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Dissolution Study Leshminiasis

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Jigyasa Singh
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0% found this document useful (0 votes)
10 views

Dissolution Study Leshminiasis

Uploaded by

Jigyasa Singh
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as XLSX, PDF, TXT or read online on Scribd
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Standard callibration Curve

Concentration µg/mAbsorbance
100 0.123
200 0.357
300 0.627
400 0.956
500 1.276

Slope 0.2614

TIME (Hours) abs concµg/ml dilution factor*10ml concentration mg/ml in 900ml


0 0 0 0 0
2 0.313 1.1973986228003 11.9739862280031 10.7765876052028
4 0.554 2.1193573068095 21.1935730680949 19.0742157612854
6 0.673 2.5745983167559 25.7459831675593 23.1713848508034
8 0.789 3.0183626625861 30.1836266258607 27.1652639632747
10 0.993 3.7987758224943 37.9877582249426 34.1889824024483
12 1.006 3.8485080336649 38.4850803366488 34.6365723029839
14 1.156 4.4223412394797 44.2234123947972 39.8010711553175
16 1.145 4.38026013772 43.8026013771997 39.4223412394797
18 1.254 4.7972456006121 47.9724560061209 43.1752104055088
20 1.379 5.2754399387911 52.7543993879112 47.4789594491201
22 1.453 5.5585309869931 55.5853098699311 50.026778882938
24 1.445 5.5279265493497 55.2792654934966 49.7513389441469
Miltefosine
1.4
1.2 f(x) = 0.002905 x − 0.2037
R² = 0.995127204685468
1
ABSORBANCE

0.8
0.6
0.4
0.2
0
50 100 150 200 250 300 350 400 450 500 550
CONCENTRATION

cumultative %Drug realease


0 0
10.776587605 10.7765876052
29.850803366 29.8508033665 % Drug release
42.245600612 42.2456006121 120
50.336648814 50.3366488141
100 f(x) = 4.03143050522546 x + 12.2063781665924
61.354246366 61.3542463657 R² = 0.951634271762939
80
% drug release

68.825554705 68.8255547054
74.437643458 74.4376434583 60
79.223412395 79.2234123948 40
82.597551645 82.597551645
90.654169855 90.6541698546 20
97.505738332 97.5057383321 0
99.778117827 99.7781178271 0 5 10 15 20 25
Time
µg

g release

22546 x + 12.2063781665924
62939

15 20 25 30
Time

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