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Bio Pre Lab

The document discusses two articles: one on enzyme evolution and temperature dependence, highlighting how enzymes from different environments adapt to temperature variations and the experimental techniques used to study them, and another on enzyme therapy, which explores the therapeutic roles of enzymes in treating various disorders, emphasizing the potential and challenges of enzyme-based treatments in biotechnology.

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4 views1 page

Bio Pre Lab

The document discusses two articles: one on enzyme evolution and temperature dependence, highlighting how enzymes from different environments adapt to temperature variations and the experimental techniques used to study them, and another on enzyme therapy, which explores the therapeutic roles of enzymes in treating various disorders, emphasizing the potential and challenges of enzyme-based treatments in biotechnology.

Uploaded by

pelluzoterorebeca
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Prelab Unit 2 Week 6

Enzyme evolution and the temperature dependence of enzyme catalysis


The article discusses how enzymes are temperature dependent and how they have
evolved and function under certain conditions. For example, enzymes from organisms living in
cold environments have different optimal temperatures than those living in hot environments.
They compare thermophilic enzymes (more rigid) to psychrophilic enzymes (less rigid). They
mention a concept called enthalpy-entropy trade off (enzymes reduce the activation energy for
reactions at different temperatures by making a trade off between enthalpy and entropy. They
gave an example on how thermophilic (heat loving enzymes) are less active at lower
temperatures due to the tradeoff. They talk about Nonlinear Arrhenius behavior (didn’t really
understand this part). Lastly, they talk about the role that temperature plays in enzyme activity
and how it can be studied through experimental techniques such as x-ray crystallography,
computational simulations, and Cryogenic electron microscopy.
https://www.sciencedirect.com/science/article/pii/S0959440X20301007

Enzyme Therapy: Current Challenges and Future Perspectives


The article highlights the diverse roles of enzymes in therapeutic applications across
several pathologies. They talk about several therapeutic treatments with enzymes that have been
put into place to treat and manage the symptoms of the following disorders. Lysosomal Storage
diseases (LDL): enzyme replacement therapy has proven effective in treating this rare group of
genetic disorders caused by enzyme deficiencies that lead to an accumulation of specific
molecules within the cell. Other disorders include PKU (phenylketonuria) (rare inherited
disorder that causes the amino acid phenylalanine to build up in the body. This is significant
because it can result in brain damage). Those are just some of the diseases/ disorders that the
article talks about. Lastly, it also mentions how the use of enzymes in therapies have an evolving
and seem promising in the field of biotechnology with a huge potential to offer new treatment
options for a wide range of pathologies. Researchers still must do extensive research and address
the challenges associated with the treatments including the immune responses of patients to
make sure that the therapies are safe and effective.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431097/

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