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Grade 12 – Worksheet-01– Biology – Human Health And Disease
Level 1
1. Which of the following diseases is not transmitted by houseflies?
a) Cholera b) Typhoid
c) Dysentery d) Yellow fever
2. The confirmatory test used to diagnosis AIDS is
a) ESR b) Widal
c) ELISA d) Western Blot
3. Cancer is generally caused due to activation of …………….to………………and/or inactivation of …………….
a) Oncogene, tumour suppressor gene, protooncogenes
b) Tumour suppressor gene, oncogene, protooncogene
c) Oncogene, protooncogene, tumour suppressor gene
d) Protooncogene, oncogene, tumour suppressor gene
4. A person is injected with globulin against hepatitis. This is
a) naturally acquired active immunity b) naturally acquired passive immunity
c) artificially acquired active immunity d) artificially acquired passive immunity
5. Select the correct statement from the ones given below
a) Cocaine is given to patients after surgery as it stimulates recovery
b) Barbiturates when given to criminals make them tell the truth
c) Morphine is often given to persons who have undergone surgery as a pain killer
d) Chewing tobacco lowers blood pressure and heart rate
6. Recently chikungunya cases were reported from various parts of the country. Name the vector
responsible.
7. What is humoral immunity?
8. What is neoplasm?
9. Mention the site in the body where the B-cells and T-cells are formed
10. What causes swelling of lower limbs in patients suffering from filariasis?
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Level 2
Directions: In the questions from 11 to 13, a statement of assertion is followed by a statement of reason.
Mark the correct choice as:
(a) If both Assertion and Reason are true and Reason is the correct explanation of Assertion.
(b) If both Assertion and Reason are true but Reason is not the correct explanation of Assertion.
(c) If Assertion is true but Reason is false.
(d) If both Assertion and Reason are false.
11. Assertion: Many visitors to the hills suffer from skin and respiratory allergy problems.
Reason: Conifer trees produce a large quantity of wind-borne pollen grains.
12. Assertion: Organ transplantation patients are given immune suppressive drugs
Reason: Transplanted tissue has antigens which stimulate the specific immune response of the recipient.
13. Assertion: A person who has received a cut and is bleeding needs to be given anti-tetanus vaccine.
Reason: Anti-tetanus injection provides immunity by producing antibodies for tetanus.
14. The sporozoites that cause infection when a female Anopheles mosquito bites a human being are formed
in
a) Liver of the person b) RBCs of mosquito
c) salivary glands of mosquito d) intestine of mosquito
15. Each immunoglobin has two heavy chains and two light chains, the antigen binding site is present in
a) variable region of light chain b) variable region of heavy chain
c) variable region of both heavy and light chain d) constant region of both light and heavy chain
16. A ten-year-old boy had chicken pox. He is not expected to have the same disease for the rest of his life.
Why?
17. How does transmission of the disease ‘ascariasis’ takes place?
18. What are interferons? Explain their role in providing immunity.
19. What would happen to the immune system, if thymus gland is removed from the body of a person?
20. Why are anabolic steroids banned in sports?
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Level 3
21. Study the diagram showing replication of HIV in humans and answer the following questions accordingly:
(i) Write the chemical nature of the coat ‘A’.
(ii) Name the enzyme ‘B’ acting on ‘X’ to produce molecule ‘C’. Name ‘C’.
(iii) Mention the name of the host cell ‘D’ the HIV attacks first when it enters into the human body.
(iv) Name the other cells the new viruses ‘E’ subsequently attacks.
22. (i) Explain the life cycle of Plasmodium starting from its entry in the body of female Anopheles till the
completion of its life cycle in humans.
(ii) Explain the cause of periodic recurrence of chill and high fever during malarial attack in humans.
23. Highlight the structural importance of an antibody molecule with a diagram. Name the four types of
antibodies found to give a humoral immune response, mentioning the functions of two of them you have
studied.
24. A person shows strong unusual hypersensitive reaction when exposed to certain substance present in
air.
(i) Identify the condition.
(ii) Mention the term used for these substances.
(iii) Name the cells responsible for such reactions.
(iv) List some symptoms related to this condition.
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(v) Mention the drugs which quickly reduce the symptoms of this condition.
25. The data below shows the concentration of nicotine smoked by a smoker taking 10 puffs/ minute.
(i) With reference to the above graph explain the concentration of nicotine in blood at 10 minutes.
(ii) How will this affect the concentration of carbon monoxide and haem bound oxygen at 10 minutes?
(iii) How does cigarette smoking result in high blood pressure and increase in heart rate?
(iv) How does cigarette smoking result in lung cancer and emphysema?
Level 4
26. Which of the following statements is not true for cancer cells in relation to mutations. [NEET-2016]
a) Mutations inhibit production of telomerase
b) Mutations in proto-oncogenes accelerate the cell cycle
c) Mutations destroy telomerase inhibitor
d) Mutations inactivate the cell control
27. Antivenom injection contains preformed antibodies while polio drops that are administered into the body
contain [NEET-2016]
a) attenuated pathogens b) activated pathogens
c) harvested antibodies d) gamma globulin
28. Grafted kidney may be rejected in a patient due to
a) innate immune response b) humoral immune response
c) cell- mediated immune response d) passive immune response
29. Which of the following immunoglobulins does constitute the largest percentage in human milk?
[Re-AIPMT-2015]
a) IgG b) IgD
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c) IgM d) IgA
30. Common cold differs from pneumonia in, that [AIPMT(Prelims)-2012]
a) pneumonia pathogen infects alveoli whereas the common cold affects nose and respiratory passage but not
the lungs
b) pneumonia is a communicable disease whereas the common cold is a nutritional deficiency disease
c) pneumonia can be prevented by a live attenuated bacterial vaccine whereas common cold has no effective
vaccine
d) pneumonia is caused by a virus while the common cold is caused by the bacterium Haemophilus influenzae
31. The pathogen Microsporum responsible for ringworm disease in humans belongs to the same kingdom of
organisms as that of [AIPMT(Mains)-2012]
a) Rhizopus, a mould b) Ascaris, a round worm
c) Taenia, a tapeworm d) Wuchereria, a filarial worm
32. In higher vertebrates, the immune system can distinguish self-cells from non-self-cells. If this property is
lost due to genetic abnormality and it attacks self- cells then it leads to [NEET-2016]
a) active immunity b) allergic response
c) graft rejection d) auto-immune disease
33. Cornea transplant in humans is almost never rejected. This is because [AIPMT(Prelims)-2008]
a) It is a non-living layer b) Its cells are least penetrable by bacteria
c) It has no blood supply d) It is composed of enucleated cells
34. Antibodies in our body are complex [AIPMT(Prelims)-2006]
a) lipoproteins b) steroids
c) prostaglandins d) glycoproteins
35. The active form of Entamoeba histolytica feeds upon [AIPMT-2015]
a) blood only b) erythrocytes; mucosa and submucosa of colon
c) mucosa and submucosa of colon only d) food in intestine
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