Job offer
Postdoctoral researcher in molecular virology : Dynamic of viral
and cellular transcriptomes during HIV infection
36 months Start before Oct 2024 Paris, FRANCE PhD
Host structure
Team « Host-virus Interactions » is part of the Institut Cochin located in the center of
Team Paris, 22 rue Méchain – 75014 Paris, France.
Team leader Team leader: Clarisse Berlioz-Torrent and Stéphane Emiliani
Principal investigator: Sarah Gallois-Montbrun
About the structure The Institut Cochin is a research center affiliated to INSERM, CNRS, Université Paris
Cité. The Institut Cochin is composed of 41 teams and 10 core facilities.
The team Host-Virus Interaction is composed of 15 collaborators, including 4
permanent researchers, 3 technical support staff, 3 post-doctoral researchers, 4
doctoral students and 1 M2 student
www.institutcochin.fr
Director Florence Niedergang
Adresse 22 rue Méchain 75014 Paris, France
Structure employeur INSERM
Job description
Research With over 38 million people infected worldwide, HIV remains a major public health issue.
project Antiviral therapies are effective in limiting virus replication, but its persistence in viral
reservoirs hinders the hope of curing patients. The objective of the project developed by the
postdoctoral researcher is to deepen knowledge of the molecular mechanisms which
contribute to the regulation of the viral and cellular transcriptomes during viral replication and
latency. The research program will be based on techniques in cell biology (cell culture,
isolation of T lymphocytes from blood samples), virology (viral production and infections),
molecular biology (RT-qPCR, Western blot, immunopurification of complexes...), flow
cytometry, imaging (immunofluorescence), as well as sequencing analyses (short and long
reads).
Institut national de la santé et de la recherche médicale
Emploi type
Main Activities • Conduct a research project to understand the dynamic of HIV and cellular
transcriptomes during infection: Formulate hypotheses related to the research project
within the context of existing literature, design the experimental approach, conduct
experiments, process data, and analyze the results.
• Provide regular reports on experimental results to the project supervisor and during
laboratory meetings.
• Disseminate and showcase the results (reports, contribution to figure formatting,
scientific article writing, participation in conferences).
• Supervision and training of students/Ph.D. candidates.
Job specification(s) • High throuput sequencing analyses
and environment • Work in BSL2 and BSL3 environment
• Work with blood samples
• Possible variability in working hours
Expertise • Good understanding of molecular biology, genomic, transcriptomic and preferably
specializing in virology.
• Knowledge and expertise in bioinformatic would be a strong asset.
• Proficiency in spoken and written English.
Savoir-faire • Skills in experimental laboratory work with the ability to independently plan and
Know-how execute experiments.
• Previous experience in working in BSL2 environment is required and experience in
BSL3 is preferred or a willingness to be trained for work in BSL3 conditions.
• Previous experience in molecular biology, cellular biology, and biochemistry (cloning,
western blot, RT-qPCR, isolation and analysis of protein and ribonucleoprotein
complexes, gene silencing or editing, siRNA/shRNA/CRISPR-CAS9) is required.
• Computer skills and proficiency in biology software, with a willingness to learn new
programs and software as necessary.
• Proficiency in flow cytometry technology and immunofluorescence would be a plus.
Aptitudes • Organizational skills, ability to prioritize multiple tasks and set and meet deadlines
Ability • Ability to analyze information, write clear and concise research reports, documents and
prepare research papers
• Communications skills and ability to work well collaboratively with colleagues from
multidisciplinary background.
Experience(s) • PhD in molecular virology
required • Bioinformatic skills
Diploma level and PhD
training Virology, molecular biology, transcriptomic, bioinformatic
Informations Générales
Biginning: between June and September 2024
Duration 36 months
Working time Full time☒ - Part time☐
Number of hours per week: 38h30
Institut national de la santé et de la recherche médicale 2
Emploi type
Annual leave and Rtt : 44
Teleworking activities ☐ OUI/YES ☒ NON/NO
Remuneration Contract workers: from 2997,20 € gross per month depending on professional experience in
equivalent positions (to be completed with your HR manager)
The opening position is funded by the ANRS (Agence Nationale de Recherche sur le SIDA et les
Hépatites Virales).
Modalités de candidature/ Modalités de candidature/How to apply
Application
July 2024
deadline
To apply Applicants should send their CV, letter of motivation and name of 2 references:
• Sarah Gallois-Montbrun
• Email : [email protected]
Institut national de la santé et de la recherche médicale 3
