AFE4500

www.ti.com SBASAC6 – AFE4500

APRIL 2021
SBASAC6 – APRIL 2021

AFE4500 Ultra-Small, Integrated AFE for Bio-Impedance Analysis, Electrical Bio-

sensing and Optical Bio-sensing
– 8-bit LED Offset Subtraction DAC with range
1 Features from 32 to 64 µA
• Integrated signal chains for Bio-Z, EDA, ECG, – Automatic ambient & LED DC cancellation
PPG – Supports external clock and internal oscillator
• Synchronized ECG, PPG enables PTT-based BP modes
• Bio-Z signal chain – FIFO with 256-sample Depth
– Multi-frequency Body impedance Analysis (BIA) – SPITM, I2C interfaces: Selectable by pin
with frequency programmable up to 250 kHz – Supplies: Rx:1.7-1.9V (LDO Bypass); 1.9 V to
– Low frequency excitation mode for EDA/GSR -3.6 V (LDO Enabled), Tx: 3 V to 5.5 V, IO:1.7-
– Complex (I,Q) Tetrapolar impedance RX_SUP
measurement
2 Applications
– Sine-wave excitation with a 7-bit DAC
– Calibration scheme compensates for electrode • Bio-Z, ECG, PPG, EDA, BP on wearable devices
impedance to achieve accurate Bio-Z • Impedance spectroscopy
– State machine for Automatic Calibration • Weight scales with body composition
• ECG signal chain: • Current, voltage, impedance sensing
– 1-lead ECG signal acquisition up to 2 kHz 3 Description
– INA gain programmable from 2-21
– RLD output to set body bias through third The AFE4500 is a versatile signal acquisition system
electrode that supports three signal chains. An impedance
– Input noise (0.5-150 Hz): 0.75 µVrms at 1 kHz measurement signal chain with integrated excitation
– ± 0.6 V differential DC offset and ± 0.3 V CM and sense can be used for applications like Bio-
range impedance analysis (BIA), Electro-dermal analysis
– HPF with 0.4 Hz corner, quick saturation (EDA) and Impedance spectroscopy.
recovery Device Information
– >1 GΩ input impedance, CMRR > 100 dB PART NUMBER PACKAGE(1) BODY SIZE (NOM)
– Integrated 300 Hz anti-aliasing low pass filter
AFE4500 DSBGA 3 mm x 2.6 mm
– AC, DC lead-off detect: 1.6-nA to 100-nA
• PPG signal chain (1) For all available packages, see the orderable addendum at
– Supports acquisition of up to 24 PPG signals the end of the data sheet.
– Flexible allocation of 8 LED, 4 PD in each

PPG_TX7

PPG_TX8
PPG_TX3

PPG_TX4

PPG_TX5

PPG_TX6
LDO_BYP

PPG_TX1

PPG_TX2
RX_SUP

TX_SUP
IO_SUP

phase
– Supports PPG sensors at different data rates PPG_INP1
PPG_INM1 PPG RECEIVE VDD_INT

– Optical loopback SNR of 100-dB, extendable to

LDO

PPG_INP2
SWITCH

PPG_INM2 PPG TRANSMIT

110-dB with on-chip filtering

+ NOISE
TIA
– FILTER
PPG_INP3
PPG_INM3

– Low Current for Continuous Operation with a PPG_INP4

AACM
PPG_INM4
Typical Value: 15-μA for an LED, 15-μA for the ECG_CAPP
SPI, I2C

Receiver ECG_CAPM HPF DECIMATION

(PPG)

• PPG Transmitter
DIG DEMOD/ 256-FIFO
LEAD-OFF INA LPF ADC DEC (BIA)

– 8-Bit Programmable LED Current with range

DECIMATION
ECG RECEIVE
(ECG)
RLD AMP

adjustable from 25 mA to 250 mA

Timing
Engine
ECG_RLD

– Programmable LED On-Time per-phase BIA_E1

BIA_CAL1
CLK_I,CLK_Q
OSC

– Support of 8 LEDs in Common Anode BIA_E2

BIA_CAL2 DEMOD LPF

• PPG Receiver BIA_E3

ECG_INM
HPF1 INA
DEMOD LPF

– Supports 4 PDs, 2 parallel receive paths

BIA_E4 BIO-Z RECEIVE
ECG_INP
CLK_I,CLK_Q
– Noise filtering with programmable bandwidth LEAD-
ON DET +
7b

– Trans-impedance Gain: 3.7 kΩ to 1 MΩ

TIA DAC DDS
– BIO-Z TRANSMIT

PLL
– 8-bit Ambient Offset Subtraction DAC with
range from16-256 µA Simplified Schematic

An©IMPORTANT
Copyright NOTICEIncorporated
2021 Texas Instruments at the end of this data sheet addresses availability, warranty, changes, use in safety-critical
Submit Document applications,
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intellectual property matters and other important disclaimers. PRODUCTION DATA.
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Table of Contents
1 Features............................................................................1 6.2 Receiving Notification of Documentation Updates......4
2 Applications..................................................................... 1 6.3 Support Resources..................................................... 4
3 Description.......................................................................1 6.4 Trademarks................................................................. 4
4 Description (continued).................................................. 3 6.5 Electrostatic Discharge Caution..................................4
5 Revision History.............................................................. 3 6.6 Glossary......................................................................5
6 Device and Documentation Support..............................4 7 Mechanical, Packaging, and Orderable Information.... 5
6.1 Documentation Support.............................................. 4

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4 Description (continued)
An ECG receiver with a Right-leg drive (RLD) can enable acquisition of a single-lead ECG from a pair of
electrodes shared with the Bio-impedance measurement. A PPG signal chain comprises of a current driver for
LEDs and a receiver that senses the signal from PDs. The outputs of the three signal chains are digitized by a
common ADC and stored in a FIFO which can be read out using an SPI or I2C interface

5 Revision History
NOTE: Page numbers for previous revisions may differ from page numbers in the current version.
DATE REVISION NOTES
April 2021 * Initial release

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6 Device and Documentation Support

TI offers an extensive line of development tools. Tools and software to evaluate the performance of the device,
generate code, and develop solutions are listed below.
6.1 Documentation Support

Abbreviations used in this datasheet:

Bio-Z: Bio-impedance. Can be substituted with any other impedance that needs to be measured
BIA: Bioelectrical Impedance analysis/ Bio-impedance analysis. Refers to the measurement and analysis of
Bio-impedance at one or more excitation frequencies. In this datasheet, the abbreviations BIA and Bio-Z are
used interchangeably.
ECG: Electrocardiography
EDA: Electro-dermal activity
GSR: Galvanic Skin response. Used interchangeably with EDA.
HF-BIA: High frequency Bio-impedance analysis.
LF-BIA: Low frequency Bio-impedance analysis
MF-BIA: Medium frequency Bio-impedance analysis
OHRM: Optical Heart-rate monitoring
PPG : Photoplethysmography
PRF: Pulse repetition frequency. Derived from the PPG terminology which refers to the rate at which the LEDs
are turned on (pulsed). Extended to denote the frequency of a periodically repetitive set of operations involving
signal acquisition of PPG, ECG and/or Bio-Z signals.
RLD: Right leg drive. Derived from the clinical ECG terminology where the right leg is driven to set the DC bias
of the body
6.1.1 Related Documentation

6.2 Receiving Notification of Documentation Updates

To receive notification of documentation updates, navigate to the device product folder on ti.com. Click on
Subscribe to updates to register and receive a weekly digest of any product information that has changed. For
change details, review the revision history included in any revised document.
6.3 Support Resources
TI E2E™ support forums are an engineer's go-to source for fast, verified answers and design help — straight
from the experts. Search existing answers or ask your own question to get the quick design help you need.
Linked content is provided "AS IS" by the respective contributors. They do not constitute TI specifications and do
not necessarily reflect TI's views; see TI's Terms of Use.
6.4 Trademarks
TI E2E™ is a trademark of Texas Instruments.
All trademarks are the property of their respective owners.
6.5 Electrostatic Discharge Caution
This integrated circuit can be damaged by ESD. Texas Instruments recommends that all integrated circuits be handled
with appropriate precautions. Failure to observe proper handling and installation procedures can cause damage.
ESD damage can range from subtle performance degradation to complete device failure. Precision integrated circuits may
be more susceptible to damage because very small parametric changes could cause the device not to meet its published
specifications.

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6.6 Glossary
TI Glossary This glossary lists and explains terms, acronyms, and definitions.

7 Mechanical, Packaging, and Orderable Information

The following pages include mechanical, packaging, and orderable information. This information is the most
current data available for the designated devices. This data is subject to change without notice and revision of
this document. For browser-based versions of this data sheet, refer to the left-hand navigation.

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 PACKAGE OPTION ADDENDUM

www.ti.com 1-May-2021

PACKAGING INFORMATION

Orderable Device Status Package Type Package Pins Package Eco Plan Lead finish/ MSL Peak Temp Op Temp (°C) Device Marking Samples
(1) Drawing Qty (2) Ball material (3) (4/5)
(6)

AFE4500YBGR ACTIVE DSBGA YBG 42 3000 RoHS & Green SAC396 Level-1-260C-UNLIM -40 to 85 AFE4500

AFE4500YBGT ACTIVE DSBGA YBG 42 250 RoHS & Green SAC396 Level-1-260C-UNLIM -40 to 85 AFE4500

(1)
The marketing status values are defined as follows:
ACTIVE: Product device recommended for new designs.
LIFEBUY: TI has announced that the device will be discontinued, and a lifetime-buy period is in effect.
NRND: Not recommended for new designs. Device is in production to support existing customers, but TI does not recommend using this part in a new design.
PREVIEW: Device has been announced but is not in production. Samples may or may not be available.
OBSOLETE: TI has discontinued the production of the device.

(2)
RoHS: TI defines "RoHS" to mean semiconductor products that are compliant with the current EU RoHS requirements for all 10 RoHS substances, including the requirement that RoHS substance
do not exceed 0.1% by weight in homogeneous materials. Where designed to be soldered at high temperatures, "RoHS" products are suitable for use in specified lead-free processes. TI may
reference these types of products as "Pb-Free".
RoHS Exempt: TI defines "RoHS Exempt" to mean products that contain lead but are compliant with EU RoHS pursuant to a specific EU RoHS exemption.
Green: TI defines "Green" to mean the content of Chlorine (Cl) and Bromine (Br) based flame retardants meet JS709B low halogen requirements of <=1000ppm threshold. Antimony trioxide based
flame retardants must also meet the <=1000ppm threshold requirement.

(3)
MSL, Peak Temp. - The Moisture Sensitivity Level rating according to the JEDEC industry standard classifications, and peak solder temperature.

(4)
There may be additional marking, which relates to the logo, the lot trace code information, or the environmental category on the device.

(5)
Multiple Device Markings will be inside parentheses. Only one Device Marking contained in parentheses and separated by a "~" will appear on a device. If a line is indented then it is a continuation
of the previous line and the two combined represent the entire Device Marking for that device.

(6)
Lead finish/Ball material - Orderable Devices may have multiple material finish options. Finish options are separated by a vertical ruled line. Lead finish/Ball material values may wrap to two
lines if the finish value exceeds the maximum column width.

Important Information and Disclaimer:The information provided on this page represents TI's knowledge and belief as of the date that it is provided. TI bases its knowledge and belief on information
provided by third parties, and makes no representation or warranty as to the accuracy of such information. Efforts are underway to better integrate information from third parties. TI has taken and
continues to take reasonable steps to provide representative and accurate information but may not have conducted destructive testing or chemical analysis on incoming materials and chemicals.
TI and TI suppliers consider certain information to be proprietary, and thus CAS numbers and other limited information may not be available for release.

In no event shall TI's liability arising out of such information exceed the total purchase price of the TI part(s) at issue in this document sold by TI to Customer on an annual basis.

Addendum-Page 1
 PACKAGE OPTION ADDENDUM

www.ti.com 1-May-2021

Addendum-Page 2
 PACKAGE MATERIALS INFORMATION

www.ti.com 7-May-2021

TAPE AND REEL INFORMATION

*All dimensions are nominal

Device Package Package Pins SPQ Reel Reel A0 B0 K0 P1 W Pin1
Type Drawing Diameter Width (mm) (mm) (mm) (mm) (mm) Quadrant
(mm) W1 (mm)
AFE4500YBGR DSBGA YBG 42 3000 330.0 12.4 2.74 3.14 0.64 8.0 12.0 Q1
AFE4500YBGT DSBGA YBG 42 250 330.0 12.4 2.74 3.14 0.64 8.0 12.0 Q1

Pack Materials-Page 1
 PACKAGE MATERIALS INFORMATION

www.ti.com 7-May-2021

*All dimensions are nominal

Device Package Type Package Drawing Pins SPQ Length (mm) Width (mm) Height (mm)
AFE4500YBGR DSBGA YBG 42 3000 345.0 365.0 55.0
AFE4500YBGT DSBGA YBG 42 250 345.0 365.0 55.0

Pack Materials-Page 2
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