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BIOLOGY
Chapter 5: Principles of Inheritance and Variation
 PRINCIPLES OF INHERITANCE AND VARIATION
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Principles Of Inheritance and Variation

Introduction:
Genetics is the study of principles and mechanism of heredity and variation. Gregor Johann
Mendel is known as ‘father of Genetics’. important attributes to the reproductive health of a
society.

Inheritance:
Inheritance is the process by which characters are passed on from parent to progeny. It is
the basis of heredity.

Variation:
Variation is the degree by which progeny differ from their parents. Variation may be in terms
of morphology, physiology, cytology and behavioristic traits of individual belonging to same
species.

Variation arise due to:

• Reshuffling of gene/ chromosomes.

• Crossing over or recombination
• Mutation and effect of environment.

Inheritance of one gene (Monohybrid cross):

Mendel crossed tall and dwarf pea plant and collected all the seeds obtained from this cross.
He grew all the seeds to generate plants of first hybrid generation called F 1 generation. He
observed that all the plants are tall. Similar observation was also found in other pair of traits.
Mendel self-pollinated the F1 plants and found that in F 2 generation some plants are also
dwarf. The proportion of dwarf plants is 1/4th and tall plants of 3/4th.

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• Mendel called the ‘factors’ that passes through gametes from one generation to next
generation. Now a day it is called as genes (unit of inheritance).
• Genes that code for a pair of contrasting traits are known as alleles.
• Alphabetical symbols are used to represent each gene, capital letter (TT) for gene
expressed in F1 generation and small letter (tt) for other gene.
• Mendel also proposed that in true breeding tall and dwarf variety allelic pair of genes
for height is homozygous (TT or tt). TT, Tt or tt are called genotype and tall and dwarf
are called phenotype.
• The hybrids which contain alleles which express contrasting traits are called
heterozygous (Tt).
• The monohybrid ratio of F2 hybrid is 3 : 1 (phenotypic) and 1 : 2 : 1 (genotypic).

Dominance: When a factor (allele) expresses itself in the presence or absence of its
dominant factor called dominance. It forms a complete functional enzyme that perfectly
express it.
Recessive: It can only express itself in the absence of or its recessive factor allele. It forms a
incomplete defective enzyme which fails to express itself when present with its dominant
allele, i.e., in heterozygous condition.

Test cross:
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Test cross is the cross between an individual with dominant trait and a recessive organism in
order to know whether the dominant trait is homozygous or heterozygous.

Mendel’s Experiment:
Gregor Mendel, after performing his experiments on pea plants, discovered the fundamental
laws of inheritance. He proposed three laws of inheritance which we are studying to date.
He has chosen pea plants having seven opposite traits of particular characters and
conducted his experiment on 14 true-breeding pea plant varieties.

Mendel’s Laws:
There were 3 laws that were proposed by Mendel

Law of Dominance: It is explained in this law that all of the traits, or the characters are
controlled by the unit called the factors. These factors are found to be in pairs and are called
alleles. If they occur in the same pair they are called homozygous, they can be either
dominant or recessive and if the alleles occur in a different pair then it is called
heterozygous, It will always be dominant. “For example Allele for tallness is dominant over
the allele for dwarfism”.

Law of Segregation of Genes: Law of segregation is based on the fact that alleles do not
show any blending and that both the characters are recovered as such in the second filial
generation though one of these is not seen in the first generation. The segregation of factors
or a pair of alleles occurs in such a manner that the gamete receives only one of the two
factors from each other. Examples of the law of segregation of alleles. In this R is dominant
over r.

Law of Independent Assortment: It states that pairs of traits in the parental generation sort
independently from one another when passing from one generation to the next. It is
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explained with the help of a dihybrid cross.

Inheritance of Two Genes (Dihybrid Cross):

The inheritance of two genes requires two characters of the same trait. This can be observed
with the help of a dihybrid cross. Mendel has chosen two traits that involve the color and
the shape of the seed to explain the inheritance of two genes. Y represents the dominant
yellow color seed color, y represents a recessive green color while R represents the round
shape of the seed, and r represents the wrinkled shape of the seed. The genotype of the
parents can then be written as RRYY and rryy. The gametes RY and ry will unite after
fertilization and will produce the F1 hybrid RrYy. The dihybrid cross is also useful in the study
of the Law of Independent Assortment. After the self-pollination of the F1 hybrid, the F2 ratio
was found to be 9 : 3 : 3 : 1.

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Incomplete Dominance:

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Incomplete dominance is a type of inheritance in which one allele for a specific trait is not
completely dominant over the other allele i.e. neither allele is dominant over the other in
heterozygous organisms. This results in a combined phenotype. Incomplete dominance is
also called mosaic or partial dominance. Here new phenotypic characters are expressed
entirely.
Mirabilis Jalapa, the marvel of Peru commonly called a 4 o'clock plant. It is a very good
example of incomplete dominance because of its Inheritance of flower color. It is shown in
the figure given below where red flowers (dominant) were crossed with white flowers
(recessive), the F1 generation contains flowers that are pink in color (intermediate). The
phenotypic and the genotypic ratio observed will be the same, that is 1 : 2 : 1.

Co-dominance:
It is the phenomenon of two alleles lacking dominance-recessive relationship and both
expressing themselves in the organism.

Human beings, ABO blood grouping are controlled by gene I. The gene has three alleles IA, IB
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and i. Any person contains any two of three allele I A, IB are dominant over i.

The plasma membrane of the red blood cells has sugar polymers that protrude from its
surface and the kind of sugar is controlled by the gene.

When IA and IB are present together, both express their own types of sugars because of co-
dominance.

Difference between Incomplete Dominance and Co-Dominance:

Incomplete Dominance Co-Dominance

Effect of one of the two alleles is more Effect of both the alleles are equally
conspicuous. conspicuous.
It produces a mixture of the There is no mixing of the effect of the
expression of two alleles. two alleles.
The F1 does not resemble either of The F1 resembles both the parents.
the parents.
E.g.: Flower colour in dog flower. E.g.: ABO blood grouping in humans,

Multiple Allelism or Codominance:

The condition in which three or more alternative forms of alleles present for a single gene on
the same chromosome is known as Multiple Allelism and the alleles are known as multiple
alleles. For example, Multiple allelism is better understand with the help of the ABO blood
group system in humans. The inheritance of the ABO blood group is a gene I (in which I
represent isohemagglutinin) that remains in the 3 allelic expressions: IA, IB, and i which are
codominant in humans. An individual can possess any two of these alleles. Gene IA is
responsible for blood group A and codes for glycoprotein A while gene IB is responsible for
blood group B and codes for glycoprotein B.
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The gene ‘i’ does not produce any glycoprotein and so the person who will be having these
two alleles together in a homozygous condition will have O group blood. The genes IA and IB
are dominant over ‘i’ but alleles IA and IB are dominant equally and produce both the
glycoproteins A and B simultaneously and results in the blood group AB. Such alleles are
known as co-dominant alleles.

Chromosomal Theory of Inheritance:

• Chromosome as well as gene both occurs in pair. The two alleles of a gene pair are
located on the same locus on homologous chromosomes.
• Sutton and Boveri argued that the pairing and separation of a pair of chromosomes
would lead to segregation of a pair of factors (gene) they carried.
• Sutton united the knowledge of chromosomal segregation with mendelian principles
and called it the chromosomal theory of inheritance.

Linkage and Recombination:

When two genes in a Dihybrid cross were situated on same chromosome, the proportion of
parental gene combination was much higher than the non-parental type. Morgan attributed
this due to the physical association or the linkage of the two genes and coined the linkage to
describe the physical association of genes on same chromosome.
The generation of non-parental gene combination during Dihybrid cross is called
recombination. When genes are located on same chromosome, they are tightly linked and
show very low recombination.

Crossing over:
It leads to separation of linked genes, It involves exchange of segments between non-sister
chromatics of homologous chromosomes. The frequency of crossing over can never exceed
50%. It increases variability by forming new gene combinations.

Sex Determination:
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Sex determination is the process where the gender of the child can be revealed. Sex
chromosomes are responsible for the determination of the sex of a child. In the case of
humans, females have XX types of chromosomes while males have one X and one Y type of
chromosomes. Thus, when the egg (female gamete) formed will be having identical X-
chromosome each but male sperms (male gametes) are not identical as they have one X-
chromosome and one Y-chromosome. So it's a matter of chance that which sperm fuses with
the egg (X or Y). Thus, the females are said to be homogametic (same type of chromosomes)
while males are said to be heterogametic (different types of chromosomes).
In the case of insects, the mechanism of sex determination is of XO type. Here the eggs
consist of the X chromosomes while the sperms may have one or none X chromosomes.
Thus, the males are said to be homogametic (same type of chromosomes) while females are
said to be heterogametic (different types of chromosomes).

Mutation: Mutation is a phenomenon which results in alternation of DNA sequence and

consequently results in the change in the genotype and phenotype of an organism. The
mutations that arise due to due to change in single base pair of DNA are called point
mutation e.g., Sickle cell anaemia.
Pedigree Analysis: The analysis of traits in several of generation of a family is called the
pedigree analysis. The inheritance of a particular trait is represented in family tree over
several generations. It is used to trace the inheritance of particular trait, abnormality and
disease.

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Genetic Disorders: Broadly, genetic disorders may be grouped into two categories
Mendelian disorders.

Chromosomal disorders: They are transmitted as the affected individual is sterile. This is
always dominant in nature.

Mendelian disorder includes:

Haemophilia:
Sex linked recessive disease in which, in an infected individual, a minor cut leads to non-stop
bleeding. Heterozygous female (carrier) can transmit the disease to their son. The possibility
of a female becoming a haemophilic is extremely rare because mother of such a female has
to be at least carrier and the father should be haemophilic (unviable in the later stage of
life).

Sickle cell anaemia:

An autosome linked recessive trait in which mutant haemoglobin molecules undergo
polymerization under low oxygen tension causing change in shape of the RBC from biconvex
disc to elongated sickle like structure. The defect is caused by the substitution of Glutamic
acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin
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molecule. The substitution of amino acid in the globin protein results due to the single base
substitution at the sixth codon of the beta globin gene from GAG to GUG.

Phenylketonuria:
Inborn error of metabolism inherited as autosomal recessive trait. The affected individual
lacks an enzyme that converts the amino acids phenylalanine to tyrosine. As a result of this
phenylalanine is accumulated and converted into phenyl pyruvic acid and other derivatives
that results into mental retardation.

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Aneuploidy:
It is chromosomal disorder Failure of segregation of chromatids during cell division results in
loss or gain of chromosome called aneuploidy.

Polyploidy:
The failure of cytokinesis leads to two sets of chromosome called polyploidy.

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Down’s Syndrome:
Down’s Syndrome is due to presence of additional copy of the chromosome number 21. The
affected individual is short statured with small, rounded head, furrowed tongue and partially
opened mouth. Mental development is retarded.

Klineflener’s Syndrome:
Klineflener’s Syndrome due to presence of an additional copy of X-chromosome (XXY). Such
persons have overall masculine development however, the feminine development
(development of breast, i.e., Gynaecomastia) is also expressed. They are sterile.

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Turner’s Syndrome:
Turner’s Syndrome caused due to the absence of one of the X chromosomes. 45 with XO,
such females are sterile as ovaries are rudimentary. They lack secondary sexual characters.

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Important Questions
➢ Multiple Choice Questions:
1. All genes located on the same chromosome:
(a) form different groups depending upon their relative distance
(b) form one linkage group
(c) will not form any linkage groups
(d) form interactive groups that affect the phenotype
2. Conditions of a karyotype 2n + 1 and 2n ± 2 are called:
(a) Aneuploidy
(b) Polyploidy
(c) Allopolyploidy
(d) Monosomy.
3. Distance between the genes and advantage of recombination shows:
(a) a direct relationship
(b) an inverse relationship
(c) a parallel relationship
(d) no relationship.
4. If a genetic disease is transferred from a phenotypically normal but carrier female to only
some of the male progeny, the disease is:
(a) Autosomal dominant
(b) Autosomal recessive
(c) Sex-linked dominant
(d) Sex-linked recessive.
5. In sickle cell anaemia glutamic acid is replaced by valine. Which one of the following
triplets codes for valine?
(a) GGG
(b) AAG
(c) GAA
(d) GUG.
6. Person having genotype lA lB would show the blood group as AB. This is because of:
(a) Pleiotropy
(b) Co-dominance
(c) Segregation
(d) Incomplete dominance.

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7. ZZ / ZW type of sex determination is seen in:

(a) Platypus
(b) Snails
(c) Cockroach
(d) Peacock.
8. A cross between two tall plants resulted in offspring having a few dwarf plants. What
would be the genotypes of both the parents?
(a) TT and Tt
(b) Tt and Tt
(c) TT and TT
(d) Tt and tt.
9. In a dihybrid cross, if you get 9 : 3 : 3 : 1 ratio it denotes that:
(a) The alleles of two genes are interacting with each other
(b) It is a multigenic inheritance
(c) It is a case of multiple alleles m
(d) The alleles of two genes are segregating independently.
10. Which of the following will not result in variations among siblings?
(a) Independent assortment of genes
(b) Crossing over
(c) Linkage
(d) Mutation.
11. Mendel’s law of independent assortment holds good for genes situated on the:
(a) non-homologous chromosomes
(b) homologous chromosomes
(c) extra nuclear genetic element
(d) same chromosome.
12. Occasionally, a single gene may express more than one effect. The phenomenon is called:
(a) multiple allelism
(b) mosaicism
(c) pleiotropy
(d) polygeny.
13. In a certain taxon of insects some have 17 chromosomes and the others have 18
chromosomes. The 17 and 18 chromosome-bearing organisms are:
(a) males and females, respectively
(b) females and males, respectively
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(c) all males

(d) all females.
14. The inheritance pattern of a gene over generations among humans is studied by the
pedigree analysis. Character studied in the pedigree analysis is equivalent to:
(a) quantitative trait
(b) Mendelian trait
(c) polygenic trait
(d) maternal trait.
15. It is said that Mendel proposed that the factor controlling any character is discrete and
independent. This proposition was based on the:
(a) results of F3 generation of a cross.
(b) observations that the offspring of a cross made between the plants having two
contrasting characters shows only one character without any blending.
(c) self-pollination of F1 offsprings
(d) cross-pollination of parental generations.
➢ Very Short Question:
1. Name any one plant that shows the phenomenon of incomplete dominance during the
inheritance of its flower colour.
2. Name the base change and the amino acid change, responsible for sickle cell anaemia.
3. Name the disorder with the following chromosome complement.
(i) 22 pairs of autosomes + X X Y
(ii) 22 pairs of autosomes + 21st chromosome + XY.
4. A haemophilic man marries a normal homozygous woman. What is the probability that their
daughter will be haemophilic?
5. A test is performed to know whether the given plant is homozygous dominant or
heterozygous. Name the test and phenotypic ratio of this test for a monohybrid cross.
6. Name the phenomena that occur when homologous chromosomes do not separate during
meiosis.
7. Name one trait each in humans & in drosophila whose genes are located on sex
chromosome.
8. What is meant by aneuploidy?
9. What genetic principle could be derived from a monohybrid cross?
10. Which one change is the cause of sickle – cell anaemia?
➢ Short Questions:
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1. Mention two differences between Turner ’ s syndrome and Klinefelter’s syndome.

2. The human male never passes on the gene for haemophilia to his son. Why is it so?
3. Mention four reasons why Drosophila was chosen by Morgan for his experiments in
genetics.
4. Differentiate between point mutation and frameshift mutations.
5. Give any two similarities between behavior of genes (Mendel’s factor) during inheritance &
chromosomes during cell division.
6. Which law of Mendel is universally accepted? State the law?
7. Why do sons of haemophilic father never suffer from this trait?
8. How is the child affected if it has grown from the zygote formed by an XX-egg fertilized by Y-
carrying sperm? What do you call this abnormality?
➢ Long Questions:
1. Study the given pedigree chart and answer the questions that follow:
(a) Is the trait recessive or dominant?
(b) Is the trait sex-linked or autosomal?
(c) Give the genotypes of the parents shown in generation I and their third child is shown in
generation II and the first grandchild shown in generation III.

2. Mention the advantages of selecting a pea plant for the experiment by Mendel.
3. What is recombination? Discuss the applications of recombination from the point of view of
genetic engineering.
➢ Assertion and Reason Questions:
1. For question two statements are given-one labelled Assertion and the other labelled Reason.
Select the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
a) Both assertion and reason are true and reason is the correct explanation of assertion.
b) Both assertion and reason are true, but reason is not the correct explanation of
assertion.
c) Assertion is true, but reason is false.
d) Both assertion and reason are false.
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Assertion: Number of chromosomes in one genome is equal to number of linkage groups.

Reason: Two homologous chromosomes form a linkage group.
2. For question two statements are given-one labelled Assertion and the other labelled Reason.
Select the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
a) Both assertion and reason are true and reason is the correct explanation of assertion.
b) Both assertion and reason are true but reason is not the correct explanation of assertion.
c) Assertion is true but reason is false.
d) Both assertion and reason are false.
Assertion: Linked gene show dihybrid ratio of 9 : 3 : 3 : 1.
Reason: Linked gene undergo independent assortment.
➢ Case Study Questions:
1. Read the following and answer any four questions from (i) to (v) given below:
While studying inheritance of characters, a teacher gave the example of inheritance of
attached earlobe and hypertrichosis of the ear to her students. A man with attached earlobes
and extensive hair on pinna married a woman having free earlobes. The couple had four
children, one son with attached earlobes and hairy pinna, one son with a free earlobes and
hairy pinna and two daughters with attached earlobes. One of the daughters married a man
with free earlobes and sparse hair on pinna. Teacher said if this couple would have sons there
would be equal chances for both having free or attached earlobes and sparse hair on pinnae.
(i) Attached and free earlobe are respective example of?
a) Dominant and recessive traits.
b) Recessive and recessive traits.
c) Recessive and dominant traits.
d) Dominant and dominant traits.
(ii) Hypertrichosis of the ear is.
a) X linked trait
b) Y linked trait
c) Autosomal dominant trait
d) Autosomal recessive trait.
(iii) If a female with attached earlobe married a male homozygous for free earlobe sparse hair
on pinna then what would be the chances of daughter to have attached earlobe?
a) 0%
b) 100%
c) 25%
d) 75%

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(iv) If a man with attached earlobe and hairy pinna married a woman with attached earlobe
then what would be the chances of son to have hairy pinna?
a) 50%
b) 100%
c) 75%
d) 0%
(v) A male with attached earlobe, sparse hair on pinna married a female with attached
earlobe. Which of the following is correct regarding their progenies?
a) All sons have a free earlobe with hairy pinna.
b) All daughters have an attached earlobe.
c) 50% daughters have an attached earlobe whereas 50% daughters have a free earlobe.
d) 50% sons have attached earlobe with hairy pinna and 50% sons have a free earlobe
2. Read the following and answer any four questions from (i) to (v) given below:
According to Mendel, one gene control the expression of one character only. The ability of a
gene to have multiple phenotypic effect because it influences a number of characters is an
exception. The gene having a multiple phenotypic effect because of its ability to control of two
or more characters can be seen in cotton. In cotton, a gene for the lint also influences the
height of plant, size of the ball, number of ovules and viability of seeds.
(i) Genes with multiple phenotypic effects are known as?
a) Hydrostatic genes.
b) Duplicate genes.
c) Pleiotropic genes.
d) Complimentary genes.
(ii) Which of the following disorder is an example of genes with multiple phenotypic effects?
a) Phenylketonuria.
b) Haemophilia.
c) Sickle cell anaemia.
d) Both (a) and (c)
(iii) Which of the following is an example of gene with multiple phenotypic effect?
a) Drosophila white eye mutation.
b) Kernel colour in wheat.
c) Height in human beings.
d) Skin colour in human beings.
(iv) Which of the following statements is not correct regarding genes with multiple
phenotypic effect?
a) It is not essential that all the traits are equally influenced.
b) Occasionally a number of related changes are caused by a gene.
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c) It occurs due to effect of the gene on two or more inter-related metabolic pathways.
d) None of these.
(v) Assertion: ln garden pea, the gene which controls the flower colour also controls the colour
of the seed coat and presence of red spots in the leaf axils.
Reason: A pleiotropic gene influences more than one trait.
a) Both assertion and reason are true and reason is the correct explanation of assertion.
b) Both assertion and reason are true but reason is not the correct explanation of
assertion.
c) Assertion is true but reason is false.
d) Both assertion and reason are false.
✓ Answer Key-
➢ Multiple Choice Answers:
1. (b) form one linkage group
2. (a) Aneuploidy
3. (a) a direct relationship
4. (d) Sex-linked recessive.
5. (d) GUG.
6. (b) Co-dominance
7. (d) Peacock.
8. (b) Tt and Tt
9. (d) The alleles of two genes are segregating independently.
10. (c) Linkage
11. (a) non-homologous chromosomes
12. (c) pleiotropy
13. (a) males and females, respectively
14. (b) Mendelian trait
15. (b) observations that the offspring of a cross made between the plants having two
contrasting characters shows only one character without any blending.
➢ Very Short Answers:
1. Dog flower (Snapdragon or Antirrhinum sp.)
2. GAG changes as GUG, Glutamic acid is substituted by valine.
3. Ans.(i) Klinefelter’ s Syndrome (ii) Downs syndrome

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4. Their daughter can never be haemophilic. (0%).

5. Test cross 1 : 1.
6. Non – disjunction.
7. Humans – Colorblindness
Drosophila – Eye colour
8. Aneuploidy is the phenomena of gain or loss of one or more chromosomes that results due
to failure of separation of members of homologous pair of chromosomes during meioses.
9. Law of dominance.
10.It is caused due to a point mutation at 6th position in B-chain of hemoglobin in which
glutamic acid is replaced by valine.
➢ Short Answer:
1. Turners Syndrome : The individual is female and it has 45 chromosomes
i.e., one X chromosome is less.
Klinefelters Syndome : The individual is male and has 47 chromosomes
i.e., one extra X chromosome.
2. The gene for haemophilia is present on X chromosome. A male has only one X chromosome
which he receives from his mother and Y chromosome from father. The human male passes
the X chromosome to his daughters but not to the male progeny (sons).
3.
i. Very short life cycle (2-weeks)
ii. Can be grown easily in laboratory
iii. In single mating produce a large no. of flies.
iv. Male and female show many hereditary variations
v. It has only 4 pairs of chromosomes which are distinct in size and Shape.
4. Point Mutations : Arises due to change in a single base pair of DNA e.g., sickle cell anaemia.
Frame shift mutations : Deletion or insertion/duplication/addition of one or two bases in
DNA.
5. (i). In diploid cells, the chromosomes are found in pairs just like that of mendelian factors.
(ii). During meiosis, the chromosomes of different homologous pairs are assorted
independently into gametes at random showing parallelism with mendelian factors.
6. Mendel’s law of segregation is universally accepted It states that – “the two alleles of a gene
remain separate & do not contaminate each other in F1 or the hybrid. At the time of gamete
formation two alleles separate & pars into deferent gametes.

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7. Since haemophilic is a sex – linked character, it shows criss – cross inheritance i-e from
father to his daughter therefore son of haemopilic father is never haemophilic.
8. If a child has grown from the zygote formed by XX-egg fertilized by Y-sperm, the child will
suffer from klinefiter syndrome & will have XXY genotype. It is characterized by prominent
feminine characters e.g. tall stature with feminised physique, Breast development pubic hair
pattern, poor beard growth & sterility.
➢ Long Answer:
1. (a) Dominant.
(b) Autosomal.
(c) The genotype of parents in generation I – Female: aa and Male: Aa
The genotype of a third child in generation II-Aa Genotype of the first grandchild in
generation III – Aa
2. Advantages of selecting pea plant as experimental material:
Mendel selected pea plant (Pisum sativum) because:
i. Many varieties were available with observable alternative forms for a trait or a
characteristic.
ii. Peas normally self-pollinate; as their corolla completely encloses the reproductive
organs until pollination is complete.
iii. It was easily available.
iv. It has pure lines for experimental purpose, i.e. they always breed true.
v. It has contrasting characters. The traits were seed colour, pod colour, pod shape,
flower shape, the position of flower, seed shape and plant height.
vi. Its life cycle was short and produced a large number of offsprings.
vii. The plant can be grown easily and does not require care except at the time of
pollination.
3. Answer: Recombination refers to the generation of a new combination of genes which is
different from the parental types. It is produced due to crossing over that occurs during
meiosis prior to gamete formation.
Applications of recombination:
i. It is a means of introducing new combinations of genes and hence new traits.
ii. It increases variability which is useful for natural selection under changing environment.
iii. It is used for preparing linkage chromosome maps.
iv. It has proved that genes lie in a linear fashion in the chromosome.
v. Breeders have to select small or large population for obtaining the required cross-overs.
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For obtaining cross-overs between closely linked genes, a very large population is
required.
vi. Useful recombinations produced by crossing over are picked up by breeders to produce
useful new varieties of crop plants and animals. Green revolution and white revolution
were implemented using the selective recombination technique.
➢ Assertion and Reason Answers:
1. (b) Both assertion and reason are true, but reason is not the correct explanation of
assertion.
Explanation:
Linkage group is linearly arranged groups of genes which fail to show independent
assortment as these are present on the same chromosomes.
2. (d) Both assertion and reason are false.
Explanation:
Linked genes are those genes which occurs on the same chromosome while unlinked genes
are the ones found on different chromosomes. Linked gene show dihybrid ratio of 3 : 1.
Linked genes do not show independent assortment.
➢ Case Study Answers:
1.
(i) (c) Recessive and dominant traits.
Explanation:
ln humans, free earlobes is dominant over attached earlobes
(ii) (b) Y linked trait
(iii) (a) 0%
Explanation:
If a female with attached earlobes (ee) married a male with free lobe (EE) and sparse
hair on pinna then chance of any progeny to have attached ear lobe is zero. It can be
depicted as follows

(25)
 PRINCIPLES OF INHERITANCE AND VARIATION
05

(iv) (b) 100%

Explanation:
If a man with attached earlobe (ee) and hairy pinna married a woman with attached
earlobes (ee) than 100% chances of sons to have hairy pinna as hypertrichosis or hairy
pinna is Y linked feature.
(v) (b) All daughters have an attached earlobe.
Explanation:
If a male with attached earlobe sparse hair on pinna married a female with attached
earlobe then all daughters have an attached earlobe.

2.
(i) (c) Pleiotropic genes.
(ii) (d) Both (a) and (c)
Explanation:
The ability of a gene to have multiple phenotypic effects because it influences a
number of characters simultaneously is known as pleiotropy. ln human beings
pleiotropy is exhibited by syndromes, i.e., sickle cell anaemia and phenylketonuria.
(iii) (a) Drosophila white eye mutation.
Explanation:

(26)
 PRINCIPLES OF INHERITANCE AND VARIATION
05

Kemel colour in wheat, height in human beings and skin colour in human beings are
examples of polygenic inheritance, i.e., inheritance controlled by three or more genes.
ln Drosophila, white eye mutation pleiotropic effect, it causes depigmentation in
many part of the body.
(iv) (d) None of these.
(v) (a) Both assertion and reason are true and reason is the correct explanation of
assertion.

(27)
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