COLLAGEN
GUIUDE
MAXIMIZE YOUR COLLAGEN LEVELS
Introduction
You already know that collagen is good for
overall skin and anti-aging. As we age our body
starts producing less collagen.
Yes, this is my first post.
I make this thread "an understanding about
collagen" for people with an average
understanding of looksmax. I make this thread
simple and make it easy to understand for u
guys so have fun reading all this📖👀
What is Collagen? 🤔 ⁉️
Collagen is a natural protein
that our body produces and
makes about 30% of our
body's total protein.
Different types of collagen
make up our skin, bones,
muscles, and joints. there are
16 types of collagen and the
common are I, II, and III
Collagen Type I
Found in skin, bones, tendons, and other
connective tissues.
Collagen Type II
Found in our cartilage and connective tissues,
providing flexibility and support to bone joints.
Collagen Type III
Found in organs, the heart, and skin.
Collagen helps 🎯
Skin
Bones & Teeth
Joints
Muscle tissues, ligaments, and tendons
Gut
Ways To Increase Collagen
Diet
What you should be eating-
Animal Protein
Vegetables
Fruits
Bone broth
Animal protein contains the amino acids that
make up collagen, such as glycine, proline, and
hydroxyproline. those are essential for collagen
synthesis.
You’re probably thinking, “Oh, I eat chicken
every day—I’m fine.”
But here’s the catch. Collagen is not in a
salmon fillet or a piece of
chicken breast—but in the animals’ skin, joints,
bones, and muscle
tissue. - Sally Olivia Kim (Author of The
Collagen Glow)
Vegetables & Fruits increase collagen cus of
the nutrients n stuff, this is self-explanatory
Microneedling
Derma Stamp VS Roller VS Pen
Microneedling or Collagen induction therapyis
a cosmetic procedure that involves a tiny
needle to puncture the skin.
Shorten : The micro-injuries stimulate collagen
production.
A derma stamp or pen is better for collagen
production because it creates more precise and
controlled punctures in the skin
Skincare Collagen Booster
Tretinoin : Stimulates fibroblasts (Fibroblasts
are the cells responsible for producing
collagen).
Vitamin C : stimulating the biosynthesis of
collagen,
Retinol : Stimulates fibroblasts to produce
more collagen
Niacinamide : increases the production of
NAD/NADP, which serve as reduction-
oxidation (redox) coenzymes in more than 40
enzymatic reactions, including collagen
synthesis
Aloe Vera : contains sterols (It promotes the
production of collagen)
AHAs & BHAs : They work by breaking the
connections that hold dead skin cells together,
causing the old cells to disappear and the new
ones to appear and stimulate fibroblast.
Sunscreen : Protects your skin from UV
radiation, UV radiation decreases collagen
Hyaluronic Acid : fibroblast again.
Collagen Peptides
Pills VS Powder VS Liquid VS Gummies
Collagen powder is the best choice since it is
absorbed most efficiently. Most collagen candies
& liquids have unnecessary additives like
artificial sweeteners and corn syrup, and they
have lower concentrations. Pills on the other
hand have a lower dosage than collagen powder
so drinking 5-10 pills is just nah. Collagen powder
is more affordable than collagen pills anyway.
Red light therapy increases fibroblast (the cells
that produce collagen)
Other Supplements
Beta Carotene
Vitamin C
Ginseng
Zinc
Cooper
Astaxanthin
Pycnogenol
Things to avoid!??!
Smoking 🚭
Lack Of Sleep🚫🛌
Stress :rage:
🍬
High Sugar Intake
Alcohol🍻
Excessive Sun Exposure 🌅
🥗
Poor Diet :no:
Here I did some research-
To fully optimize our skin's ability to promote
collagen production, we need to understand the
process of collagen synthesis on a fundamental
level. When mRNA moves into the cytoplasm
and interacts with ribosomes, both magnesium
and zinc are needed for translation to occur.
After translation, this polypeptide chain travels
to the endoplasmic reticulum (ER). The
polypeptide chain undergoes enzymatic
modifications, including hydroxylation of
proline and lysine which requires iron and
vitamin C as cofactors (and oxygen). This
process creates procollagen which is released
from the fibroblast. The ends of the procollagen
molecule are removed by peptidases and the
molecule becomes tropocollagen.
Tropocollagen undergoes covalent bonding
through lysyl oxidase and this creates a
collagen fibril. tl;dr magnesium, zinc, iron,
vitamin C are necessary co-factors.
Now I know PSL autists are obsessed with
carotenoids. Beta-carotene increases type I
procollagen mRNA levels, but procollagen is a
precursor and not collagen itself so this will not
give us noticeable enough results. We need to
upregulate gene expression in order to
synthesize a functional product. Astaxanthin
with hydrolyzed collagen upregulates type I
procollagen gene expression and decreases
MMP-1 and -12. MMP-1, the prototypical MMP,
degrades collagen types 1 and 3. Polyphenols
will take this a step further within the sub-class
of proanthocyanidins. Specifically, pycnogenol
stimulates type I collagen synthesis in subjects’
skin by increasing gene expression by 41%. tl;dr
astaxanthin, collagen peptides, and
pycnogenol (OPCs).
The main goal should be to find exogenous ways
to stimulate type I collagen synthesis since it’s
the most abundant collagen found in the skin,
and it is the most significant one we lose as we
age. Orthosilicic acid stimulates collagen type 1
synthesis and osteoblastic differentiation in
human osteoblast-like cells. Processed panax
ginseng, sun ginseng stimulates type I collagen
by regulating MMP-1 and TIMP-1 expression in
human dermal fibroblasts. 10-hydroxy-2-
decenoic acid, a characteristic constituent of
lipids from honeybee royal jelly extract,
stimulates normal human dermal fibroblast cell
lines and produce transforming growth
factor(TGF) β1, a cytokine that stimulates
collagen synthesis. Aloe vera is already
mentioned on this forum, but the polysaccharide
acemannan in aloe is what causes collagen
biosynthesis. tl;dr orthosilicic acid (BioSil), red
panax ginseng, honeybee royal jelly extract, and
aloe vera.
There are other nutraceuticals, but all the oral
supplements I listed are the most evidence-based to
promote collagen production. When it comes to
skincare, water is wet. But tretinoin increases type I
and type III collagen as well as inhibits the expression
of MMP-1, which I mentioned breaks down collagen.
Topical vitamin C also stimulates type I and type III
collagen synthesis. Vitamin C suppresses MMPs
responsible for collagen degradation and increases the
tissue inhibitor of MMPs, as well as mRNA levels of
collagens I and III. Ferulic acid stabilizes solutions of
vitamins C and E and doubles its photoprotection of
skin so if you’re buying a vitamin C serum without it
then it’s over for you. The vitamin C serum also must
have a pH below 3.5 for effective penetration. Ascorbic
acid serums must be at least 10% to be effective. The
maximum amount of ascorbic acid penetration was
seen at 20% with a pH of 3.2, so a vitamin C serum with
this concentration will give you the best results. Topical
5% niacinamide may stimulate collagen synthesis and
the epidermal proteins. Apparently niacinamide had no
strong documented effect on collagen, but a study
showed that niacinamide was able to increase dermal
matrix collagen production. 20% Glycolic acid
treatment also increases type I collagen mRNA and
hyaluronic acid content of human skin. tl;dr 0.025%+
tretinoin, 20% vitamin c with e and ferulic acid, 5%
niacinamide, 20% glycolic acid peels.
For cosmetic peptides, would often shill the use
of GHK-cu since copper peptides do stimulate
collagen synthesis by a noticeable percent. But if
they’re overused, GHK-cu can cause more
damage than good (can cause a crepey skin
texture). So no need to use it yet since you’re all
still teencels. Also there are better proven
peptides for collagenmaxxing pursuits. Matrixyl
3000 (trademark for palmitoyl tripeptide-1 and
palmitoyl tetrapeptide-7) stimulates type I
collagen, fibronectin, and hyaluronic acid. The
8% concentration is the highest concentration
proven to be effective in vivo. Matrixyl synthe'6
(trademark for palmitoyl tripeptide-38)
stimulates type I, type III, and type IV collagen, as
well as fibronectin and hyaluronic acid. The 2%
concentration is the highest concentration
proven to be effective in vivo. The original
Matrixyl (trademark for palmitoyl pentapeptide-
4) also stimulates collagen types I, III, and IV, as
well as elastin and fibronectin. Tetrapeptide-21
and EGF (human oligopeptide-1) are also often
sought after by the foid skincare community. tl;dr
matrixyl, matrixyl 3000, matrixyl synthe'6,
tetrapeptide-21, and egf.
Another skincare ingredient this site has never
heard of is centella asiatica extract or
madecassosides. Madecassosides stimulate
type I collagen synthesis in human dermal
fibroblast cells. Referring back to process of
collagen synthesis, centella asiatica increased
the metabolism of lysine and proline, the
amino acids that I mentioned that build the
collagen molecule. In addition, these
compounds increased the synthesis of
tropocollagen and mucopolysaccharide in the
connective tissues. You need to find a cream
with at least 0.1% madecassosides.
As a reminder for sunscreen, it needs to be SPF
50+ PA++++. UVA rays cause tanning,
hyperpigmentation, fine lines and wrinkles,
while UVB causes sunburn. SPF only rates UVB,
while the PA system (or PPD) rates UVA. The
sunscreen should consist of photostable UV
filters too so ingredients like zinc oxide and
titanium dioxide mog oxybenzone and
benzophenone
