MMSU-­‐College

 of  Medicine  
PATHOLOGY    
COURSE  OUTLINE  
SY  2022-­‐2023  
 
DATE   TOPICS   LECTURER  
  I. FIRST  SEMESTER    
August  16                                A.    Cell  as  a  Unit   Dr.  Tanawit  
1. The  Genome  
2. Cellular  Housekeeping  
3. Cellular  Metabolism  and  Mitochondrial  
Function  
4. Cellular  Activation  
5. Signal  Transduction  Pathways  
6. Growth  Factors  and  Receptors  
7. Interaction   with   the   Extracellular  
Matrix  
8. Maintaining  Cell  Populations  
August  30   B. Cell  injury  and  cell  death  &  Adaptation   Dr.  Alcaraz  
1. Introduction  to  Pathology  
2. Overview   of   Cellular   Response   to  
Stress  and  Noxious  Stimuli  
3. Reversible  Cell  Injury  
4. Mechanism  of  Cell  Injury  
5. Clinicopathologic  Correlations  
6. Adaptations   of   Cellular   Growth   &  
Differentiation  
7. Intercellular  Accumulations  
8. Pathologic  Calcifications  
9. Cellular  Aging  
September  6   C.  Inflammation  and  Repair   Dr.  Natoza  
1. Overview  
2. Acute  Inflammation  
3. Chronic  Inflammation  
4. Systemic  Effects  of  Inflammation  
5. Tissue  Repair  
September  12-­‐16      
PRELIM  EXAMINATION  
 
September  20   D.  Hemodynamic  disorder     Dr.  Leaño  
1. Edema  and  Effusion  
2. Hyperemia  and  congestion  
3. Hemorrhage  
4. Hemostasis    and  thrombosis    
5. Embolism  
6. Infraction  
7. Shock  
September  27   E.  Genetic  Disorder   Dr.  Tanawit  
1. Mutation  
2. Mendelian  Disorder  
3. Normal  karyotype  
4. Cytogenetic  disorder  
5. Single  gene  disorder  with  a  non-­‐classic  
inheritance  
6. Molecular  diagnosis  
October  4   F.  Immune  System   Dr.  Alcaraz  
1. Normal  Immune  Response  
2. Hypersensitivity    
3. Autoimmune  Diseases  
4. Rejection  of  Tissue  Transplants  
5. Immunodeficiency  Diseases  
6. Amyloidosis  
October  11   G.    Neoplasia   Dr.  Natoza  
1. Definition  
2. Nomenclature  
3. Characteristic  of  benign  and  malignant  
neoplasia  
4. Molecular  basis  of  cancer  
5. Biology  of  tumor  growth  
6. Carcinogenic   agents   and   their   cellular  
interaction  
7. Host   defense   against   tumor   -­‐   tumor  
immunity  
8. Clinical  Aspects  of  Neoplasia  
October  18   H.  Infectious  Diseases   Dr.  Leaño  
1. General   Principles   of   Microbial  
Pathogenesis  
2. Viral  Infection  
3. Bacterial  Infection  
4. Fungal  Infection  
5. Parasitic  Infection  
6. STI  
7. Emerging  Infectious  Diseases  
8. Techniques   for   Diagnosis   of   Infectious  
Agents  
October  25      
MIDTERM  EXAMINATION  

November  8   I.  Environmental  &  nutritional  pathology   Dr.  Tanawit  

1. Health  Effects  of  Climate  Change  
9. Toxicity   of   Chemical   and   Physical  
Agents  
10. Environmental  Pollution  
11. Occupational  Health  Risks  
12. Effects  of  Alcohol  
13. Injury  of  Drugs:  Therapeutic  &  Abuse  
14. Injury  by  Physical  Agents  
15. Nutritional  Disease  
November  15            J.  Disease  of  Infancy  and  Childhood   Dr.  Alcaraz  
1. Congenital  Anomalies  
2. Prematurity   and   Fetal   Growth  
Restriction  
3. Perinatal  Infections  
4. Fetal  Hydrops  
5. Inborn   Errors   of   Metabolism   and  
Genetic  Disorders  
6. SIDS  
7. Tumor  and  Tumor  like  Lesions  
November  22   K.  Blood  Vessels   Dr.  Natoza  
1. Vascular  Structures  and  Functions  
2. Vascular  Anomalies  
3. Vascular  Wall  Response  to  Injury  
4. Hypertensive  Vascular  Disease  
 5. Arteriosclerosis  
6. Aneurysm  and  Dissection  
7. Vasculitis  
8. Disorder   of   Blood   Vessel  
Hyperreactivity  
9. Veins  and  Lymphatics  
10. Vascular  Tumors  
11. Vascular  Intervention  Pathology  
November  29   L.  Heart   Dr.  Leaño  
1. Cardiac  Structures  
2. Cardiac  Pathophysiology  
3. Heart  Failure  
4. Cardiac  Development  
5. Congenital  Heart  Disease  
6. Ischemic  Heart  Disease  
7. Arryhtmias  
8. Hypertensive  Heart  Disease  
9. Valvular  Heart  Disease  
10. Cardiomyopathies  
11. Pericardial  Disease  
12. Tumors  of  the  Heart  
13. Cardiac  Transplantation  
14. Cardiac  Devices  
December  6   M.    WBC,  Lymph  Nodes,  Spleen  &  Thymus   Dr.  Alcaraz  
1. Leukopenia  
2. Reactive  Proliferations  
3. Neoplastic  Proliferations  
4. Lymphoid  Neoplasm  
5. Myeloid  Neoplasm  
6. Spleen    
7. Thymus  
December  12-­‐16   Final  Examination    
 
December  20-­‐21   REMEDIAL    
 
December  22   Promotion  Board    
 
SECOND  SEMESTER  
January  3   I.    Red  Blood  Cells  &  Bleeding  Disorders   Dr.  Tanawit  
1. Anemias  
2. Polycythemias  
3. Bleeding   Disorders:   Hemorrhagic  
Diatheses  
January  10   II.  Lung   Dr.  Natoza  
1. Congenital  Anomalies  
2. Atelectasis  
3. Pulmonary  Edema  
4. Acute  Lung  Injury  &  ARDS  
5. Obstructive   and   Restrictive   Lung  
Disease  
6. Chronic  Diffuse  Interstitial  Disease  
7. Disease  of  Vascular  Origin  
8. Pulmonary  Infections  
9. Lung  Transplantation  
10. Tumors  
11. Pleura  
January  17   III.  Head  and  Neck   Dr.  Leaño  
1. Oral  Cavity  Lesions  
2. Upper  Airway  Lesions  
3. Ear  Lesions  
4. Neck  Lesions  
5. Salivary  Gland  
January  24   IV.  Gastrointestinal  Tract   Dr.  Tanawit  
1. Congenital  Anomalies  
2. Esophageal  Lesions  
3. Gastric  Lesions  
4. Small  Intestine  and  Colon  
5. Peritoneal  Cavity  
January  31   V.  Liver  and  Gallbladder   Dr.  Alcaraz  
1. General  Features  
2. Infectious  Disoders  
3. Autoimmune  Hepatitis  
4. Fatty  Liver  
5. Inherited  Disease  
6. Cholestatic  Disease  
7. Structural  anomalies  
8. Circulatory  Disorders  
9. Pregnancy  associated  Disease  
10. Nodules  and  Tumors  
11. Gallbladder  
February  6-­‐10   PRELIMINARY  EXAMINATION    
 
February  14     VI.  Pancreas   Dr.  Natoza  
1. Congenital  Anomalies  
2. Pancreatitis  
3. Nonneoplastic  Cysts  
4. Neoplasm  
February  21     VII.  Kidney   Dr.  Tanawit  
1. Glomerular  Disease  
2. Tubular  and  Interstitial  Diseases  
3. Vascular  Diseases  
4. Congenital  Anomalies  
5. Cystic  Disease  
6. Obstructive  Uropathy  
7. Urolithiasis  
8. Neoplasm  
February  28   VIII.  Lower  Urinary  Tract  and  Male  Genital   Dr.  Leaño  
1. Ureter  
2. Urinary  Bladder  
3. Urethra  
4. Penile    
5. Testis  and  Epididymis  
6. Prosate  
March  7   IX.  Female  Genital  Tract    
1. Infections   Dr.  Alcaraz  
2. Vulvar  Lesions  
3. Vaginal  Lesions  
4. Cervical  Lesions  
5. Uterine  Lesions  
6. Ovarian  Lesions  
7. Gestational  and  Placental  Lesions  
March  14   X.  Breast   Dr.  Natoza    
1. Developmental  Diseases  
 2. Inflammatory  Disorders  
3. Benign  Lesions  
4. Carcinoma  
5. Stromal  Tumors  
6. Other  Malignancies  
March  20  -­‐  24   MIDTERM  EXAMINATION      
 
March  28   XI.  Endocrine  System   Dr.  Tanawit  
1. Pituitary  Gland  diseases  
2. Thyroid  Gland  diseases  
3. Parathyroid  Gland  diseases  
4. Pancreatic  Diseases  
5. Adrenal  Gland  Diseases  
6. MEN  
7. Pineal  Gland  
April  4   XII.  Skin   Dr.  Alcaraz  
1. Disorders  of  pigmentation  
2. Benign  Lesions  
3. Adnexal  Tumors  
4. Dermal  Tumors  
5. Tumor  of  Cellular  Migrants  
6. Epidermal  Maturation  disorders  
7. Acute   and   Chronic   Inflammatory  
disorders  
8. Bullous  Diseases  
9. Epidermal  Appendage  Disease  
10. Paniculitis  
11. Infection  
April  11   XIII.  Bones,  Joints  &  Soft  Tissue  Tumors   Dr.  Natoza  
1. Basic  Structure  and  Functions  
2. Developmental  Disorders  
3. Metabolic  Diseases  of  Bone  
4. Fractures  
5. Osteonecrosis  
6. Osteomyelitis  
7. Bone  Tumors  
8. Arthritis  
9. Joint  Tumors  
10. Soft  Tissue  Tumors  
April  18   XIV.  Peripheral  Nerves  and  Skeletal  Muscles   Dr.  Leaño  
1. Diseases  of  PNS  
2. Diseases  of  NMJ  
3. Diseases  of  Skeletal  Muscle  
4. Peripheral  Nerve  Sheath  Tumors  
April  25   XV.  CNS   Dr.  Tanawit  
1. Cellular  Pathology  
2. Cerebral    Edema  &  Pressure  
3. Malformations  
4. Perinatal  Brain  Injury  
5. Cerebrovascular  disease  
6. Infections  
7. Demyelinating  Diseases  
8. Neurodegenerative  Diseases  
9. Genetic  Metabolic  Diseases  
10. Toxic  and  Metabolic  Diseases  
11. Tumors  
 May  2                                XVI.  Eye   Dr.  Alcaraz  
1. Orbit  
2. Eyelid  
3. Conjunctiva  
4. Sclera  
5. Cornea  
6. Anterior  Segment  
7. Uvea  
8. Retina  &  Vitreous  
9. Optic  Nerve  
10. End  Stage  Eye  
 
May  9   LABORATORY  ACTIVITY     a.  
QUIZZES  
COMPLETION  
May    15-­‐19   FINAL  EXAMINATION   b.  
May    22-­‐24   REMEDIAL  EXAMINATION   a.  
May  25   PROMOTION  BOARD   b.  
 
 

Grading  System:  

ITEMS   EQUIVALENT  (%)  

Quizzes   20  
Prelim,  Midterm,  Final  Exams   60  
Long  Practical  Exam   20  
Laboratory  Application   5  
Class  participation  and  Attendance   5  
TOTAL   100  
 

Textbook:  

  Robbins  and  Cotran  Pathologic  Basis  of  Disease  10th  Edition  

  Junqueira’s  Basic  Histology  16th  Edition  
 
Optional  
  Rosai  and  Ackerman’s  Surgical  Pathology  11th  Edition    
  Blausteins  Pathology  of  the  Female  Genital  Tract  7th  Edition  
  WHO  Classification  of  Different  Tumors  
AJCC  Cancer  Staging  Manual  8th  Edition