Roll No. Total No.
of Pages : 02
Total No. of Questions : 13
B.Pharmacy (Sem.-8)
ADVANCED INSTRUMENTATION TECHNIQUES
Subject Code : BP811ET
M.Code : 79774
Date of Examination : 10-01-2023
Time : 3 Hrs. Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
1. SECTION-A is COMPULSORY consisting of TEN questions carrying T WO marks
each.
2. SECTION-B contains T HREE questions carrying T EN marks each and student
has to attempt any T WO questions.
3. SECTION-C contains NINE questions carrying FIVE marks each and student has
to attempt any SEVEN questions.
SECTION-A
1. Write briefly :
a) Define the Braggs law.
b) What is Spin-Spin coupling?
c) Define coupling constant.
d) Give applications of DTA.
e) Enlist the ICH guidelines.
f) Enlist the different X-ray Diffraction techniques.
g) What is MALDI?
h) Write about analyzer Time of flight.
i) Explain significance of solid phase extraction.
j) What is hyphenated technique LC-MS/MS?
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SECTION-B
2. Explain the principle and working of TGA. (Thermal Gravimetric Analysis).
3. Discuss background and principles of analytical method validation as per USFDA
guidelines.
4. Explain the fundamental principles and instrumental arrangements of NMR.
SECTION-C
5. Explain chemical shift and factors influencing on Chemical shift.
6. Write a note on single crystal diffraction and powder diffraction.
7. Discuss the instrumentation and application of DSC.
8. Write limitations and application of RadioImmuno Assay.
9. Write a comparative account on calibration and validation.
10. Describe the rules for fragmentation of molecules in Mass Spectrometry with suitable
examples.
11. Describe instrumentation and applications of C-NMR.
12. Explain the principle and procedure involved in the liquid-liquid extraction.
13. Enlist different ionizers used in Mass Spectrometry and explain any one detail.
NOTE : Disclosure of Identity by writing Mobile No. or Marking of passing request on any
paper of Answer Sheet will lead to UMC against the Student.
2 |M-79774 (S29)-1672
