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BP801T - Biostatistics and Research Methodology - Theory

Biostatistics notes

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42 views2 pages

BP801T - Biostatistics and Research Methodology - Theory

Biostatistics notes

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subiagulfishan12
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FACULTY OF PHARMACY

Eighth Semester Bachelor of Pharmacy


In Effect from Academic Year 2020-21

Subject Code: BP801T Subject Title: BIOSTATISTICS AND RESEARCH METHODOLOGY-THEORY


Pre-requisite Subject - NONE -

Scope: To understand the applications of Biostatics in Pharmacy. This subject deals with descriptive statistics,
Graphics, Correlation, Regression, logistic regression Probability theory, Sampling technique, Parametric tests, Non
Parametric tests, ANOVA, Introduction to Design of Experiments, Phases of Clinical trials and Observational and
Experimental studies, SPSS, R and MINITAB statistical software’s, analyzing the statistical data using Excel.

Objectives: Upon completion of the course the student shall be able to


 Know the operation of M.S. Excel, SPSS, R and MINITAB®, DoE (Design of Experiment)
 Know the various statistical techniques to solve statistical problems
 Appreciate statistical techniques in solving the problems

Teaching Scheme (Hours per week) Evaluation Scheme (Marks)


Theory(T)
Total Marks
Lecture Tutorial Practical Credit University Continuous
Assessment Assessment Theory
3 1 NA 4 75 25 100

Subject Contents
Total Weight
Sr. Hours (%)
Topic
No. (45
hours)
1 UNIT-I 10 22
Introduction: Statistics, Biostatistics, Frequency distribution
Measures of central tendency: Mean, Median, Mode- Pharmaceutical examples
Measures of dispersion: Dispersion, Range, standard deviation, Pharmaceutical
problems
Correlation: Definition, Karl Pearson’s coefficient of correlation, Multiple correlation -
Pharmaceuticals examples
2 UNIT-II 10 22
Regression: Curve fitting by the method of least squares, fitting the lines y= a + bx and
x = a + by, Multiple regression, standard error of regression– Pharmaceutical Examples
Probability: Definition of probability, Binomial distribution, Normal distribution,
Poisson’s distribution, properties - problems
Sample, Population, large sample, small sample, Null hypothesis, alternative
hypothesis, sampling, essence of sampling, types of sampling, Error-I type, Error-II
type, Standard error of mean (SEM) - Pharmaceutical examples
Parametric test: t-test (Sample, Pooled or Unpaired and Paired), ANOVA, (One way
and Two way), Least Significance difference
3 UNIT-III 10 22
Non Parametric tests: Wilcoxon Rank Sum Test, Mann-Whitney U test, Kruskal-Wallis
test, Friedman Test
Introduction to Research: Need for research, Need for design of Experiments,
Experiential Design Technique, plagiarism
Graphs: Histogram, Pie Chart, Cubic Graph, response surface plot, Counter Plot graph
FACULTY OF PHARMACY
Eighth Semester Bachelor of Pharmacy
In Effect from Academic Year 2020-21

Designing the methodology: Sample size determination and Power of a study, Report
writing and presentation of data, Protocol, Cohorts studies, Observational studies,
Experimental studies, Designing clinical trial, various phases.
4 UNIT-IV 08 18
Blocking and confounding system for Two-level factorials
Regression modeling: Hypothesis testing in Simple and Multiple regression models
Introduction to Practical components of Industrial and Clinical Trials Problems:
Statistical Analysis Using Excel, SPSS, MINITAB®, DESIGN OF EXPERIMENTS, R - Online
Statistical Software’s to Industrial and Clinical trial approach
5 UNIT-V 07 16
Design and Analysis of experiments:
Factorial Design: Definition, 22, 23design. Advantage of factorial design
Response Surface methodology: Central composite design, Historical design,
Optimization Techniques

Recommended Books (Latest Editions)


1. Pharmaceutical statistics- Practical and clinical applications, Sanford Bolton, publisher Marcel Dekker Inc.
NewYork.
2. Fundamental of Statistics – Himalaya Publishing House- S.C.Guptha
3. Design and Analysis of Experiments –PHI Learning Private Limited, R. Pannerselvam,
4. Design and Analysis of Experiments – Wiley Students Edition, Douglas and C. Montgomery

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