Comprehensive Guide To Post Cycle Therapy Desbloqueado
Comprehensive Guide To Post Cycle Therapy Desbloqueado
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There are a few ways to come off your Steroid Cycle to restart HPTA and produce
Testosterone and Semen in the Testicles again. In this eBook, we’ll discuss the
most effective ways to follow Post-Cycle Therapy (PCT) correctly for normal &
healthy Testosterone levels, which should represent your age & current state
of health! Keep in mind that the Fertility Drugs & Supplement Protocols
incorporated during PCT improve fertility tremendously; the use of
Contraceptives might be required!!
GH & Clenbuterol don’t negatively affect HPTA & HPAA and might even improve
the success of your PCT by improving nutrient partitioning and metabolic rate.
At the same time, improving fat loss or minimizing body fat gain in a slight
caloric surplus.
Assuming you sleep according to your Circadian Rhythm, falling asleep between
10-11 PM and waking up around 6-7 AM, the highest natural GH pulse of the day
occurs somewhere between 1-3 AM when you’re in deep REM sleep. Those who
sleep outside of the regular Circadian Rhythm often see their night-time GH
pulse diminish as Cortisol levels fluctuate according to the day & night cycles.
Sunlight at dawn or dusk instructs the body to release Cortisol, to wake you
from sleep according to the Circadian Rhythm.
This eBook doesn’t cover Growth Hormone Secretagogues like GHRP-6, MK-677,
or Ipamorelin. For more information about Growth Hormone and
Secretagogues, consider purchasing the “Comprehensive Guide to Growth
Hormone | Insulin-like Growth Factor-1” eBook on The VigorousSteve.com Shop:
www.vigoroussteve.com/shop/
Clenbuterol
Clenbuterol does not actively burn fat by stimulating the Beta-2 Receptors of
the fat cells, although it does induce Lipolysis and increases Free Fatty Acids
(FFA) concentrations in the bloodstream. Clenbuterol stimulates the Beta-2
Receptors on cardiac & skeletal muscle, which increases fatty acid metabolism
& body temperature in a dose-dependent fashion. This allows the individual to
burn dietary fat and body fat at an accelerated rate. Cardiac muscle
predominantly utilizes FFAs. A continuously elevated heart rate contributes to
most of Clenbuterol’s fat-burning effects.
Headaches & blood pressure issues are rare at low-moderate dosages but not
impossible to occur. Individuals who suffer from pre-existing high blood
pressure shouldn’t use Clenbuterol. Beta-Blocker like Bisoprolol or Nebivolol
mitigate the side-effects but also reduce Clenbuterol’s effectiveness
significantly! Especially Butaxamine, which is a Beta-2-Selective Beta-Blocker.
For more information about Clenbuterol, consider purchasing the “Fat Loss
Pharmacology Handbook” eBook on The VigorousSteve.com Shop:
www.vigoroussteve.com/shop/
NOTE: Healthy reference ranges for these hormone markers will differ on each
country’s standards for medical care.
You can slowly taper down the Testosterone dosages over a few weeks,
depending on the total dose of AAS or Testosterone you were using previously.
For the sake of convenience, it’s probably easiest to switch to a Testosterone
Ester with a longer Half-Life, such as Enanthate or Cypionate, which allows for
bi-weekly injections. For example; 1,000mg Testosterone per week tapered to
750mg Testosterone for 2 weeks, 500mg Testosterone for 2 weeks, 250mg
Testosterone for 2 weeks, 125mg Testosterone for 2-4 weeks until that becomes
your new baseline!
Depending on the other AAS or SARMs you were using during your Cycle, you
might need to stay on Testosterone Replacement Therapy for several months
for the compounds and their metabolites to clear from your system entirely!
SARMs also suppress HPTA & HPAA and lower Testosterone levels in individuals
who use SARMs without a Testosterone Base. Unfortunately, the medical data
is extremely limited at this point. Most SARMs are still undergoing Clinical
Trials, or further research has already been abandoned. For successful recovery
of HPTA, SARMs need to be discontinued well before starting PCT!
Below is a list of commonly used AAS & SARMs, their known Half-Lives,
Calculated Active-Lives (5x the duration of the Half-Life), and known Detection
Times of their metabolites. Keep in mind that the carrier oil also contributes to
the Half-Life & Active-Life of a particular compound. Pharmaceutical grade
Testosterone or Primobolan in Castor Oil might have a biological Half-Life of up
to 33.9 days!
Injectable Compounds
Oral Compounds
• S-4 (Andarine): Half-Life; 3-6 hours, Active-Life; 15-30 hours, Detection Time;
unknown.
Once these compounds have cleared your system entirely and you’ve given
yourself enough time TRT until that feels normal, then you can safely stop the
Testosterone injections entirely in preparation for PCT. After discontinuing TRT,
you patiently wait until you feel lethargic, have reduced sex drive & libido, lack
the usual pump in the gym, and lack the motivation to go to the gym altogether.
That’s the perfect time to start PCT after a long Cycle with AAS or SARMs, as that
means there’s ZERO AAS or SARMs left in your system to suppress HPTA and
prevent the PCT from being successful!
Although the common practice of using HCG on Cycle is anywhere between 100-
250iu HCG 2-3x per week, this results in constant activation of the Luteinizing
Hormone / Chorio-Gonadotropin (LHCG) Receptors. As LH or HCG activates the
LHCG receptors on the cell membrane, Guanine Nucleotide-Binding Proteins (G-
Proteins) release into the Leydig Cell’s interior (cytoplasm), which starts a
cascade of processes, eventually resulting in Testosterone & Semen
production.
To prevent the downregulation of LHCG Receptors, HCG should only be used for
short-term periods to restore libido when hormone balance is off. Or for the
complete restoration of HPTA by following a Post-Cycle Therapy (PCT) correctly!
Serum Estradiol (E2) levels are directly correlated to the production &
upregulation of Luteinizing Hormone / Chorio-Gonadotropin (LHCG) Receptor in
the Leydig Cells of the Testicles. FSH also upregulates the LHCG Receptors. It
might be beneficial to end up with serum Estrogen levels towards the middle-
top of the reference range, between 25-44 pg/mL but not above the reference
range when you start your PCT protocol.
Medium Estrogen levels give you a buffer in which serum Estrogen levels can
naturally increase with fertility drugs like HCG, HMG, or Triptorelin. While
stimulating Luteinizing Hormone (LH) & Follicle-Stimulating Hormone (FSH)
production with Triptorelin, Nolvadex & Clomid, or replacing LH with HCG, you
don’t require any additional AI.
HCG, HMG & Triptorelin increase Estrogen production directly in the Testicles.
Aromatase Inhibitors aren’t able to reduce Testosterone’s conversion into
Estrogen, as they’re unable to enter the Testicles to potentiate their effects on
the Aromatase Enzymes. Individuals that noticed relatively high Aromatase
Activity & serum Estrogen levels during their Cycle can consider
Diindolylmethane (DIM) & Calcium D-Glucarate (CDG). These supplements help
to keep serum Estrogen levels around the reference range while you’re
restarting HPTA & HPAA. DIM & CDG can be discontinued 4 weeks after the last
HCG, HMG, or Triptorelin injection, usually around the time you finish the PCT
with Nolvadex & Clomid. Men with relatively high body fat levels (over 20%) can
continue with DIM & CDG to keep serum Estrogen levels in range after
completing their PCT.
Diindolylmethane (DIM)
NOTE: If you’re using an excessively high dose of CDG to reduce toxins & Phyto-
Estrogens, these Neuro-Steroid & Sex-Hormones will also undergo optimized
glucuronidation, resulting in decreased serum concentrations while CDG
supplementation is high!
HCG used to be extracted from pregnant women’s urine, as their urine contains
a relatively high HCG concentration. Nowadays, HCG is synthesized with
recombinant technology, allowing for pure HCG production, which is not
contaminated by other proteins present after urinary extraction.
HCG has structural similarities to LH, FSH & Thyroid-Stimulating Hormone (TSH),
and can activate the LCHG Receptors. Exogenous HCG acts similarly to
Luteinizing Hormone (LH), produced in the Pituitary Gland, and is used as a
temporary replacement for LH to recover HPTA & HPAA function, while LH
production is downregulated. HCG mimics LH’s action and signals the Testicles
to produce Testosterone & Semen again. Depending on the Cycle’s duration,
you might have to take between 500-2,000iu HCG every other day (EOD).
The following HCG protocols are under the assumption that you didn’t use HCG
during the Cycle’s full duration.
Over the last few years, fertility treatments have transitioned into the use of
recombinant gonadotropins, largely replacing extracted HMG. The recombinant
process allows for pure FSH & LH production, which are not contaminated by
other proteins present after urinary extraction. Traditional HMG Formulations
often contain FSH & LH at a 1:1 Ratio. In contrast, more recent recombinant
Menotropin medications have a much higher amount of FSH to LH ratio.
Daily HMG administration stimulates the ovaries to mature follicles and release
egg cells, making Women more fertile. Hypogonadal Men can use HMG daily to
stimulate Semen production. HMG can be run alongside HCG to increase
Spermatogenesis and help with fertility after the PCT has finished.
A 2-3 week protocol of 75-150iu HMG per day, while also using 500-2,000iu HCG
every other day, is enough to make a difference in Semen count, but not in
volume & motility, which are also required for healthy fertility levels. If you
want to use HMG to improve fertility, it’s advised to use it 2-3 weeks before
you’re trying to get your partner pregnant, AFTER you’ve been off ALL AAS or
SARMs completely, for at least 90 days to ensure healthy Semen production.
When using HMG after completing PCT, motility & volume will increase
alongside Semen count, as there’s no HPTA suppression from AAS or SARMs!
When using 75-150iu HMG, we’re looking to utilize about 37.5-75iu of FSH for
Spermatogenesis, while the remainder of 37.5-75iu LH alongside HCG,
contributes to Testosterone production in the Leydig Cells. However, 37.5-75iu
LH or HCG isn’t sufficient for complete HPTA recovery. Additional HCG is required
alongside HMG administration for both fertility & Testosterone production to
return to baseline after a Steroid or SARMs Cycle.
Triptorelin
Triptorelin is a medication that acts as a Gonadotropin-Releasing Hormone
(GnRH) agonist. It stimulates both Luteinizing Hormone (LH) and Follicle-
Stimulating Hormone (FSH) production directly in the Pituitary Gland and starts
recovery of HPTA & HPAA, without merely mimicking LH as HCG does.
Triptorelin is an earlier step in the HPTA & HPAA compared to HCG & HMG. It
replaces the signal between the Hypothalamus to the Pituitary, whereas HCG &
HMG replace the signal between the Pituitary to the Testes & Adrenal Glands.
Triptorelin should be considered the preferred medication to restore HPTA &
HPAA function after prolonged periods of Blasting & Cruising.
Triptorelin has a relatively short Half-Life of a few hours, although these Half-
Lives are based on Intra-Venous (IV) administrations of 3.75-11.25mg, not Sub-
Cutaneous (SubQ) administrations of 50-100mcg. Either way, serum LH & FSH
levels remain elevated for up to 48 hours after a single Triptorelin injection
before returning to baseline.
You can start treatment with Nolvadex & Clomid simultaneously, 2 days after
the last administration of HCG & HMG (if applicable) or 5 days after the last
administration of Triptorelin. Below are a few guidelines to assess your required
Nolvadex Protocol, depending on the duration of the Steroid Cycle and
compounds used:
The main side effect of Clomid is overly emotional reactions, as Clomid acts as
an Estrogen in the Brain. Mood instability usually triggers during emotional
scenes in movies or television series but generally doesn’t occur in real life.
Clomid can block the Estrogen Receptors in the Eyes, resulting in temporary
vision changes, noticeable as tracers or blurry vision. While this effect isn’t as
pronounced as the SARM S-4, it’s still possible to occur. The emotional & vision-
related side effects dissipate within several days of discontinuation. Other side
effects of long-term Clomid use include liver toxicity, although this is generally
not observed during the 4-6 weeks of Clomid treatment.
You can start treatment with Clomid & Nolvadex simultaneously, 2 days after
the last administration of HCG & HMG (if applicable) or 5 days after the previous
administration of Triptorelin. Below are a few guidelines to assess your required
Clomid Protocol, depending on the duration of the Steroid Cycle and
compounds used:
Contrary to popular belief, both Nolvadex & Clomid are required for a successful
PCT and complete recovery of HPTA. You might be able to get away with either
Nolvadex or Clomid if you’re below 25 years old, and the Steroid or SARMs Cycle
was of relatively short duration (less than 13 weeks). Still, it’s better to be safe
than sorry and run both compounds together for HPTA recovery. Nolvadex and
its metabolites have a slightly higher affinity for the Estrogen Receptor-Beta,
while Clomid has a higher affinity for the Estrogen Receptor-Alpha. Blocking
both Receptors ensures HPTA recovery.
Suppose you followed the information provided in this eBook correctly, but you
didn’t recover HPTA sufficiently, and your Neuro-Steroids & Sex-Hormones
markers aren’t favorable for your bodybuilding, strength, or fitness aspirations.
In that case, you might have to consider indefinite Hormone Replacement
Therapy.
For more information about Organ Health & Blood Work Markers, consider
purchasing the organ-specific eBooks on The VigorousSteve.com Shop:
www.vigoroussteve.com/shop/
• 800iu Vitamin E (Mixed Tocopherol & Tocotrienols) per day: 400iu Vitamin E
with Breakfast & Dinner. Vitamin E activates Spermatogenesis & enhances
Pregnenolone, DHEA, Testosterone & Estrogen production while using HCG,
HMG, or Triptorelin. It also contributes to healthy levels of serum FSH & LH
when using Nolvadex & Clomid.
• 50-100mg Zinc per day: 25-50mg Zinc with Breakfast & Dinner. Plays an
essential role in the HPTA & HPAA, increases sensitivity to LH or & FSH. Zinc
helps to manage Leydig Cell & Adrenal Gland function & maintains healthy
Spermatogenesis once HPTA recovers.
• 3-6mg Boron per day: 3mg Boron with Breakfast or 3mg with Breakfast &
Dinner. Sufficient Boron intake might prevent Sex Hormone-Binding Globulin
(SHBG) levels from climbing too high during PCT. Managing SHBG levels with
supplemental Boron allows for relatively high Free Testosterone levels
throughout the full PCT duration.
• 500mg+ Dietary Cholesterol per day: 2 whole eggs or 1,000g beef, chicken,
pork, or salmon, also contain about 500mg Cholesterol. Cholesterol is a building
block for ALL Sex-Hormones & Neuro-Steroids. Fertility drugs utilize dietary
Cholesterol or Cholesterol produced in the Liver and other bodily tissues to
synthesize Pregnenolone, DHEA, Testosterone & Estrogens, and many other
intermediate Sex-Hormones & Neuro-Steroids.
Cholesterol is ESSENTIAL for normal HPTA & HPAA function! Besides including
dietary Cholesterol throughout the entire duration of your Post-Cycle Therapy,
it’s imperative to discontinue lipid-altering supplements or medications,
including; Citrus Bergamot, Red Yeast Rice & Statins, unless medically
prescribed. Nolvadex improves HDL synthesis and LDL metabolism within the
Liver by acting like Estrogen. Simultaneously, adequate serum concentrations
of LH & FSH throughout Triptorelin, Nolvadex & Clomid treatment improves
Cholesterol metabolism within the Adrenal Glands & Testes.
Citrus Bergamot, Red Yeast Rice & Statins all reduce Cholesterol synthesis,
which is undesired during the entirety of your PCT!
Attempting to minimize fat gain or restricting calories to burn body fat during
PCT usually impairs recovery of HPTA & HPAA and might lead to chronically low
Testosterone levels afterward! If that happens, you need to go back on TRT
while improving your metabolism before attempting another PCT a few months
later. Ensure you’re in a sufficient caloric surplus and follow the ENTIRE PCT
protocol without caloric restriction for proper recovery of the HPTA & HPAA!
Coach Steve found that the Ketogenic diet is the most successful diet for the
complete recovery of HPTA after PCT has finished. The Ketogenic or Carnivore
Diet minimize Insulin release by restricting dietary carbohydrates, which also
reduces the potential for accumulating body fat during the time your natural
hormone production is recovering during PCT.
These diets also allow you to easily reach the required amounts of Cholesterol,
Vitamin E, Vitamin D3, Magnesium, Zinc, Selenium, Manganese & Boron for
healthy Testicular function. A Ketogenic or Carnivore Diet also allows you to
keep strength consistently high, although the rep-ranges are generally lower
due to limited ATP production from fatty acids, while Glycogen stores are
moderately depleted.
It’s advised to reduce your training volume and intensity to maintenance levels,
as you lack the Anabolics (AAS or SARMs) to recover from hypertrophy stimulus
and training to failure and beyond. If you decided to use Growth Hormone,
Clenbuterol, or other non-suppressive Anabolic Agents during your PCT, you
might be able to sustain training intensity to a certain extent. Coach Steve
recommends bodybuilders, strength athletes, and fitness enthusiasts to reduce
training volume to the (bare) minimum required to maintain strength & muscle
mass. At least until you’ve restored HPTA function and physiological levels of
Testosterone, feel completely normal again.
As soon as you feel your natural HPTA function is restored, you can increase
your training intensity, caloric intake, incorporate a few working sets to failure,
add a few back-off sets, and perhaps some intensifying techniques. Keep in
mind that you’ll have limited recovery capability on physiological levels of
Testosterone and are always pushing against your natural potential.
DIM: Diindolylmethane
HPTA/HPAA: Hypothalamic-Pituitary-Testes/Adrenal-Axis
IM: Intra-Muscular
SubQ: Sub-Cutaneous
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