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BP601TP 2021

This document is an examination paper for the B. Pharm Semester VI course at Gujarat Technological University, focusing on Medicinal Chemistry III. It includes various questions related to drug classifications, mechanisms of action, synthesis of specific drugs, and concepts such as drug design and prodrugs. Students are instructed to attempt any five questions and make suitable assumptions where necessary.

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ShyaM Patel
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34 views1 page

BP601TP 2021

This document is an examination paper for the B. Pharm Semester VI course at Gujarat Technological University, focusing on Medicinal Chemistry III. It includes various questions related to drug classifications, mechanisms of action, synthesis of specific drugs, and concepts such as drug design and prodrugs. Students are instructed to attempt any five questions and make suitable assumptions where necessary.

Uploaded by

ShyaM Patel
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Seat No.: _____ Enrolment No.

_____________

GUJARAT TECHNOLOGICAL UNIVERSITY


B. Pharm – SEMESTER VI– • EXAMINATION – SUMMER -2021

Subject Code:BP601TP Date:03/08/2021


Subject Name: Medicinal Chemistry III
Time: 02:30PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Do as directed 06


I. Comment – Tetracyclines are contraindicated with milk.
II. Comment: Cephalosporins are more resistant towards β-lactamase
enzyme than penicillin in general.
III. How the problem of crystalluria is avoided while using sulpha drug as
chemotherapeutic agent.
(b) Define and classify sulfonamides with structural examples. 05
(c) Give structure of following drugs. 05
i) Chlortetracycline ii) Azithromycin iii) Artemether
iv) Griseofulvin v) Norfloxacin
Q.2 (a) Define and classify Penicillines and Tetracyclines with its mechanism of action. 06
(b) Give synthesis of Pamaquine and Nitrofurantoin. 05
(c) Give name and structure of any five drug containing imidazole ring system. 05
Q.3 (a) Define and classify anti-tubercular agents with synthesis of any one drug. 06
(b) Give brief note on SAR of sulfonamides with structural examples. 05
(c) Define and classify antiviral agents with structural examples of any five drugs. 05
Q.4 (a) Define and classify Macrolides and Chloramphenicol with its mechanism of 06
action.
(b) Give brief note on SAR of Quinolones with structural examples. 05
(c) Give brief note on MDR TB, XDR TB and TDR TB. 05
Q.5 (a) Define drug design. Give brief note on physicochemical parameters used in 06
QSAR.
(b) Give synthesis of Chloramphenicol and Chloroquine. 05
(c) Define Prodrug and application of prodrug design. Give name and structure of 05
any three prodrug.
Q. 6 (a) Define and classify Quinolones with synthesis of any one drug. 06
(b) Give synthesis of Miconazole and Mebindazole. 05
(c) Give brief note on etiology of malaria. 05
Q.7 (a) Give synthesis of Dapson and Trimethoprime. 06
(b) Do as directed. 05
I. Comment: Amoxycillin and Ampicilin are frequently combined with
clavulanic acid.
II. Why tetracyclins are amphoteric in nature?
(c) Give brief note on combinatorial chemistry. 05

***************

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