Seat No:

Department Of Pharmacology
Dr. M.K. Shah Medical College & Research Centre, Ahmedabad
1" Internal Exam - Pharmacology Paper (Batch 22-23)
Date: 0I/04/24 Time: 1.30 to 4.30 pm Max Marks: 100
Instruetions:
Use separate answer book for each section.
2. Write roll mumber on cach answer shecet. Do not write name on answer sheet.
3. Figure to the right indicates full marks.Write legibly and draw diagrams where necessary
SECTION-I
Q.1 Classify antiparkinsonian drugs with important examples. Describe mechanism of action
of levodopa, and pharmacological basis for combining carbidopa and levodopa.List
adversee effects of levodop. (2+2+3+3=10)
OR
Q.1 Classify drugs used for Bronchial asthma with important examples. Deseribe mechanism
of action and adverse effects of Salbutamol. Deseribe the management of Status
asthmaticus. (2+2+2+ 4=10)

0.2 Answer ANY TWO of the following: (2x6-12)

I. A 45 years old male gardener known to spray insecticide in farm presented with
complaints of irritation of eyes, blurry vision, increased salivation. vomiting, diarrhea and
breathlessness. Examination revealed constricted pupils and tachycardia. The patient was
diagnosed with acute organophosphate poisoning. low will you manage this patient?
Adult female patient of 25 years taking oral contraceptive pills for prevention of
pregnancyfor last 6 months, devcloped pulmonary tuberculosis and was prescribed
isoniazid. rifampicin, cthambutot and pyrazinamide in standard doses. Next month she
complaints of' amenorrhea and pregnancy test was positive.
a) What is likely cause of contraceptive ailure? (3)
b) How wvill you prevent such problem in future? (3)
3. A lady aged 55 years presented with complaints of visual ditliculties over the past few
months and dull chronic ache in the frontal region. Tonometry contined diagnosis of
chronic simple glaucoma.
a) Mention various groups uscd for management of this patient along with
pharmacological basis of each (2+2)
b) List one important adverse eflect of each drug group (2)
(3i6=18)
Q.3 Write short notes on ANY THREE of the following:
i) Phases of clinical trials
ii) Factors afiecting patient compliance
iii Compare and contrast competitive and non competitive untagonisn
iv) Alpha blockers
two to three sentences (512=10)
Q.4 Answer ANY FIVE of the following brietly in anauphyluxis.
ol adrenuline in
i) Mention pharmacological basis for use cxamples of' prodrug.
i) What is prodrug. Enlist (wo important cach.
agents and mention one adverse eflect of
In) Enlist two antitussive therapeutic index
drug? Mention two drugs with nurrow meubolisn.
IV) What is therapeutic indcx of a
Mention twvo drugs wvith high irst pass
V) What is first pass metabolism? blockers and mention (wo advantages.
Vi) Enlist two cardioselective betu
 SECTION-||

Q.5 Enumerate four non-sclective COX inhibitors and selective COX 2 inhibitors. Describe
pharmacological actions. therapeuticuse and adverse cffects of aspirin. (2+3+3+2=10)
OR
Q.5 Classify drugs used in peptic ulcer. Describe mechanism of action. therapeutic uses and
adverse effects of ranitidine. (2+3+3+2=10)

Q.6 Answer ANY TVO of the following: (2x6=12)

1. A 32 year old Temale presents with complaints of throbbing headache. nuusea and one
episode of vomiing 4 to S times a month. She often develops blurred vision just before
onset of headache. It is diagnosed as severe acute atack of migrainc.
a) Mention drugs tused for treatment of acute attack ot' migraine in this patient? (4)
b) Mention drugs used to prevent future attack of migraine? (2)
2. A30 years old nale patient has developed pain and swelling of great toe in both fet
since last two days with increasing intensity. He also had similar attack one month back.
Synovial fluid analysis from metatarsophalangeal joint reveals presence of monosodium
urate crystals. His serum uric acid level is 11.8 mg/dL. This confirns the diagnosis of
acute gouty arthritis.
a) Mention drugs that are used to treat acute attack of gout? (3)
b) Mention mechanism of action and therapeutic status of probenecid in chronic gout (3)
speech that worsens when she
3. A 25 year old female presents with recurrent slurring of
cOntinues to lalk. She has trouble swalloving and has double vision. She reports ihat her
progressively deteriorated (over
head is heavy and hard to hold up. Her symptoms have
way and she has trouble combing her hair or putting on
fa!ling due to her legs giving occasionally short of brcath.
deodora1nt. She reportsa feeiing of generalised fatigue and isinhibitor is preseribed to the
Diagnosis of myaestheria gravis is made. Cholinesterase
patient. myaesthenic crisis (3)
a) Compare and contrast cholinergic crisis and their respecive therapeutic status in
b) Mention 3 cholinesterase inhibitors with
myaesthenia gravis(3)
of the following: (3x6=18)
Q.7 Write short notes on ANY THREE
i) Factors affecting bioavailability
ii) Anti-rheumatoid drugs
iii) Prokinetic drugs.
iv) Centrally acting
muscle relaxants
(512=10)
following briefly in two to three sentences
Answer ANY FIVE of the motion sickness.
Q.8 used for prevention of
Enlist two drugs mechanism of action.
i) anaesthetic agents and mention their
ii) Mention two local coMmunication with the patient
points to practice in
iii) Mention4 important paracetamoloverdose.
iv) Mention antidote for analogues and two important uses.
prostaglandin
v) Mention two purgatives.
Mention drawbacks of chronic use of'
vi)
k***** * * * 2
 DR. M. K. SHAH MEDICAL COLLEGE &RESEARCH CENTER
DEPARTMENT OF PATHOLOGY
SECOND M.B.B.S Batch 2022-2023
1 INTERNAL EXAMINATION
Date: 02/04/2024 Max. Marks: 100
Time: 3 hours
Instructions: 1) Answer To the Point.
2) Figures to the right indicates marks
3) Write Legibly
4)) Draw Diagrams wherever necessary
SECTION-I

Long Assay Question (Any One) (10

Q.1
(a) Pathogenesis and Morphology of lrreversible Cell Injury. (4+6)
(b)) Chemical mnediators of Inflammation.

(12)
Q.2 (a) Write Briely About (Any Two)
(a) Histopathology of Leprosy.
Complications of Wound healing. (3+3).
(b) Factors affecting Wound healing &
& Complications of Pulmonary
(c) Define Embolism .Write briefly about Etio-pathogenesis
Embolism. (1 +2+3)
(18)
Q.2 (b) Short Notes (Any Three)
Amyloid & Diagnosis of Amyloidosis. (4+2)
(a) Write Physical and Chemical Characteristic of
(b) Vitamin-D Deficiency.
disease? Write briefly about Down syndrome.
(c) What is Numerical Abnormality in genetic
(d) Phagocytosis.

three Sentences (Any Five) (10)

Q.3 Write Answers to the point in two or
(a) Reperfusion Injury.
thrombus.
(b) Define Thrombus & Types of
(c) TORCHComplex.
Hyperplasia.
(d) Hypertrophy v/s
Hypersensitivity Reaction.
(e) Write types of
() Lipofuscin.

(Page 1 of 2)
 Q.4 Long Assay Question (Any One)
SECTION-II
(a) Define Anemia. Give (10)
Classification Anemia, Describe
of
Anemia-Etiopathogenesis, Clinical Features and laboratorybriefly
(b) Describe Etiology,
about Iron Deficiency
diagnosis. (1+2+2+2+3)
Patho-Physiology &Laboratory Findings of Disseminated Intravascular
Coagulation.(3+3-+4)
Q.5 (2) Sbort Notes (Any 'Two)
(12)
(a) 5 year old male present with severe pallor,
He required frequent blood frontal bossing of skull and hepatosplenomegaly.
transfusions since 2 years.
Hb 3.5 gm/dl. WBC-13000/cmm Platelet
count-203000/cmm.
target cells with basophilic stippling is present On peripheral smear, many
with normoblasts.
On HPLC, HbA2-3.8%, HbF - 85%. (2+2+2)
i) What is Probable Diagnosis?
ii) Which genetic defect is responsible for this disease?
ii)Can this disease be preyented? What are the prenatal diagnostic tests available?
(b) A 4 year old boy admitted to the i:ospital, because of profuse bleeding. He had swelling of
both knees. Family history revcals that his brother has Bleeding Problem.
On physical examination he had swollen kzees with areas of ecchymoses over knee.
Laboratory studies-screening tests: (2+2+2)
Hb-10.2. gm%, TLC 7600 /chum, PLT count 326000/cumm, Bleeding time 3.5 min,
Drothrombin time 12.3 ce(ogntro! 12.5), APTT49 sec (contro! 25.!).
i) What is Probabie Diagnosis?
i) What additionai test should be done to confirm the diagnosis?
i) Which component of blood (prepared in blood bank) would you transfuse therapeutically
in this patient and content of that blood component?
(C) Aplastic Anemia.
Q.5 (b) Short Notes (Any Three) (18)
(a) Pathopysiology & Laboratory Features of Chronic Myeloid Leukemia.
(b) Glycogen Storage Diseases.
(c) Blood Components
(d) Quality Control in Hematology.
(10)
Q.6 Write Answers to the point in two or three Sentences (Any Five)
(a) Myeloblast v/s Lymphoblast.
(b) Bleeding Time & Clotting Time.
(c) Liquid Based Cytology v/s Conventional Pap smear.
(d) Russell Bodies.
(e) Hemolytic disease of the newborn.
Biopsy.
() Enlist the indications & Complications of Bone marrow
(Page 2 of 2)
 SECOND M.B.B.S. (BATCH 2020-21)
1st Internal
MICROBIOLOY PAPER
MARKS: 100
Date: 03/04/2024
Section -1
Q:1 Time: 1.304.30 pm
Structured long Question (Write any One)
A. Define sterilization and (10 Marks)
disinfection (2 Marks), Write in details about
oxide (ETO) Sterilizer (3 Marks). Autoclave (5 Marks) and Ethylene
OR
B. Define Antimicrobial Agents (1 Marks). Classify
Marks). Write in brief regarding Antimicrobial Antibiotics based on their mechanism of action (5
resistance (4 Marks).
Q.2 (A) Applied short notes/case based
scenarios (Write any two) (12 = 2X6)
1. A 40year old Male developed Fever,
burning micturition after 72
surgery. Catheter catch Urine sample was sent for culture. Culture hours of Urinarycatheterization following
showed growth of E. coli (colony count> 10
CFU/ml.)
a) Is this considered as HAI (Hospital acquired
Infection)? (1 Mark)
b) Which type of HAI is this?
c) Mention criteria for diagnosis of this HAI?
(1Mark)
(2 Marks)
d) Mention procedure, for collection of Catheter catch Urine
sample for culture and sensitivity
2.. A 45 year old Patient is on central line for more than 2 (2Marks)
days, Patient was having fever and hypoteDsion.
Catheter site has erythema and swelling. Blood culture was sent from central and peripheral
line. Both botles
flagged positive with time to positivity (TTP) 12 hours and 15 hors respectively. Blood culture
of E. coli from both the bottles.
showed gzowth

a) Is this considered as HAI (Hospital acquired Infection)? (1 Mark)

b) Which type of HAIis this? (1 Mark)
c) Mention criteria for diagnosis of this HAI. (2 Marks)
d) Mention care bundle for prevention of this HAI (2Marks)

3. Write in brief regarding various modes of trans1mission for Disease causation (6 Marks)

Q. 2(B.) Write Three out of Four (6x3=18 marks)

1. Polymerase Chain Reaction
2. Phase contrast Microscope
3. Bacterial Growth curve
4. Loius Pasteur
Q.3 Write only in 2-3 sentences (Any 5) (5x2=10 narks)
1. Mention 2 Transport Medias and its uses.
2. What is jumping genes and mention it's types.
3. Define obligate aerobes and give two examples.
4. Mention 2methods of AST (Antimicrobial Suscecptibility Testing).
5. Mention 4 component of Standard Predautions
6. Mention 2 Anerobic Culture methods
 Section -2
Q:4 Structured long
Question (Wrileany One)
A.
Describe in detal iegarding bacterial cell (10 Mar s)
Marks), differencc betweenGram wail: Structure (4 Marks),
diagram (2 Marks), Function (2
nositive and Gram negative cell wa!l
B. Define (2 Marks)
OR
crplencnt (1 Mark)
con:picrcnt puhwav (5 marks),classiiy conuplemcnt patnways (2 Mark:) Lxpiai: in delril abot
list various eiYector 'unctions of compiricat (2 la,sicai
Q.5 (A) Appiri siort ra:ks)
Otes/case based seenarios (Write any lwo)
1.A 19 year cld suden! at! (12=2%G natks)
ndeda Dinner partvat her
Suddenly, she devcloped iives on her body, she iriend'splace. AccidYntiy, sthe
o:sd Sea food
alsodeveloped diarrhea and
a) what type of
ImmuC response is
voniting.
b) this?
Describe the pathogisis and (| Mark)
managemert (5 Marks)
2. Rh Negative Village wOIen narried to Rh
medical inicrvenion ws done al that tirne. Positive men. She had miscarriage in lier first rinester. No
Ater2 years She conceivcd but again had
a) Whai is this condition? misrnge.
b) What iype of Innune respunse is this? (1 MMark)
c) DsCIibe tmc palioyeresis and (1 Mark)
management (4 Marks)

3. 30 years old patient had urdergonc Boe marrowv

transpiant for leukemia. Paticnt was im:munosuppressec
Bone marow of Donor coniained inunocompetentT cells. 50 days
post-transplant patient developed
Hepatomegaly, skin rash.
a) What is the Immunological process of rejection (I Mark)
b) Mention Types of this immunological reaction (1 Marks)
c) Mention 3 conditions associated with this immunological reaction (3 Marks)
d) Treatment in this case (1 Mark)

Q.5 (B.) Write Three out of Four i5x3=18 marks)

1. Ig M Antibody
2. Hand Hygiene
3. Bio medical waste Management
4. Cell Mediated Immune Response
Q.6 Write only in 2-3 sentences (Any 5) (5x2=10 narke)
1. Mention4 types of Vaccines
independent Antigen.
2. Mention 4 differences beween T dependent and T
3. What is anergy?
4. Mention 2 Primary In1munodeficiency Disorder
Passive Immunity.
5. Mention 2 differences between Active and
6. Define Antimicrobial stewardship.
 Department Of Pharmacology
Dr. M.K. Shah Medical College &
2d Internal Exam Rescarch Centre, Ahmedabad
Date: 15/07/24 Pharmacology
Time: 1.30 to 4.30
Paper (Batch 22-23)
Max Marks: 100
Instructions:
1. Use
separate answer book for each section.
2. Write rollnumber on each answer
3. Figure to the right indicates full sheet. Do not write name on answer sheet.
marks
Q.1 SECTION-I
Classify antimalarial drugs giving important examples.
adverse effects and regimens of artemisinin based Describe pharmacological basis,
falciparum malaria. combination therapy in uncomplicated
OR
(2+2+3+3=10)
Q.1 Enlist important examples of
indications and adverse effects ofmacrolides. Describe
azithromycin
the mechanism of action, and list
(2+2+3+3=10)
Q.2 Answer ANY TWO of the
i) A 31 year old male recently following: (2x6=12)
diagnosed with HIV infection, was started on first-line highly
active antiretroviral therapy (HAART) that included
protease
investigations revealed elevated LDL cholesterol. Patient was inhibitors. Recent laboratory
Protease inhibitors inhibit the CYP3A4 isoenzyme prescribed simvastatin.
a) List other important examples of that metabolises many statins.
b) List adverse effects of simvastatinhypolipidemic
(2)
drugs (2)
c) Mention potential drug-drug interaction in above case and therapeutic
ii) A 28 year old female has been prescribed implications (2)
metronidazole for 7 days to treat bacterial
vaginosis. The clinician has communicated she should abstain from alcohol while
metronidazole. Ms. Shah states that she is unable to comply, due to regular drinkingtaking
a) List other inportant adverse effects of metronidazole (2) habit.
b) Mention reason for abstaining from alcohol during metronidazole therapy(2)
c) Mention alternative drug treatment for the above patient (2)
iiül) Mr. Haresh is a 59 year old man with stable coronary artery disease and
exertional angina
that is being medically managed. He also suffers from chronic obstructive pulmonary
disease (COPD) and is a current smoker.
a) List anti anginal drugs that the patient should avoid
b) List adverse effects of amlodipine
c) Mention treatment of acute attack of angina

Q.3 Write short notes on ANY THREE of the following:

(3x6=18)
i) Prophylaxis of HIV infection
ii) Adverse effects of oral contraceptive pills
iii) Role of empathy in patient care
iv) Compare and contrast oral and parenteral iron preparations

Q.4 Answer ANY FIVE of the following bricfly in two to three sentences (5x2=10)
i) Enlist antipseudomonal penicillins
ii) Enlist the drugs used in management of paroxysmal supraventricular tachycardia (PSVT).
ii) Mention the drugs used for treatment of multibacillary leprosy.
iv) Mention two antihypertensive drugs used during pregnancy.
v) Enlist important examples of selective estrogen receptor modulators
vi) Mention adverse effects of digoxin
 SECTION-II

Q.5 Classify oral antidiabetic drugs giving important cexamples. Deseribe the mechanism of
actions, and list the therapeutic uscs and adverse effects of metformin. (2-+2+3+3=10)
OR
Q.5 Describe the mechanism of actions, and list the therapeutic uses and adverse effects of
enalapril. Mention important advantages of angiotensin receptor blockers (2+2+3+3=10)
Q.6 Answer ANY TWOof the folloving: (2x6=12)
i) A 45 year old male was admitted to ICU 10 days ago with 3rd degree
burns over 45% of his
body. He was stable till yesterday. Now he has fever and elevated white blood cell count.
Blood culture results are pending. Empiric treatment includes
a) List important examples of aminoglycosides.
b) List adverse effects of aminoglycosides (2)
c) Mention the rationale ofaminoglycosides (2)
using aminoglycosides in this patient. (2)
ii) A 62 year old female with newly diagnosed
for the same. She has had history of coronary hypothyroidism. She is prescribed levothyroxine
artery revascularization about 2 months ago.
She is taking aspirin, clopidogrel, atorvastatin and
a) List adverse effects and amlodipine.
contraindications
b) Mention importance of therapeutic drug
of levothyroxine (2+2)
iii) A 75 year old female diagnosed monitoring in this patient (2)
with osteoporosis to reduce her fracture risk.
a) List important examples and
b) Mention specific instructions adverse effects of bisphosphonates (2+2)
to patient when administering
bisphosphonates (2)
Q.7 Write short notes on ANY THREE of the
i) following: (3x6=18)
Pharmacotherapy of tapeworm infestation
ii) Compare and contrast loop and thiazide diuretics
iii) Adverse effects of corticosteroids
iv) Compare and contrast warfarin and heparin
Q.8 Answer ANY FIVE of the following briefly in tvo to
i) Mention drug/s causing red man syndrome three sentences (5x2=10)
(flushing syndrome) and mechanism for the same.
ii) Mention pharmacological basis for the use of erythropoietin in anemia of chronic renal
failure.
iii) Mention two ovulation inducing agents
iv) Enlist adverse effects of mifepristone
v) Mention the pharmacological basis of combining trimethoprim and
vi) Enlist topical antifungal drugs sulfamethoxazole
 DR. M. K. SHAH MEDICAL COLLEGE &RESEARCH CENTER
DEPARTMENT OF PATHOLOGY
SECOND M.B.B.S Batch 2022-2023
2nd INTERNAL EXAMINATION
Date: 16/07/2024 Max. Marks: 100
Time: 3 hours( 1:30 to 4:30 pm)
Instructions: 1) Answer To the Point.
2) Figures to the right indicates marks
3) Write Legibly
4) Draw Diagrams wherever necessary.

SECTION-I
Q.1 Long Assay Question (Any One) (10)
(a) Classify carcinogens with examples. Discuss chemical and biological carcinogens in detail.
(4+3+3)
(b) Describe etiology, pathophysiology, gross and microscopic features, diagnosis and
complications of infective endocarditis.(2+2+3+3)

Q.2 (a) Write Briefly About (Any Two)

(12)
(1) A S ycar pediatric male, weighing 1Skg with 10 days history of swelling around eyes, both
legs and generalized body swelling. He had history of fever, cough and decreased urine
output. On cxamination, there is bilateral pedal edema. Lab investigations shows protein in
urinc, decreased serum albumin (2.0gm/dl) and elevated lipid levels. (2+2+2)
n) What is your probable diagnosis?
b) Pathogenesis of this condition.
c) Different causes of this discase.
(2) A55 year male patient present to OPD with complains of increasing abdominal distension,
pedal edema over past 6 months. He has a history of alcohol consumption for past 20 years.
On examination, yellowish sclera, spider nevi on chest is seen. Abdominal examination
reveal distended abdomen with shifting dullness and palpable liver cdge 5cm below right
costal margin. (2+2+2)
a) What is your probable diagnosis?
b) Which further tests would you like to do to confirm diagnosis?

e) Pathophysiology of diagnOs0s in brief.

-(3) Etiopathogenesis and lab diagnosis of rheumatic fever (3+3)
Q.2 (b) Short Notes (Any Three) (18)
(a) Describe ovarian surface epithelial tumors in detail.
(b) Nevus and Melanoma.
(c) Classification of testicular tumors.
(d) Definition and examples of metaplasia.
(Page 1 of 2
 Q.3 Write Answers to the point in two or three Sentences (Any Five) (10)
(a) Tuberculous granuloma- draw and label diagram.
(b) Two diference between nephritic and nephrotic syndrome.
(c) Bence Jones Proteinuria.
(d) Autonomy versus Decision making.
(e) Four risk factors for peptic ulcers.
() Draw and label diagram of aschoff body

SECTION-II

Long Assay Question (Any One) (10)

Q.4
(a) Define inflammatory bowel disease. Write distinguishing feature of crohn's disease and
ulcerative colitis in detail (2+4+4)
(b) Define and write entities of COPD (Chronic Obstructive Pulmonary Disease). Write in detail
about etiopathogenesis, types, clinical features and microscopic features of Bronchiectasis.
(3+2+2+3)
Q.5 (a) Short Notes (Any Two) (12)
(a) Write etiology, pathogenesis, gross and microscopic features of cervical carcinoma. (2+2+2)
(b) Etiology, spread and histological grading of prostatic cancer (2+2+2)
(C) Intestinal polyps.
Q.5 (b) Short Notes (Any Three) (18)
(a) Morphological features of lobar pneumonia.
(b) Serological markers of viral hepatitis.
(c) Types and morphology of restrictive cardiomyopathy.
(d) Paraneoplastic syndrome.
Q.6 Write Answers to the point in two or three Sentences (Any Five) (10)
(a) PAP smear.
(b) Reid Index.
(c) Types of jaundice.
(d) Urinary casts and crystals
(e) Name any four tumor suppressor genes.
() GIST
(Page2 of)
End
 SECOND M.R.R.S, P 2nd Internal EAm (BATCH 2022-23)
MICROBIOLOY PAPER
MARKS: 100 Date: 18.07.2024 Time: 1.30 pm to 4.30 pm
Section-I

Q:1 Structured long Question (Write any One) (10 marks)

A. Draw labelled diagram of HIV vinus (2 marks), mention mode of transmission (2 Marks), wTite in detail
regarding laboratory diagnosis of HIV with NACO strategy (6 marks).
OR
B
Define Gas Gangrene (lmark). Write etiological agents (I mark), Pathogenesis (2 marks). Clinical
manifestation (2 marks), Lab diagnosis (3 marks) and managenent of Gas Gangrene (1 mark).

Q. 2(A) Applied short notes/case based scenarios (Write any two) (12 marks=2x6)
Young Female visits hospital with complaints of high-grade fever, abdominal discomfort, malaise for the past
4 days. The fever is of remittent type (Step ladder pyrexia) and rises gradually and on patient's pulse rate
is 64/min and couted tongue is seen Blood tests show mild lvmphopenia, clevated Iiver enzymes level.
Typhidot test is weakly positive. Based on this answer of the following.
a. What is the most probable clinical dagnosis? (| Mark)
b. What are the etiological agent responsible for this condition? (2 Marks)
c. Discuss the laboratory diagnosis for this condition (3 Marks)

A 28 ycar lady presented with fever, chills and rigor for the duration of4 days, Fever is periodic in naturc
Patient had given history of mosquito bites. On Physical examination ancmia and Splenomegaly were present
Peripheral blood smear examination showed "'accole" form, Multiple ring form and erscent shuped
gametocyte are seen inside the RBCs.
What is the clinical dd iost probable
organism) (I markS)
b. Enlist any 4 Comnnlent icaused by this organism (2 marks)
Write the laboratory diagnosis of ctiological agent in briet. (3 marks)

A 25-year-old male presented with complain of high-grade fever, severe headache, and retroorbitual pan for 1
da ys. Patient developed rash over body. Routine blood investigation showed thrombocytopenia.
a. What is the clinical diagnosis and most probable organism? (2 marks)
b. Write in brief regarding clinical classification of the disease (2 marks)
Write the laboratory diagnosis of this etiological agent. (2 marks)

0. 2 (B) Write Short notes (Write any Three) (18 marks =3x6)

a) Candida
b) Leptospirosis
c) Virulence factors and clinical manifestation of staphylococcus aureus
d) Lepromin test and complication of Leprosy

(10 marks -512)

.3 Answer only in 2-3 sentences(Write any five)
a) Mention four Opportunistic Fungi.
b) Mention four non suppurative,complication of Streptococci
c) Mention definitive and intermediate host of Leshmania donovani with it's morphological forns
d) Enlist HACEK organism causing endocarditis
e) Mention ctiological agents of Serub typhus and endemic typhus
) What is DEC provocation test?
1
 Section lI
(10 marks)
Q. 4Structured long Question(Write any One)
A. Define Dysentery (1 mark). Write ctiologicalagcnt (1 mark), Pathogcnesis (2 marks), Clinical manifestation (3 marks),
Lab diagnosis (3 marks) of Amocbic Dyscntery
OR
B. Classify Hepatitis viruscs (2 narks), Write in bricf regarding morphology (I mark), clinical features (I mark).
complications (2 marks) and Lab diagnosis of Hepatitis B virus (4 marks).
Q.5 A Write Short notes (Write any 2) (12 marks=2x6)

Agroup of patients presented to the emergency department with complain of feve, vomiting and diarrhea. Allof
them had attended a party 12 hours back and consumed fried rice
a. What is the most probable provisional clinical diagnosis? (1 mark)
b. What is the etiological agents responsible for this condition? (3 mark)
c. Write the laboratory diagnosis of this etiological agent in detail. (2 marks)

II. A 32years old female was admitted with complain of vomiting (6-8 times within 12 hours) and diarrhea (10
12 times within 12 hours). She complained of muscle cramps. On examination her lips and skin were dry and
Blood pressure was 80/60 mm of Hg. Stool was rice water in appearance and sent for microbiological
examination.
a. What is the clinical diagnosis and most probable organis1m? (1 mark)
b. Write in brief regarding Pathogenesis of this etiological agent (2 marks)
c. Write the laboratory diagnosis of this condition in detail. (3 marks)

III. An 8ycar girlcame to PacdiatricOPD for school heath check up. On examination she had pallor. Peripheral
blood smear showed microcytic hypochromic anaemia. Stool wet mount showed round to oval non bile
stained egg with segmented ovum (4 blastomeres)
a. Which is the most likely etiological agent? (lmark)
b. Write the life cycle of this agent. (2 marks)
c. Write the pathogenesis of this agent. (2 marks)
d. Draw the diagnostic form of this agent present in stool sample. (l mark)

Q. 5 B Write Short notes (Write any 3) (18 marks =3x6)

a) Confidentiality in Medical Report.
b) Giardiasis
c) Clostridium difficile
d) Hydatid cyst
. 6 Answer in 2-3 sentences (Write any 5) (10 marks=Sx2)

a) Mention mode of transmission and infective form of Ascariasis lumbricoides and Strongyloides.
b) Mention definitive host and intermediat host of Taenia saginata and Taenia solium
c) Draw 3 different types of eggs of Ascaris lumbricoides
d) Draw labeled diagram of eggs of Enterobius vermicularis
e) Mention mode of transmission of Hepatitis C virus
f) Mention etiological agent andvector of yellow fever