SAFETY DATA SHEET
Creation Date 11-Jun-2009 Revision Date 28-Dec-2021 Revision Number 6
1. Identification
Product Name Toluene
Cat No. : AC610950000; AC610951000
CAS No 108-88-3
Synonyms Tol; Methylbenzene
Recommended Use Laboratory chemicals.
Uses advised against Food, drug, pesticide or biocidal product use.
Details of the supplier of the safety data sheet
Company
Fisher Scientific Company Acros Organics
One Reagent Lane One Reagent Lane
Fair Lawn, NJ 07410 Fair Lawn, NJ 07410
Tel: (201) 796-7100
Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887
2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Flammable liquids Category 2
Skin Corrosion/Irritation Category 2
Serious Eye Damage/Eye Irritation Category 2
Reproductive Toxicity Category 2
Specific target organ toxicity (single exposure) Category 3
Target Organs - Respiratory system, Central nervous system (CNS).
Specific target organ toxicity - (repeated exposure) Category 2
Target Organs - Kidney, Liver, spleen, Blood, Neurological effects, Eyes, Ears.
Aspiration Toxicity Category 1
Label Elements
Signal Word
Danger
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Hazard Statements
Highly flammable liquid and vapor
May be fatal if swallowed and enters airways
Causes skin irritation
Causes serious eye irritation
May cause drowsiness or dizziness
Suspected of damaging the unborn child
May cause damage to organs through prolonged or repeated exposure
Precautionary Statements
Prevention
Obtain special instructions before use
Do not handle until all safety precautions have been read and understood
Use personal protective equipment as required
Wash face, hands and any exposed skin thoroughly after handling
Wear eye/face protection
Do not breathe dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Keep cool
Response
IF exposed or concerned: Get medical attention/advice
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Skin
If skin irritation occurs: Get medical advice/attention
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Wash contaminated clothing before reuse
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Ingestion
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
Do NOT induce vomiting
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store locked up
Store in a well-ventilated place. Keep container tightly closed
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
Harmful to aquatic life with long lasting effects
WARNING. Reproductive Harm - https://www.p65warnings.ca.gov/.
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3. Composition/Information on Ingredients
Component CAS No Weight %
Toluene 108-88-3 <=100
4. First-aid measures
General Advice If symptoms persist, call a physician.
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,
call a physician.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if
symptoms occur. Risk of serious damage to the lungs (by aspiration).
Ingestion Clean mouth with water and drink afterwards plenty of water. Do NOT induce vomiting. Call
a physician or poison control center immediately. If vomiting occurs naturally, have victim
lean forward.
Most important symptoms and . Causes central nervous system depression: Inhalation of high vapor concentrations may
effects cause symptoms like headache, dizziness, tiredness, nausea and vomiting
Notes to Physician Treat symptomatically
5. Fire-fighting measures
Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may
be used to cool closed containers.
Unsuitable Extinguishing Media No information available
Flash Point 4 °C / 39.2 °F
Method - No information available
Autoignition Temperature 535 °C / 995 °F
Explosion Limits
Upper 7.1 vol %
Lower 1.1 vol %
Oxidizing Properties Not oxidising
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available
Specific Hazards Arising from the Chemical
Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of
ignition and flash back.
Hazardous Combustion Products
Carbon monoxide (CO). Carbon dioxide (CO2).
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.
NFPA
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Health Flammability Instability Physical hazards
3 3 0 N/A
6. Accidental release measures
Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Remove all
sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions Do not flush into surface water or sanitary sewer system.
Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.
7. Handling and storage
Handling Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on
clothing. Avoid ingestion and inhalation. Ensure adequate ventilation. Keep away from open
flames, hot surfaces and sources of ignition. Use only non-sparking tools. To avoid ignition
of vapors by static electricity discharge, all metal parts of the equipment must be grounded.
Take precautionary measures against static discharges.
Storage. Keep containers tightly closed in a dry, cool and well-ventilated place. Flammables area.
Keep away from heat, sparks and flame. Incompatible Materials. Strong oxidizing agents.
Strong acids. Strong bases. Halogenated compounds.
8. Exposure controls / personal protection
Exposure Guidelines
Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Toluene TWA: 20 ppm (Vacated) TWA: 100 ppm IDLH: 500 ppm TWA: 20 ppm
(Vacated) TWA: 375 mg/m3 TWA: 100 ppm
Ceiling: 300 ppm TWA: 375 mg/m3
(Vacated) STEL: 150 ppm STEL: 150 ppm
(Vacated) STEL: 560 mg/m3 STEL: 560 mg/m3
TWA: 200 ppm
Legend
ACGIH - American Conference of Governmental Industrial Hygienists
OSHA - Occupational Safety and Health Administration
NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health
Engineering Measures Ensure that eyewash stations and safety showers are close to the workstation location. Use
explosion-proof electrical/ventilating/lighting equipment. Ensure adequate ventilation,
especially in confined areas.
Personal Protective Equipment
Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.
Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.
Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.
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9. Physical and chemical properties
Physical State Liquid
Appearance Colorless
Odor aromatic
Odor Threshold 1.74 ppm
pH No information available
Melting Point/Range -95 °C / -139 °F
Boiling Point/Range 111 °C / 231.8 °F @ 760 mmHg
Flash Point 4 °C / 39.2 °F
Evaporation Rate 2.4 (Butyl acetate = 1.0)
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 7.1 vol %
Lower 1.1 vol %
Vapor Pressure 29 mbar @ 20 °C
Vapor Density 3.1
Specific Gravity 0.866
Solubility Insoluble in water
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 535 °C / 995 °F
Decomposition Temperature No information available
Viscosity 0.6 mPa.s @ 20 °C
Molecular Formula C7 H8
Molecular Weight 92.14
10. Stability and reactivity
Reactive Hazard None known, based on information available
Stability Stable under normal conditions.
Conditions to Avoid Incompatible products. Excess heat. Keep away from open flames, hot surfaces and
sources of ignition.
Incompatible Materials Strong oxidizing agents, Strong acids, Strong bases, Halogenated compounds
Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)
Hazardous Polymerization Hazardous polymerization does not occur.
Hazardous Reactions None under normal processing.
11. Toxicological information
Acute Toxicity
Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Toluene > 5000 mg/kg ( Rat ) 12000 mg/kg ( Rabbit ) 26700 ppm ( Rat ) 1 h
Toxicologically Synergistic No information available
Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Irritation Irritating to eyes, respiratory system and skin
Sensitization No information available
Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.
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Component CAS No IARC NTP ACGIH OSHA Mexico
Toluene 108-88-3 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects Not mutagenic in AMES Test
Reproductive Effects Experiments have shown reproductive toxicity effects on laboratory animals.
Developmental Effects Developmental effects have occurred in experimental animals.
Teratogenicity Possible risk of harm to the unborn child.
STOT - single exposure Respiratory system Central nervous system (CNS)
STOT - repeated exposure Kidney Liver spleen Blood Neurological effects Eyes Ears
Aspiration hazard No information available
Symptoms / effects,both acute and Causes central nervous system depression: Inhalation of high vapor concentrations may
delayed cause symptoms like headache, dizziness, tiredness, nausea and vomiting
Endocrine Disruptor Information No information available
Other Adverse Effects The toxicological properties have not been fully investigated.
12. Ecological information
Ecotoxicity
The product contains following substances which are hazardous for the environment. Contains a substance which is:. Toxic to
aquatic organisms.
Component Freshwater Algae Freshwater Fish Microtox Water Flea
Toluene EC50: = 12.5 mg/L, 72h 50-70 mg/L LC50 96 h EC50 = 19.7 mg/L 30 min EC50: = 11.5 mg/L, 48h
static (Pseudokirchneriella 5-7 mg/L LC50 96 h (Daphnia magna)
subcapitata) 15-19 mg/L LC50 96 h EC50: 5.46 - 9.83 mg/L, 48h
EC50: > 433 mg/L, 96h 28 mg/L LC50 96 h Static (Daphnia magna)
(Pseudokirchneriella 12 mg/L LC50 96 h
subcapitata)
Persistence and Degradability Persistence is unlikely
Bioaccumulation/ Accumulation No information available.
Mobility Is not likely mobile in the environment due its low water solubility.
Component log Pow
Toluene 2.7
13. Disposal considerations
Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.
Component RCRA - U Series Wastes RCRA - P Series Wastes
Toluene - 108-88-3 U220 -
14. Transport information
DOT
UN-No UN1294
Proper Shipping Name TOLUENE
Hazard Class 3
Packing Group II
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TDG
UN-No UN1294
Proper Shipping Name TOLUENE
Hazard Class 3
Packing Group II
IATA
UN-No UN1294
Proper Shipping Name TOLUENE
Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1294
Proper Shipping Name TOLUENE
Hazard Class 3
Packing Group II
15. Regulatory information
United States of America Inventory
Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory
Active-Inactive Flags
Toluene 108-88-3 X ACTIVE -
Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed
TSCA 12(b) - Notices of Export Not applicable
International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).
Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Toluene 108-88-3 X - 203-625-9 X X X X X KE-33936
KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)
U.S. Federal Regulations
SARA 313
Component CAS No Weight % SARA 313 - Threshold
Values %
Toluene 108-88-3 <=100 1.0
SARA 311/312 Hazard Categories See section 2 for more information
CWA (Clean Water Act)
Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants
Substances Quantities
Toluene X 1000 lb X X
Clean Air Act
Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors
Toluene X -
OSHA - Occupational Safety and Not applicable
Health Administration
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CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
substance under the Comprehensive Environmental Response Compensation and Liability
Act (CERCLA) (40 CFR 302)
Component Hazardous Substances RQs CERCLA EHS RQs
Toluene 1000 lb 1 lb -
California Proposition 65 This product contains the following Proposition 65 chemicals.
Component CAS No California Prop. 65 Prop 65 NSRL Category
Toluene 108-88-3 Developmental - Developmental
U.S. State Right-to-Know
Regulations
Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island
Toluene X X X X X
U.S. Department of Transportation
Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N
U.S. Department of Homeland This product does not contain any DHS chemicals.
Security
Other International Regulations
Mexico - Grade Serious risk, Grade 3
Authorisation/Restrictions according to EU REACH
Component REACH (1907/2006) - Annex XIV - REACH (1907/2006) - Annex XVII - REACH Regulation (EC
Substances Subject to Restrictions on Certain Dangerous 1907/2006) article 59 - Candidate
Authorization Substances List of Substances of Very High
Concern (SVHC)
Toluene - Use restricted. See item 48. -
(see link for restriction details)
Use restricted. See item 75.
(see link for restriction details)
https://echa.europa.eu/substances-restricted-under-reach
Safety, health and environmental regulations/legislation specific for the substance or mixture
Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of
Pollutant Potential Hazardous
Substances (RoHS)
Toluene 108-88-3 Listed Not applicable Not applicable Not applicable
Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Toluene 108-88-3 Not applicable Not applicable Not applicable Annex I - Y42
16. Other information
Prepared By Regulatory Affairs
Thermo Fisher Scientific
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Email: [email protected]
Creation Date 11-Jun-2009
Revision Date 28-Dec-2021
Print Date 28-Dec-2021
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text
End of SDS
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