This is to certify that the following product(s) have been produced under the supervision of the Islamic Food

and Nutrition Council of America (IFANCA).

The production facility as well as component ingredients have been reviewed and approved. The product(s) are in compliance with the halal requirements under
Islamic laws.

Date: July 22, 2021

Document #: 14994.14995.II210003

Company Name & Address: Jiangsu Hongyuan Pharmaceutical Co., Ltd. Fangzhuang, Xushe Town Yixing, Jiangsu 214246 China
Product Name Product Code Halal-ID Product Certificate #

1. Titanium Dioxide 13463-67-7 C57804 HC-21JITY85

Muhammad Munir Chaudry, Ph.D.

President
This certificate is valid until July 31, 2024 and subject to renewal at that time.

Page 1 of 1
 江苏宏远药业有限公司
JIANGSU HONGYUAN PHARMACEUTICAL CO.,LTD.
FANGZHUANG ,XUSHE TOWN,YIXING, JIANGSU PROVINCE, CHINA
TEL:+86 510 87678811 FAX:+86 510 87678812

PRODUCT SPECIFICATION
TITANIUM DIOXIDE 3100
VERSION:1.8
REVISION DATE:May.01,2020
PRODUCT NAME: TITANIUM DIOXIDE
CHARACTERISTICS: WHITE TO SLIGHTLY COLORED POWDER
CAS NO. 13463-67-7
MOLECULAR WEIGHT: 79.88
MOLECULAR FORMULA: TIO2 COLOR INDEX: 77891
COLOR NAME: PIGMENT WHITE 6
SHELF LIFE: FIVE YEARS
STANDARDS: USP43

ITEMS TEST METHODS LIMITS

IDENTIFICATION USP43 ORANGE-RED COLOR WITH H2O2

CHARACTERISTICS N/A WHITE ODORLESS POWDER

LOSS ON DRYING (105℃, 3 HOURS) USP43 0.5% MAX

LOSS ON IGNITION(800℃) USP43 0.5% MAX

ACID SOLUBLE SUBSTANCE(0.5N HCl) USP43 0.5% MAX

WATER-SOLUBLE SUBSTANCE USP43 0.25% MAX

ANTIMONY(0.5N HCl SOLUBLE) USP43 2PPM MAX

ARSENIC(0.5N HCl SOLUBLE) USP43 1 PPM MAX

LEAD(0.5N HCl SOLUBLE) USP43 10 PPM MAX

CADMIUM (0.5N HCl SOLUBLE) USP43 1 PPM MAX

MERCURY(0.5N HCl SOLUBLE) USP43 1 PPM MAX

ORGANIC VOLATILE IMPURITIES

CHLOROFORM 60 µG PER G MAX
1,4-DIOXANE USP43 380 µG PER G MAX
DICHLOROMETHANE 600 µG PER G MAX
TRICHLOROETHYLENE 80 µG PER G MAX
ASSAY (TIO2) USP43 99.0~100.5%

MICROBIOLOGY TEST
BACTERIA, IN HOUSE 100 CFU/G MAX
MOULDS AND YEASTS 100 CFU/G MAX
SPECIFIED MICROBIAL TEST
STAPHYLOCOCCUS AUREUS IN HOUSE NOT DETECTED
GRAM NEGATIVE BACTERIA NOT DETECTED
 Safety Data Sheet
According to Regulation (EC) No 1907/2006, Annex II,
Amended by COMMISSION REGULATION (EU) 2015/830,
According to REGULATION (EC) No 1272/2008
Titanium dioxide
Version 1.2
Issue date: 18/03/2020
Revision date: 18/03/2020 SDS Record Number: CSSS-TCO-010-140282

Section 1 Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier:
Identification on the label/Trade name: Titanium dioxide
Additional identification: Titanium oxide (TiO2)
Identification of the product: CAS# 13463-67-7；EC# 236-675-5
Index Number: Not available
REACH registration No.: 01-2119489379-17-0063
1.2 Relevant identified uses of the substance and uses advised against:
1.2.1 Identified uses:
White pigment for application in following industries: Coatings, plastics, printing inks, paper, man-made fibers, glass, vitreous
enamels, ceramic products, textile, textile, rubber, cement, chemical industry, food / feedstuff additives, drugs, cosmetics.
PC 1: Adhesives, sealants
PC 2: Adsorbents
PC 3: Air care products
PC 4: Anti-freeze and de-icing products
PC 7: Base metals and alloys
PC 8: Biocidal products (e.g. disinfectants, pest control)
PC 9a: Coatings and paints, thinners, paint removes
PC 9b: Fillers, putties, plasters, modelling clay
PC 9c: Finger paints
PC 11: Explosives
PC 12: Fertilisers
PC 13: Fuels
PC 14: Metal surface treatment products
PC 15: Non-metal-surface treatment products
PC 16: Heat transfer fluids
PC 17: Hydraulic fluids
PC 18: Ink and toners
PC 20: Products such as ph-regulators, flocculants, precipitants, neutralisation agents
PC 21: Laboratory chemicals
PC 23: Leather treatment products
PC 24: Lubricants, greases, release products
PC 25: Metal working fluids
PC 26: Paper and board treatment products

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 PC 27: Plant protection products
PC 28: Perfumes, fragrances
PC 29: Pharmaceuticals
PC 30: Photo-chemicals
PC 31: Polishes and wax blends
PC 32: Polymer preparations and compounds
PC 33: Semiconductors
PC 34: Textile dyes, and impregnating products
PC 35: Washing and cleaning products
PC 36: Water softeners
PC 37: Water treatment chemicals
PC 38: Welding and soldering products, flux products
PC 39: Cosmetics, personal care products
PC 40: Extraction agents
SU 1: Agriculture, forestry and fishing
SU 2a: Mining (without offshore industries)
SU 2b: Offshore industries
SU 4: Manufacture of food products
SU 5: Manufacture of textiles, leather, fur
SU 6a: Manufacture of wood and wood products
SU 6b: Manufacture of pulp, paper and paper products
SU 7: Printing and reproduction of recorded media
SU 8: Manufacture of bulk, large scale chemicals (including petroleum products)
SU 9: Manufacture of fine chemicals
SU 11: Manufacture of rubber products
SU 12: Manufacture of plastics products, including compounding and conversion
SU 13: Manufacture of other non-metallic mineral products, e.g. plasters, cement
SU 14: Manufacture of basic metals, including alloys
SU 15: Manufacture of fabricated metal products, except machinery and equipment
SU 16: Manufacture of computer, electronic and optical products, electrical equipment
SU 17: General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment
SU 18: Manufacture of furniture
SU 19: Building and construction work
SU 20: Health services
SU 23: Electricity, steam, gas water supply and sewage treatment
SU 24: Scientific research and development
1.2.2 Uses advised against:
Not available.
1.3 Details of the supplier of the safety data sheet:
Supplier(Only representative): Chemical Inspection & Regulation Service Limited
Supplier(Manufacturer): Jiangsu Hongyuan Pharmceutical Co.,Ltd
Address: Fangzhuang Xushe Town ,Yixing,Jiangsu Province,China
Contact person(E-mail): [email protected]
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Telephone: +86-510-87678811
Fax: +86-510-87678810
1.4 Emergency telephone Number:
+353 (1) 477 3710 (Only available during office hours (9:00a.m.-17:30p.m.)
Available outside office hours? YES NO X

Section 2 Hazards Identification

2.1 Classification of the substance/mixture:
2.1.1 Classification:
The substance is classified as following according to REGULATION (EC) No 1272/2008:
REGULATION (EC) No 1272/2008
Hazard classes/Hazard categories Hazard codes
Carc. 2 H351
For full text of H- phrases: see section 2.2.

2.2 label elements:

Hazard Pictograms:

Signal Word(S): Warning

Hazard Statement: H351: Suspected of causing cancer
Precautionary statement: P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P308 + P313: If exposed or concerned: Get medical advice/attention.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local regulation.
2.3 Other hazards:
PBT assessment does not apply.

Section 3 Composition/information on ingredients

Substance/Mixture: Substance
Ingredient(s):

Chemical Name Registration No. CAS No. EC No. Concentration

Titanium Dioxide 01-2119489379-17-0063 13463-67-7 236-675-5 ≥98%

Section 4 First aid measures

4.1 Description of first aid measures:
In all cases of doubt, or when symptoms persist, seek medical attention.
4.1.1 In case of inhalation:
Move to a fresh air atmosphere. In case of persistent symptoms, consult a doctor.

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 4.1.2 In case of skin contact:
Wash with soap and water.
4.1.3 In case of eyes contact:
Rinse immediately with plenty of water. If irritation persists, seek medical attention.
4.1.4 In case of ingestion:
No adverse health effects anticipated by this route, however, in the event of ingestion, increase intake of liquid in order to flush
from the body. In case of persistent symptoms, consult a doctor.
4.2 Most important symptoms and effects, both acute and delayed:
Suspected of causing cancer.
4.3 Indication of any immediate medical attention and special treatment needed:
If skin irritation or rash occurs, get medical advice/attention.

Section 5 Fire-Fighting measures

5.1 Extinguishing media:
Suitable extinguishing media: Use any media appropriate for combustible material in the area.
Unsuitable extinguishing media: Not available.
5.2 Special hazards arising from the
Product is inert, non flammable and non combustible.
substance or mixture
5.3 Advice for firefighters: As in any fire, wear a self-contained breathing apparatus in pressure-demand,
MSHA/NIOSH (approved or equivalent), and full protective gear.

Section 6 Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures:
6.1.1 For non-emergency personnel: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use
personal protective equipment. Information regarding personal protective
measures see, Section 8.
6.1.2 For emergency responders: Wear an appropriate NIOSH/MSHA approved respirator if mist, vapor or dust is
generated.
6.2 Environmental Precautions: Prevent run-off from entering ground, storm sewers and ditches which lead to
natural waterways.
6.3 Methods for Containment and Cleaning Use any feasible mechanical means (e.g. vacuum, sweeping) but avoid dusting
up: during clean-up. The product can cause slippery conditions if wet. Even at low
concentration, the product renders the discharge in liquid effluent highly visible.
6.4 Reference to other sections: See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for information on disposal.

Section 7 Handling and storage

7.1 Precautions for safe handling:
7.1.1 Protective measures: Avoid raising dust. Handling systems and areas should be operated in such a way
as to minimise exposure to dust.
7.1.2 Advice on general occupational Do not eat, drink and smoke in work areas. Wash hands after use. Remove
hygiene: contaminated clothing and protective equipment before entering eating areas.
7.2 Conditions for safe storage, including Stored in a cool, dry, ventilated area. Pigments should not be stored in outside
any incompatibilities: areas exposed to the weather. Care should be taken to avoid exposure to moisture.
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 Packing material: Paper, Plastic.
7.3 Specific end use(s): Not applicable.

Section 8 Exposure Controls/Personal Protection

8.1 Control parameters:
8.1.1 Occupational exposure limits:
Occupational Exposure Limit Occupational Exposure Limit
Value (8-hour reference Value (15-minute reference
period) period)
Country Substance EINECS No. CAS No. ppm mg/ m3 ppm mg/ m3 Note
Ireland Titanium dioxide
total inhalable dust 215-185-5 1310-73-2 - 10 - - -
respirable dust - 4 - - -
8.1.2 Additional exposure limits under the Not available.
conditions of use:
8.1.3 DNEL/DMEL and PNEC-Values: Not available.
8.2 Exposure controls:
8.2.1Appropriate engineering controls: Production facilities should be provided with running drinking water, local and
general aspiration system. In facilities, where titanium dioxide is handled, eating
and food storage are not permitted.
8.2.2 Individual protection measures, such as personal protective equipment:
Eye/face protection: The use of dustproof goggles or glasses with side protections is recommended if
dust concentrations are likely to exceed the occupational exposure limit.
Hand protection: Glove material: Use protective gloves according to EN374 to prevent skin contact
with dust., Break through time: > 60 min.
Body protection: Respect main rules concerning the protection clothes for chemicals handling.
Respiratory protection: Avoid breathing dust. In case of insufficient ventilation, wear suitable respiratory
equipment.
Thermal hazards: Wear suitable protective clothing to prevent heat.
8.2.3 Environmental exposure controls: Avoid discharge into the environment.
According to local regulations, Federal and official regulations.

Section 9 Physical and chemical properties

9.1 Information on basic physical and chemical properties:
Appearance: Solid
Colour: White
Odour: Odorless
Odour threshold: Not available
pH: 7
Melting point/range (°C): 1560 °C
Boiling point/range (°C): ca. 3000 °C
Flash point (°C): Not available
Evaporation rate: Not available
Flammability limit - lower (%): Not available
Flammability (solid, gas): Not available
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 Ignition temperature (°C): Not available
Upper/lower flammability/explosive limits: Not available
Vapour pressure (20°C): Not available
Vapour density: Not available
Relative Density: 4.17 , 20 °C
Bulk density (kg/m3): Not available
Water solubility (g/l): Insoluble (< 0.1 mg/L)
n-Octanol/Water (log Po/w): Not available
Auto-ignition temperature: Not available
Decomposition temperature: Not available
Viscosity, dynamic (mPa.s): Not available
Explosive properties: Not available
Oxidising properties: Not available
Molecular Formula: TiO2
Molecular Weight: 79.8658
9.2. Other information:
Fat solubility(solvent– oil to be specified) Insoluble
etc:
Surface tension: Not available
Dissociation constant in water( pKa): Not available
Oxidation-reduction Potential: Not available
Specific gravity: Not available

Section 10 Stability and reactivity

10.1 Reactivity: The substance is stable under normal storage and handling conditions.
10.2 Chemical stability: Stable at room temperature in closed containers under normal storage and
handling conditions.
10.3 Possibility of hazardous reactions: No dangerous reactions known.
10.4 Conditions to avoid: Incompatible materials.
10.5 Incompatible materials: Strong oxidizing agents.
10.6 Hazardous decomposition products: Titanium/titanium oxides.

Section 11 Toxicological information

11.1 Information on toxicological effects:
Acute toxicity:
LD50(Oral, Rat): > 2000 mg/kg bw
LD50(Dermal, Rabbit): Not available
LC50(Inhalation, Rat): > 6.82 mg/L,4h, male
Skin corrosion/Irritation: Not classified
Serious eye damage/irritation: Not classified
Respiratory or skin sensitization: Not classified
Germ cell mutagenicity: Not classified
Carcinogenicity: Suspected of causing cancer.

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Reproductive toxicity: Not classified
STOT- single exposure: Not classified
STOT-repeated exposure: Not classified
Aspiration hazard: Not classified

Section 12 Ecological information

12.1 Toxicity:
Acute (short-term) toxicity:
LC50(96h, Fish): Not available
EC50 (48h, Crustacea): > 100 mg/L
EC50(72h, Algae/aquatic plants): Not available
Chronic (long-term) toxicity:
NOEC(Fish): >= 160 mg/L
NOEC(Crustacea): >= 100 mg/L
NOEC (Algae/aquatic plants): >= 1 mg/L
12.2 Persistence and degradability: Biodegradability [BD = (BOD5 : COD) • 100 %] : <10% (practically
nonbiodegradable)
Chemical oxygen demand (COD): nonoxidizable.
Biological oxygen demand (BOD): nonoxidizable.
The substance half life: > 30 days.
Persistence and biodegradability-is resistant to degradation and isn’t subject to
biodegradation.
12.3 Bioaccumulative potential: Cumulativeness: weak.
12.4 Mobility in soil: Toxic effect on soil invertebrates: bacterial toxicity: EC0> 5000 mg/l (Pseudomonas
fluorescens, Escherichia coli; 24 hours).
12.5 Results of PBT&vPvB assessment: PBT assessment does not apply.
12.6 Other adverse effects: Do not empty into drains.

Section 13 Disposal considerations

13.1 Waste treatment methods: Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. Additionally, waste generators must consult state
and local hazardous waste regulations to ensure complete and accurate
classification. If empty container retains product residues, all label precautions
must be observed. Return for reuse or dispose according to national or local
regulations.

Section 14 Transport information

Land transport Inland waterways Sea transport Air transport

(ADR/RID) (ADN) (IMDG) (ICAO/IATA)

UN number Not regulated Not regulated Not regulated Not regulated

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UN Proper shipping name Not regulated Not regulated Not regulated Not regulated

Transport hazard Class(es) Not regulated Not regulated Not regulated Not regulated

Packing group Not regulated Not regulated Not regulated Not regulated

Environmental hazards No No No No

Special precautions for user See section 2.2 See section 2.2 See section 2.2 See section 2.2

Transport in bulk according to

Annex II of Marpol and the IBC Not regulated Not regulated Not regulated Not regulated
Code

Section 15 Regulation information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture:
Relevant information regarding authorization: Not applicable.
Relevant information regarding restriction: Not applicable.
Other EU regulations: Employment restrictions concerning young person must be observed. For
use only by technically qualified individuals.
Other National regulations: Not applicable
15.2 Chemical Safety Assessment has been carried out? YES X NO

Section 16 Other information

16.1 Indication of changes:
Version 1.2 Amended by EU No 830/2015
16.2 Abbreviations and acronyms:
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation for rail International transportation of Dangerous goods
ADN: European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways
IMDG: Code international maritime dangerous goods code
ICAO: International Civil Aviation Organization
IATA: International Air Transport Association
LC50: median lethal concentration
EC50: The effective concentration of substance that causes 50% of the maximum response.
NOEC: No Observed Effect Concentration
DNEL: derived no-effect level
PNEC: predicted no-effect concentration
16.3 Key literature references and sources for data
ECHA Registered substances data
16.4 Classification and procedure used to derive the classification for mixtures according to Regulation (EC)
1272/2008 [CLP]
Classification according to Regulation (EC) No. 1272/2008 Classification procedure
Carc. 2 H351 On basis of test data
16.5 Relevant H-statements (number and full text):
H351: Suspected of causing cancer
16.6 Training instructions:
Not applicable.

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16.7 Further information:
This information is based upon the present state of our knowledge. This SDS has been compiled and is solely intended for this
product.
16.8 Notice to reader:
Employers should use this information only as a supplement to other information gathered by them, and should make
independent judgment of suitability of this information to ensure proper use and protect the health and safety of employees. This
information is furnished without warranty, and any use of the product not in conformance with this Safety Data Sheet, or in
combination with any other product or process, is the responsibility of the user.
Author: Hangzhou REACH Technology Group Co., Ltd. Website:www.cirs-group.com Tel:0571-87206555 Email:[email protected]

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