Roll No. Total No.

of Pages : 02
Total No. of Questions : 13
B.Pharma (2017 & Onward) (Sem.–3)
PHYSICAL PHARMACEUTICS-I
Subject Code : BP-302T
M.Code : 75106
Time : 3 Hrs. Max. Marks : 75

INSTRUCTIONS TO CANDIDATES :
1. SECTION-A is COMPULSORY consisting of TEN questions carrying T WO marks
each.
2. SECTION-B contains T HREE questions carrying T EN marks each and student
has to attempt any T WO questions.
3. SECTION-C contains NINE questions carrying FIVE marks each and student has
to attempt any SEVEN questions.

SECTION-A

1. Define briefly :

a) Distinguish between solvation and association giving one example each.

b) State Raoult’s Law and its applications.

c) What is meant by diffusion?

d) What is a liquid crystal? Give an example and mention its applications.

e) What is dipole moment?

f) Mention the important properties of an amorphous solid.

g) What is interfacial tension?

h) Define HLB value and its scale.

i) What are chelates? Give two examples.

j) What is buffer capacity?

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 SECTION-B

2. Discuss the factors influencing the solubility of drugs. Write a note on approaches used
for enhancing drug solubility.

3. Discuss the distribution method for determination of stoichiometric ratio in a complex.

4. Differentiate between surface tension and interfacial tension. With the help of suitable
equations explain spreading of one liquid on another liquid.

SECTION-C

5. Discuss the relationship between vapour pressure and critical point.

6. The following eye drop has to be prepared: Naphazoline HCl (0.02%), Zinc sulphate
(0.25%), P. water qs 30 ml. How much sodium chloride should be added to make the
preparation isotonic with tears. (Given ‘E’ value of Naphazoline HCl is 0.27 and that of
Zinc sulphate is 0.15).

7. What are amorphous and crystalline solids? Give examples of polymorphism and
highlight the advantages and disadvantages of polymorphic behavior of solids.

8. Explain aerosols and their ingredients.

9. Write a note on surfactants and their applications in formulation design.

10. Write a note on dissociation constant and its significance.

11. Comment on glassy state of a solid with respect to its advantages in dosage form
performance.

12. Give a brief description of buffers and their applications.

13. Briefly discuss isotonicity and the methods used for preparing isotonic solutions.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.

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Roll No. Total No. of Pages : 02

Total No. of Questions : 13
B.Pharma (2017 Batch) (Sem.–3)
PHYSICAL PHARMACEUTICS-I
Subject Code : BP-302T
M.Code : 75106
Time : 3 Hrs. Max. Marks : 75

INSTRUCTIONS TO CANDIDATES :
1. SECTION-A is COMPULSORY consisting of TEN questions carrying T WO marks
each.
2. SECTION-B contains T HREE questions carrying T EN marks each and student
has to attempt any T WO questions.
3. SECTION-C contains NINE questions carrying FIVE marks each and student has
to attempt any SEVEN questions.

SECTION-A

1. Define briefly :

a) Binary Solutions

b) Eutectic mixture

c) Critical solution temperature

d) Refractive index

e) HLB scale

f) Interfacial tension

g) Buffer capacity

h) Complexation

i) Protein binding

j) Aerosol

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 http://www.ptustudy.com

SECTION-B

2. Discuss various factors influencing solubility

3. Enumerate and discuss physicochemical properties of drug molecule.

4. Define Surface tension. Enumerate different techniques that can be used to measure it.
Explain any one.

SECTION-C

5. Briefly discuss diffusion in biological system.

6. What is the significance of critical solution temperature?

7. Discuss the adsorption at solid interface with example.

8. How complexation affects the action of a drug?

9. Discuss the thermodynamics of stability constant.

10. Discuss Raoults Law.

11. How dipole moment is determined?

12. Discuss the significance of polymorphism.

13. How pH is determined, discuss?

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.

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Roll No. Total No. of Pages : 02
Total No. of Questions : 22
B.Pharma (2017 & Onward) (Sem.–3)
PHYSICAL PHARMACEUTICS-I
Subject Code : BP-302T
M.Code : 75106
Time : 3 Hrs. Max. Marks : 75

INST RUCT IONS T O CANDIDAT ES :

1. SECTION-A is COMPULSORY cons is ting of TEN questions carrying TWO marks
each.
2. SECTION-B contains THREE questions carrying TEN marks each and s tudents
have to atte mpt any TWO questions.
3. SECTION-C c ontains NINE questions ca rrying FIVE marks eac h and s tudents
have to atte mpt any SEVEN que stions .

SECTION-A

Define briefly :

1. Define Spreading Coefficient.

2. Define Surface Free Energy.

3. How is adsorption different from absorption?

4. What is critical micelle concentration?

5. What is meant by surface excess?

6. How are degrees of freedom calculated?

7. What do you mean by triple point of water?

8. Define Solubility.

9. Define Contact angle.

10. What are chelates?

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 SECTION-B

11. Draw and explain Phase diagram of water?

12. What is interfacial tension? How is it determined?

13. Draw various adsorption isotherms and explain their behaviour?

SECTION-C

14. Define HLB. Explain the Griffin scale of HLB?

15. Explain various types of metal ion complexes with suitable examples.

16. Write a note on protein binding.

17. Derive expression for spreading coefficient.

18. Describe the factors which influence solubility of drugs.

19. Explain any one method for analysis of complexation.

20. What is critical solution temperature? What is its application?

21. Describe the applications of buffers in pharmaceutical systems.

22. Explain the determination of pH of a solution electrometrically.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.

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Roll No. Total No. of Pages : 02
Total No. of Questions : 13
B.Pharma (Sem.–3)
PHYSICAL PHARMACEUTICS-I
Subject Code : BP-302T
M.Code : 75106
Date of Examination : 14-12-22
Time : 3 Hrs. Max. Marks : 75

INSTRUCTIONS TO CANDIDATES :
1. SECTION-A is COMPULSORY consisting of TEN questions carrying T WO marks
each.
2. SECTION-B contains T HREE questions carrying T EN marks each and student
has to attempt any T WO questions.
3. SECTION-C contains NINE questions carrying FIVE marks each and student has
to attempt any SEVEN questions.

SECTION-A

1. Answer briefly :

a. Solutions

b. Raoult’s Law

c. Amorphrous

d. Dipole moment

e. HLB

f. Surface tension

g. Buffers

h. Drug

i. Isotonic solutions

j. Complexation.

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 SECTION-B

2. a. Give methods for the determination of surface and interfacial tension.

b. Explain methods for the determination of CMC.

3. Classify complexation. Highlight methods of its analysis.

4. What are the ideal solubility parameters? Explain mechanism of solute-solvent

interaction.

SECTION-C

5. Explain the quantitative approach to the factors influencing solubility of drugs.

6. Write short note on eutectic mixture and sublimation.

7. How refractive index and optical rotation determined.

8. Explain adsorption at solid interface.

9. How pH determined? Give its significance.

10. What is Buffer Capacity? Explain with example.

11. Explain the crystalline structure of complexes.

12. Explain surface active agents with examples.

13. Write short note on :

a) Inhalers

b) Critical solution temperature.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.

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Roll No. Total No. of Pages : 02
Total No. of Questions : 13
B.Pharma (Sem.–3)
PHYSICAL PHARMACEUTICS-I
Subject Code : BP-302T
M.Code : 93324
Date of Examination : 14-01-23
Time : 3 Hrs. Max. Marks : 75

INST RUCT IONS T O CANDIDAT ES :

1. SECTION-A is COMPULSORY cons is ting of TEN questions carrying TWO marks
each.
2. SECTION-B contains THREE ques tions ca rrying T EN marks ea ch and student
has to attempt any TWO questions.
3. SECTION-C contains NINE questions ca rrying FIVE marks each and student ha s
to attempt any SEVEN questions.

SECTION-A

1. Define briefly :

a) What do you mean by physical pharmaceutics?

b) How chemical kinetics helps in stability?

c) What do you know about raoult law?

d) What is the relative humidity?

e) Define glassy state.

f) What is the refractive index.

g) Discuss the detergency.

h) Define buffer.

i) What is complexation?

j) Describe protein binding.

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 SECTION-B

2. Give a note on solubility expression.

3. Discuss the complete note on the physiochemical properties of the drug entity.

4. Write a comment on the measurement of surface and interfacial tensions.

SECTION-C

5. Give a detailed note on the detergency with an example.

6. Discuss in detail aerosols.

7. What is the various role of buffers in the pharma sector?

8. Elaborate on the scale of HLB.

9. Discuss the various necessary aspects for stability.

10. Comment on partially miscible liquids.

11. Justify the solubility of a gas in the liquid.

12. What are optical rotations?

13. Mention for absorption at the solid interface.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.

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