A REPORT ON PRACTICE SCHOOL/INDUSTRIAL TRANING

“PRACTICE SCHOOL REPORT”

A Project Submitted In Partial Fulfillment of the Required for the Degree of

BACHELOR OF PHARMACY
By

ASHISH RATHOR
0923PY211023
Under the Supervision of
DR. BHARAT TYAGI
Associate Professor
COLLEGE OF PHARMACY

INSTITUTE OF PROFESSIONAL STUDIES COLLEGE OF

PHARMACY, GWALIOR, M.P 474002

[1]
 INSTITUTE OF PROFESSIONAL STUDIES COLLEGE OF
PHARMACY

CERTIFICATE
This is to certified that ASHISH RATHOR has carried out the entitled “PRACTICE
SCHOOL REPORT” for the award of BACHELOR OF PHARMACY From RAJIV
GANDHI PROUDYOGIKI VISHWAVIDYALAY UNIVERSITY BHOPAL, under
my supervision. This practice school report work and the studies carried out by
the student and the content of the report do not form the award of any other
degree to the candidate or to anybody else.

Principal Supervision
Dr. Pradeep Chauhan Dr. Bharat Tyagi

Institute of professional studies Associate Professor

College of pharmacy, Gwalior I.P.S College of Pharmacy,

Gwalior

[2]
 INSTITUTE OF PROFESSIONAL STUDIES COLLEGE OF
PHARMACY

DECLARATION

I hereby declare that this "PRACTICE SCHOOL/INDUSTRIAL TRAINING"

entitled in "PRACTICE SCHOOL REPORT" at" REVANTIS HEALTHCARE "
BADDI DISST. SOLAN ( H.P ) . submitted to RGPV, BHOPAL is a bonafide
and genuine work carried out by us under the guidance of Dr. BHARAT
TYAGI. I also declare that the material entitled in it is original and the
same has not previously formed the basis for the award of any diploma,
degree, association ship or fellowship of other university or institute.

ASHISH RATHOR

0923PY211023

Date………………

[3]
 INSTITUTE OF PROFESSIONAL STUDIES COLLEGE OF
PHARMACY

CERTIFICATE BY THE GUIDE

This is certifying that the report entitled the study of "PRACTICE SCHOOL
/INDUSTRIAL TRAINING REPORT" is a bonafide work done by
MANEESH RATHORP in a partial fulfillment of the requirement of the degree
of "Bachelor of Pharmacy" of RGPV Bhopal.

Signature

Dr. Bharat Tyagi

Associate professor

I.P.S COLLEGE OF

Date ……….. PHARMACY, GWALIOR

[4]
 ACKNOWLEDGMENT

It is always a pleasure to remind the fine people in Institute of

professional studies College of Pharmacy, Gwalior for their
guidance, I received to uphold my practical as well as laboratory
skills in Pharmacy.

First of all Thanks to my parent for giving me encouragement,

enthusiasm & assistance to me. Without all this I might not be
able to complete this subject properly.

Second, I would like to Thanks to Mrs. Shobha Mishra The

Chairman of IPS GOC and Mr. Arun Kumar Tyagi The Director of
IPS GOC and Mr. PK Ghosh The CEO of IPS GOC for giving us the
opportunity to undergo industrial training.

Thirdly, I also want to express my deepest thanks to GRISH

TIWARI sir as industry Training advisory for Quality assurance
and Quality control department that has helped me a lot in
dealing with Industrial Training. He supported me showing
different methods of information collection about the
manufacturing plant.

Also, I express my special Thanks to Dr. Bharat Kumar Tyagi, Dr.

Atul Kaushik Dr. Sandeep Jain, Dr. Amit Jain, Mr. Urvesh Singh
Narwaria Associate professors of Institute of professional
studies, college of Pharmacy as the report advisor. All helped all

[5]
time when we needed and he gave right direction toward
completion

of project.

I express my thanks to Mr. Janmenjay Singh Tomar, Dr. Aman

Shrivastava, Mrs. Poonam Bhadouriya, Mr. Rahul Khanna, Mr.
Radharaman Tiwari, Mr. Hiresh Dutt, faculty of Institute of
professional studies College of Pharmacy Gwalior.

All helped all time when we need and he gave right direction
toward completion of Training.

Besides, I would like to Thank Dr. Pradeep Chauhan The

principal of Institute of professional studies College of
Pharmacy Gwalior for extending their belief on me and making
a pleasure Training environment.

Finally, I apologize all other unnamed who helped me in various

ways to have a good training.

NAME :- ASHISH RATHOR

( B.PHARMA 7TH ‘SEM’ )

ENROLLMENT NO. 0923PY211023

BATCH :- “A”

[6]
 INDEX

Sr. No. CONTENTS Page No.

1 Introduction 8

2 Industry Profile 9

3 Product 10

4 Manufacture of Pharmaceutical Tablets 11 - 19

5 Capsule Manufacturing Process 20 - 26

6 27 - 35
Types of Syrups and Their Uses

7 CONCLUSIO 36
N

[7]
 INTRODUCTION

Now a day, the craze of pharmacy is on the top of the world, because a pharmacist is

that one, who studied the complete history of drug from invention of drug to launch in the

market for welfare of human and animals.

In the olden age, medical science was not well developed and there by the human

suffered a lot to survive. The medical science has been developed along with civilization.

At that time, human used the natural sources for medication purpose. With the

development of science, inventions, and discoveries of various instruments were made

possible to study the medicinal compounds that are present in the sources which was

used in old time. In the view of UG program B. Pharmacy as per PCI curriculum in 7TH

semester includes the Practice School cum industrial Training to gain the knowledge, skills

acquired about pharmaceutical industry / Scientific Laboratories, Hospitals (clinical

pharmacy & community pharmacy) and we have submit Practice School cum industrial

Training report

[8]
 INDUSTRY PROFILE
REVANTIS HEALTHCARE PRIVATE LIMITED, a tested & trusted
name in Indian pharmaceutical industry having more
than 1 years of experience in manufacturing and
exporting of pharmaceutical formulations, trading of raw
materials and Research & Development for
pharmaceutical Industry and company is establish since
2023 GMP and GLP certified company.

Selection tablets, capsule and oral liquid general, cardiac

diabetic, general antibiotics etc.

Our MISSION is to provide humanity as a whole with a

wide choice of cost effective, quality products and
services for the improvement of health and treatment of
medical conditions.

Our VISION is to product innovation and technology

upgradation thereby strengthening our position to strive
for leadership in pharmaceutical and allied services.

[9]
Products

[10]
Manufacture of Pharmaceutical Tablets
The design and manufacture of pharmaceutical tablets isa
complex multi-stage process whereby formulation scientists
ensure that the correct amount of drug substance in the right
form is delivered at the appropriatetime, at the proper rate
and in the desired location with its chemical integrity
protected to that point. Most drug substances do not possess
the required properties whichgive satisfactory flow from the
hopper to the die cavity
of tablet presses. As a result, they are subjected to pre-
treatment either alone or in combination with suitable
excipients to form free-flowing granules that lend
themselves to tabletting.

Tablets are commonly manufactured by wet granulation,

dry granulation or direct compression. Thesemethods may be
considered to consist of a series of steps (unit processes) –
weighing, milling, mixing, granulation, drying, compaction,
(frequently) coating and packaging. Regardless of the method
used the unit processes – weighing, milling and mixing, are
the same; subsequent steps differ.

Primary goals of tablet manufacturing processThe

primary goals include:
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1. To formulate tablets that are strong and hard to withstand
mechanical shock encountered during manufacturing,
packing, shipping, dispensing and use.
2. To formulate tablets that are uniform in weight and indrug
content.
3. To formulate tablets that are bioavailable according to
indication requirements.
4. To formulate tablets that are chemically and physically
stable over a long period of time.
5. To formulate tablets that have elegant product identity
which is free from any tablet defects.
Factors that influence the choice of manufacturingprocess
used during tablet formulation

In general, the choice of formulation process employedduring

tablet manufacture is dependent upon such factors as:

1. Compression properties of the Active Pharmaceutical

Ingredient (API)/ drug substance.
2. Physical and chemical stability of the API during the
manufacturing process.
3. Particle size of the formulation ingredients.
4. Availability of the necessary processing equipment.
5.Cost of the manufacturing/formulation process.
Personnel requirements during manufacture of
pharmaceutical tablets

 Production pharmacists/ supervisors

[12]
 Manufacturing chemist
 Analytical chemist
 Quality assurance manager
 Machine operators
 Mechanics
In addition to the job-specific responsibilities of these personnel, all
manufacturing employees must be versedand trained in Current
Good Manufacturing Practices (CGMPs) and in the appropriate
Standard Operating Procedures (SOPs) governing their area.

Area required for manufacture of tablets

 Raw material warehouse

o Receiving quarantine
o Approved raw material section
 Dispensary
 Production room
o Mixing, Granulation
and Drying Section
o Tablet Punching
Section
o Coating Section
 Quality control section
 Packaging Section.
Excipients used in tablet formulation/ Tablet raw

[13]
materials

Tablets in addition to the therapeutic agent(s) also contain

excipients that are required to ensure satisfactory production
process. These materials which are inert may be added to the
drug substance to increase its bulk and give those desirable
properties lacking in the drug substance alone. Depending on
the intended use, tablet excipients may be subcategorized into:
1. Those that help to impart satisfactory processing and compression
properties to the formulation and
2. Those that help to give additional desirable physical characteristics to
the compressed tablet.

Many excipients used in tablet formulation are multi-functional that

is, they may serve more than one function and thus can affect the
properties of powders or tablets in various ways at varying
concentrations.

Evaluation/ quality control of raw materials used

inthe manufacture of tablets
Quality control of tablet raw materials (APIs and excipients) is one of the main
tasks of the quality control unit in any drug manufacturing industry. Raw
materials described in monograph of relevant Pharmacopoeia must undergo the
necessary tests as stated in the monograph. It is often sufficient if identification
testing is conducted onthe individual packages/containers and content and
purity determination in mixed samples.

Every manufacturer has the opportunity to carry out further testing if they
deem it necessary for guaranteeing a smooth-running productionprocess or a
very high-quality product. Starting materials are releasedonly after their quality
are established or judged as satisfactory. Raw materials that fail the quality
control test are rejected and returned to the supplier.

Any risks that may emanate from starting materials of inappropriatequality

must be avoided to prevent product failure and to ensure a

[14]
 consistent level of quality, as well as safety in consumer and industrial products.

Tablet Manufacturing Equipment/ Machines

Common equipment used in pharmaceutical tablet manufacturing include:

1. Size reduction equipment/ communition equipment e.g., hammer mill,

vibration mill, roller mill, pin mill, fluidized energy mill, end-runner mill, edge-
runner mill, cutter mill and ball mill.
2. Weighing balance/ balances e.g., bulk weighing balance (weighs in
kilogram), electronic weighing balance (weighs in grams and milligrams).
3. Mixing equipment e.g., pneumatic mixers (air-mix mixer or air-driven mixer),
diffusion/ tumbling mixers (e.g., V-blender, double cone blender, cubic mixer,
drum blender), convective mixers (e.g., ribbon blenders, orbiting screw mixers,
horizontal high-intensity blenders, planetary blenders, diffusion mixer with
intensifier bar/agitator, Forbergblenders, horizontal double arm mixers, vertical
high-intensity mixer).
4. Granulators e.g., rotating shape granulators, mechanical agitator granulators
(e.g., ribbon or paddle blender, sigma blade mixer, planetary mixer, orbiting
screw mixers), high-shear granulator, fluidizedbed granulator, dry granulator etc.
5. Dying equipment e.g., spray dryer, rotary dryer, fluidized bed dryer
etc.
6. Tabletting machine – single punch tablet press and multi-station/ rotary
tablet press (e.g., High-speed rotary tablet machines and multi-layer rotary
tablet machines).
7. Quality control equipment e.g., disintegration equipment (Manestysingle
unit disintegrating apparatus or Erweka multiple unit disintegrating
apparatus), USP Dissolution Tester, Tablet Hardness Tester, Tablet Thickness
Tester, Tablet Friability Testers etc.
8. Coating and polishing machines for coated tablets e.g., standardcoating
pan, perforated pan, fluidized bed/ Air suspension coating system etc.
9. Packaging machines e.g., blister packaging machines, strip packingmachine,
aluminium foil packaging machine, etc.

[15]
 Tablet Manufacturing Equipment continues to improve in
both production speed and uniformity of the tablets
compressed.

Steps Involved In Tablet Formulation/ Procedure for

Manufacturing Tablets
1. Dispensing: Each ingredient in the tablet formula is weighed and accurately
dispensed as per dose. This is one of the critical steps inany type of
formulation process and should be done under technicalsupervision.
2. Sizing: Formulation ingredients must be in finely divided form, otherwise, size
reduction should be carried out for better flow propertyand easy mixing.
3. Powder blending: Powders are mixed using a suitable blender to obtain a
uniform and homogeneous powder mix. The drug substanceand excipients are
mixed in geometric dilution.
4. Granulation: Here small powder particles are gathered together intolayers,
and permanent aggregates to render them into free-flowing states.
5. Drying and dry screening: Screened wet granules need to be dried for a
particular time period in tray dry or fluid bed dryer at controlled temperature not
exceeding 550C. Dried granules are screened throughthe appropriate mesh
screen.
6. Tablet compression: This step involves the compression of granulesinto a flat
or convex, round, oblong, or unique shaped, scored or unscored tablets;
engraved with an identifying symbol and/ or code number using tablet press.
7. Coating: Tablets and granules are coated if there is need to mask the
unpleasant taste/odour of some drug substance or to increase the aesthetic
appeal of uncoated tablets as well as to modify the release orcontrol the release
of drug substance from tablets. This is achieved by enclosing or covering the
core tablet or granules with coating solutions.

Some of the steps above are skipped depending on the manufacturingprocess

used during tablet formulation.

Techniques/ Methods Used in Tablet Formulation

Tablets are commonly manufactured by

[16]
1. Wet granulation
2. Dry granulation or
3. Direct compression.
One important requirement is that the drug mixture flows freely from the hopper of the
tabletting machine into the dies to enable high-speed compression of the powder mix
into tablets.

Manufacture of tablets by wet granulation method

Wet granulation is a widely used method for the production of compressed

tablet. It is essentially a process of size enlargement involving several steps and
the use of an adhesive substance knownas

[17]
 binder. The granules produced using this method of granulation has a greater
probability of meeting all the physical requirements for tablet formation.

Flowchart of wet granulation process

A stepwise summary of the manufacturing steps used in the manufacture of tablets

by the wet granulation method are listed below.

1. Weighing, milling and mixing of the APIs with powdered excipients(excluding the
lubricant)
2. Preparation of binder solution
3. Mixing of binder solution with powders to form a damp mass
4. Screening the dampened powder into pellets or granules (wetscreening) using 6-
to 12-mesh screen
5. Drying of moist granules
6. Sizing the granulation by dry screening using 14- to 20-mesh screen
7. Mixing of the dried granules with lubricant and disintegrants
8. Compression of granules into tablets.

Tablets manufactured by wet granulation exhibit sufficient mechanical

properties to be subsequently exposed to other unit operations,
e.g. film coating

Manufacture of tablets by dry granulation method

The formation of granules by compacting powder mixtures into large pieces or
compacts which are subsequently broken down or sized into granules (often referred
to as dry granulation, double compression or pre-compression) is a possible
granulation method which, however, is not widely used in the manufacture of tablets.
This method is used when tablet excipients have sufficient inherent binding
properties. The procedure can also be used as a means to avoid exposure of drug
substances to elevated temperatures (during drying) or moisture.
Double compression method eliminates a number of steps but still

[18]
includes weighing, mixing, slugging, dry screening, lubrication, and
compression of granules into tablets. Compaction for the dry
granulation process is generally achieved either by slugging or roller
compaction.

Slugging

In this method, the powder mix is compressed into a soft large flat tablet
(about 1 inch in diameter) using a tablet press that is capable of
applying high stress. Following this, the slugs are broken by hand or
milled using conventional milling equipment to produce granules of the
required size. Lubricant is added in the usual manner, and the granules
then compressed into tablets. Aspirin is a good example of where
slugging is satisfactory. Other materials, such as aspirin combinations,
acetaminophen, thiamine hydrochloride, ascorbic acid, magnesium
hydroxide, and other antacid compounds, may be treated similarly.

Roller Compaction
Results similar to those accomplished by the slugging process are also
obtained with powder compactors. In roller compaction method, the
formulation ingredients are mixed and are passed between high- pressure
(oppositely) rotating rollers that compress the powder at 1 to 6 tons of
pressure. The compacted material is then milled to a uniform granule size
and compressed into tablets after the addition of a lubricant. The roller
compaction method is often preferred to slugging.
Excessive pressures that may be required to obtain cohesion of certain
materials may result in a prolonged dissolution ra

[19]
Capsule Manufacturing Process

The process of capsule manufacturing is essential for

companies that deal with supplements and medicines. Usually,
the process involves the steps that need to be followed for
expected outcomes. It involves the whole parts, from melting
the raw material to printing to shipping the packaged capsules.

Understanding the process will help your workers and company

to manufacture the capsules successfully. So, let’s get into it
and learn the overall steps in the following section!

[20]
Capsule Raw Materials &
Manufacturing Environment
If you want to know how capsules are made, you must know about some basic
requirements before starting manufacturing. Check some crucial things that will help
you!

RAW MATERIAL

In the capsule manufacturing process, you should use high-quality raw materials—a few
examples to meet the highest standards, including USP-NF, JP, and EP.

COLORANT

[21]
 You can decide what type of capsule you want, colored or
opaque. Colorants are generally used in the melting phase to
give color to the pills.

CLEANLINESS
The most vital thing to do is the proper cleanliness of the
manufacturing area. It is maintained to the ISO 14644-1 class 8

standard in pharmaceutical and medicine companies.

HYGIENE
The employees or workers involved in capsule production must strictly
follow the hygiene guidelines. Before entering the manufacturing area,
they must maintain hygiene from the beginning.

Capsule Manufacturing Process

The first part of the capsule manufacturing process involves melting the
raw material. Moreover, the coloration is also done for easy
distinguishability. Let’s check out the appropriate details and steps to
make capsules:

. Before entering the manufacturing area, they must maintain hygiene

from the beginning.

PART 1: Raw Material Melting & Coloration

Step 1: The raw material that meets the acceptance test requirements is

brought into the manufacturing area.

[22]
Step 2: Raw material contained in the hopper is automatically weighed in
the container.

Step 3: Now, the weighted material will be shifted from the container to
the melting tank.

Step 4: Purified water is added to the melting tank before finally

starting the melting process.

[23]
 Step 5: After initiating the melting, the mixture gets stirred to create a
uniform jelly.

Step 6: In this step, the colorant can be added to the colored capsules.

PART 2: Capsule Molding & Cutting

Step 1: In the capsule production room, the capsule
manufacturing machines receive the colored jelly.

Step 2: The pins are then dipped into the jelly mixture. M
Molding
olding pins are
then shifted to the drying unit.

Step 3: The drying process will be at a constant temperature and humidity.

After the drying process, these are sent to the next section.

Step 4: Now, the dried caps and bodies are removed from the molding pins.

[24]
Step 5: The caps and bodies will be trimmed to an appropriate length and
then pre-locked.

Step 6: Next, an immediate visual inspection of all the capsules will be done.
The light is flashed on the rotating capsules, and the digital images are
captured with cameras. Besides, image processing technology is used to
detect abnormal shapes.

Step 7: In the last step, the conformed capsules will be packed into the
containers.

PART 3: Printing, Inspection & Packaging

CAPSULE PRINTING
Step 1: Now, the printing of the capsules started for the product
identification purpose.

[25]
 Step 2: The specified design is printed in the capsules by utilizing the ink
and printing machine of the company.

Step 3: An alternate option can also be used for printing without ink. In this
part, you can use the laser printing machine.

Syrup manufacturing facilities are commonly found in regions with access to raw
materials and production resources. Geographical location plays a significant role in
the availability of ingredients and the overall manufacturing process.

1. Raw Material: These facilities cozy up to the sources of their main ingredients, like
sugar. Being close to sugar refineries means a steady supply and less transportation
fuss, which can save both time and money.
2. Quality Quest: They pick spots where top-notch ingredients grow. After all, better
ingredients lead to better syrups. Being where premium ingredients are abundant
ensures syrup superiority.
3. Resource Ready: Making syrup is like orchestrating a grand symphony; it takes
energy, water, and a bunch of equipment. Facilities in regions with these resources
readily available keep the syrup-making show running smoothly.
4. Green Syrup Secrets: Some locations offer cleaner energy sources, which align
with the syrup industry’s eco-friendly aspirations. It’s like syrup-making with a green
twist, helping reduce the environmental footprint.

[26]
 Types of Syrups and Their Uses

Syrups come in various types, each designed for a specific purpose. These include cough syrups, sugar syrups,
and pharmaceutical syrups.Cough syrups help alleviate discomfort caused by respiratory issues, sugar syrups serve
as sweeteners and bases for beverages, and pharmaceutical syrups deliver medication in a liquid form.

Here are some of the most common cough syrups:

Amoxicillin Paracetamol Chlorpheniramine Salbutamol

Bromhexine Maleate Dextromethorphan
Cetirizine Hydrochloride
Cefpodoxime Proxetil Erythromycin
Protein Powder
Cefixime Ambroxol Ephedrine/Guaifenesin Syrup
Cloxacillin
Iron Tonic
Pseudoephedrine
Cefadroxil Multivitamins Clarithromycin
Cephalexin Cefaclor Phenylephrine
Cefuroxime

Ingredients Used in Syrup Manufacturing

The core ingredients of syrups typically include sugars, sweeteners, and active ingredients. These
components play a crucial role in defining the flavor, texture, and therapeutic properties of the
final product.

Chesty Coughs Ingredients

[27]
 A chesty cough is a result of too much mucus being produced, whichmay be thick and
difficult to cough up.
 Expectorants are active ingredients that help to break up any excessmucus that may have
accumulated.
Dry Coughs Ingredients

 For a dry tickly cough, an over-the-counter medicine containing acough suppressant

to block the natural coughing reflex, such as pholcodine and dextromethorphan,
should help.
Sugar Syrups Ingredients/Maple Syrup
Sweeteners and bases for beverages. Common applications include: Flavoring
drinks, making cocktails, and desserts
Here’s a typical list of ingredients and percentages in the solution for cough syrups:

Ingredients Percentage Function

Paracetamol 2.5% Active ingredient

Polyethylene Glycol 10% Solubilizer

Glycerin 2.5% Diluent and

sweetener

Sucrose 30% Sweetening agent

Distilled Water 20% Diluent

Sweetener 0.2% Sweetener

Sodium Methyl Paraben 0.150% Preservative

Sodium Propyl Paraben 0.03% Preservative

Sodium Benzoate 0.150% Preservative

Citric Acid Monohydrate 0.07% pH modifier

Coloring Agent 2.5% Coloring agent

Flavor 0.25% Flavoring agent

[28]
The Syrup Making Equipment

To produce high-quality syrups, specialized equipment is essential. Mixers,

dissolvers, storage tanks, and filtering systems ensure the manufacturing process
is efficient and the product meets industry standards.

The Syrup Manufacturing Process

[29]
The syrup manufacturing process consists of several key
steps, ensuring the final product is consistent, safe, and
high in quality.

1. Sugar Preparation and Melting

Before manufacturing begins, sugar is graded, sieved, and
transferred to a vessel to remove impurities. Distilled water is
introduced and heated, creating a sugar-water solution. This melted
sugar solution serves as the base for syrup production.

2. Mixing and Dissolution

In the mixing vessel, the sugar solution is vigorously mixed with
other ingredients, such as active pharmaceutical ingredients or
flavorings. The high-speed mixing, coupled with heat, efficiently
disperses the ingredients into the solution, creating a
homogeneous product.

3. Cooling and Filtering

[30]
After the initial mixing, the syrup undergoes cooling and filtering to remove
impurities and maintain its quality. The filtration process ensures the syrup is free
of unwanted particles and agglomerates.
4.Packaging and Quality Control

Once the syrup is ready, it is transferred into small bottles and undergoes a final
quality control check. Packaging is essential to ensure the product reaches consumers
in optimal condition.

Syrup Mixing Process

 Prior to mixing the ingredients, the preliminary steps are grading and sieving the
sugar to remove impurities and unwanted particles from the ingredients.
 Then the partially cleaned sugar is transferred through vacuum to a vessel to
melt it.
 Distilled water is introduced into the vessel with the sugar in it and heated,
melting the sugar and producing a sugar water solution.
 The melted sugar will be filtered further, removing impurities, and then transferred
into a manufacturing/main mixing vessel.
 In the mixing vessel, the pharmaceutical syrup is made by vigorously mixing the
sugar water with other ingredients such as drugs, medicine powders, and vitamins.
 A cooling system cools the syrup transfer through an inline homogenizer and filter
press for homogenized mixing and filtering up to 5 microns size in the storage tank.
 Post-processing of syrup is done before transferring it to small bottles and packing.

Factors Affecting Syrup Quality

Maintaining high-quality standards in syrup manufacturing is crucial. Challenges

such as improper dissolution, varying viscosities, and equipment quality can affect
the final product. Employing specialized equipment and rigorous quality control measures
mitigates thesechallenges.

[31]
 Factors Impact on Quality

Dissolution Ensures even consistency

Viscosity Affects the syrup’s texture

Equipment Quality Influences production

Quality Control Measures Ensures product consistency

The Problem

Using conventional mixers and agitators for this process leads to several
potential problems:

 The sugars are not properly dissolved to form the syrup.

 Hydration of powdered ingredients.
 Varying viscosities of ingredients and inefficient mixing systems lead to a
non-uniform mixture and undissolved active ingredients.
 The end product is not smooth, agglomerate-free, and homogeneous.
 The equipment does not conform to GMP standards, which means that it
doesn’t have self-cleaning features.
 High-energy heating is required to heat the sugar solution.
 Crystallization of the syrup can occur during heating/cooling.
 Heat can damage active ingredients.

The Solution

 When the mixing vessel is charged with the sugar-water solution and

[32]
 the powdered ingredients are added, the high-speed rotation of the
rotor blades creates a powerful suction that draws liquid and solid
ingredients into the workhead, mixing it thoroughly.
An electric motor drives the shaft inside the mixing tank. This shaft is
coupled with an impeller which it is rotated at a high speed, driving the
sugar-water solution and powdered materials with strong centrifugal force.
The mixer incorporates a high fluid shear inside the tank.

 The intake and expulsion of materials through the workhead ensures that
the contents of the vessel pass many times through the workhead. The
combination of heat, vigorous mixing, and particle size reduction
accelerates the melting process of the ingredients and rapidly disperses
the powder grinds into the sugar and water to produce a homogeneous
end product.
 In this way, the syrup mixer rapidly disperses solids into liquids,
hydrates the thickening and stabilizing agents, breaks down the
remaining agglomerates, and finely reduces particle and globule size.

Advantages of Ginhong Syrup Mixer:

 Efficiency and Energy Savings: Ginhong’s mixer can produce

66% sucrose syrup at ambient temperatures, significantly
saving energy while ensuring that the heat of dissolution is
imparted in the form of shear. This not only benefits the
environment but also your production costs.
 Consistency and Repeatability: Batch-to-batch product
consistency and stability are paramount in pharmaceuticals.
Ginhong’s mixer excels in maintaining these crucial factors,
[33]
 offering not only reliable quality but also high manufacturing
savings.
 Texture and Quality: Ginhong’s mixer can create a uniformly
mixed product, resulting in a smoother texture and better
consistency in cough syrups. This ensures that each dose is
as effective as the last.
 Agglomerate-Free Mixture: The mixer’s technology ensures that
your mixture is agglomerate-free, avoiding clumps or
inconsistencies in the final product.
 Reduced Waste and Sanitary Conditions: Ginhong’s mixer
features a scraper that efficiently gathers material wastes
without interrupting the production process. Moreover, the mixer
and auxiliaries conform to Good Manufacturing Practice (GMP)
standards and Cleaning-in-Place (CIP) regulations, ensuring
sanitary and safe production.

These advantages make Ginhong’s cough syrup and liquid medicine

mixer a valuable asset for pharmaceutical companies, ensuring high-

quality, efficient, and environmentally friendly production of

cough syrups.

Recommended Ginhong Syrup Mixing Equipment

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1.Ginhong High
Shear Mixers

 JX Lab Batch
Homogenizer
 ZX Powder Liquid Mixer
 DX Bottom Entry
Homogenizer
 ZX Inline Homogenizer
 FS High-Speed
Disperser

1. Ginhong Vacuum Emulsifier Homogenizer

 RX Vacuum Homogenizer Mixer: Performing mixing under

vacuum conditions, this mixer eliminates the unwanted
effects of aeration, making it ideal for producing high-quality,
bubble- free cough syrups.
 RS Vacuum Emulsifier Mixer: The RS Vacuum Emulsifier Mixer
ensures that your cough syrup remains free from aeration,
resulting in consistent and top-quality products.

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 CONCLUSION

In the end I am glad to tell that training in REVANTIS HEALTHCARE

PRIVATE LIMITED was an excellent end fabulous experience. During
the training I actually learned about the Pharmaceutical Company and
above it’s working the theoretical knowledge is worth from getting a
degree, and it is accessible in the book. We can only imagine about the
thing we read, but practical life is always different and excellent one.
During my training period. I had seen the various instrument that work
preciously must be operated with intense care for optimum use. We could
acquire a lot of information regarding the latest instrument and their working
procedure.

Similarly from practical point of view a pharmaceutical company is very

difficult. During the training session I tried to my level best to gain practical
knowledge as much as I can. I improved my basic classified doubts and
also understood the importance to maintaining of quality of products at
pharmaceutical company.

I was successfully able to complete my short venture of training.

Lastly I hope that my training report fulfill the intended requirements.

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