparin sodium in the infusion, in units/mL (02marks)
(b) The length of time the infusion would run, in hours (03marks)
(c) The dose of heparin sodium administered to the patient, on a unit/kg/minute basis
(05marks)
2a) the label instructions for an ampicillin product call for addition of 78 mL of water to
make 100 mL of constituted suspension such that each 5mL contains 125 mg of Ampicillin.
What is the volume occupied by dry powder and the total drug present? (05marks)
2b) the label instructions for an ampicillin product call for addition of 78 mL of water to
make 100 mL of constituted suspension such that each 5mL contains 125 mg of Ampicillin.
If the physician desires an ampicillin concentration of 100 mg/5 mL (rather than 125 mg/5
mL), how many millilitre of water should be added to the dry powder? (05marks)
