COWELL®
Regenerative Solution
Help your daily practice superior V e r . 11
The Pioneers in Dental Implant & E.rhBMP-2
1st
World’s first
E.rhBMP-2
For the
first time
in Korea,
beginning with the localization of dental implants,
the company has been leading the biomedical industry
with its rhBMP-2 fusion technology.
COWELLMEDI is a leading company of dental healthcare products specialized in dental implants,
regenerative materials, instruments, and products for digitally guided implant process.
COWELLMEDI serves dental clinics, laboratories, healthcare institutes, governments and other
related sites. COWELLMEDI offers a comprehensive selection of products and services including
education, technology trades, commercial consulting services and other extensive solutions.
With the development and localization of Korea’s first dental implant in 1994, COWELLMEDI
became the pioneer of Korea’s dental implant industry. COWELLMEDI received a bronze tower
medal for the contribution of the development of Korea’s first dental implant from Korean
government.
COWELLMEDI’s efforts over the last 2 decades along with its continuous research have become
the core of the country’s dental implant industry.
In 2010, COWELLMEDI attracted the world’s attention once again by successfully developing
E.coli derived rhBMP-2 bone graft for the first time in the world. That led COWELLMEDI to become
a global company in the biomedical field.
COWELL® Regenerative Solution_02
COWELLMEDI has been committed to innovating
human life based on pushing boundaries of
dental healthcare system and changing the
way how the world treats the dental healthcare
system.
At COWELLMEDI, we are always thinking beyond
products. We are pulling all our weight to
realize our motto, “Help your daily practice
superior ”, by providing our best level services
and the highest quality products which have
been clinical safety, efficacy and reliability
proven in multiple clinical cases and studies.
Our motto-oriented services, products and
our continuous research on innovation and
clinical & scientific networks have let us be one
of the greatest companies in world biotechnology
industry.
COWELL® Regenerative Solution_03
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We all kno
W noww that no single factor can achieve al
alll re
requirements and indicat
atio
ions of soft
ft and
nd har
ard
d tissuee
regeneraati
tion
on.
Factor
Fact orss suchh as stem celells, scaffol
olds
ds,, signal mol
o ec
e ul
ular
a and biological type e, ag
a e, hyygien
ne and
treaatmen
entt p
pllan
n req
equi
uire
re a sop
ophiist
stic
icated
ed approach h wi
with
t diff
ffer
erently coordinated prooductss.
oduc
The COWELL
The LL®® Re
Regene
nerar ti
t vee Matateriaals inclu
lude all pro
ove
ven
n ma
m te
t ri
rial
a s like E.rhBMP-2-2, di
dive
vers
rsee ty
types of
bone
bo nee substitutes
es, resoorrb
bablee & non-ressor o bablb e memmbraane
ness, wouound
n dreessssin
ing
gs, autooge
geninicc bo
bonne
harvessting instrum
ha ment an andd bone aug gme
m ntat atio
io
on abut
ab
butme
m nts & sc
me scrrews
e whichhich can bee used in vaarir ouss
cases fo
or ea
each
ch specific
fic ind
dicicat
atio
ionn.
n.
All produc
ucts
ts are man
anag
aged
e und
ndeer the
he highest quality co
ontrol
ol sysste
t m.
COWELL® Regenerative Solution_04
& ' ( ( ( '
COWELLLME
COWE M DI iss keeen
e to develop relationships with new partners and does look forward to fully exploring
h w be
ho bests wee can co
c lllabor
o atte to deliver mutual benefit. It is our belief that working on a partnership-basis,
youu wi
w ll ultimat
a elly pr
p ove to add value for our business and thereby enhance the customer and patient
e pe
ex peri
riien
ence
ce at ou
ur attractions.s
Partne
Partners
r hi
h pss witth di
diffe
ffere
ent orgganizations are fundamental to our strategic priorities of growing a global
busi
busine
ness
ss and del
e iv
iverrin
ing
g mo
m rer pro
oducts and services of value.
COWE
CO WELLLLME
MEDID has a div iver
e se
s rangee of partnerships and we are always looking for new opportunities.
One of currre
One entt key
e obj bjec
ective
vess of partnership is to address partner consolidation and also to look at
glob
gl obal
al opp
ppor
o tu
tuni
niti
t es for busin
i es
e s expansion. COWELLMEDI recognizes that we need to have the right.
Shou
Shou
uld
l you
our bu
b si
sine
nesss be as amb
m itious as ours and you believe you can add value for your customers,
then
then
n we wo
would
d be delelig
ight
h ed
d forr you to continue this process.
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COWELL® Regenerative Solution_05
INDEX
C O W E L L ®
R E G E N E R AT I V E
M AT E R I A L S
E.RHBMP-2 BASED BONE GRAFT RESORBABLE MEMBRANE
• COWELL® BMP • MegaDerm Plus
• COWELL® BMP Plus • DiaDerm® M
• INNO GF Kit
SYNTHETIC GRAFT WOUND DRESSING
• INNO CaP • DiaDerm® Plug S
• DiaDerm® Tape
ALLOGRAFT
• INNO Oss Plus
• DO BONE GBR SYSTEM &
• Renew Oss™ NON-RESORBABLE MEMBRANE
• BOSS®
XENOGRAFT • InnoGenic™ Wifi-Mesh
• InnoGenic™ PTFE-Mesh
• DiaBONE® • InnoGenic™ Ti-Mesh
• InnoGenic™ Autobone Harvester
COWELL® Regenerative Solution_06
E.rhBMP-2 based Bone Graft
®
Osteoinductive Bone Graft
rhBMP-2 + BCP COWELL BMP
Composition of COWELL® BMP Bone Graft
• Bone graft material initially made in South Korea by freeze-drying recombinant human bone morphogenic protein type 2 (rhBMP-2)
on the surface of BCP
• BCP as a carrier allows maintenance of space
Features of COWELL® BMP Bone Graft
• Primary closure for soft tissue regeneration is not required
• Regenerates adherent gingiva
• Simplifies challenging bone grafting and soft tissue regeneration
• Acts directly on stem cells
• Induces bone regeneration without infection in extraction socket
• Contains 1 mg of bone morphogenic protein per 1g of the particle
(1g of autologous bone contains 2ng of bone morphogenic protein)
Application
The Pioneers in Dental Implant & E.rhBMP-2
A. Orthopedics
Bone grafts Injection Device
• Fractures : Tibia, Radius, Ulna • Lengthening : Distraction Osteogenesis
• Spine Fusion (Degenerative Disc Disease) : • Osteoporosis : Hip joint fracture
Interbody cage, Posteolateral • Bone Defect : Bone cyst
• Bone Fusion : Foot/shoulder revision
B. Dentistry C. Dermatology
Bone grafts Soft Tissue grafts
• Severely resorbed alveolar ridges • Damaged skin regeneration
• Tooth extraction socket • Diabetes ulcer
• Alveolar bone loss
• Maxillary sinus bone loss
• Bone-inductive implant : Coted implant
• Maxillofacial reconstruction
COWELL® Regenerative Solution_07
E.rhBMP-2 based Bone Graft
Mechanism of Action of COWELL® BMP Bone Graft
A. Migration of Cells with lamellipodia
filopodium A. Filopodial extensions
A lamellipodium Ror2
cdc42
Brld
brll
Myo-x LIMK
B adhesions
B. Cell protrusion
extracellalar space P13K Rho-
Intergrins GTPase
stationary cell actin filaments FAK
microtubule
microtubule C. Nuclear effectors
GTP GDP organizing center R-smad MAPK
Rho-GDP Rho-GTP C nucleus
I-smad p38
LIMK1
Cofilin
D adhesions D. Retraction
Intergrins FAK
Actin remodeling cytoplasm polarized cell
migrating cell
B. Cellular mechanisms
A : BISC BMP-2 B : PFC
BRII BRI
DRM Clsthrin-
The Pioneers in Dental Implant &• BMP-2
E.rhBMP-2
adheres to the membrane of
coated
pit
stem cell and induces expression of
genes of nucleus. Then, BMP-2 migrates
non-transcriptional to recipient site.
responses early
endosome
• BMP-2 growth factor, Twist-2
cytoskeletal transcriptional factor, and VEGF growth
rearrangements
factor synthesize and secrete
caveosome
endogenous growth factor.
crosstalk • Proliferation of osteoblast of osteocyte,
non-Smad & Smad
pathway fine tuning pathway R-Smad1/5/8 and proliferation of fibroblast in dermis
and keratinocyte of the skin.
p38 co-smad4
ERK miRNA • Twist-2 transcriptional factor induces
P13K tissue regeneration in osseous tissue
and adherent gingival area.
non-smad-responsive genes smad-responsive genes
COWELL® Regenerative Solution_08
E.rhBMP-2 based Bone Graft
Product Type
INNO GF Kit (Two vials + Saline Solution + Syringe)
BMP Powder BCP Particle
icle
e Saline Solution
& Syringe
BMP + BCP +
• Dose and Particle Size of INNO GF Kit
BMP 0.1mg BMP 0.25mg
Product Code BMP Dose Particle Dose Particle Size Product Code BMP Dose Particle Dose Particle Size
IBB0125 0.1mg 0.25g 0.41~1.0mm IBB2525 0.25mg 0.25g 0.41~1.0mm
IBB0105 0.1mg 0.5g 0.41~1.0mm IBB2505 0.25mg 0.5g 0.41~1.0mm
IBB1110 0.1mg 1g 0.41~1.0mm IBB1125 0.25mg 1g 0.41~1.0mm
IBB1220 0.1mg 2g 0.41~1.0mm IBB1225 0.25mg 2g 0.41~1.0mm
BMP 0.5mg BMP 1mg
Product Code BMP Dose Particle Dose Particle Size Product Code BMP Dose Particle Dose Particle Size
IBB0525 0.5mg 0.25g 0.41~1.0mm IBB1025 1mg 0.25g 0.41~1.0mm
IBB0505 The
0.5mg Pioneers in DentalIBB1050
0.5g 0.41~1.0mm Implant
1mg &0.5g
E.rhBMP-2
0.41~1.0mm
IBB1150 0.5mg 1g 0.41~1.0mm IBB1011 1mg 1g 0.41~1.0mm
IBB1250 0.5mg 2g 0.41~1.0mm IBB1012 1mg 2g 0.41~1.0mm
BMP 2mg
Product Code BMP Dose Particle Dose Particle Size
IBB2025 2mg 0.25g 0.41~1.0mm
IBB2050 2mg 0.5g 0.41~1.0mm
IBB2011 2mg 1g 0.41~1.0mm
IBB2012 2mg 2g 0.41~1.0mm
COWELL® Regenerative Solution_11
Synthetic Graft
Calcium Phosphate , Synthetic Bone Graft
Osteoconductive resorbable synthetic bone graft material
• INNO-CaP is a osteoconductive synthetic resorbable bone graft material consisting of Calcium Phosphate.
• INNO-CaP is completely resorpted and progressively replaced by normal-structured bone in the healing period.
Excellent Biocompatibility and Conductivity
• The characteristic biocompatibility and conductivity of INNO-CaP represent the most safety.
Cell culture SEM images (14 days)
The Pioneers in Dental Implant & E.rhBMP-2
X1,000 X1,000
COWELL® Regenerative Solution_15
Synthetic Graft
A porosity for new bone ingrowth
• The porosity promotes ingrowth of osteoblast, osteoclast and growth factors.
Pariticle surface SEM image
X50 X100 X500
Indications
Sinus graft surgery
• For sinus graft, INNO-CaP is used alone or in combination with the other graft materials.
• Various healing period according to residual bone height.
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TheBone
GBR (Guided Pioneers in Dental Implant & E.rhBMP-2
Regeneration)
• Minimize the amount of autogenous bone.
• Sub-graft materials.
Dose and Particle Size
Product Code Particle Size Particle Dose
IG1025 0.25g
IG1050 0.5g
0.41~1.0mm
IG1001 1g
IG1002 2g
IG1425 0.25g
IG1450 0.5g
1.0~1.4mm
IG1401 1g
IG1402 2g
COWELL® Regenerative Solution_16
